Clinical trials: Spinal Disorders/Injuries
Spinal Cord Injuries
Transcutaneous Spinal Cord Electrical Stimulation Combined With Kunming Locomotor Training for the Treatment of Spinal Cord Injury
Spinal cord injury (SCI) is a common and severe traumatic central nervous system injury in clinical practice. Currently, the treatment of SCI remains a worldwide challenge.International studies have confirmed that TSCS is an…
- Trial name
- NCT06802640
- Testing
- Transcutaneous spinal cord electrical stimulation and Kunming Locomotor Training
- Volunteers
- 18 people
- Sponsor
- Kunming Tongren Hospital
Spinal Cord Injury
Autologous Stem Cells for Spinal Cord Injury (SCI) in Children
The purpose of this research study is: 1. To see if Bone Marrow Cell harvest and transplantation are safe in children with Spinal Cord Injury, and 2.
- Trial name
- NCT01328860
- Testing
- bone marrow progenitor cells (BMPC) autologous transplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Aryn Knight
Acute Spinal Cord Injury, Spinal Cord Injuries
Optical Monitoring With Near-Infrared Spectroscopy for Spinal Cord Injury Trial
The study involves the 'first-in-human' evaluation of a novel optical sensor which uses near-infrared spectroscopy (NIRS) technology to assess oxygenation and hemodynamics of the injured spinal cord.
- Trial name
- NCT04811235
- Testing
- Near Infra-Red Spectroscopy (NIRS) Sensor
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of British Columbia
Fibrolipoma of Filum Terminale, Lipomyelomeningocele
Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence
Purpose of study : to determine the preventive effect of acetazolamide administration, prone positioning, and the combination of both following the neurosurgical interventions in lumbosacral region for cerebrospinal fluid (CSF)…
- Conditions
- Fibrolipoma of Filum Terminale, Lipomyelomeningocele, Split Cord Malformation, Dermal Sinus
- Trial name
- NCT01867268
- Testing
- Acetazolamide, prone positioning, Acetazolamide+ prone positioning
- Where
- Iran
- Volunteers
- 144 people
- Sponsor
- Tehran University of Medical Sciences
Spinal Cord Injury, Spinal Cord Involvement
Clinical Trial of a Serious Game for Individuals With SCI/D
This study will evaluate the efficacy of a newly developed serious game, SCI HARD, to enhance self-management skills, self-reported health behaviors, and quality of life among adolescents and young adults with spinal cord injury…
- Conditions
- Spinal Cord Injury, Spinal Cord Involvement, Spina Bifida, Transverse Myelitis
- Trial name
- NCT02341950
- Testing
- SCI Hard
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- University of Michigan
Spinal Cord Injuries
NeuroSuitUp: Neurorehabilitation Through Synergistic Man-machine Interfaces
NeuroSuitUp is a multidisciplinary neurophysiological \& neural rehabilitation engineering project, developed by the Lab of Medical Physics \& Digital Innovation, School of Medicine, Faculty of Health Science Aristotle University…
- Trial name
- NeuroSuitUp (NCT05465486)
- Testing
- Brain-Computer Interface control of robotic arms with augmented reality, Serious game with augmented reality
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Spinal Cord Injury
Scheduled Telephone Intervention for Individuals With Spinal Cord Injury and Their Families
The purpose of this study is to evaluate whether scheduled telephone intervention with individuals with spinal cord injury (SCI) and their caregivers in the first year following discharge from acute inpatient rehabilitation will…
- Trial name
- SCILink (NCT00693563)
- Testing
- Scheduled Telephone Intervention
- Where
- 2 sites in United States
- Volunteers
- 168 people
- Sponsor
- Jeanne Hoffman
Chronic Constipation
Sacral Neuromodulation as Treatment for Chronic Constipation
The objective of this study is to study if low level laser therapy will do more good than harm for patients with severe chronic refractory constipation. It is a proof of concept study without a placebo arm.
- Trial name
- NCT03819062
- Testing
- Low Level Laser Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Spinal Cord Injuries
Living With Spinal Cord Injury.
A Spinal Cord Injury (SCI) often drastically disrupts the lives of affected patients and their relatives and caregivers. This observational study will provide new knowledge on how patients and their family caregivers cope in the…
- Trial name
- NCT03709732
- Testing
- no intervention
- Where
- Norway
- Volunteers
- 2,654 people
- Sponsor
- St. Olavs Hospital
Spinal Cord Injury Cervical, Stroke
BoMI for Muscle Control
People with spinal cord injury (SCI), stroke and other neurodegenerative disorders can follow two pathways for regaining independence and quality of life. One is through clinical interventions, including therapeutic exercises.
- Trial name
- NCT04641793
- Testing
- Motion and Emg Control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Safety of Cultured Allogeneic Adult Umbilical-cord or Placental Derived Mesenchymal Stem Cell Intrathecal Injection for SCI
This trial will study the safety and efficacy of intrathecal injection of cultured allogeneic adult umbilical-cord or placental derived mesenchymal stem cells for the treatment of spinal cord injury
- Trial name
- NCT05018793
- Testing
- Cultured Allogeneic Adult Umbilical-cord or Placental Derived Mesenchymal Stem Cell Intrathecal injection
- Where
- 2 sites in United States, Greece
- Volunteers
- 15 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Spinal Cord Injuries
Neuro-navigated TMS for Chronic SCI Patients
Can neuro-navigated Transcranial Magnetic Stimulation be used as an additional outcome measure to EM-SCI assessments in a Spinal cord injury trial? Compare EM-SCI assessment with nTMS in ten chronic thoracic SCI patients Compare…
- Trial name
- NCT06075056
- Testing
- No Intervention
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- King's College Hospital NHS Trust
Pressure Injury
Effectiveness of the Freedom Bed as Compared to Alternating Pressure Mattress in Treatment of Pressure Injuries in Persons With Limited Mobility Due to Traumatic Brain Injury and /or Spinal Cord Injury
This non-randomized clinical study will compare pressure injuries and the change in pressure injuries for subjects who are placed on the Freedom Bed compared to those placed on a standard Group II Low Air Loss/Alternating…
- Trial name
- NCT03118960
- Testing
- Freedom Bed, Group II Low Air Loss/Alternating Pressure Mattress
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Northeast Center for Rehabilitation and Brain Injury
Spinal Cord Injuries
Influence of Spinal Stimulation Frequency on Spasticity, Motor Control, and Pain After Spinal Cord Injury
The goal of this study is to identify the effect of different types of noninvasive spinal stimulation on spasticity (involuntary muscle activity), muscle strength, and pain in people with spinal cord injury.
- Trial name
- NCT06214208
- Testing
- Transcutaneous Spinal Stimulation
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Shepherd Center, Atlanta GA
Neuromuscular Disorders, Neurodevelopmental Disorders
Efficacy and Usability of the EXPLORER Exoskeleton in Children With Neurodevelopmental Disorders in Natural Environments
Neurodevelopmental disorders often lead to abnormal development of the Central Nervous System (CNS), frequently causing motor dysfunctions such as an inability to stand and walk.
- Trial name
- NCT06765070
- Testing
- EXPLORER
- Where
- 6 sites in Spain
- Volunteers
- 15 people
- Sponsor
- MarsiBionics
Traumatic Brain Injury, Spinal Cord Injuries
Continuous Passive Motion Versus Heterotopic Ossification
The investigators hypothesize that Heterotopic Ossification (HO) formation can be suppressed if the application of a Continuous Passive Motion (CPM) device can be performed for a substantial amount of time.
- Conditions
- Traumatic Brain Injury, Spinal Cord Injuries, Stroke
- Trial name
- CPMversusHO (NCT05906056)
- Testing
- Continuous Passive Motion (CPM), Conventional physiotherapy (PT), Zoledronic Acid Injection
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- University of Ioannina
Cardiac Arrest, Stroke
Prevalence of Acute Critical Neurological Disease in Children: a Global Epidemiological Assessment
PANGEA is an international prospective point prevalence study to describe the epidemiology, interventions, and outcomes in children with acute critical brain disease.
- Conditions
- Cardiac Arrest, Stroke, Traumatic Brain Injury, Brain Mass
- Trial name
- PANGEA (NCT02381977)
- Testing
- No intervention
- Volunteers
- 922 people
- Sponsor
- University of Pittsburgh
Spinal Cord Injury
S-100B and Neuron-specific Enolase (NSE) in Spinal Trauma
The investigators are studying the clinical worth of the serum markers S-100B and NSE in patients with spinal cord injuries e.g. in patients with vertebral fractures.
- Trial name
- WBS (NCT00980434)
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Scoliosis, Acute Kidney Injury
Effects of Goal-directed Fluid Therapy on Post-operative Outcomes in Children Undergoing Scoliosis Repair
Surgery for scoliosis correction, the abnormal curvature of the spine, is a major procedure often undertaken in adolescents. In adult anesthesia, there is a large volume of literature debating how to optimize fluids administered…
- Trial name
- CardioQ-RP (NCT02463175)
- Testing
- Plasmalyte, Goal-directed fluid therapy (GDT)
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of British Columbia
Spinal Cord Injury at C5-Th10 Level With Complete Lesion, Spinal Cord Transection
Autologous Bulbar Olfactory Ensheathing Cells and Nerve Grafts for Treatment of Patients With Spinal Cord Transection
The purpose of this experimental therapy is to evaluate the safety and efficacy of transplantation of autologous olfactory ensheathing cells (OECs) and olfactory nerve fibroblasts (ONFs) obtained from the olfactory bulb with…
- Trial name
- NCT03933072
- Testing
- obtaining of autologous human olfactory bulb, autologous sural nerve preparation, production of Glial Neuropatch, microsurgical reconstruction of the transected spinal cord with autologous Glial Neuropatch-nerve bridges
- Where
- Poland
- Volunteers
- 2 people
- Sponsor
- Nicholls Spinal Injury Foundation