Clinical trials: Spasticity
Cerebral Palsy
Moderate Versus High-intensity Interval Training in Children With Diplegia.
The aim is to compare the effects of moderate-intensity training and high-intensity interval training on gait, energy expenditure, and functional mobility in children with spastic diplegia.
- Trial name
- NCT07289373
- Testing
- Moderate intensity training, High intensity interval training
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Cerebral Palsy
Short-term Spinal Stimulation Effects in Cerebral Palsy
This research study will examine the acute effects of non-invasive spinal stimulation on spasticity and walking in individuals with cerebral palsy.
- Trial name
- NCT07826494
- Testing
- Spinal Stimulation, Treadmill Walking
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Pediatrics, Muscle Spasticity
BOTOX® Treatment in Pediatric Upper Limb Spasticity
This study will evaluate the safety and efficacy of BOTOX® (botulinum toxin Type A) in pediatric patients with upper limb spasticity.
- Conditions
- Pediatrics, Muscle Spasticity, Cerebral Palsy, Stroke
- Trial name
- NCT01603602
- Testing
- botulinum toxin Type A
- Where
- 45 sites in United States, Canada and 7 more
- Volunteers
- 235 people
- Sponsor
- Allergan
Cerebral Palsy, Spastic
Incentive Spirometer as a Visual Feedback in Children With Spastic Cerebral Palsy
Objective: To compare the effects of incentive spirometer as a visual feedback versus deep breathing via mirror mediated therapy on pulmonary function in children with spastic cerebral palsy.
- Trial name
- NCT05945953
- Testing
- Incentive spirometer as visual feedback, Diaphragmatic breathing exercise (Mirror mediated therapy)
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Cerebral Palsy, Whole Body Vibration
Effects of WBV in Children With Hemiparetic CP
The aim of this study was to investigate short and long-term effects of Whole Body Vibration therapy on spasticity and motor performance in children with hemiparetic cerebral palsy in addition to conventional physiotherapy.
- Conditions
- Cerebral Palsy, Whole Body Vibration, Spastic Hemiplegia, Motor Performance
- Trial name
- NCT04528966
- Testing
- Whole-Body Vibration, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Pamukkale University
Diplegia, Spastic
The Effect of Fine Motor Skills Training Through Telerehabilitation in Children With Diplegic Cerebral Palsy
The aim of this study is to compare the effect of occupational therapy intervention through two-way video call, versus occupational therapy home program in written form; on handwriting skills, occupational performance, fine motor…
- Trial name
- NCT05169294
- Testing
- Telerehabilitation Program, Written Home Program
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ekin Akpınar
Cerebral Palsy
The Effect of Instrument Assisted Soft Tissue Mobilization and Stretching Exercises in Cerebral Palsy
The aim of the study; To investigate the effects of Instrument Assisted Soft Tissue Mobilizations and Stretching Exercises on flexibility, spasticity, balance and functional mobility in patients with CP.
- Trial name
- IASTM (NCT05042570)
- Testing
- Instrument Assisted Soft Tissue Mobilization, Stretching Exercises, Control Group / NDT program
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Cerebral Palsy Spastic Hemiplegic, Functionnal Neurological Disorder
Virtual Reality-Augmented Constraint-Induced Movement Therapy Versus Conventional Constraint-Induced Therapy for Upper Limb Rehabilitation in Children With Unilateral Cerebral Palsy.
Cerebral palsy (CP) causes persistent motor and postural impairments that can limit children's functional independence and participation.
- Conditions
- Cerebral Palsy Spastic Hemiplegic, Functionnal Neurological Disorder, Upper Limb Functions, Virtual Reality Based Therapy
- Trial name
- NCT07853937
- Testing
- Rehabilitation intervention
- Where
- Tunisia
- Volunteers
- 30 people
- Sponsor
- Faculty of Medicine, Sousse
Spastic/Dystonic Quadriplegia, Cerebral Palsy (CP)
Outcomes of Neurosurgical Tone Management
Patients with spastic/dystonic quadriplegia (GMFCS IV/V) are often severely disabled by their tone, and require surgical tone management to improve quality of life, allow for better function, improve comfort, and range of motion.
- Trial name
- NCT07817745
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Cerebral Palsy, Spastic, Hemiplegia, Spastic
Changes in Motor and Cognitive Function on Unilateral Spastic Cerebral Palsy, Associated With Videogame Therapy
The use of interactive applications associated with position and movement sensors has begun to spread as an option for the reinforcement of physical rehabilitation therapies in patients with congenital or acquired motor disorders…
- Trial name
- NCT05557305
- Testing
- Videogame therapy, Conventional therapy
- Where
- Mexico
- Volunteers
- 84 people
- Sponsor
- Universidad Nacional Autonoma de Mexico
Cerebral Palsy
Individual Patient Expanded Access IND of Hope Biosciences Autologous Adipose-derived Mesenchymal Stem Cells for the Treatment of Cerebral Palsy
This is an Individual Patient Expanded Access Protocol of Autologous HB-adMSCs for the Treatment of Cerebral Palsy (CP) with the primary goal of treating 1 individual with CP who has exhausted all treatment options, his condition…
- Trial name
- NCT04029896
- Testing
- HB-adMSCs
- Where
- United States
- Sponsor
- Hope Biosciences Research Foundation
Cerebral Palsy
Effects of Multimodal Neuro Rehabilitation on Cortical Activity and Muscle Syenergy in Spastic Cerebral Palsy
To determine the effects of tDCS in conjunction with task-oriented training (TOT) and virtual reality (VR) as compared with sham stimulation and conventional physiotherapy on cortical activity and muscle synergy.
- Trial name
- NCT07574996
- Testing
- Active Anodal Transcranial Direct Current Stimulation (tDCS) + Task-Oriented Training, Active Anodal Transcranial Direct Current Stimulation + Virtual Reality, Conventional Physiotherapy
- Volunteers
- 150 people
- Sponsor
- Riphah International University
Cerebral Palsy, Spastic
Comparison of Short- and Long-time Action Observation Training on Upper Limb Function in Children With Cerebral Palsy
To compared short- and long-time action observation training (AOT) in terms of grip strength, the Jebsen Taylor Hand Function Test (JTHF), the Quality of Upper Extremities Skills Test (QUEST), and the ABILHAND-Kids test.
- Trial name
- NCT03201237
- Testing
- Action observation training
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Inje University
Cerebral Palsy, Spastic Diplegia
MEOPA to Improve Physical Therapy Results After Multilevel Surgery
Children with cerebral palsy commonly undergo "multilevel surgery", meaning several lower limb combined procedures performed during the same surgical intervention.
- Conditions
- Cerebral Palsy, Spastic Diplegia, Quadriplegia, Hemiplegia
- Trial name
- KINOPA (NCT00632528)
- Testing
- MEOPA, Medicinal air
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Palsy
Effects of Dynamic Flex Cast With Neurodevelopmental Treatment on Gross Motor Functions in Cerebral Palsy
The study aims to determine the effects of dynamic flex cast with neurodevelopmental treatment on gross motor functions and gait in children with cerebral palsy.
- Trial name
- NCT05751122
- Testing
- Dynamic flex cast with neurodevelopmental treatment, Rigid Ankle foot Orthosis with neurodevelopmental treatment
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Muscle Spasticity
Effects of Soft Tissue Lengthening on Gait in Children With Spasticity
This research project is being conducted to investigate changes in secondary impairments, functional mobility skills, and gait variables in children with spasticity following selective percutaneous myofascial lengthening.
- Trial name
- NCT04090892
- Testing
- selective percutaneous muscle release
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Texas Southwestern Medical Center
Hereditary Spastic Paraplegia, Neurodegenerative Diseases
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)
The purpose of the HSP Sequencing Initiative is to better understand the role of genetics in hereditary spastic paraplegia (HSP) and related disorders.
- Conditions
- Hereditary Spastic Paraplegia, Neurodegenerative Diseases, Pediatric Disorder, Spasticity, Muscle
- Trial name
- NCT05354622
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Boston Children's Hospital
Cerebral Palsy, Cerebral Palsy, Spastic
Effects of Hand and Arm Bimanual Intensive Therapy Including Lower Extremity in Spastic Cerebral Palsy
Cerebral palsy (CP), particularly the spastic diplegic subtype, is characterized by motor impairments such as spasticity and mobility limitations.
- Trial name
- HABIT-ILE (NCT07253857)
- Testing
- GROUP -A , Hand and Arm Bimanual Intensive Therapy Including Lower Extremity, GROUP-B , Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Diplegic Spastic Cerebral Palsy
Effects OF NMES With and Without Dynamic Bracing on Spasticity and Movement Quality in CP
The study aims at comparing Neuromuscular electrical Stimulation with and without dynamic bracing on spasticity and movement quality of lower limb in Children with Cerebral Palsy
- Trial name
- NCT06303336
- Testing
- NMES with Dynamic Bracing, NMES without Dynamic Bracing, Dynamic Bracing Only
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Spastic Diplegia Cerebral Palsy
Post Facilitation Stretch, Post Isometric Relaxation and Myofascial Release in Spastic Cerebral Palsy.
The purpose of the study is to compare the effect of Post Facilitation Stretch, Post Isometric Relaxation and Myofascial Release on Lower Limb Spasticity in Spastic Cerebral Palsy.
- Trial name
- NCT06686719
- Testing
- Post Facilitation, Post Isometric Relaxation, Myofascial Release
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University