Clinical trials: sponsored by Zhujiang Hospital
Relapsed or Refractory Acute Leukemia, Relapsed or Refractory Acute Lymphoblastic Leukemia
Clinical Study on the Safety and Efficacy of PID23 Injection in Patients With Relapsed/Refractory Acute Leukemia
Relapsed or refractory acute leukemia (R/R AL) is a life-threatening blood cancer with poor outcomes and limited treatment options.
- Conditions
- Relapsed or Refractory Acute Leukemia, Relapsed or Refractory Acute Lymphoblastic Leukemia, Relapsed or Refractory Acute Myeloid Leukemia (AML)
- Trial name
- R/R AL (NCT07696481)
- Testing
- PID23 Injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Zhujiang Hospital
Parenting Intervention
A Randomized Controlled Trial of the Efficacy of the Lighthouse Parenting Programme in Addressing Parenting Difficulties in China
The study will be conducted in three phases: assessments, group intervention and individual intervention. All participants will engage in the full program over a period of five weeks, divided into ten sessions.
- Trial name
- NCT06858059
- Testing
- psychological intervention
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Zhujiang Hospital
Chronic Glomerulonephritis, Chronic Kidney Disease
The Clinical Application of Artificial Intelligence Assisted Renal Biopsy Diagnosis System.
This research project aims to collect images from patients with chronic glomerulonephritis. For each subject, the images obtained from renal biopsy will undergo evaluation by both the diagnostic model and the 'gold standard'…
- Trial name
- NCT07330362
- Where
- 2 sites in China
- Volunteers
- 2,900 people
- Sponsor
- Zhujiang Hospital
Microecological Therapy, Probiotic Intervention
Effects of DL-endopeptidase Producing Probiotics on Human Intestinal NOD2 Ligands and Related Functions
We have discovered a type of probiotic that can target activating intestinal NOD2, which is related to a series of human health issues.
- Trial name
- probiotics (NCT06716047)
- Testing
- Oral administration
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Electrolyte Disorder, Arrhythmia
Validation of the Accuracy of a Novel POCT Dry Electrolyte Analysis System in the Acute Care Setting
The goal of this study is to compare the performance of a novel Point-of-Care Testing (POCT) dry electrolyte analyzer (P1) with the Nova Stat Profile pHOx Ultra Analyzer System (Nova) in an acute care setting.
- Conditions
- Electrolyte Disorder, Arrhythmia, Stroke
- Trial name
- NCT06726460
- Testing
- Nova Stat Profile pHOx Ultra Analyzer System(Nova), Novel POCT dry electrolyte analysis system(P1)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhujiang Hospital
Respiratory Failure, Acid-Base Balance Disorder
Validation of the Accuracy of a Novel POCT Dry Blood Gas Analyzer in Acute Care Settings
The goal of this observational study is to validate the performance of the novel POCT dry blood gas analyzer EG-i30, against the currently widely used traditional wet blood gas analyzer, Radiometer ABL90, in acute care settings.
- Conditions
- Respiratory Failure, Acid-Base Balance Disorder, Sepsis, Shock
- Trial name
- NCT06726473
- Testing
- Wet Blood Gas Analyzer (ABL90), Dry Blood Gas Analyzer (EG-i30)
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Zhujiang Hospital
Acute Lymphoblastic Leukemia
CD19 CAR-T Cell Infusion as Consolidation Therapy in Adolescent and Adult Patients With Acute B-ALL Ineligible for Allogeneic HSCT: A Clinical Study
This clinical study investigates a novel treatment option for adolescents and adults with acute B-lymphoblastic leukemia (B-ALL).
- Trial name
- NCT07072494
- Testing
- CD19 CAR-T cells injection
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Zhujiang Hospital
Monoclonal Gammopathies, Multiple Myeloma
Screening and Therapeutic Monitoring of Multiple Myeloma by MALDI-TOF MS Analysis
To provide a comprehensive MALDI-TOF mass spectrometry method for detecting, characterizing, and quantifying M-protein, and to track M-protein in a very sensitive and specific manner during patient treatment, providing a more…
- Conditions
- Monoclonal Gammopathies, Multiple Myeloma, M-protein
- Trial name
- NCT05686447
- Testing
- Observational studies, no intervention
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Cervical Cancer, Papillomavirus Infections
DNA Methylation and the Increased Risk of Cervical Cancer Development
This study aims to investigate the correlation between reproductive tract microbiota and DNA methylation in cervical epithelial cells, as well as its impact on the development of cervical cancer, through a paired case-control…
- Trial name
- NCT06859151
- Testing
- Reproductive tract microbiota
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Treatment Outcome by Stent-assisted Embolization
Safety and Efficacy of Stent Deployment for Intracranial Aneurysms (SESIA)
Intracranial aneurysms (IA) regarded the third cause of cerebral vascular disease is the majoy cause of subarachnoid hemorrhage (SAH). The mortality and morbidity account for 22% to 25% in cerebrovascular disease.
- Trial name
- SESIA (NCT03387995)
- Testing
- LVIS stent, Solitaire stent, Enterprise stent
- Where
- China
- Volunteers
- 4,157 people
- Sponsor
- Zhujiang Hospital
Intracranial Aneurysm, Stent Embolisation
Treatment of Unruptured Intracranial Aneurysms in China
Un-ruptured intracranial aneurysm is a complex disease that seriously affects human life and health. At present, the treatment of intracranial aneurysm is divided into interventional treatment and craniotomy clipping, the two…
- Conditions
- Intracranial Aneurysm, Stent Embolisation, Craniotomy, Coil-assissted Embolisation
- Trial name
- NCT03133598
- Where
- China
- Volunteers
- 5,126 people
- Sponsor
- Zhujiang Hospital
Healthy
Application of Bioimpedance Vector Analysis in Neonates
The goal of this observational study is to learn about the distribution of bioimpedance vector of healthy neonates in China in health conditions.
- Trial name
- NCT06188377
- Testing
- measured by a impedance analyzer
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Congenital Biliary Dilatation, Choledochal Cyst
The Application of Digital Intelligent Diagnostic and Therapeutic Technology in Biliary Dilation Diagnosis
This research discusses the clinical application value of augmented reality navigation technology combined with three-dimensional visualization technology in improving surgical safety and promoting the development of precision…
- Trial name
- DIIBD (NCT06418490)
- Testing
- Three-dimensional visualization technology
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhujiang Hospital
Colorectal Cancer
A Cross-sectional Study on the Association of Peptidoglycan Fragments Derived From Gut Microbiota With Colorectal Cancer
The goal of this observational study is to explore the association of peptidoglycan fragments derived from gut microbiota with colorectal cancer (CRC).
- Trial name
- NCT06379412
- Testing
- observational study, no intervention
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Fusobacterium Infections
Developing a Real-Time PCR Assay for Fusobacterium and Epidemiological Analysis of Tumor Patients
This study presents an academic approach to developing a fluorescence quantitative PCR detection method capable of accurately measuring the presence of Fusobacterium (specifically F. nucleatum, F. mortiferium, F. varium, F.
- Trial name
- NCT06168513
- Where
- China
- Volunteers
- 490 people
- Sponsor
- Zhujiang Hospital
B-cell Acute Lymphoblastic Leukemia, B-Cell Lymphoma, Unspecified
CD19 CAR T-cell Target Relapsed/Refractory Acute B Cell Leukemia/Lymphoma
This study aims to evaluate the safety and efficacy of humanized Anti-CD19 Chimeric Antigen Receptor-T cell (CAR19T2 T cell) in children with refractory/relapsed B-cell acute lymphoblastic leukemia/lymphoma.
- Trial name
- CAR19T2 (NCT05613348)
- Testing
- CD19 CAR T-Cell(CAT19T2)
- Where
- 2 sites in China
- Sponsor
- Zhujiang Hospital
B-Cell Leukemia, B-Cell Lymphoma
Interleukin-2 Following 4SCAR19/22 T Cells Targeting Refractory and/or Recurrent B Cell Malignancies
Clinical studies of CD19 CAR-T cells in the treatment of blood and lymphatic system tumors have achieved unprecedented successes.
- Trial name
- NCT03098355
- Testing
- 4SCAR19/22 T cells, Interleukin-2
- Where
- China
- Sponsor
- Zhujiang Hospital
Neuroblastoma, Effects of Immunotherapy
Anti-GD2 4th Generation CART Cells Targeting Refractory and/or Recurrent Neuroblastoma
Patients with refractory and/or recurrent neuroblastoma have poor prognosis despite complex multimodel therapy and therefore, novel approaches are urgently needed.
- Trial name
- 4SCAR-GD2 (NCT02765243)
- Testing
- Anti-GD2 CART
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Zhujiang Hospital
Papillary Thyroid Cancer
Treatment Efficacy and Safety of Low-dose Radioiodine Ablation for Intermediate-risk Differentiated Thyroid Carcinoma
Primary objective: The 3-years disease-free survival was compared between low-dose group (30 mCi) and high-dose group (100 mCi).
- Trial name
- NCT04354324
- Testing
- Radioiodine
- Where
- China
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Chronic Obstructive Pulmonary Disease, Type 2 Diabetes Mellitus
The Early Predictors for Developing Type 2 Diabetes Mellitus in Patients With Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease(COPD), characterized by persistent airflow limitation, associated with an progressive chronic inflammatory response of the lung to noxious particles or gases, can lead to dyspnea and limited…
- Trial name
- NCT03152994
- Testing
- Checking fasting blood glucose(FBG)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Zhujiang Hospital