Clinical trials: Traumatic Head Injury
Traumatic Brain Injury
MLC901 for Moderate to Severe Traumatic Brain Injury (Specified Drug Code)
Patients with a diagnosis of moderate to severe traumatic brain injury (TBI) will be enrolled. Subjects will be randomly assigned to receive either MLC901 (Specified Drug Code) or placebo capsules three times per day over 6…
- Trial name
- MLC901 (NCT04487275)
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Ali Amini Harandi
Traumatic Brain Injury, Coagulation Disorder
Evaluating the Use of Thromboelastography to Diagnose Coagulopathy After Traumatic Brain Injury
The investigators will obtain thromboelastography (TEG) on pediatric patients admitted to the Rady Children's Hospital ICU after traumatic brain injury on admission to our ICU and after 24 hours of care.
- Trial name
- NCT01589172
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Diego
Brain Concussion, Post-Concussion Symptoms
Perceptual-Cognitive Training After a Mild Traumatic Brain Injury: Towards a Sensitive Marker for Recovery
This study is part of a larger, multi-centered project done with the collaboration of University Of Victoria. This study holds three separate studies on the mild traumatic brain injured population and the use of…
- Conditions
- Brain Concussion, Post-Concussion Symptoms, Concussion
- Trial name
- NCT03213730
- Testing
- 3D-MOT Neurotracker, Visual Attention Intervention
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Brain Injuries, Traumatic
CREACTIVE - Collaborative REsearch on ACute Traumatic Brain Injury in intensiVe Care Medicine in Europe
CREACTIVE is a large-scale observational cohort study concerning Traumatic Brain Injury (TBI) care in the ICU setting
- Trial name
- CREACTIVE (NCT02004080)
- Testing
- Intensive Care treatment
- Where
- 20 sites in Italy
- Volunteers
- 8,000 people
- Sponsor
- Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
Traumatic Brain Injury, Depression
The Effect of Exercise on Mood After Traumatic Brain Injury
We proposed to examine the effect of an aerobic exercise intervention on depression in persons with Traumatic Brain Injury (TBI).
- Trial name
- NCT00571545
- Testing
- Aerobic exercise, No exercise
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Washington
Brain Trauma
Magnetic Resonance (MR) Spectroscopy and Diffusion Tensor Imaging in Determining Brain Injury and Subsequent Clinical Outcome in Patients of Moderate Brain Trauma
The purpose of this study is to use magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) to assess for traumatic brain injury and determine if there is any correlation of these findings to clinical outcome.
- Trial name
- NCT00760903
- Testing
- Conventional MRI of the brain, MR spectroscopy (MRS), MR Diffusion Tensor Imaging (DTI)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Vestibular Disorder
Vestibular Treatment in Adolescents Following Sport Related Concussion
Each year, nearly 2 million children and adolescents have a sport-related concussion (SRC) in the U.S., but 57% of them do not receive appropriate clinical care following their injury.
- Trial name
- NCT03555370
- Testing
- Vestibular Exercise Intervention, Standard of Care
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
TBI (Traumatic Brain Injury)
MR Imaging Study of TBI in Children
This project will combine the data collected from structural and functional MRI scans and neuropsychology performance post-TBI in children.
- Trial name
- MISTIC (NCT03034031)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Middle Meningeal Artery Embolization, Chronic Subdural Hematomas
Middle Meningeal Artery Embolization in Patients With Chronic Subdural Hematoma
Primary : to evaluate the efficacy of MMAE on resolution and recurrence of hematoma in patients with CSDH. Secondary : evaluate the effect of MMAE on functional outcome, radiological changes, the need to repeat surgery, duration…
- Trial name
- NCT07806552
- Testing
- middle meningeal artery embolization
- Volunteers
- 35 people
- Sponsor
- Assiut University
Sports Injury, Concussion, Mild
Turkish Translation of SportsConcussion Assesment Tool 6
Concussions, a significant type of sports injury caused by head, face, or neck trauma, are common in contact sports and require serious attention due to potential fatal consequences of mismanagement.
- Conditions
- Sports Injury, Concussion, Mild, Concussion, Brain, Concussion, Severe
- Trial name
- SCAT 6-tr (NCT06739785)
- Testing
- SCAT6-tr
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ordu University
Concussion
Concussion Testing: A Novel Non-invasive Concussion Detection Device
The purpose of this study is to establish and evaluate a distinctive signal for concussion.
- Trial name
- NCT02370914
- Testing
- Nautilus NeuroWaveTM System, SCAT
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Jan Medical, Inc.
Traumatic Brain Injury, Subarachnoid Hemorrhage
Cerebral Blood Flow (CBF) Disturbances Following Traumatic Brain Injury (TBI) and Subarachnoid Hemorrhage (SAH)
It is a "proof of concept" study, aimed to evaluate whether the "optimal CPP", defined by the best PRx, corresponds to the acceptable CBF values in patients affected by CBF disfunction caused by TBI or SAH.
- Trial name
- NCT00807833
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Cerebral Palsy, Traumatic Brain Injury
Hybrid Approach to Pediatric Rehabilitation
Children and youth recovering from acquired injuries typically receive therapy via in-patient or outpatient rehabilitation (OPR).
- Conditions
- Cerebral Palsy, Traumatic Brain Injury, Orthopedic Disorder
- Trial name
- NCT06547762
- Testing
- Hybrid approach (in-person and remote) to pediatric rehabilitation: A look beyond the COVID-19 crisis
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Alyn Pediatric & Adolescent Rehabilitation Hospital
Mild Traumatic Brain Injury, Concussion, Mild
Feasibility of a Cognitive Intervention for Youth Post Concussion
The purpose of this study is to evaluate the feasibility and effects of a cognitive intervention for youth following concussion
- Trial name
- NCT03195738
- Testing
- Cognitive Orientation to Occupational Performance (CO-OP)
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Traumatic Brain Injury
Evaluation of Discriminating Power of Two Biomarkers in the Evaluation of Cerebral Lesions Due to Head Injuries in Infants and Children
Head injury is a frequent motive of consultation in paediatric emergency units and the first cause of mortality in infants of more than one year old in developped countries.
- Trial name
- TCOP100 (NCT02855034)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 167 people
- Sponsor
- University Hospital, Montpellier
Brain Injuries, Traumatic
Hypertonic Resuscitation Following Severe Traumatic Brain Injury (TBI)
The purpose of this study is to determine if hypertonic saline with and without dextran can improve neurologic outcomes in victims of severe traumatic brain injury (TBI).
- Trial name
- NCT00316004
- Testing
- 7.5% Hypertonic Saline in 6% Dextran-70 (HSD), 7.5% Hypertonic Saline (HS), 0.9% Normal Saline (NS)
- Where
- 12 sites in United States, Canada
- Volunteers
- 1,331 people
- Sponsor
- University of Washington
Traumatic Intracranial Hemorrhage, Brain Injuries
Mild Traumatic Brain Injury and the Risk for Traumatic Intracranial Hemorrhage
Management of traumatic brain injuries causes significant efforts on emergency departments (ED) and overall health care. Patients on antithrombotic treatment with even minor trauma to the head, although without significant…
- Trial name
- NCT05609721
- Testing
- no intervention, only observational study
- Where
- Sweden
- Volunteers
- 2,044 people
- Sponsor
- Umeå University
Head Injury, Traumatic Brain Injury
Outcomes of Early Versus Late Tracheostomy in Critically Ill Patients Due to Head Injury: A Randomized Controlled Trial
Tracheostomy is a surgical procedure that involves creating an opening in the trachea and bringing it to the skin surface to form a stoma. It may be performed as an emergency or elective operation.
- Trial name
- NCT07872865
- Testing
- Tracheostomy
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- University Of Anbar
Brain Injury, Concussion
Safety Study for Adolescents With Concussion
The purpose of the study was to determine if administration of an exercise stress test within the first ten days after a sports related concussion would delay or otherwise interfere with recovery.
- Trial name
- NCT02714192
- Testing
- Exercise stress test (BCTT)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University at Buffalo
Post-Traumatic Seizure Disorder, Head Injuries
Phase III Double Blind Trial of Valproate Sodium for Prophylaxis of Post Traumatic Seizures
OBJECTIVES: I. Determine whether treating head injured patients with valproate sodium will reduce the risk of developing seizures as a result of the head injury. II.
- Trial name
- NCT00004817
- Testing
- phenytoin, valproate sodium
- Volunteers
- 385 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)