Clinical trials: Third Molars Extraction
Dental Pain
Study of Acetaminophen (ACE) in Post-operative Dental Pain
This is a dental pain study evaluating the efficacy and safety of a single dose of test acetaminophen (ACE) (1000 mg) compared to commercial acetaminophen (1000 mg), ibuprofen (IBU) (400 mg), and placebo over a 6 hour period.
- Trial name
- NCT02320708
- Testing
- Acetaminophen (ACE) (1000 mg), Commercial ACE (1000 mg), Commercial Ibuprofen (IBU) (400 mg)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Johnson & Johnson Healthcare Products Division of McNEIL-PPC, Inc.
Impacted Third Molar Tooth
Computer Guided Versus Conventional Surgical Removal of Deeply Impacted Mandibular Third Molar With Preservation of External Oblique Ridge
in patent have deeply impacted lower third molar ,dose computer guided enhance surgical outcome versus conventional surgical remove of wisdom teeth
- Trial name
- NCT03447067
- Testing
- computer guided surgical, Conventional surgery, CBCT
- Volunteers
- 18 people
- Sponsor
- Alaadden Mahmoud Abu Al Enein
Class II Malocclusion
Effect of Maxillary Third Molar Extraction vs. Non-extraction on Distalization of First Molars in a Group of Adolescent Patients
There is a scarcity in literature regarding the influence of maxillary third molar on distalization . This study aimed to compare the influence of unerupted maxillary third molars and their extraction on the bilateral…
- Trial name
- NCT05647720
- Testing
- Distalization combined with upper third molars extraction, Distalization without upper third molars extraction
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Pain, Tooth Extraction
Rofecoxib and Bupivacaine to Prevent Pain After Third Molar (Wisdom Tooth) Extraction
This study will evaluate the ability of the drugs rofecoxib and bupivacaine to prevent pain following third molar (wisdom tooth) extraction. Rofecoxib is approved to treat pain of arthritis and menstrual cramps.
- Trial name
- NCT00050362
- Testing
- Rofecoxib and Bupivacaine
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Third Molar
Positional Changes of Mandibular Molar After Orthodontic Treatment
This retrospective study was carried out on pre and posttreatment digital standardized panoramic radiographs of 30 cases previously orthodontically treated with four first premolar extraction.
- Trial name
- NCT06933979
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Fayoum University
Class II Malocclusion
Effect of Upper Third Molar Extraction on Distalization Carriere Motion Appliance :A Prospective Clinical Study
This clinical study will be directed to compare the effect of presence or absence of third molar on distalization of the upper posterior segment by using carriere motion appliance
- Trial name
- NCT05166928
- Testing
- carriere motion appliance
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Third Molar Extraction Surgery, Third Molar Impaction
Difficulty, Time & M3 Surgery Outcomes
This prospective observational cohort study is designed to evaluate early postoperative complications and patient-reported satisfaction following surgical extraction of impacted mandibular third molars under local anesthesia in…
- Conditions
- Third Molar Extraction Surgery, Third Molar Impaction, Satisfaction Survey
- Trial name
- NCT07296172
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Bahçeşehir University
Impacted Third Molar Tooth, Healing Surgical Wounds
Evaluation of Hydrogen Peroxide and Hyaluronic Acid (BMG0703) in the Healing of Post-extraction Sites
A clinical study to evaluate the efficacy and safety of a mouthwash containing Hydrogen Peroxide, Sodium Hyaluronate and Glycine in the healing of post-extraction sites of wisdom teeth by film forming action.
- Trial name
- NCT04438434
- Testing
- Filming Formulation of Hydrogen Peroxide and Hyaluronic Acid, Chlorhexidine mouthwash
- Where
- Italy
- Volunteers
- 57 people
- Sponsor
- University of Milan
Impacted Third Molar Tooth
Extraction of Impacted 3rd Molars, Can Bone Support of the Second Molar be Promoted by a Bio-Oss Graft?
A prospective study examining bilateral 3rd molar extraction, by a split mouth protocol the investigators augment unilaterally and compare periodontal parameters in between.
- Trial name
- NCT02753439
- Testing
- Geistlich Bio Oss
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Molar, Third, Wisdom Teeth
Effect of Hilotherm Therapy on Post-operative Pain and Swelling Following Surgical Wisdom Tooth Removal
This study evaluates the efficacy of Hilotherm therapy on the incidence of swelling and pain following the surgical removal of lower wisdom teeth.
- Trial name
- NCT02284841
- Testing
- Hilotherm cooling face mask
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Bleeding, Tooth Extraction
Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery
Tranexamic acid (TXA) is an effective hemostatic agent used to reduce blood loss and the need for transfusion. It is a relatively safe drug with minimal significant side effects.
- Trial name
- NCT06806241
- Testing
- Tranexamic acid, saline irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Pain
Evaluation of a TNF-Alpha Modulator for Clinical and Molecular Indicators of Analgesic Effect
This study will evaluate the role of thalidomide, a tumor necrosis factor (TNF)-alpha modulator, on severe inflammation and relief of pain following extraction of wisdom teeth.
- Trial name
- NCT00121563
- Testing
- Thalidomide, Ibuprofen or Diazepam
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Nursing Research (NINR)
Wisdom Tooth Avulsion
Non-closure of Alveoli After Avulsion of Wisdom Teeth
The main objective of this study is to evaluate postoperative pain (measured by visual analogue scale (VAS) on day 2 post surgery) in patients operated for avulsion of four wisdom teeth under general anesthesia and for whom the…
- Trial name
- AlvéCare (NCT02583997)
- Testing
- Suturing of lower alveoli, Non suturing of lower alveoli
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Edema, Pain
The Impact of Arnica Montana Following the Surgical Extraction of Impacted Third Molars
Aim: The aim of this study is to evaluate the action of the homeopathic plant Arnica Montana on postoperative edema, pain and trismus after surgical extraction of impacted wisdom teeth.
- Conditions
- Edema, Pain, Trismus
- Trial name
- NCT06193720
- Testing
- Arnica montana
- Where
- Lebanon
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Third Molar Extraction Surgery
Effect of Systemic Antibiotic Therapy on Postoperative Complications in Patients Undergoing Wisdom Teeth Removal Surgery.
59 medically healthy patients, who are scheduled for third molar extraction surgery and give informed consent for the trial, are operated using a split-mouth technique.
- Trial name
- NCT05142449
- Testing
- Amoxilan
- Where
- Austria
- Volunteers
- 59 people
- Sponsor
- Medical University of Graz
Pain
Multiple Dose Dental Pain Study Of Ibuprofen Extended Release
The study hypothesis is that single and multiple doses of ibuprofen 600 mg ER caplets provide analgesic efficacy superior to placebo over 12-hour dosing intervals.
- Trial name
- NCT01266161
- Testing
- Ibuprofen 600 mg ER
- Where
- 2 sites in United States
- Volunteers
- 106 people
- Sponsor
- Pfizer
Oral Surgery
The Effect of Platelet-rich Fibrin on Clinical and Patient-centered Outcomes of Third Molar Extractions
The fear of oral surgeries is mostly dedicated to pain and swelling in the following days. It is not surprising, that it is of high interest to do anything to reduce these consequences.
- Trial name
- PRF (NCT05089812)
- Testing
- Third-molar extraction using platelet-rich fibrin as a filling of the alveolus
- Where
- Austria
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Pain
Local Flurbiprofen to Treat Pain Following Wisdom Tooth Extraction
This study will evaluate the effectiveness of the non-steroidal anti-inflammatory drug flurbiprofen (Ansaid® (Registered Trademark)) in relieving pain following oral surgery.
- Trial name
- NCT00001724
- Testing
- Flurbiprofen
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Impacted Mandibular Third Molar
Comparison of Electrocautery and Scalpel Blade Incisions of Impacted Mandibular Third Molars
This randomized controlled trial aims to compare electrocautery and scalpel blade incisions during surgical extraction of impacted mandibular third molars.
- Trial name
- NCT07723326
- Testing
- scalpel blade incision, electrocautery incision
- Where
- Pakistan
- Volunteers
- 78 people
- Sponsor
- Riphah International University
Pain
Study Evaluating A Novel Ibuprofen Formulation In The Treatment Of Dental Pain
This study will compare the analgesic efficacy of a single-dose of a novel ibuprofen formulation to placebo and acetaminophen in the treatment of post-surgical dental pain following "wisdom" tooth (third molar) removal.
- Trial name
- NCT01216163
- Testing
- Novel Ibuprofen, Acetaminophen
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- Pfizer