Clinical trials: Therapy Strategies
Neuronal Ceroid Lipofuscinosis
Italian NCL Registry: a Registry for NCL as an Integration Tool for Future Therapeutic Strategies
The goal is to create a solid and harmonious disease registry of patient affected by neuronal ceroid lipofuscinosis (NCLs) that facilitates the collection and management of patients' data over time encouraging the research and…
- Trial name
- NCT06844877
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Fondazione Stella Maris
Cerebral Palsy (CP)
Metacognitive Strategy Training Intervention for Transition-Age Youth With Cerebral Palsy
This exploratory randomized controlled trial will examine the feasibility and preliminary effects of a remote PREP intervention compared to an attention control for transition-age youth with cerebral palsy and their caregivers.
- Trial name
- NCT07424079
- Testing
- Pathways and Resources for Engagement and Participation, Attention Control Condition
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Missouri-Columbia
Inflammatory Bowel Diseases
Therapeutic Monitoring of Infliximab and Adalimumab
Anti tumor necrosis factor (TNF agents), particularly infliximab and adalimumab, changed the way chronic inflammatory bowel disease (IBD) refractory to conventional therapies is treated, including in pediatric patients.
- Trial name
- NCT06033469
- Testing
- Infliximab, Adalimumab
- Where
- 3 sites in Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Burlo Garofolo
Myocardial Infarction
Early Percutaneous Coronary Intervention (PCI) After Fibrinolysis Versus Standard Therapy in ST Segment Elevation Myocardial Infarction (STEMI) Patients
Several recent trials (1,2) suggest that all STEMI patients receiving fibrinolysis in non-PCI centres should be routinely transferred for elective early PCI within 24 hours from hospitalization, with no additive risk of major…
- Trial name
- NCT01014182
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
COVID-19 Respiratory Infection
Insight Into the UAE Experience With Monoclonal Antibodies (Sotrovimab )
Sotrovimab is a newly developed monoclonal antibody for the treatment of mild and moderate COVID-19 patient, who are at high risk for progression to severe COVID-19, including hospitalization or death.
- Trial name
- EHS-Strategy (NCT05144178)
- Where
- United Arab Emirates
- Volunteers
- 3,500 people
- Sponsor
- Emirates Health Services (EHS)
HIV Infections
Vaccine (ALVAC-HIV vCP1452) Use and Intermittent Withdrawal of Anti-HIV Drugs in Patients With HIV
Long-term control of HIV depends on improvement in an individual's immune system. The purpose of this study is to see if either stopping anti-HIV drugs for short periods of time and/or adding a vaccine to the anti-HIV drugs being…
- Trial name
- NCT00011011
- Testing
- ALVAC(2)120(B,MN)GNP (vCP1452)
- Where
- 16 sites in United States
- Volunteers
- 94 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Congenital Mitral Insufficiency
Study of Innovative Drug Treatment Therapy for Pediatric Mitral Regurgitation
The goal of this observational study is to compare the safety and effectiveness of a modified drug therapy with traditional drug therapy in pediatric patients with mild to moderate mitral valve regurgitation.
- Trial name
- NCT06037434
- Testing
- Captopril Tablets, Metoprolol Oral Tablet, Spironolactone Tablets
- Where
- China
- Volunteers
- 122 people
- Sponsor
- China National Center for Cardiovascular Diseases
Urinary Incontinence in Children
Strategy for Withdrawal of Pharmacological Treatment for Urinary Incontinence in Children (StayDry)
The primary objective is to investigate if abrupt withdrawal versus gradual withdrawal of pharmacotherapy (solifenacin and/or mirabegron) influences the risk of recurrence of incontinence.
- Trial name
- NCT06465576
- Testing
- Solifenacin, Mirabegron, Solifenacin + Mirabegron
- Where
- 5 sites in Denmark
- Volunteers
- 216 people
- Sponsor
- University of Aarhus
Eosinophilic Gastrointestinal Disorders (EGID)
Elimination Diet Strategies and Histologic Remission in Children With Eosinophilic Gastrointestinal Disorders
This prospective observational cohort study aims to evaluate clinical and histologic outcomes of elimination diets in children aged 2-17 years with eosinophilic gastrointestinal disorders (EGIDs).
- Trial name
- NCT07779772
- Testing
- Elimination Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Cukurova University
Reducing Tuberculosis Incidence
DeMONSTRATE-TB Study in Ethiopia
Ending the TB epidemic by 2035 in Ethiopia would be possible if TB notification declines by an annual factor of at least 15% from the current notification rate of 132 per 100,000 population.
- Trial name
- NCT06719193
- Testing
- Enhanced community-wide TB intervention, Routine TB program activities
- Where
- 2 sites in Ethiopia
- Volunteers
- 131,438 people, healthy volunteers welcome
- Sponsor
- Management Sciences for Health
HIV, Hypertension
SEARCH SAPPHIRE Phase A: A Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa
The randomized trials in this record will assess effectiveness, fidelity and cost of prevention and treatment interventions for HIV and hypertension with the objective of informing a population-based study of multi-sectored…
- Conditions
- HIV, Hypertension, Alcohol Drinking, Maternal Child Health
- Trial name
- SAPPHIRE PhA (NCT04810650)
- Testing
- Mobility Dynamic Treatment Intervention, Health Living Intervention for Heavy Alcohol Users, Hypertension Linkage
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 2,233 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Anxiety
The Relationship Between Emotional Regulation Strategies And Cognitive Behavioral Treatment Effectiveness In Childhood Anxiety Disorders: A Longitudinal Prospective Study
The current study will focus on two phases of anxiety process: Generating Anxiety (reported, direct and physiological) and Emotional Regulation Strategies (Reappraisal, Mindfulness, Expressive Suppression and Rumination).
- Trial name
- NCT01145261
- Where
- Israel
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Pain
Analgesic Strategies in Newborns Receiving Prostaglandin Therapy
This is a randomised trial comparing the efficacy of 3 different analgesic strategies in newborns on prostaglandin for ductus dependent congenital heart disease.
- Trial name
- NCT00200590
- Testing
- acetaminophen and nalbuphine, acetaminophen and morphine, acetaminophen and reduced dosage of prostaglandin
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Respiratory Diseases, Congenital Heart Defects
Development of Methods for Effective Treatment and Improvement of Common Somatic Diseases in Children
The goal of the clinical study is to clarify the course of common congenital, infectious, and non-infectious diseases in children living in Uzbekistan, and to develop methods for their treatment and rehabilitation.
- Trial name
- NCT06267859
- Testing
- The use of a combination of microelements and vitamins against the background of physiotherapy
- Where
- Uzbekistan
- Volunteers
- 600 people
- Sponsor
- Tashkent State Medical University (Tashkent Pediatric Medical Institute), Uzbekistan
Motivation, Sports Physical Therapy
Motivation as a Strategy for Adherence to a Stretching Program for Basketball Players
Background: Basketball is considered a medium-high injury sport, because of the mechanisms of injury, which can be acute, by repetition mechanisms or by overload.
- Conditions
- Motivation, Sports Physical Therapy, Muscle Tightness
- Trial name
- MOTBAS (NCT05499338)
- Testing
- Stretching program
- Where
- Spain
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
SARS-CoV Infection
Comparison of Strategies Based on RT-PCR or Antigenic Test for the Screening of SARS-CoV-2 Infection (COVID-19).
The virological diagnosis of SARS-CoV-2 infection is pivotal for the control of the outbreak by large screening of a- or pauci-symptomatic subjects.
- Trial name
- AutoCoV (NCT04859023)
- Testing
- saliva sample combined to an anterior nare self-swabbing (Self-samples), saliva sample (Self-sample), Survey of SARS-COV-19 knowledge
- Where
- France
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Neuroblastoma
Ethanol-Lock Treatment in Preventing Central Venous Catheter Infections in Patients With High-Risk Neuroblastoma
RATIONALE: Ethanol-lock treatment may help prevent central venous catheter infections in patients with high-risk neuroblastoma. PURPOSE: This phase I trial is studying the side effects of ethanol-lock treatment in preventing…
- Trial name
- NCT00471679
- Testing
- ethanol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI), Dual Anti-platelet Therapy
Aspirin-Free Strategy After 3-6 Month Dual Antiplatelet Therapy in Acute Coronary Syndrome
This randomized controlled trial aims to evaluate the safety and efficacy of an aspirin-free strategy after 3-6 months of dual antiplatelet therapy (DAPT) in patients with acute coronary syndrome (ACS) who have undergone complete…
- Trial name
- NCT07736196
- Testing
- Aspirin-Free Strategy, Dual Antiplatelet Therapy
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Tuberculosis, Pre-XDR-TB
Building Evidence for Advancing New Treatment for Rifampicin Resistant Tuberculosis (RR-TB) Comparing a Short Course of Treatment (Containing Bedaquiline, Delamanid and Linezolid) With the Current South African Standard of Care
BEAT Tuberculosis is a phase 3, open label, multi-centre, randomized controlled trial. The purpose of this trial is to compare the efficacy and safety of a Study Strategy consisting of 6 months of bedaquiline (BDQ), delamanid…
- Conditions
- Tuberculosis, Pre-XDR-TB, Extensively Drug-Resistant Tuberculosis, Multi Drug Resistant Tuberculosis
- Trial name
- NCT04062201
- Testing
- Bedaquiline Oral Tablet, Linezolid Oral Tablet, Delamanid in Oral Dosage Form
- Where
- 2 sites in South Africa
- Volunteers
- 402 people
- Sponsor
- Wits Health Consortium (Pty) Ltd
Systolic Heart Failure, Heart Failure With Reduced Ejection Fraction
Evaluation of Left Bundle Branch Area Pacing As A Rescue Strategy for Cardiac Resynchronization Therapy Non-Response
This study aims to investigate whether the investigators can improve heart function in patients with heart failure who have undergone cardiac resynchronization therapy, but have not had an improvement in their heart function at…
- Conditions
- Systolic Heart Failure, Heart Failure With Reduced Ejection Fraction, CRT Non-Response, Left Bundle Branch Area Pacing
- Trial name
- NCT05884411
- Testing
- Left bundle branch area pacing, Cardiac MRI
- Where
- United States
- Sponsor
- VA Office of Research and Development