Clinical trials: Substance Use Disorder
Substance Use, Gender Role
Peer Education for Gender Inclusion and Substance Use in Southern Africa
The goal of this trial is to test the effectiveness of a brief, behavioral peer group intervention called "PEGISUS" (Peer Education for Gender Inclusion and Substance Use in Southern Africa), on substance use, which will be…
- Trial name
- PEGISUS (NCT06489899)
- Testing
- PEGISUS
- Where
- 3 sites in South Africa, Zambia and 1 more
- Volunteers
- 264 people
- Sponsor
- University Hospital, Basel, Switzerland
Substance Abuse Disorder
To Assess the Effectiveness of Structured Occupational Therapy (OT) Interventions on Patients With SUD in Inpatient Department (IPD) Settings, Focusing on Improvements in Cognitive, Physical, and Functional Domains
OT emphasis lies within the scope of improving daily life activities, cognitive and physical performance in order to regain the proper social role.
- Trial name
- NCT06809504
- Testing
- Exercise based intervention
- Where
- Pakistan
- Volunteers
- 12 people
- Sponsor
- Hammad Mursaleen
Substance Use
Rapid Adaptation to Prevent Drug Use
Using a 2-group, mixed method cluster randomized trial design, this study will compare standard implementation versus RAPD implementation strategy in Michigan Middle Schools
- Trial name
- RAPD (NCT05806840)
- Testing
- Rapid Adaptation to Prevent Drug Use (RAPD), Standard Implementation
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Tobacco Dependence
Safety, Tolerability and Efficacy of the Nicotine Patch and Gum for the Treatment of Adolescent Tobacco Dependence
The purpose of this study is to test the safety, tolerability, compliance and efficacy of two different forms of nicotine replacement therapy (NRT) (the nicotine transdermal patch and the nicotine gum) in a nicotine-dependent…
- Trial name
- NCT01208935
- Testing
- Nicotine Patch, Nicotine Gum
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use, Substance Abuse
Evaluation of Thiwáhe Gluwáš'Akapi Substance Use Prevention Program
Researchers at the Centers for American Indian and Alaska Native Health in the Colorado School of Public Health at the University of Colorado completed an intensive community-engaged process to rigorously adapt the Strengthening…
- Conditions
- Substance Use, Substance Abuse, Suicide
- Trial name
- NCT04222556
- Testing
- Thiwáhe Gluwáš'akapi, Woyute Waśte
- Where
- United States
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alcohol Dependence
Post-Marketing Surveillance Study of Nalmefene Hydrochloride Hydrate in Patients with Alcohol Dependence
The purpose of this study is to investigate the safety and the prognosis after achieving reduced alcohol intake in patients with alcohol dependence who received treatment for the reduction of alcohol intake in the routine…
- Trial name
- NCT04107051
- Testing
- Nalmefene Hydrochloride Hydrate
- Where
- Japan
- Volunteers
- 533 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Opioid-use Disorder
Feasibility of Pediatric Emergency Department-Initiated Treatment for Adolescents With Opioid Use Disorder
ED-initiated buprenorphine with brief intervention and facilitated referral to treatment has been shown to be highly successful in increasing treatment engagement rates and reducing opioid use among adults.
- Trial name
- PEDsTREATOUD (NCT04737603)
- Testing
- ED-Initiated treatment with buprenorphine / naloxone
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Davis
Substance Abuse, Mindfulness
Master Mind Program Evaluation Study
The purpose of this study is to conduct a randomized controlled trial to evaluate the efficacy of the Master Mind program, a mindfulness education substance abuse prevention program.
- Trial name
- MasterMind (NCT03212066)
- Testing
- Master Mind
- Where
- United States
- Volunteers
- 518 people, healthy volunteers welcome
- Sponsor
- Innovation Research & Training
COVID-19, Cancer
COVID EHR COHORT at the University of Wisconsin
This cohort study will obtain electronic health record (EHR) data (limited data set) from 21 health systems affiliated with the Cancer Center Cessation Initiative (C3I) network or health systems with large numbers of COVID-19…
- Conditions
- COVID-19, Cancer, Nicotine Dependence, Pulmonary Disease
- Trial name
- CEC-UW (NCT04506528)
- Where
- United States
- Volunteers
- 1,634,381 people
- Sponsor
- University of Wisconsin, Madison
Tobacco Use Disorder
Tobacco Zero: Interactive Tobacco Education for Teens
There have been a number of tobacco prevention programs developed and tested in the past few years, and some of the comprehensive programs have been promoted by the Office on Smoking and Health at the Centers for Disease Control…
- Trial name
- NCT00670995
- Testing
- Interactive Tobacco Education
- Where
- United States
- Volunteers
- 1,864 people, healthy volunteers welcome
- Sponsor
- Deschutes Research, Inc.
Substance Use, Sexual Behavior
Telling Our Daughters Our Story
The objective of this research study is to evaluate a culturally grounded program among American Indian (AI) female children and the children's female caregivers.
- Trial name
- TODOS (NCT06276595)
- Testing
- Nowhi Isdza bit Nadagoldi: Telling Our Daughters Our Story (TODOS), Control condition - 3 Monthly Group Activities in the Community
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Nicotine Dependence, Substance Use Disorders
Healthy People Initiative (HPI)
Addictions do not occur in isolation. Tackling addictions requires addressing social determinants such as isolation, homelessness, marginalization, and unemployment.
- Trial name
- HPI (NCT03506867)
- Testing
- Life skills, training, education and work/volunteer opportunities, Usual Care
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Opioid Dependence
Comparing Opium Tincture (OT) With Methadone for Medication-assisted Treatment of Opioid Use Disorder
Patients with opioid use disorder seeking medication-assisted treatment will be recruited. Each participant will be allocated to one of the two study groups with the equal chance of receiving either opium tincture (OT) or…
- Trial name
- OT-RCT (NCT02502175)
- Testing
- opium, methadone
- Where
- 4 sites in Iran
- Volunteers
- 204 people
- Sponsor
- University of British Columbia
Child Abuse, Child Neglect
Fostering Healthy Futures for Teens: An RCT
This study will implement and evaluate a mentoring program designed to promote positive youth development and reduce adverse outcomes among maltreated adolescents with open child welfare cases.
- Conditions
- Child Abuse, Child Neglect, Risk Behavior, Delinquency
- Trial name
- FHF-T (NCT03707366)
- Testing
- FHF-T
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- University of Denver
Gambling
Evaluation of Effectiveness of the Unplugged Program on Gambling Among Adolescents (GAPUnplugged)
The main aim of this study is to assess the effectiveness of a new component on gambling prevention to be added to the evidence-based school based prevention curriculum "Unplugged".
- Trial name
- GAPUnplugged (NCT05630157)
- Testing
- Unplugged plus gambling component
- Volunteers
- 3,046 people, healthy volunteers welcome
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Nicotine Dependence
Bupropion Treatment for Youth Smoking Cessation
The purpose of this study is to 1) evaluate the safety and efficacy of two doses of bupropion SR (150mg/day and 300mg/day) when compared to placebo, as an aid to smoking cessation in adolescents and 2) to examine which factors…
- Trial name
- NCT00344695
- Testing
- bupropion SR
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Arizona
Substance Use Disorders, Criminal Behavior
The Effectiveness of A-CRA in Compulsory Institutional Care for Youth
Youth with substance use disorder (SUD) and socially disruptive behaviour (such as criminality) who are placed in compulsory institutional care are at high risk of continuing a destructive lifestyle into adulthood.
- Trial name
- A-CRA at SiS (NCT06094972)
- Testing
- Adolescent Community Reinforcement Approach, A-CRA, TAU
- Where
- 4 sites in Sweden
- Volunteers
- 220 people
- Sponsor
- Karolinska Institutet
Alcohol Abuse, Tobacco Use Disorder
Computer Adaptation of Screening, Brief MET Intervention to Reduce Teen Drinking
The goal of this project is to evaluate the feasibility, acceptability, and effect size of a new computerized Motivational Enhancement Therapy (cMET) intervention for alcohol-involved adolescents in primary care.
- Conditions
- Alcohol Abuse, Tobacco Use Disorder, Substance Use
- Trial name
- NCT01881841
- Testing
- cMET
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Boston Children's Hospital
Substance Use, Delinquency
Family-Based Juvenile Drug Court Services
The objective of the proposed study is to adapt and implement an efficacious adolescent substance abuse treatment, Multidimensional Family Therapy (MDFT), within the juvenile drug court service system.
- Trial name
- JDC (NCT01668303)
- Testing
- Miami Juvenile Drug Court-MDFT, Miami Juvenile Drug Court -TAU
- Where
- 4 sites in United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Miami
Pediatric Pain, Anxiety
PURSUIT: A Technologically Augmented School-based Program to Improve Child Coping and Prevent Substance Use.
The study investigators aim to test an online support platform for Michigan youth aged 8-18 years enrolled in elementary, middle, or high school and their parent/caregiver.
- Conditions
- Pediatric Pain, Anxiety, Mood, Stress
- Trial name
- NCT07266740
- Testing
- PURSUIT
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Michigan State University