Clinical trials: Transdiagnostic
Social Anxiety, Major Depression Mild
Transdiagnostic REBT Prevention Program for Adolescents
Anxiety and depressive disorders are common in adolescents, however they are often unrecognized. Rational emotive behavioral therapy (REBT), a form of cognitive behavioral therapy (CBT) is efficient for children and adolescents.
- Conditions
- Social Anxiety, Major Depression Mild, Panic Disorder, Specific Phobia
- Trial name
- NCT02756507
- Testing
- video-based transdiagnostic REBT, Wait list
- Where
- Romania
- Volunteers
- 381 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Anxiety Disorders, Depression
Transdiagnostic Individual Behavioral Activation and Exposure Therapy
The Overall Aim of the this project is to compare treatment outcomes and change in putative treatment mediators in Individual Behavioral Activation Therapy (IBAT) against two active psychological interventions (Coping Cat…
- Trial name
- NCT03412227
- Testing
- Individual Behavioral Activation Therapy (IBAT), The PASCET Program for Youth Depressive Disorders, The Coping Cat Program for Youth Anxiety Disorders
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Rutgers University
Psychological Distress, Trauma, Psychological
Feasibility Study of a Group Intervention for Youth Wellbeing
Psychological distress, anxiety and depression are common in adolescence, and even more so following traumatic events. On Friday 15 March 2019, two mosques in Ōtautahi, Christchurch were targeted in an act of terrorism, resulting…
- Conditions
- Psychological Distress, Trauma, Psychological, Emotional Problem
- Trial name
- NCT05030909
- Testing
- transdiagnostic group treatment
- Where
- New Zealand
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Otago
Emotional Problem, Anxiety
A Transdiagnostic Internet Intervention for Parents of Children With Anxiety and Depressive Symptoms
The purpose of this study is to evaluate the efficacy of a transdiagnostic, parent-led, Internet-delivered intervention in reducing child and adolescent internalizing problems.
- Conditions
- Emotional Problem, Anxiety, Depression, Psychological Distress
- Trial name
- ParentKIT (NCT05341297)
- Testing
- ParentKIT
- Where
- Romania
- Volunteers
- 111 people
- Sponsor
- Babes-Bolyai University
Behavioral Symptoms, Emotional Disturbances
Transdiagnostic Group Intervention for Children With Behavior Problems
This study fills a notable gap in the transdiagnostic literature by evaluating whether an evidence-based transdiagnostic treatment for emotional disorders such as the Unified Protocol for Children (UP-C) is effective for treating…
- Trial name
- NCT02794051
- Testing
- Group Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Colorado, Denver
Common Mental Health Problems, Anxiety
Trial of an Online Group Psychotherapy Intervention for Common Mental Health Disorders
The goal of this clinical trial is to understand how to deliver online group therapy for adults with common mental health problems in a personalised way.
- Conditions
- Common Mental Health Problems, Anxiety, Depression Disorders
- Trial name
- UpLift-X (NCT06722781)
- Testing
- Unified Protocol
- Where
- 2 sites in United Kingdom
- Volunteers
- 660 people
- Sponsor
- Rotherham Doncaster and South Humber NHS Foundation Trust
Depressive Disorder, Anxiety Disorders
Research of Unified Protocol for the Treatment of Common Mental Disorders in Adolescents in Hong Kong
The Unified Protocol (UP) is an emotion-focused, cognitive-behavioural intervention that is developed to target core temperamental characteristics underlying anxiety and depressive disorders.
- Trial name
- NCT04091139
- Testing
- Unified protocol for adolescents (UP-A), Treatment as usual (TAU)
- Where
- Hong Kong
- Volunteers
- 27 people
- Sponsor
- Chinese University of Hong Kong
Social Anxiety Disorder, Generalized Anxiety Disorder
Where We All Meet: ACT Approach to Adolescents Anxiety Disorders
Transdiagnostic approaches have been proposed as more truthfully representing mental health problems. Acceptance and Commitment Therapy (ACT) is a transdiagnostic approach that proposes Psychological Inflexibility/Flexibility…
- Trial name
- NCT05906849
- Testing
- ACT for anxiety disorders
- Where
- Portugal
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Anxiety Disorders, Psychotic Disorders
Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness
This research study aims to develop a brief group-based treatment called Resilience Training for Teens, then to test how well it protects high school students with mild symptoms of depression, anxiety, or having unusual feelings…
- Conditions
- Anxiety Disorders, Psychotic Disorders, Depressive Disorder, Psychosocial Functioning
- Trial name
- NCT05962879
- Testing
- Resilience Training for Teens
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Emotional Regulation
Strengthening Emotional Regulation: a Group Intervention With Adolescents
The goal of this clinical trial is to determine the initial efficacy of an emotional regulation skills training (ERST) intervention program in a group of adolescents presenting mild symptoms affecting their ability to regulate…
- Trial name
- NCT06878521
- Testing
- Emotional Regulation Skills
- Where
- Chile
- Volunteers
- 69 people
- Sponsor
- Lorena Wenger Amengual
Anxiety, Depression
Applying the Spanish Version of the UP-A as a Universal School-based Anxiety and Depression Prevention Program
The current study proposes to extend transdiagnostic treatment research to adolescents by establishing initial pre to post-treatment and follow-up outcomes associated with the use of the Spanish Version of the Unified Protocol…
- Trial name
- NCT03123991
- Testing
- UP-A adapted as a preventive intervention, Same than experimental group (EG), after EG finishes
- Volunteers
- 157 people
- Sponsor
- Universidad Nacional de Educación a Distancia
Adolescents, Mood Disorders
Mobile-enhanced Group CBT for Adolescents at Risk Severe Mood Disorders
Although cognitive-behavioral therapy (CBT) has shown efficacy in reducing symptoms and rates of mood relapse in adolescents at high risk for severe mood disorders (SMD; i.e., bipolar I/II disorder and recurrent or unremitting…
- Trial name
- NCT04887155
- Testing
- Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- University of California, Los Angeles
Bulimia Nervosa, Binge-Eating Disorder
Attachment-Based Family Therapy for Adolescents With Binge Eating
The purpose of this study is to examine whether Attachment-Based Family Therapy (ABFT), a well-validated treatment for adolescents with depression and suicidality, is feasible and acceptable for adolescents with binge eating and…
- Conditions
- Bulimia Nervosa, Binge-Eating Disorder, Other Specified Feeding or Eating Disorder
- Trial name
- ABFT (NCT04779801)
- Testing
- Attachment-Based Family Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Drexel University
Anxiety Disorders and Symptoms, Depressive Symptoms
Selective Prevention Transdiagnostic Intervention for At-risk Adolescents
Emotional disorders (anxiety and/or depression) are severely undiagnosed and untreated despite being among the most common mental disorders, particularly at a young age.
- Trial name
- PROCARE (NCT04851366)
- Testing
- PROCARE+ (with add-on modules), PROCARE (UP-A for selective purposes), Active control condition
- Where
- 3 sites in Spain
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Jaén
Non-suicidal Self-injury (NSSI)
Blended Unified Protocol for Chinese Adolescents With Non-Suicidal Self-Injury: A Randomized Controlled Trial
This study is an open-label, randomized controlled trial evaluating the efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents (UP-A) in reducing non-suicidal self-injury (NSSI) among…
- Trial name
- NCT07110181
- Testing
- a blended version of the Unified Protocol for Adolescents (UP-A), Standard psychiatric treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jian-Jun Ou
Neurodevelopmental Disorder (Diagnosis), Epilepsy
Characterization of Neurocognitive Profiles in Neurodevelopmental Disorders and Epilepsy: a Transdiagnostic Approach
Neurodevelopmental disorders (NDDs) are early-onset conditions affecting personal, social, and academic functioning, with high comorbidity rates and shared neurobiological traits.
- Trial name
- DIS-Neurodev (NCT06877260)
- Testing
- Computer based task with EEG
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Neurodevelopmental Disorder (Diagnosis)
Transdiagnostic Dimensional Profiling of Neurodevelopmental Disorders
In recent years, the growing awareness of the multifactorial nature of neurodevelopmental disorders has stimulated interest in transdiagnostic approaches aimed at investigating underlying etiological mechanisms beyond traditional…
- Trial name
- RDoC-CRAB (NCT07544199)
- Testing
- Neuropsychological assessment
- Volunteers
- 300 people
- Sponsor
- IRCCS Eugenio Medea
Inpatients
Inpatient Distress Tolerance Group Intervention Pilot
Research suggests that a low capacity to tolerate distress is a common underlying factor in the development and maintenance of a range of mental health problems.
- Trial name
- NCT03712332
- Testing
- Distress Tolerance Group
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Edinburgh
Anxiety, Anxiety Disorders
Randomized Feasibility Trial of Mind My Mind
In this feasibility RCT of the modular and flexible cognitive and behavioural therapy (Mind My Mind, MMM) compared with treatment as usual, the overall research aim was to explore the trial design and the acceptability of the…
- Conditions
- Anxiety, Anxiety Disorders, Depressive Symptoms, Depressive Disorder
- Trial name
- MindMyMind (NCT03448809)
- Testing
- Mind My Mind, TAU (Treatment as Usual)
- Volunteers
- 150 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Anxiety Disorders, Depressive Disorder
Brief Transdiagnostic Group CBT for Adolescents With Internalizing Problems: A Randomized Waitlist Controlled Trial
The investigators will evaluate a brief group-based cognitive-behavioral treatment program for adolescents aged 13-17 years with internalizing problems.
- Conditions
- Anxiety Disorders, Depressive Disorder, Anxiety, Depression
- Trial name
- NCT04716777
- Testing
- Brief Transdiagnostic group-based Cognitive-Behavioral Treatment
- Where
- Iceland
- Volunteers
- 50 people
- Sponsor
- University of Iceland