Clinical trials: in Nepal
Myopia, Astigmatism
The EYERISING Study
The purpose of this clinical trial is to see if and how well Repeated Low-Level Red Light (RLRL) therapy works to control myopia over 12 months.
- Conditions
- Myopia, Astigmatism, Anisometropia
- Trial name
- NCT07909720
- Testing
- Repeated Low-Level Red Light (RLRL) therapy
- Where
- 2 sites in United States, Nepal
- Volunteers
- 333 people
- Sponsor
- University of Wisconsin, Madison
Respiratory Tract Diseases, Influenza (Pandemic)
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia. The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of hospitalised…
- Conditions
- Respiratory Tract Diseases, Influenza (Pandemic), Influenza, Community Acquired Pneumonia
- Trial name
- REMAP-CAP (NCT02735707)
- Testing
- Ceftriaxone + Macrolide, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam + Macrolide
- Where
- 408 sites in United States, Australia and 27 more
- Volunteers
- 20,000 people
- Sponsor
- UMC Utrecht
Chronic Lung Diseases
Prospective Study on Antimicrobial RESIstance in Chronic Pulmonary DiseasE
This observational, multicentric prospective study aims to understand the prevalence and burden of antimicrobial resistance (AMR) in people with chronic lung diseases (CLD) across the globe, understanding also geographical…
- Trial name
- PRESIDE (NCT07874139)
- Where
- 68 sites in United States, Albania and 31 more
- Volunteers
- 683 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Domestic Violence, Mental Health
Testing Family Intervention to Address Mental Health and Domestic Violence Among Women
Domestic Violence (DV) is a major public health problem in low- and middle-income countries (LMICs) including Nepal, where women often live in extended, multigenerational households, and violence can be perpetrated by the husband…
- Trial name
- DV-MH (NCT07872228)
- Testing
- Multi-component family intervention
- Where
- Nepal
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Possible
Spirometry
The INTERvening for LUNG Health Trial
This research study is being done to find out whether a community health volunteer-delivered, multi-component program can improve lung health for people at risk of chronic respiratory diseases (such as asthma or COPD) in…
- Trial name
- INTERLUNG (NCT07540000)
- Testing
- Community health worker-delivered multi-component respiratory health intervention
- Where
- 2 sites in United States, Nepal
- Volunteers
- 800 people
- Sponsor
- Johns Hopkins University
Lower Respiratory Tract Infection (LRTI), Recurrent Wheezing
Prevent Wheeze Trial
This trial investigates whether a single dose of dexamethasone will prevent recurrent wheezing in children at high-risk for asthma admitted to hospital with a lower respiratory tract infection (LRTI).
- Trial name
- PRE-WHEE (NCT07858773)
- Testing
- Dexamethasone 0.6 mg/kilogram body weight single dose
- Where
- 2 sites in Nepal, South Africa
- Volunteers
- 486 people
- Sponsor
- Norwegian University of Science and Technology
Gender-Based Violence, Intimate Partner Violence
GBV Response Training for Health Assistant Students in Nepal
This study evaluated a six-day Gender-Based Violence (GBV) response training for PCL General Medicine (Health Assistant) students in Nepal.
- Conditions
- Gender-Based Violence, Intimate Partner Violence, Health Professions Education
- Trial name
- GBV-HA-RT (NCT07851883)
- Testing
- Six-Day GBV Response Training (WHO LIVES-based)
- Where
- Nepal
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Axon Infotech Research Academy Pvt. Ltd.
Suicide, Suicide Prevention
Peer Delivered Youth Suicide Prevention in Nepal
South Asia has the highest suicide rate in the world with important risk profile differences from high-income settings. Investigators will conduct formative research to co-design a package of brief interventions and…
- Trial name
- NCT07680179
- Testing
- Enhanced Usual Care (EUC), Youth-focused, Peer-delivered, Family-engaged Suicide Prevention Package (YPF-SuPP)
- Where
- Nepal
- Volunteers
- 160 people
- Sponsor
- Yale University
Intimate Partner Violence (IPV), Depression
Multi-component Family Intervention to Lower Depression and Address Intimate Partner Violence in Nepal
Intimate Partner Violence (IPV) is a major public health problem in low- and middle-income countries (LMICs). Globally, an estimated 30% of women report physical or sexual violence by an intimate partner in their lifetime.
- Conditions
- Intimate Partner Violence (IPV), Depression, PTSD - Post Traumatic Stress Disorder
- Trial name
- MILAP (NCT06834867)
- Testing
- MILAP intervention
- Where
- Nepal
- Volunteers
- 900 people
- Sponsor
- Possible
UGI Bleed
Comparison of Risk Scores in Upper Gastrointestinal Bleeding
The goal of this prospective observational study is to compare the Glasgow-Blatchford Score (GBS), AIMS65, and pre-endoscopic Rockall Score in predicting outcomes among patients with upper gastrointestinal bleeding (UGIB).
- Trial name
- NCT07819942
- Where
- Nepal
- Volunteers
- 100 people
- Sponsor
- Kathmandu Medical College and Teaching Hospital
Corneal Ulcer
Village Integrated Eye Workers Trial
VIEW is a community-randomized trial designed to determine whether it is possible to prevent corneal ulcers on a large scale. The study compares the incidence of corneal ulceration between villages in which volunteers are trained…
- Trial name
- VIEW (NCT01969786)
- Testing
- Corneal ulcer prevention program
- Where
- Nepal
- Volunteers
- 223,671 people
- Sponsor
- University of California, San Francisco
Mental Health
Effectiveness and Implementation of a School-based Mental Well-being Intervention Among Adolescents of Bharatpur, Nepal
The goal of this study is to evaluate the effectiveness and assess the implementation of CROSS-MIND, a school-based mental well-being intervention for adolescents in Nepal. The study uses a Hybrid Type 1 mixed-methods design.
- Trial name
- CROSSMIND_NP (NCT07812168)
- Testing
- CROSS-MIND
- Where
- Nepal
- Volunteers
- 1,060 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Mental Health
Stress Management Training for Nursing Professionals in a Tertiary Care Center in Nepal
The goal of this clinical trial is to learn if stress management programs can help alleviate existing and prevent future symptoms of stress in nursing professionals working in a tertiary care center in Nepal.
- Trial name
- NCT06438016
- Testing
- Stress Management Training
- Where
- Nepal
- Volunteers
- 100 people
- Sponsor
- Dhulikhel Hospital
High Risk Pregnancy
Antenatal High-Risk Pregnancy Intervention Bundle in Rural Nepal
The proposed study will assess and implement a comprehensive antenatal HRP screening and telehealth follow-up program in rural Nepal. The main questions it aims to answer are: 1.
- Trial name
- NCT07717619
- Testing
- High Risk Pregnancy Bundle
- Where
- Nepal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Post Partum Depression
Sensing Technologies for Maternal Depression Treatment in Low-Resource Settings
In certain low- and middle- income country settings, there is a disproportionate level of untreated postpartum depression that presents both acute and long-term risks to a mother's well-being.
- Trial name
- StandStrong (NCT06253676)
- Testing
- Problem Management Plus (PM+)
- Where
- Nepal
- Volunteers
- 121 people
- Sponsor
- George Washington University
Anemia
How Precision Diets, Through Gut Bacteria, Affect Anemia in Nepalese Adolescent
This study aims to evaluate whether a food-based nutrition intervention using goat liver can improve anemia among adolescent girls in Kathmandu, Nepal, and compare its effectiveness with the current standard iron and folic acid…
- Trial name
- NCT07661602
- Testing
- Iron folic acid supplement, Goat liver supplementation, Nutrition education on anemia prevention and control
- Where
- Nepal
- Volunteers
- 60 people
- Sponsor
- Southern Medical University, China
Oral Hygiene, Visually Impaired Persons
Effectiveness of Audio-Tactile Performance Technique With Sing-Along Lyrics on Oral Hygiene Instruction to Visually Impaired Individuals
The goal of this match-pair randomized study is to compare the effectiveness of the standard Audio-Tactile Performance (ATP) technique with a song-based adaptation (ATP/S) in teaching oral hygiene in visually impaired individuals…
- Trial name
- NCT07585448
- Testing
- ATP, ATP with song
- Where
- 2 sites in Nepal
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Dengue, Severe Dengue
Therapeutics for Moderate and Severe Dengue
The purpose of this multi-site, factorial randomised, platform trial is to evaluate host-directed therapeutic agents in patients hospitalised with moderate and severe dengue virus infection.
- Conditions
- Dengue, Severe Dengue, Mosquito-Borne Diseases, Vector Borne Diseases
- Trial name
- DEN-HOST (NCT07543458)
- Testing
- Dexamethasone, N-Acetylcysteine, Standard of care
- Where
- 18 sites in Bangladesh, Brazil and 8 more
- Volunteers
- 8,800 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Pneumonia
Randomised Evaluation of COVID-19 Therapy
RECOVERY is a randomised trial of treatments to prevent death in patients hospitalised with pneumonia. The treatments being investigated are: COVID-19: Lopinavir-Ritonavir, Hydroxychloroquine, Corticosteroids, Azithromycin…
- Trial name
- RECOVERY (NCT04381936)
- Testing
- Lopinavir-Ritonavir, Corticosteroid, Hydroxychloroquine
- Where
- 16 sites in Belgium, Estonia and 14 more
- Volunteers
- 70,000 people
- Sponsor
- University of Oxford
Laparoscopic Cholecystectomy, Ultrasonography
Ultrasonography vs Intraoperative Laparoscopic Cholecystectomy for Gall Stone Disease
This research is designed to correlate between intraoperative status of gallstone disease patients with their USG findings. The key question it aims to answer is: Does the ultrasonography predict laparoscopic cholecystectomy will…
- Conditions
- Laparoscopic Cholecystectomy, Ultrasonography, Difficult Surgery
- Trial name
- NCT07530874
- Testing
- laparoscopic cholecystectomy
- Where
- Nepal
- Volunteers
- 130 people
- Sponsor
- Nepal Medical College and Teaching Hospital