Clinical trials: Azithromycin
Trachoma, Lymphatic Filariasis
Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis
Trachoma and lymphatic filariasis (LF) are two 'Neglected Tropical Diseases' (NTDs), infectious diseases that affect millions of poor people in countries in the developing world.
- Trial name
- AZIVAL2 (NCT01903057)
- Testing
- azithromycin, ivermectin, albendazole
- Where
- Mozambique
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Mortality, Child Health
Azithromycin for Child Survival in Niger: Delivery Trial
This cluster-randomized trial aims to compare the impact of different delivery approaches to azithromycin distribution on coverage, costs, and feasibility outcomes.
- Conditions
- Mortality, Child Health, Implementation
- Trial name
- AVENIR (NCT04774991)
- Testing
- Azithromycin for Oral Suspension
- Where
- Niger
- Volunteers
- 10,925 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria, Sexually Transmitted Diseases
Gestational Sulfadoxine-pyrimethamine and Azithromycin Treatment to Prevent Preterm Birth
The purpose of this study is to examine whether treatment of pregnant Malawian women with repeated doses of sulfadoxine-pyrimethamine and azithromycin antibiotics will prevent preterm deliveries and result in other health…
- Conditions
- Malaria, Sexually Transmitted Diseases, Preterm Birth, Pregnancy
- Trial name
- NCT00131235
- Testing
- Sulfadoxine-pyrimethamine treatment twice during pregnancy, Sulfadoxine-pyrimethamine at 4-week intervals, Sulfadoxine-pyrimethamine every 4 weeks + azithromycin twice
- Where
- Malawi
- Volunteers
- 1,320 people, healthy volunteers welcome
- Sponsor
- Tampere University
Wound Sepsis
Efficacy of Adding Azithromycin to Cephalosporin Before Cesarean Delivery
efficacy of adding azithromycin to cephalosporin before cesarean delivery
- Trial name
- NCT04062175
- Testing
- cephalosporin, Azithromycin Tablets
- Where
- Egypt
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Bronchopulmonary Dysplasia
Azithromycin in the Prevention of Lung Injury in Premature Newborn
The introduction of invasive mechanical ventilation in the treatment of preterm infants works as an adjuvant in the treatment of acute respiratory failure, which has resulted in significantly significant survival rates.
- Trial name
- NCT03485703
- Testing
- Azithromycin
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Malaria
Gut and Azithromycin Mechanisms in Infants and Children II
Childhood mortality is decreasing worldwide. However, many sub-Saharan countries still have high children under 5 mortality rates.
- Trial name
- GAMINII (NCT04315272)
- Testing
- Azithromycin
- Where
- Burkina Faso
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Diarrhea
Effects of Probiotic in Treatment of Persistent Diarrhea in Children
Persistent diarrhea is a common health problem worldwide, particularly in low-income countries. Approximately 3% to 20% of acute diarrhea episodes in children under 5 years of age become persistent diarrhea.
- Trial name
- NCT05812820
- Testing
- LiveSpo DIA30, LiveSpo CLAUSY, RO
- Where
- Vietnam
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- National Children's Hospital, Vietnam
Trachoma
Enhancing the A in SAFE for Trachoma
This study will assess the cost and feasibility of two strategies of enhanced Mass Drug Administration (MDA) of Zithromax to treat trachoma in the Republic of South Sudan.
- Trial name
- NCT05634759
- Testing
- Azithromycin for Routine Community-wide MDA, Two Additional Rounds of Azithromycin for Children, Azithromycin for Second Community-wide MDA
- Where
- South Sudan
- Volunteers
- 34,630 people, healthy volunteers welcome
- Sponsor
- Emory University
Trachoma, Chlamydia Trachomatis
Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger
Trachoma is a disease of poverty, which in the hyperendemic areas affects all individuals by the time they are two years old. Active disease is concentrated in children and occurs sporadically in adults.
- Trial name
- NCT00618449
- Testing
- Azithromcyin, Azithromycin
- Where
- 2 sites in United States, Niger
- Volunteers
- 1,139 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Acne
Comparison of Efficacy of Azithromycin and Levamisole Versus of Azithromycin in in the Treatment of Acne
Different immunologic mechanisms contribute to development of inflammation in acne vulgaris and immunologic effect of levamisole has been demonstrated.
- Trial name
- NCT01348321
- Testing
- Levamisole
- Where
- Iran
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Ahvaz Jundishapur University of Medical Sciences
Stillbirths and Infant Mortality
Oral Azithromycin to Prevent Stillbirths and Infant Mortality in Mali
The double blind randomized controlled trial will assess the efficacy of oral azithromycin administered to pregnant women and/or infants during routine care in preventing stillbirths and mortality through 6-12 months of age in…
- Trial name
- SANTE (NCT03909737)
- Testing
- Azithromycin to pregnant women, Azithromycin to infants, No intervention to pregnant women
- Where
- Mali
- Volunteers
- 99,700 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Acne Vulgaris
Vitamin A and Azithromycin for Acne Vulgaris
Patients seen with acne lesions not having responded to existing treatments will be offered a placebo or a topical preparation consisting of Vitamin A USP with or without Azithromycin for a duration of 4-6 months USP for the…
- Trial name
- NCT03090048
- Testing
- Vitamin A, Azithromycin
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Manchanda Medical Clinic
Trachoma
A Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation: The ASANTE Trial
Infection with C. Trachomatis has decreased substantially in trachoma endemic areas following repeated annual mass drug administration (MDA) with azithromycin, although not as rapidly as anticipated.
- Trial name
- ASANTE (NCT01767506)
- Testing
- Surveillance and treatment with azithromycin of newcomer and traveler families, Usual care
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy
A Pediatric Taste Test Study of Omnicef Versus Zithromax Antibiotic Suspension Medications
To compare the taste and smell acceptability of cefdinir (Omnicef) antibiotic suspension and azithromycin (Zithromax) antibiotic suspension following a single dose of each medication.
- Trial name
- NCT00644774
- Testing
- cefdinir (Omnicef), azithromycin
- Where
- 3 sites in United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Abbott
Child Mortality, Azithromycin
Resiliency Through Azithromycin for Children (REACH), Côte d'Ivoire
The aim of the study is to gather preliminary evidence on the operational feasibility and acceptability of integrating bi-annual mass drug administration (MDA) of single-dose azithromycin for children ages 1 to 11 months in high…
- Trial name
- REACH (NCT04617626)
- Testing
- Azithromycin
- Where
- Côte d’Ivoire
- Volunteers
- 1,735 people, healthy volunteers welcome
- Sponsor
- FHI 360
Yaws
Evaluation of an Intensive 3-round MDA Strategy Towards Yaws Eradication
The current principle of yaws eradication (the Morges strategy) is based on single round mass drug administration (MDA) of azithromycin (AZI) called total community treatment (TCT) followed by targeted treatment of active cases…
- Trial name
- NCT03490123
- Testing
- R1-Total community treatment with azithromycin, R2-Total community treatment with azithromycin, R3-Total community treatment with azithromycin
- Where
- Papua New Guinea
- Volunteers
- 56,000 people, healthy volunteers welcome
- Sponsor
- Lihir Medical Centre
Resistance Bacterial, Morality
Azithromycin for Child Survival in Niger: Programmatic Trial (AVENIR)
The MORDOR trial found that biannual distribution of azithromycin to children 1-59 months old reduced child mortality. The World Health Organization (WHO) released conditional guidelines for this intervention, which include…
- Conditions
- Resistance Bacterial, Morality, Child Health, Implementation
- Trial name
- AVENIR (NCT05288023)
- Testing
- Azithromycin for Oral Suspension
- Where
- United States
- Volunteers
- 169,707 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pneumonia, Diarrhea
Azithromycin to Prevent Post-discharge Morbidity and Mortality in Kenyan Children
Children hospitalized with severe illness in sub-Saharan Africa are at high risk of morbidity and mortality following discharge from hospital.
- Conditions
- Pneumonia, Diarrhea, Malaria, Co-infection
- Trial name
- Toto Bora (NCT02414399)
- Testing
- Azithromycin
- Where
- Kenya
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Washington
Child Mortality
Improving Care Through Azithromycin Research for Infants in Africa
Infectious diseases are among the most common causes of mortality in the over 2.5 million children under 5 years of age (U5) who died in 2018 in sub-Saharan Africa (SSA).
- Trial name
- ICARIA (NCT04235816)
- Testing
- Azithromycin
- Where
- Sierra Leone
- Volunteers
- 20,560 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Hypertension (HTN), Diarrhea
Mortality Control Program for Economically Productive Age Group in Tribal Area of Melghat.
Background: Age specific mortality rate (ASMR) of 16-60 years is very high in Indian tribal areas due to communicable and non-communicable diseases.
- Conditions
- Hypertension (HTN), Diarrhea, Pneumonia, Malaria Fever
- Trial name
- MCPEPAG (NCT07436104)
- Testing
- Trained village health workers (VHWs) , provided treatment of HTN, diarrhoea, malaria, pneumonia, asthma and COPD by Amlodipine, ORS, Norfloxacin, Chloroquine, Azithromycin, salbutamol rotacaps, Appropriate referral
- Where
- India
- Volunteers
- 72,564 people, healthy volunteers welcome
- Sponsor
- MAHAN Trust