Clinical trials: Systemic Inflammation
Home Parenteral Nutrition, Intestinal Failure
Overview of Botriomycoma in Children with a Central Line: Epidemiology, Risk Factors, Treatments
Botriomycomas are frequent benign tumors in children. Their appearance on the central catheter orifice is a known event in clinical practice, but one that has been little studied.
- Conditions
- Home Parenteral Nutrition, Intestinal Failure, Central Line, Botriomycoma
- Trial name
- NCT06708689
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Hospices Civils de Lyon
Sepsis
Construction of a Database for the Life-cycle Sepsis-specific Disease Cohort
Establish a structured clinical database for sepsis screening, and establish a special data set standard for sepsis throughout the life cycle.
- Trial name
- NCT04872010
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Neonatal Sepsis
Effect of N-acetylcysteine as Adjunct Therapy on the Clinical Outcome of Neonatal Sepsis
Neonatal sepsis (NS) is a life-threatening condition characterized by systemic inflammation in response to infection during the first 28 days of life.
- Trial name
- NCT07380347
- Testing
- N-Acetyl Cysteine (NAC), Normal Saline
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Malaria
Impact of TMP-SMX Prophylaxis on Malaria Infection and Immunity in Children in Uganda
Background: Malaria is a disease that affects many children and adults in Uganda and Africa. If it is not treated, it can make some people severely ill.
- Trial name
- NCT02094508
- Where
- Uganda
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Infection, Sepsis
Short-course Antimicrobial Therapy in Sepsis
The purpose of this study is to compare the effect of a short course antimicrobial therapy (5-days) versus a 10-days therapy on sepsis-related organ dysfunction.
- Conditions
- Infection, Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02899143
- Testing
- Antibiotic
- Where
- 4 sites in Italy
- Volunteers
- 320 people
- Sponsor
- Ospedale Santa Maria delle Croci
Neonatal Sepsis, Markers
Tissue Doppler Echocardiographic Assessment of Cardiac Function in Neonatal Sepsis
1. To assess myocardial function in neonates with sepsis using tissue doppler echocardiography. 2. To assess sepsis induced cardiac dysfunction. 3.
- Trial name
- NCT07572916
- Testing
- cardiac troponin, and blood culture
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sepsis Newborn
Is Neutrophil to Lymphocyte Ratio a Prognostic Factor of Sepsis in Newborns With Operated Congenital Heart Disease
The use of neutrophil lymphocyte ratio is useful for the detection of infection status in newborns after surgery
- Trial name
- NCT03923543
- Testing
- Neutrophil to lymphosit ratio
- Volunteers
- 60 people
- Sponsor
- Firat Ergin
Sepsis, Disseminated Intravascular Coagulation
Thrombin Generation and Thromboelastography in Non-overt DIC
Sepsis is the 13th most common cause of death in the United States, causing approximately 210,000 deaths per year. Once DIC has developed, irreversible organ injury has already occurred and the mortality rate is 70%.
- Trial name
- NCT00299949
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The University of Texas Health Science Center, Houston
Sepsis, Critical Illness
Methionine Metabolism in Enterally Fed Pediatric Sepsis
Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Protein synthesis is increased mainly in the form of immune and signaling proteins, while muscle and structural protein synthesis…
- Trial name
- NCT01889264
- Testing
- Observational
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The Cleveland Clinic
Sepsis, Diagnosis
The RightCall: Implementing a Sepsis Diagnostic Toolkit to Improve Pediatric Diagnosis in ED Transfer Calls
Sepsis is a leading cause of death in children, and an early diagnosis that improves outcomes is less likely in children who are treated in general Emergency Departments (EDs), that treat adults and children, compared to…
- Conditions
- Sepsis, Diagnosis, Emergencies
- Trial name
- RightCall (NCT07051668)
- Testing
- Pediatric Sepsis Diagnostic Toolkit
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Colorado, Denver
Dengue, Dengue With Warning Signs
Anakinra in Dengue With Hyperinflammation ( AnaDen )
This study aims to evaluate the effect of anakinra in dengue patients with hyperinflammation as compared to placebo Primary Objective: To evaluate the efficacy of Anakinra in moderate-severe dengue patients with…
- Conditions
- Dengue, Dengue With Warning Signs, Severe Dengue, Anakinra
- Trial name
- NCT05611710
- Testing
- Anakinra
- Where
- Vietnam
- Volunteers
- 160 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Sepsis
Management of Sepsis in Resource Limited Settings Using a Delphi Method.
Rapid evolution of sepsis syndromes means that timely diagnosis and treatment are critical in improving outcomes but this may be difficult to achieve in many low- and middle- income countries (LMICs) and there is a lack of high…
- Trial name
- NCT05909384
- Testing
- Survey
- Where
- Vietnam
- Volunteers
- 36 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Acute Myeloid Leukemia, Neutropenia
Home Away From Home - Medical Outcomes
Treatment for pediatric acute myeloid leukemia (AML) involves intensive chemotherapy regimens that result in periods of profound neutropenia leaving patients susceptible to severe infectious complications.
- Conditions
- Acute Myeloid Leukemia, Neutropenia, Bacteremia
- Trial name
- Aim 1 (NCT02774850)
- Where
- 17 sites in United States
- Volunteers
- 610 people
- Sponsor
- Children's Hospital of Philadelphia
Neonatal SEPSIS, Prematurity
Neonatal Bacterial Colonization Study
This study will evaluate the effect of skin antisepsis and/or emollient therapy on bacterial colonization dynamics in very low birth weight, hospitalized infants.
- Conditions
- Neonatal SEPSIS, Prematurity, Very Low Birth Weight Baby, Bloodstream Infection
- Trial name
- NCT03896893
- Testing
- Skin antisepsis, Emollient
- Where
- South Africa
- Volunteers
- 80 people
- Sponsor
- University of Stellenbosch
Septic Shock
Lung Ultrasound-guided Fluid Resuscitation in Neonatal Septic Shock
object name: Lung ultrasound-guided fluid resuscitation in neonatal septic shock. type of study: prospective observational study.
- Trial name
- LUGFRINSS (NCT06144463)
- Testing
- lung ultrasound-guided fluid resuscitation
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Guangdong Second Provincial General Hospital
Late-Onset Neonatal Sepsis
Clinical Impact of Donor Milk Pasteurized by HTST Treatment in Preterm Infants
Randomized double-blind clinical trial to compare the incidence of microbiological proven late onset sepsis in extremely preterm infants (<1000 grams) that are supplemented with donor milk pasteurized by High Temperature Short…
- Trial name
- NCT04424667
- Testing
- donor milk
- Where
- 2 sites in Spain
- Volunteers
- 211 people
- Sponsor
- Carmen Rosa Pallas
Sepsis
Assessment of qSOFA in the Latin America Sepsis Institute Database
Recently, the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM) have published new definitions of sepsis, known as Sepsis 3, based on a fairly robust analysis of large…
- Trial name
- NCT03158493
- Volunteers
- 8,435 people
- Sponsor
- Federal University of São Paulo
Neonatal Late Onset Sepsis
Validation of Biomarkers Performance to Reduce Antibiotics overUse in newBorns With Suspected Clinical Signs of InfectionS
Late-onset neonatal sepsis (LOS), occurring in newborn of at least 7 days of life, is frequently observed in Neonatal Intensive Care Units (NICUs) and potentially severe (mortality, neurologic and respiratory impairments).
- Trial name
- RUBIS (NCT06058819)
- Testing
- Newborns suspected of Infections
- Where
- 3 sites in France
- Volunteers
- 285 people
- Sponsor
- Hospices Civils de Lyon
Covid19, Thrombosis
Registry of Hospitalized Patients in University Hospital Dubrava Respiratory Center
Aim of this project is to understand clinical features, clinical outcomes and efficacy and safety profiles of different therapies by analyzing a cohort of COVID-19 patients hospitalized and treated in a tertiary-level…
- Conditions
- Covid19, Thrombosis, Bleeding, Sepsis
- Trial name
- COVID-19 (NCT05151094)
- Testing
- Observation
- Where
- Croatia
- Volunteers
- 6,000 people
- Sponsor
- University Hospital Dubrava
Stable Coronary Artery Disease Undergoing PCI
Rosuvastatin for Reduction of Myocardial Damage and Systemic Inflammation During Coronary Angioplasty
Myocardial necrosis is relatively frequent after percutaneous coronary intervention and is associated with higher mortality during the follow-up.
- Trial name
- REMEDY (NCT02205775)
- Testing
- Atorvastatin, Rosuvastatin, Ezetimibe
- Where
- 6 sites in Italy
- Volunteers
- 280 people
- Sponsor
- G. d'Annunzio University