Clinical trials: Traumatic Brain Injuries
Concussion
Q-collar and Brain Injury Biomarkers
Significant morbidity, mortality, and related costs are caused by traumatic brain injury (TBI). A simple, effective, and lightweight device worn by athletes or war fighters in the field, designed to mitigate TBI resulting from…
- Trial name
- NCT02271451
- Testing
- Q collar
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
MTBI - Mild Traumatic Brain Injury, Concussion, Mild
Evaluation of Helmet Technology and Head Impact Exposure
The purpose of the study is to monitor longitudinal changes in brain structure and function between the preseason and postseason, in a population of football playing athletes grouped by helmet make and model.
- Trial name
- NCT03883451
- Testing
- Helmet Model
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Traumatic Brain Injury, Pain
Characterization & Treatment of Chronic Pain After Moderate to Severe TBI
This is a five year multi-site, cross sectional, observational study designed to examine chronic pain and pain treatment after moderate to severe TBI.
- Trial name
- NCT03739307
- Where
- 13 sites in United States
- Volunteers
- 3,805 people
- Sponsor
- Craig Hospital
Hyperbaric Oxygen Therapy, Traumatic Brain Injury
Hyperbaric Oxygen Therapy Effect on Post Concussion Syndrome in Children
Due its high incidence, mTBI and its consequences of PPCS are a major public health issue. There is no consensus regarding the treatment of PPCS in pediatrics.
- Conditions
- Hyperbaric Oxygen Therapy, Traumatic Brain Injury, Post-Concussion Syndrome
- Trial name
- TBIPED (NCT03339037)
- Testing
- Hyperbaric oxygen therapy
- Where
- Israel
- Volunteers
- 52 people
- Sponsor
- Assaf-Harofeh Medical Center
Brain Concussion, Head Injury
ReCoUPS: Post-Concussion Patient Reports
Physical and cognitive rest are recommended as treatment for concussion, but debate persists about the utility of this recommendation for patients recovering from concussion.
- Trial name
- NCT04499937
- Testing
- Streak incentive, Loss-based incentive, Flat-fee control status quo condition
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Philadelphia
Mild Traumatic Brain Injury
Evaluating Huddles as a Novel Approach to Improving Concussion Safety
Investigators will conduct a randomized controlled trial assessing the effectiveness and implementations of Pre-Game Safety Huddles (Huddles) in youth soccer.
- Trial name
- NCT06864611
- Testing
- Pre-Game Safety Huddles
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Non Traumatic Acute Brain Injury
Non Traumatic Neuro-Vascular Diseases Critical Complications : a Prospective Cohort Study
The purpose of this observational epidemiological study is to investigate the management and the complications associated with Non Traumatic Neuro-Vascular Diseases.
- Trial name
- ATLANREA (NCT02714387)
- Testing
- Collection of medical data
- Where
- 6 sites in France
- Volunteers
- 5,000 people
- Sponsor
- Nantes University Hospital
Post-Concussion Syndrome
Move&Connect: A Program for Youth With Concussion and Their Caregivers.
Move\&Connect is an interdisciplinary group-based program co-designed with youth and caregivers that provides skills training, mental health support, and psychoeducation to caregivers and combines these tenets with active…
- Trial name
- NCT05631301
- Testing
- Exercise Circuits, Goal Setting, Psychoeducation-Youth
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Concussion, Brain, Mild Traumatic Brain Injury
A Highly Portable Device for Assessment of Mild Traumatic Brain Injury in Deployed and Far-Forward Settings
The purpose of this study is to develop a highly portable, ruggedized diagnostic tool for concussion, EyeBOX Lens (EBLens), that can be utilized in deployed field and far-forward settings.
- Trial name
- NCT05527041
- Testing
- EyeBOX Lens (EBLens)
- Where
- United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Oculogica, Inc.
Concussion, Mild
Sex and Age Ultrasound Response to Differential Jugular Vein Pressure
Clinical trials have suggested that this device is effective in mitigating changes in brain structure and function in athlete populations.
- Trial name
- NCT03017937
- Testing
- Q-collar
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Brain Concussion, Brain Injuries
Screening Brain MRI in High School Football: Does the Guardian Cap Reduce the Risk of Traumatic Brain Injury
Screening Brain magnetic resonance imaging (MRI) with Fluid-attenuated Inversion Recovery (FLAIR) and Susceptibility Weighted Imaging (SWI) sequences will be performed pre and post season on high school football players.
- Conditions
- Brain Concussion, Brain Injuries, Diffuse Axonal Injury, Athletic Injuries
- Trial name
- NCT02757053
- Testing
- Guardian Cap
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Mosaic Life Care
Mild Traumatic Brain Injury, Concussion, Mild
Neural Injury in Adolescents With Concussion
This study utilizes multimodal brain imaging to obtain quantitative biomarkers of brain injury and to improve understanding of the biological basis of brain pathology in adolescents with concussion.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Mild, Acute Brain Injury
- Trial name
- NCT03011983
- Testing
- MEG, MRI, Neuropsychology assessment
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Brain Injury Traumatic Mild
Evaluation of the Impact of a Dietary and Nutritional Intervention on Persistent Post-concussive Symptoms
Concussions affect thousands of Canadians every year. Although the effects are usually temporary, 10-15% of adults experience persistent symptoms likely to last several weeks or even months.
- Trial name
- NCT05589064
- Testing
- Experimental: Dietetic counseling, Active Comparator: Omega-3, vitamin D3 and creatine monohydrate, Other : Physiotherapy treatment
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Universite de Moncton
Traumatic Brain Injury
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for TBI
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of traumatic brain injury
- Trial name
- NCT05018832
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- Antigua and Barbuda
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Fracture, Scoliosis Idiopathic Adolescent
Opioid Analgesia Impacts on Neurological Development
Background: Pain in childhood - whether from injuries like fractures or long-term conditions like scoliosis - is often treated with opioid medicines. These drugs are effective for pain relief.
- Conditions
- Fracture, Scoliosis Idiopathic Adolescent, Traumatic Injury, Adolescent
- Trial name
- OPAL (NCT07855952)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Brain Injuries, Traumatic, Concussion, Brain
Objective Brain Function Assessment of mTBI/Concussion in High School Athletes
This study (Part 2) is designed to build a database including EEG, neurocognitive performance, clinical symptoms, history and other relevant data, which will be used to derive a multimodal EEG based algorithm for the…
- Conditions
- Brain Injuries, Traumatic, Concussion, Brain, Concussion, Mild, Concussion, Intermediate
- Trial name
- AheadCAS-HS (NCT02661633)
- Testing
- BrainScope Ahead 200iD, Advanced MRI Neuroimaging
- Where
- 4 sites in United States
- Volunteers
- 177 people
- Sponsor
- BrainScope Company, Inc.
Mild Traumatic Brain Injury, Concussion, Mild
Feasibility of a Cognitive Intervention for Youth Post Concussion
The purpose of this study is to evaluate the feasibility and effects of a cognitive intervention for youth following concussion
- Trial name
- NCT03195738
- Testing
- Cognitive Orientation to Occupational Performance (CO-OP)
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Critical Illness, Pediatric Critical Illness
Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children
This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit…
- Conditions
- Critical Illness, Pediatric Critical Illness, Respiratory Failure, Traumatic Brain Injury
- Trial name
- NCT07613918
- Testing
- Transcranial Doppler
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Wisconsin, Madison
Traumatic Brain Injury
Transforming Research and Clinical Knowledge in TBI Pilot
The global aim of this proposal is to test and refine Common Data Elements (CDEs), neuroimaging standards, and best practices for genetics and proteomics in Traumatic Brain Injury (TBI) studies.
- Trial name
- NCT01565551
- Testing
- N/A (Observational Study)
- Where
- 4 sites in United States
- Volunteers
- 650 people
- Sponsor
- University of California, San Francisco
Mild Traumatic Brain Injury, Concussion
A Randomised, Double-blind, Placebo-controlled Phase 2a Pilot Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ONP-002 in Adults With Mild Traumatic Brain Injury
This is a Phase IIa, randomized, double-blind, placebo-controlled pilot study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of ONP-002 in adults with mild traumatic brain injury (mTBI).
- Trial name
- NCT06870240
- Testing
- Neurosteroid enantiomer
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Oragenics, Inc.