Clinical trials: Transplantation, Cornea
Corneal Burn
Modified Corneal EA With Middle LKP for Severe Corneal Burn
The purpose of this pilot study is to explore whether modified corneal epithelial autograft (EA) combined with allogeneic middle lamellar keratoplasty (AMLK) is more effective than limbal autograft (LA) with AMLK for ocular…
- Trial name
- NCT03498846
- Testing
- Modified EA and AMLK, LA and AMLK
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-sen University
Ocular Burns
Corneal Epithelial Autograft With Middle Lamellar Keratoplasty for Severe Ocular Burns
The purpose of this pilot study is to explore whether corneal epithelial autograft (EA) combined with allogeneic middle lamellar keratoplasty (AMLK) is more effective than limbal autograft (LA) with AMLK for ocular surface…
- Trial name
- NCT03421769
- Testing
- EA and AMLK, LA and AMLK
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Yingfeng Zheng
Corneal Transplantation
The German Keratoplasty Registry of the German Ophthalmological Society (DOG)
Aim of this study is to reflect on the changing trends in absolute numbers, surgical techniques and indications of corneal transplantations being performed in Germany.
- Trial name
- NCT03381794
- Testing
- Corneal transplantation
- Where
- Germany
- Volunteers
- 100,000 people
- Sponsor
- Universität des Saarlandes
Corneal Transplant
Post Operative Visual Acuity for DSAEK and UT-DSAEK
To study the correlation between graft size in DSAEK (Descemet Stripping Automated Endothelial Keratoplasty) and UT (ultra thin)-DSAEK type corneal transplants to the visual acuity 6 months postoperatively.
- Trial name
- POVIAD (NCT03685851)
- Testing
- DSAEK type corneal transplant
- Volunteers
- 111 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Corneal Transplantation
Retrospective Analysis of Surgical Outcomes After Corneal Transplantation
Currently, no demographic and surgical results comparing different donor cornea sources were available in Taiwan. National Taiwan University Hospital (NTUH), as one of the largest tertiary medical centers in northern Taiwan, is…
- Trial name
- NCT01547975
- Where
- Taiwan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Graft Rejection
Pathogenetic Risk Factors for Corneal Graft Rejection
There are many predictors that may influence the development of corneal graft rejection after penetrating keratoplasty. In our study investigators analysed the results of keratoplasty and the risk factors for graft rejection.
- Trial name
- NCT06281587
- Testing
- penetrating keratoplasty
- Where
- Russia
- Volunteers
- 93 people
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
Unilateral Limbal Stem Cell Insufficiency
The Application of Cultured Cornea Stem Cells in Patients Suffering From Corneal Stem Cell Insufficiency
Name of the project：The application of cornea stem cells cultured on amniotic membrane in patients suffering from corneal stem cell insufficiency Purpose: To develop the technique of using ex vivo expansion of autologous limbal…
- Trial name
- NCT01377311
- Testing
- Transplant of cultured limbal stem cells on cornea
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Pupillary Block After DMEK, Laser Iridotomy / Surgical Iridectomy
Impact of Iridotomy/Iridectomy Size on Postoperative Pupillary Block and Dysphotopsia Following DMEK
Descemet membrane endothelial keratoplasty (DMEK) is the standard surgical treatment for corneal endothelial disorders. A postoperative pupillary block may occur despite routine preoperative laser iridotomy or intraoperative…
- Conditions
- Pupillary Block After DMEK, Laser Iridotomy / Surgical Iridectomy, Dysphotopsia, Descemet Membrane Endothelial Keratoplasty (DMEK)
- Trial name
- NCT07577635
- Testing
- Anterior Segment Optical Coherence Tomography (AS-OCT), Dysphotopsia Questionnaire
- Volunteers
- 100 people
- Sponsor
- University of Leipzig
Corneal Epithelial Defects After Ocular Surgeries
Topical Autologous Insulin Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries
Topical insulin application has been proved recently to increase corneal reepithelization rate over diabetic animals. However, its effectiveness on corneal epithelial wound healing in patients who received pars planar vitrectomy…
- Trial name
- NCT01031888
- Testing
- Topical insulin eye drops, Conventional postoperative eye drops
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- National Taiwan University Hospital
Limbal Stem Cell Deficiency
Corneal Epithelial Allograft From Living-related Donor for LSCD
The purpose of the study is to explore whether femtosecond laser-assisted corneal epithelial allograft from living-related donor is more effective than limbal conjunctival allograft from living-related donor for ocular surface…
- Trial name
- NCT03217435
- Testing
- Corneal epithelial allograft, Limbal conjunctival allograft, Femtosecond laser
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chunxiao Wang
Keratoconus, Fuchs Dystrophy
Femtolaser Assisted Keratoplasty Versus Conventional Keratoplasty
This pilot study will compare upto 15 patients undergoing femtolaser assisted keratoplasty (using CE[Conformité Européene] approved femtolaser apparatus) with upto 15 patients undergoing conventional keratoplasty with a manual…
- Conditions
- Keratoconus, Fuchs Dystrophy, Corneal Disease
- Trial name
- NCT03619434
- Testing
- Femtosecond Laser, Trephine blade
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Southampton
Limbal Stem-cell Deficiency
The Effects of Autologous SLET
This study aims to prospectively evaluate the therapeutic effects of autologous simple limbal epithelial transplantation for patients with limbal stem cell deficiency.
- Trial name
- NCT04021875
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Corneal Transplantation
Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea
The performance of keratoplasty is hampered by the limited availability of donor cornea in many countries, especially in Asia. For this reason, attempts have been made to fabricate artificial substitutes for natural human cornea.
- Trial name
- NCT03105466
- Testing
- Deep anterior lamellar keratoplasty, Acellular Porcine Cornea, Tacrolimus eye drops
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Keratoconus
Comparison of Anwar and Melles Techniques in Deep Anterior Lamellar Keratoplasty (DALK) for Keratoconus Patients
This study will be performed on patients who come to labbafinejad ophthalmic clinic from 20 March 2008. Keratoconus diagnosis will be determined by clinical finding in slit lamp, keratometery and topographic characteristics.
- Trial name
- NCT00850148
- Testing
- Anwar, Melles
- Where
- 2 sites in Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Persistent Corneal Epithelial Defect
Comparison of Topical Insulin and Amniotic Membrane Transplant for Persistent Corneal Epithelial Defects
After an initial period of standard treatment, they received further care aimed at helping the surface of the eye heal. Clear instructions were given on how to use and store the treatment properly.
- Trial name
- NCT07561398
- Testing
- Topical insulin eye drops, Amniotic Membrane Graft
- Where
- Pakistan
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Al-Shifa Trust Eye Hospital
Keratoconus
The Homburg Keratoconus Center (HKC)
Aim of this study is to conduct longitudinal and cross-sectional analyses about the corneal ectatic disease Keratoconus based on data obtained from Keratoconus patients in the Homburg Keratoconus Center (HKC).
- Trial name
- NCT03923101
- Testing
- Topographic, tomographic and biomechanical analysis.
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Universität des Saarlandes
Fuchs Endothelial Corneal Dystrophy, Descemet Membrane Endothelial Keratoplasty (DMEK)
Influence of Supine Positioning on the Outcomes After Descemet Membrane Endothelial Keratoplasty (DMEK)
The goal of this clinical trial is to learn if a longer period of lying on the back after corneal transplant surgery (Descemet Membrane Endothelial Keratoplasty, DMEK) helps the transplant stick better in the eye.
- Trial name
- SUPINE (NCT07373821)
- Testing
- Duration of Supine Positioning
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- University Hospital Heidelberg
Corneal Disease, Pterygium
Corneal Epithelium Repair and Therapy Using Autologous Limbal Stem Cell Transplantation
Corneal disease is a leading cause of blindness in the world. A shortage of corneal donor tissue has prevented many patients from regaining vision.
- Conditions
- Corneal Disease, Pterygium, Myopia, Hyperopia
- Trial name
- NCT02148016
- Testing
- LSCs and amniotic membrane (Modified Technique), Amniotic membrane only (Traditional Technique), PRK, LSCs, and amniotic membrane (Modified Technique)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-sen University
Corneal Transplantation, Graft Rejection
Collaborative Corneal Transplantation Studies (CCTS)
To determine whether histocompatibility matching of corneal transplant donors and recipients can reduce the incidence of graft rejection in high-risk patients.
- Trial name
- NCT00000137
- Testing
- Histocompatibility Matching
- Sponsor
- National Eye Institute (NEI)
Corneal Opacity
OCT-guided LALAK in Children
The primary goal of the trial is to determine if laser-assisted lamellar anterior keratoplasty (LALAK) will reduce the risks of post-operative complications such as adhesions, glaucoma and cataract that are associated with…
- Trial name
- LALAK (NCT01579643)
- Testing
- OCT guided laser-assisted lamellar anterior keratoplasty (LALAK), Penetrating Keratoplasty (KP)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Oregon Health and Science University