Clinical trials: Tobacco Use, Cigarette Use
Adolescent Substance Use
Guiding Good Choices for Health
This study evaluates the feasibility and effectiveness of implementing Guiding Good Choices (GGC), an anticipatory guidance curriculum for parents of early adolescents, in three large, integrated healthcare systems.
- Trial name
- GGC4H (NCT04040153)
- Testing
- Guiding Good Choices
- Where
- 3 sites in United States
- Volunteers
- 3,636 people, healthy volunteers welcome
- Sponsor
- University of Washington
Tobacco Smoking, Vaping
Testing a School-Based E-cigarette, Tobacco, and Betel (Areca) Nut Use Prevention Curriculum for Guam Youths
The people of the U.S. Affiliated Pacific Islands (USAPI) face higher cancer incidence, especially lung/bronchia and head-and-neck cancer, and poorer cancer outcomes, compared with the U.S. nationally.
- Conditions
- Tobacco Smoking, Vaping, Tobacco Chewing
- Trial name
- NCT05037656
- Testing
- School-based curriculum
- Where
- Guam
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- University of Guam
Cigarette Smoking, Alcohol Drinking
Sports, Education and Consumption of Substances in Adolescents
Adolescent substance abuse (SA), which includes the consumption of alcohol, cigarette smoking, the consumption of drugs and other behaviors, is a significant public-health issue in the world today.
- Trial name
- SESA (NCT02629679)
- Testing
- Regular scholastic system and organized sports, Regular scholastic system
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Split
Little Cigars and Cigarillos (LCC) Use
Little Cigar and Cigarillo Warnings for Youth
This study explores the effect of the little cigars and cigarillos (LCC) warnings on youth who currently use, have ever used, or are susceptible to using LCCs.
- Trial name
- NCT06413797
- Testing
- FDA warnings + Image, FDA Warnings Text-Only, Surgeon General Text-Only Warnings
- Where
- United States
- Volunteers
- 928 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
E-cigarette Use
Evaluation of the Be Vape Free Curriculum of the Tobacco Prevention Toolkit
The Stanford Tobacco Prevention Toolkit is a free online curriculum developed for use by educators and health professionals in providing tobacco-specific prevention education to middle and high school students.
- Trial name
- NCT05493982
- Testing
- Stanford Vaping Prevention curriculum
- Where
- United States
- Volunteers
- 2,779 people, healthy volunteers welcome
- Sponsor
- Stanford University
Nicotine Dependence
Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers
The purpose of this study is to evaluate reactions to, and choices to self-administer, cigarette smoke with varying nicotine content among low-frequency, non-dependent adolescent/young adult smokers between the ages of 15-25…
- Trial name
- NicRed (NCT02989038)
- Testing
- Very Low Nicotine Content Cigarettes, Intermediate Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Duke University
Cigarette Smoking
Contingency Management for Smoking Abstinence With Adolescent Smokers
The primary objective of this research is to evaluate the effectiveness of this type of smoking cessation program by comparing a treatment group with a control group.
- Trial name
- CM (NCT01056588)
- Testing
- CO-Contingent, Control condition
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Tobacco Use Cessation, Addiction
An Evaluation of the Tobacco Prevention Toolkit Healthy Futures: Alternative-to-Suspension Vaping Intervention
The Healthy Futures: Alternative-to-Suspension Curriculum is a free, online curriculum developed to educate students and provide them with resources to quit tobacco/nicotine use.
- Trial name
- NCT06483412
- Testing
- Healthy Futures: Alternative-to-Suspension Curriculum
- Where
- United States
- Volunteers
- 2,540 people, healthy volunteers welcome
- Sponsor
- Stanford University
Smoking Cessation, Smoking
Implementation and Dissemination of an Evidence-Based Tobacco Product Use Prevention Videogame Intervention With Adolescents
To examine the effects on participants who play the smokeSCREEN game in that the game will have positive changes in their attitudes, beliefs, knowledge, intentions, behaviors and other outcomes related to smoking and tobacco…
- Trial name
- NCT03815591
- Testing
- smokeSCREEN web-based game
- Where
- United States
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Yale University
Cigarette Smoking
Developing a Smartphone App With Mindfulness Training for Teen Smoking Cessation
The recent Surgeon General's Report calls for effective and readily available treatment approaches to help adolescent smokers interested in quitting.
- Trial name
- NCT02218281
- Testing
- C2Q-Teen app, NCI's QuitSTART app, Written smoking cessation materials only
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Smoking Cigarette, Smoking Tobacco
Process and Effect Evaluation of the KickAsh! Intervention
The goal of this evaluation study is to evaluate the KickAsh! intervention, an intervention aiming to prevent smoking initiation in adolescents living in vulnerable socioeconomic situations.
- Conditions
- Smoking Cigarette, Smoking Tobacco, Smoking, Smoking Prevention
- Trial name
- NCT05920772
- Testing
- KickAsh! intervention
- Where
- 2 sites in Belgium
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- University Ghent
Tobacco Use
Expanding the Click City Tobacco Prevention Program to Include E-cigarettes and Other Novel Tobacco Products
The goal of this study is to modify a smoking prevention program for 5th and 6th grade students to also target vaping e-cigarettes.
- Trial name
- NCT03682900
- Testing
- Click City®: Tobacco, Usual Tobacco Curriculum
- Where
- United States
- Volunteers
- 2,673 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Vaping, Adolescent
Nicotine and Cannabis Vape Labeling Experiment - Spring 2025
This study assesses how the ways in which nicotine and cannabis vaping devices are labeled impact use susceptibility, anticipated effects, and health harm.
- Conditions
- Vaping, Adolescent, Electronic Cigarette Use, Nicotine
- Trial name
- EPIC/ADVANCE (NCT06919276)
- Testing
- Vaping Device Labeling
- Where
- United States
- Volunteers
- 3,048 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Schizophrenia
Imaging of Brain Receptors in Healthy Volunteers and in Patients With Schizophrenia
This study will use single photon emission computed tomography (SPECT) to study brain nicotine receptors (proteins on the surface of brain cells) in healthy subjects and in patients with schizophrenia.
- Trial name
- NCT00061789
- Testing
- SPECT Imaging of Nicotinic Acetylcholine Receptors in Brain
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Nicotine Dependence, Cigarettes, Cessation, Tobacco
Reducing Nicotine Addiction in Adolescent Smokers
Adolescents are at risk for tobacco use due to factors such as impulsivity, poor perception, desire to prove themselves, and insufficient neurological development.
- Conditions
- Nicotine Dependence, Cigarettes, Cessation, Tobacco, Cessation, Smoking, Adolescent Problem Behavior
- Trial name
- NCT05477342
- Testing
- Board Game, Tobacco Cesseation Education, Combined İntervention
- Where
- Turkey (Türkiye)
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Ministry of National Education, Turkey
Cigarette Smoking Behavior
Effects of Contingency Management and Nicotine Replacement Therapy on Youth Smoking
Cigarette smoking is an important public health concern, and it is most often initiated in adolescence. Despite substantial research on smoking cessation in adults, however, relatively little effort has focused on therapeutic…
- Trial name
- NCT01359709
- Testing
- Nicotine polacrilex
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Nicotine Dependence, Cigarettes, Uncomplicated
Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco
Adolescents are an important vulnerable population to consider as the FDA moves toward a nicotine reduction policy. Such a policy, which would mandate a reduction of nicotine in all commercially available cigarettes, has the…
- Trial name
- SIREN (NCT03860077)
- Testing
- Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Brown University
Tobacco Use
Robot-Assisted Immersive Escape Room Game for Tobacco Harm Prevention Among Elementary School Students
This study evaluates the effectiveness of a robot-assisted immersive escape room intervention for tobacco harm prevention among upper-grade elementary school students.
- Trial name
- NCT07501572
- Testing
- Robot-assisted Immersive Escape Room Game, Traditional Tobacco Harm Prevention Education
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Cigarette Smoking, Nicotine Dependence
School Nurse-Delivered Smoking Cessation Intervention
The purpose of this study is to conduct a randomized controlled school-based trial to evaluate the effectiveness of a four-session school nurse-delivered smoking cessation intervention in increasing abstinence rates among high…
- Trial name
- NCT00682474
- Testing
- Counseling Intervention, Information Intervention
- Where
- United States
- Volunteers
- 1,058 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Nicotine Dependence
Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Adolescent Smokers
Background: Multiple social, psychological, and environmental factors contribute to adolescents' use of cigarettes. Environmental smoking cues have been shown to play an important role in the maintenance of nicotine addiction and…
- Trial name
- NCT01148355
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)