Clinical trials: Translational Research
Neurogenetic Disorders
Neurogenetics Patient Registry
The objective of this project is to develop a Neurogenetics patient database and bio repository - which includes clinical information regarding history, physical examination, laboratory testing including genetic testing (NextGen…
- Trial name
- NCT02995538
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Pittsburgh
Traumatic Brain Injury
A TMU/NIH Integrated Research Project Translation of Basic Research to Clinical Diagnosis and Treatment of Mild Traumatic Brain Injury (mTBI)
This integrated research project is cooperated by an fully-experienced team of Taipei Medical University and National Institutes of Health.
- Trial name
- NCT01266356
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Taipei Medical University WanFang Hospital
Posttraumatic Stress Disorder
Resilient Roots: Supporting Youth and Families
Resilient Roots is integrated into the TRANSFORM Center to promote translation of research findings into clinical interventions, to inform the next generation of research on child abuse and neglect (CAN), and to facilitate…
- Trial name
- NCT06535516
- Testing
- Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) augmented with Socialization (S)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Substance Abuse, Substance Use Disorders
Testing Strategies to Improve Substance Misuse Prevention Research Use in State Policy Contexts
If science is to inform effective substance misuse prevention policy and ultimately improve public health, the field needs an effective strategy for directly supporting policymakers' use of research evidence, yet our field lacks…
- Conditions
- Substance Abuse, Substance Use Disorders, Prevention, Legislation
- Trial name
- NCT06856148
- Testing
- Intervention: RPC Group, Active Comparator: Control Group
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Penn State University
School-based Intervention, Sleep
Educational Intervention for Sleep Hygiene Nursing in Adolescents
There is an urgent need to influence the knowledge and beliefs associated with sleep (TV viewing, use of electronic devices, sedentary activity...) of school children through holistic interventions involving students, parents…
- Trial name
- ENISHA-ST (NCT06805708)
- Testing
- Sleep hygiene training programme
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Substance Use Disorders
Juvenile Justice Translational Research on Interventions for Adolescents in the Legal System
This is a multi site experiment to evaluate the impact of various strategies for increasing the use of evidence based screening, assessment and linkage to substance use treatment.
- Trial name
- (JJ-TRAILS) (NCT02672150)
- Testing
- Core, Enhanced
- Where
- 8 sites in United States
- Volunteers
- 839 people
- Sponsor
- Chestnut Health Systems
Breast Neoplasms
Sweden Cancerome Analysis Network - Breast : Genomic Profiling of Breast Cancer
This study evaluates the genomic profiles of breast cancer in a prospective and population-based manner. In the first phase, breast tumors are analyzed by whole transcriptome RNA-sequencing.
- Trial name
- SCAN-B (NCT02306096)
- Where
- 10 sites in Sweden
- Volunteers
- 20,000 people
- Sponsor
- Lund University
Attention Deficit Hyperactivity Disorder
Autonomic Correlates of Impulsivity for Preschool Children With Attention Deficit Hyperactivity Disorder (ADHD)
The goal of this pilot feasibility and utility study is to develop and validate a method that is reproducible over time for assessing biobehavioral and autonomic markers of impulsivity and their utility in assessing treatment…
- Trial name
- NCT00856063
- Volunteers
- 5 people
- Sponsor
- University of Arizona
Refractory Cancer
Patients Who Refractory Cancer Conqueror for Bio New Drug Development Translational Research Establishment
■ Unmet medical needs for Refractory cancer Conquest Many advanced cancers are still detected Despite remarkable technological advances for the early diagnosis of cancer in the field last 20 years.
- Trial name
- NCT01932047
- Where
- South Korea
- Volunteers
- 1,523 people
- Sponsor
- Samsung Medical Center
Autism, Autism Spectrum Disorder
Biomarkers Research in Anxiety for Validation and Efficacy
A within-subjects design will be used for this preliminary investigation of four biomarkers across two contexts of use: prediction of treatment response (i.e., stratification) and quantification of response (i.e., change).
- Trial name
- BRAVE (NCT06221176)
- Testing
- Being Brave
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston Children's Hospital
Asthma
Better Pediatric Asthma Outcomes Through Chronic Care
This 3-year, multi-site study focuses on the translation of cost-effective methods to bring a chronic care model to the care of poor, minority, inner-city children with asthma, at risk of the worst outcomes for the leading…
- Trial name
- NCT00355069
- Testing
- electronic (computer based) provider feedback tool
- Where
- United States
- Volunteers
- 548 people
- Sponsor
- UConn Health
Overweight, Memory Disorder
Translation of Obesity and Cognitive Program by Lay Health Educators
Obesity is a major public health problem among older adults, with 31% of non-institutionalized older persons (60 years+) in the US obese and projections indicating that this will rise to 40% by 2010.
- Trial name
- Coaches (NCT01377506)
- Testing
- lifestyle counseling, Cognitive Training
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Breast, Breast Cancer
Clinical Translation Research on a Multi-omics Breast Cancer Distant Metastasis Prediction Model Empowered by Artificial Intelligence
Breast cancer is one of the most common malignancies in women worldwide, and distant metastasis is the main cause of poor prognosis and death.
- Conditions
- Breast, Breast Cancer, Pathology
- Trial name
- COMPASS-BC (NCT07252986)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Colorectal Neoplasms, Peritoneal Neoplasms
PIPAC for Peritoneal Metastases of Colorectal Cancer
This is multicentre, open-label, single-arm phase II study that investigates the feasibility, safety, tolerability, preliminary efficacy, costs, and pharmacokinetics or repetitive electrostatic pressurised intraperitoneal aerosol…
- Conditions
- Colorectal Neoplasms, Peritoneal Neoplasms, Appendiceal Neoplasms, Peritoneal Carcinomatosis
- Trial name
- CRC-PIPAC (NCT03246321)
- Testing
- repetitive ePIPAC-OX
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Koen Rovers
Traumatic Brain Injury
Traumatic Brain Injury - Knowledge Translation
Blunt head trauma (BHT) accounts for >450,000 emergency department (ED) visits for children annually in the US. Fortunately, >95% of head trauma in children is minor in nature.
- Trial name
- TBI-KT (NCT01453621)
- Testing
- Computerized clinical decision support
- Where
- United States
- Volunteers
- 28,669 people
- Sponsor
- Columbia University
Congenital Heart Surgery, Congenital Heart Disease in Children
Blood Based Assessment of sST2, Taken During and After Surgery, for Pediatric Patients With Heart Defects to Predict Heart Failure.
Patients younger than 18 scheduled for congenital heart surgery will be assessed during and post-operatively as well as at the first follow-up after 9-12 month for the novel biomarker sST2.
- Conditions
- Congenital Heart Surgery, Congenital Heart Disease in Children, Fontan Physiology
- Trial name
- NCT07029230
- Where
- Switzerland
- Volunteers
- 225 people
- Sponsor
- Martin Schweiger
Pregnancy, HIV Infections
Effectiveness of Integrating Prenatal Care in Reducing HIV/STDs Among Young Pregnant Women
This study will evaluate the effectiveness of CenteringPregnancy Plus, a group prenatal care treatment program with an HIV/sexually transmitted disease prevention component, in reducing health risk behaviors in pregnant teenagers…
- Conditions
- Pregnancy, HIV Infections, Sexually Transmitted Diseases
- Trial name
- NCT00628771
- Testing
- CenteringPregnancy Plus (CP+), Usual care
- Where
- 3 sites in United States
- Volunteers
- 1,233 people
- Sponsor
- Yale University
Tobacco Use Cessation, Tobacco Smoking
EHR-Based and Fax-Based Referral to a Tobacco Quitline: A Comparative Study
This study is designed to assess whether completely electronic, HIPAA-compliant, EHR-based, closed-loop referrals for tobacco cessation from primary care clinics to a state telephone tobacco quitline service can increase the…
- Trial name
- NCT02735382
- Testing
- Tobacco quitline EHR referral, Tobacco quitline Fax referral
- Where
- United States
- Volunteers
- 14,930 people
- Sponsor
- University of Wisconsin, Madison
Genetic Disease, Nervous System Diseases
Prospective Cohort Study of Neurogenetic Diseases
Neurogenetic diseases (NGD) represent rare and hereditary forms of neurological diseases. The goal of CNGD is to create a one-window approach for NGDs, to facilitate and accelerate participation in research projects through deep…
- Trial name
- CNGD (NCT06048523)
- Testing
- Patient cohort, Control cohort
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Childhood Leukemia
Advanced Translational Research on Childhood Leukemia
Prognosis of children with leukemia, the most common pediatric cancer, has improved markedly. Yet, relapse still occurs in 15-40% of patients with a probability of survival of <50%, which is unlikely to be boosted by…
- Trial name
- NCT04478006
- Testing
- RNA-seq, whole exon sequencing, Cytogenetics test
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong