Clinical trials: sponsored by Columbia University
Depression in Adolescence, Rumination
Mindfulness-Based fMRI Neurofeedback for Depression
In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients.
- Trial name
- mbNF (NCT05617495)
- Testing
- Mindfulness + fMRI Neurofeedback
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Columbia University
Pain
Evaluation of Post-PACU Pain Management in Pediatric Surgery
This study aims to assess the differences in overall pain severity, pain management, and satisfaction during recovery period between two groups of children who either receive or do not receive additional education related to…
- Trial name
- NCT02352116
- Testing
- Additional face-to-face education, Standard of care management
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Columbia University
Gastric Emptying
Gastric Emptying in Neonates and Infants After Formula Feeding
Ultrasound imaging will be used to evaluate time for gastric emptying in healthy, fasting newborns, and infants following feeding of clear liquids and/or milk (including breast or formula).
- Trial name
- NCT02665923
- Testing
- Gastric ultrasound
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Columbia University
Internalizing Disorders, Substance Use Disorders
Family Support Protocol for Adolescent Internalizing Disorders
This R34 will develop and test an adjunctive treatment protocol for addressing co-occurring internalizing disorders among adolescents enrolled in usual care for substance use problems.
- Trial name
- Fam-AID (NCT06413979)
- Testing
- Family Support Protocol for Adolescent Internalizing Disorders (Fam-AID)
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- The National Center on Addiction and Substance Abuse at Columbia University
Retinitis Pigmentosa Associated With CNGB1 Mutations
CNGB1 and Allied Disorders
Mutations in the rod-expressed gene, cyclic nucleotide-gated channel beta subunit (CNGB1) and associated inborn errors in metabolism are causes of retinal disease that causes progressive loss of vision.
- Trial name
- NCT04639635
- Testing
- No intervention, this is a natural history progression study
- Where
- 6 sites in United States, France and 2 more
- Volunteers
- 20 people
- Sponsor
- Columbia University
Respiratory Failure
Low and High Flow Suctioning in Intubated Infants
Preterm and term intubuted infants in the NICU will undergo two sequential suctioning procedures: a new, FDA-approved suction device called EXSALTA (ED) and the standard conventional wall (SCW).
- Trial name
- NCT06443970
- Testing
- Exsalta Suction Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Columbia University
Spinal Muscular Atrophy Type 3, Duchenne Muscular Dystrophy (DMD)
Establishing Walking-related Digital Biomarkers in Rare Childhood Onset Progressive Neuromuscular Disorders
The purpose of this research is (1) to identify disease specific walking-related digital biomarkers of disease severity, and (2) monitor longitudinal changes in natural environments, for extended periods of time, in DMD and SMA.
- Trial name
- NCT06839469
- Where
- 3 sites in United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Columbia University
Prematurity; Extreme, Failure to Thrive in Newborn
Targeted Fortification of Donor Breast Milk in Preterm Infants
This study is a randomized controlled trial comparing standard fortification of donor breast milk to targeted fortification of donor breast milk in preterm infants.
- Conditions
- Prematurity; Extreme, Failure to Thrive in Newborn, Growth Retardation, Growth Failure
- Trial name
- NCT04294368
- Testing
- Similac Human Milk Fortifier Extensively Hydrolyzed Protein Concentrated Liquid, Similac Liquid Protein Fortifier, Nestle Microlipid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Adolescent Idiopathic Scoliosis
Brace Monitoring for Adolescent Idiopathic Scoliosis (AIS)
The overall aim of the study is to utilize a novel device and smartphone application in order to improve measurement of patient compliance with at-home bracing for scoliosis as well as create a more accurate assessment of brace…
- Trial name
- NCT03292601
- Testing
- NYRC Brace Scoliosis Monitor
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Columbia University
Substance Use
Primary Connections for Youth and Families
The goal of this clinical trial is to compare a standard adolescent-only approach to substance use screening, brief intervention, and referral to treatment to a in primary care settings.
- Trial name
- PCYF (NCT05964010)
- Testing
- Standard Screening, Standard Psychoeducation, Standard Brief Negotiated Interview (BNI)
- Where
- United States
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- The National Center on Addiction and Substance Abuse at Columbia University
Cancer in Adolescence
Characterizing and Addressing Financial Toxicity in AYAs With Cancer
The overall aims of this study are to address two important gaps in care for AYA cancer patients: 1) a financial toxicity measurement tool to assess AYA-specific needs, and 2) an intervention for mitigating financial toxicity in…
- Trial name
- NCT06072833
- Testing
- Patient Financial Education / Navigation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Columbia University
SMA - Spinal Muscular Atrophy
HABIT-ILE + FST in Children With SMA
This single-arm pilot study will assess the feasibility and preliminary effectiveness of an intensive motor skill intervention (HABIT-ILE) combined with functional strength training (FST) in children with SMA who are receiving…
- Trial name
- NCT07223320
- Testing
- Combined Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) + functional strength training (FST)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Teachers College, Columbia University
Medical Errors, Electronic Medical Records
Pictographs for Preventing Wrong-Patient Errors in NICUs
Newborns in the neonatal intensive care unit (NICU) are at high risk for wrong-patient errors. Effective 2019, The Joint Commission requires that health systems adopt distinct methods of newborn identification as part of its…
- Trial name
- NCT03960099
- Testing
- Pictograph in Banner and Verification Alert
- Where
- 4 sites in United States
- Volunteers
- 6,250 people
- Sponsor
- Columbia University
Congenital Heart Diseases, Children
Physical Activity and Cognitive Development in Children
1. Compare physical activity and cognitive functions between children having cardiac surgery with an age-matched group of children undergoing non-cardiac surgery, as well as otherwise healthy siblings or best buddies (or age and…
- Trial name
- NCT02542683
- Testing
- structured physical activity program
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV/AIDS
MyPEEPS LITE Trial
This study will use community-informed advertisements and messages through electronic methods to recruit and retain a large (N=3,200), diverse national sample of high-risk young men who have sex with men (YMSM) and non-binary…
- Trial name
- NCT06741631
- Testing
- MyPEEPS Mobile
- Where
- 2 sites in United States
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Columbia University
Depression, Adolescent Behavior
Adolescent Depression Screening and Treatment in Mozambican Primary Care
This is a cluster-randomized pilot trial of depression screening and treatment implementation at four Youth-friendly Health Services (YFHS) in primary care clinics, two in Maputo City and two in Maputo Province.
- Trial name
- NCT05476237
- Testing
- Group Interpersonal Therapy for Adolescents (IPT-AG), Treatment as Usual (TAU)
- Where
- 4 sites in Mozambique
- Volunteers
- 95 people
- Sponsor
- Columbia University
Educational Activities
Brain Research Apprenticeships in New York at Columbia
The objective of the BRAINYAC program is to prepare high school students for, and deliver, the experience of working in a neuroscience research laboratory over a summer.
- Trial name
- BRAINYAC (NCT04728022)
- Testing
- Education program
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Columbia University
Structural Racism, Substance Use Risk
Structural Racism, Reward Related Decision Making and Substance Use Risk
The goal of this observational study, which has a pilot phase (R61) and a second, larger phase (R33), is to learn about the impact of indicators of structural racism (SR) on substance use risk in Puerto Rican adolescents living…
- Trial name
- NCT06221839
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV, Obesity
Obesogenic Origins of Maternal and Child Metabolic Health Involving Dolutegravir
A total of 1900 pregnant women in the 1st trimester and their children will be enrolled and followed for two years (ORCHID study main cohort).
- Conditions
- HIV, Obesity, Obesity, Infant, Maternal Obesity During Childbirth
- Trial name
- ORCHID (NCT04991402)
- Testing
- Dolutegravir-based antiretroviral therapy
- Where
- 2 sites in South Africa
- Volunteers
- 1,920 people, healthy volunteers welcome
- Sponsor
- Columbia University
Medication Abortion, Telemedicine
TeleMAb Retrospective Cohort Study
The objective of this study is to evaluate whether there are different clinical outcomes and unscheduled follow-ups between in-person and telemedicine medication abortion, and to better understand patients' experiences with…
- Trial name
- NCT07405294
- Testing
- Telemedicine Medication Abortion
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Columbia University