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Diabetes Mellitus, Type 1
A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults
The purpose of this study is to find out if baricitinib can delay the onset of clinical type 1 diabetes (T1D) in people who are at high risk to develop T1D. Participation in the study will last up to approximately 5 years.
- Trial name
- BARICADE-DELAY (NCT07222137)
- Testing
- Baricitinib
- Where
- 112 sites in United States, Australia and 17 more
- Volunteers
- 150 people
- Sponsor
- Eli Lilly and Company
Central Line Complication, Central Line-associated Bloodstream Infection (CLABSI)
Compassionate-Use of 4% T-EDTA Lock Solution for Central Venous Lines of Pediatric PN Patients
In this research study we want to learn more about a study drug, tetrasodium sodium EDTA (Kitelock™) for maintaining the patency (blood flow) through a central venous catheter.
- Trial name
- NCT04559334
- Testing
- Tetrasodium EDTA Catheter Lock Solution
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Boston Children's Hospital
Fungal Keratitis
Trial to Evaluate the Efficacy And Safety of IVIEW-1201 In the Treatment of Fungal Keratitis
A Phase II, Multi-center, Randomized, Masked, Parallel-Control Study to Evaluate the Clinical Efficacy and Safety of IVIEW-1201 (1.0% PVP-Iodine) Gel Forming Ophthalmic Solution in the Treatment of Fungal Keratitis.
- Trial name
- NCT06463678
- Testing
- IVIEW-1201, NATACYN®
- Volunteers
- 60 people
- Sponsor
- IVIEW Therapeutics Inc.
Medulloblastoma, Medulloblastoma, Non-WNT/Non-SHH
Digoxin Medulloblastoma Study
The purpose of this study is to evaluate the efficacy of digoxin in treating relapsed non-SHH, non-WNT medulloblastoma in pediatric and young adult patients.
- Trial name
- NCT06701812
- Testing
- Digoxin
- Where
- 18 sites in United States
- Volunteers
- 23 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Anesthesia General, Ultrasonography
Comparison of Two Airway Devices (I-Gel and Air-Q) in Children Aged 1-10 Years During General Anesthesia
This study aims to compare two commonly used airway devices (I-gel and Air-Q) in children aged 1-10 years undergoing general anesthesia for surgery.
- Conditions
- Anesthesia General, Ultrasonography, Laryngeal Mask Airways, Airway Management
- Trial name
- NCT07522957
- Testing
- I-gel supraglottic airway device, Air-Q SP supraglottic airway device
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Autoimmune Hemolytic Anemia, CD19 CAR-T Cell Infusion
CAR-T for Autoimmune Hemolytic Anemia Patients Who Have Failed Three or More Lines of Therapy
To Evaluate the Safety and Efficacy of ThisCART19A for Relapsed/Refractory Autoimmune Hemolytic Anemia Patients After Receiving Three or More Lines of Therapy
- Trial name
- NCT06212154
- Testing
- ThisCART19A
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Bronchiectasis
A Study to Learn How Well People With Bronchiectasis Tolerate Continued Treatment With Verducatib After Earlier Studies (AIRTIVITY®-ON)
This study is for adults and adolescents who are at least 12 years old and have bronchiectasis. People can participate if they completed a previous study with the study medicine called verducatib.
- Trial name
- NCT07915219
- Testing
- verducatib
- Where
- 383 sites in United States, Argentina and 37 more
- Volunteers
- 1,500 people
- Sponsor
- Boehringer Ingelheim
Allergy, Food Allergies
Evaluating Sucrose and Cold Oral Interventions for the Treatment of Oral Pruritus During Allergy Procedures.
This is a two-center, randomized, open-label, factorial controlled trial. This trial aims to evaluate the efficacy of exposure to sucrose and ice, alone and in combination, compared to control, in reducing oral pruritus during…
- Conditions
- Allergy, Food Allergies, Oral Pruritus, Environmental Allergies
- Trial name
- FROST (NCT07917312)
- Testing
- Food (sucrose), Food (popsicle), Food(Sucrose and cold)
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- Philippe Bégin
Congenital Heart Disease, Executive Dysfunction
Learning by Heart: The Effectiveness of an EF Training Program for Pre-schoolers With Critical CHD
Advances in prenatal and neonatal care have improved outcomes in children with critical congenital heart disease (CCHD). With the increase in survival, neurocognitive problems such as executive functioning (EF) impairments have…
- Trial name
- LbH (NCT06267430)
- Testing
- Kleuter Extra training program
- Where
- 3 sites in Netherlands
- Volunteers
- 103 people
- Sponsor
- Erasmus Medical Center
Vector Transmission
Attractive Targeted Sugar Bait Trial in Mali
Globally, the female mosquitoes to be effective at transmitting malaria parasites, must have a number of characteristics including: abundance, longevity (individual mosquitoes must survive long enough after feeding on infected…
- Trial name
- NCT04149119
- Testing
- Attractive Target Sugar Baits (ATSB)
- Where
- Mali
- Volunteers
- 6,068 people, healthy volunteers welcome
- Sponsor
- University Clinical Research Center, Mali
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder
Neurogenetics and Multi-omics of Neuroinflammatory Diseases in Multiplex Families to Improve Patients Health
The goal of this observational study is to learn why some families have several members with multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), or MOG antibody-associated disease (MOGAD).
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, MOG Antibody-Associated Disease, Demyelinating Autoimmune Diseases, CNS
- Trial name
- NeuroDIP (NCT07902479)
- Testing
- Blood sampling and multi-omic profiling
- Where
- 5 sites in France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Autism Spectrum Disorder, Fragile X Syndrome
Speech-in-noise Perception in Autism and Fragile X
The goal of this study is to identify which brain regions are active during speech-in-noise perception, as well as how those regions interact.
- Trial name
- NCT06088589
- Testing
- Mismatch negativity
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Neuromuscular Diseases (NMD), Pneumothorax
Incidence and Risk Factors of Pneumothorax in Patients With Neuromuscular Diseases
Neuromuscular diseases can cause weakness of the respiratory muscles, leading to respiratory pump failure and respiratory insufficiency.
- Trial name
- MYOPNEUMO (NCT07909018)
- Testing
- Cough assistance device and/or thoracic mobilization and/or mechanical ventilation
- Where
- France
- Volunteers
- 31,202 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Palsy Infantile, Upper Limb Spasticity
Peripheral Neurotomies of the Upper Limb in Children With Cerebral Palsy.
Cerebral palsy (CP) is the leading cause of neurological disability in children, with a prevalence of 2-2.5 per 1,000 live births in Europe.
- Trial name
- PN-ULCP (NCT07915466)
- Testing
- Peripheral neurotomy of the upper limb (musculocutaneous and/or median and/or ulnar).
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Hospices Civils de Lyon
Ear Infection, Otitis Media
In-Office Clinical Study of the Solo+ TTD
The objective of this study is to evaluate the safety and effectiveness of the Solo+ Tympanostomy Tube Device (Solo+ TTD) for the placement of tympanostomy tubes in paediatric patients undergoing a tympanostomy procedure.
- Trial name
- VENTY (NCT05741333)
- Testing
- Solo+ Tympanostomy Tube Device (Solo+ TTD)
- Where
- 7 sites in United States
- Volunteers
- 66 people
- Sponsor
- AventaMed DAC
Postoperative Pain, Extubation Time
Impact of Parasternal and Rectointercostal Blocks on Extubation Time
"Postoperative pain constitutes a major recovery challenge in patients undergoing open-heart surgery with median sternotomy and chest tube insertion (subxiphoid/intercostal).
- Trial name
- NCT07916558
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Samsun University
Emergency Delirium, Postoperative Delirium (POD)
Comparison of IV Dexmedetomidine Versus Clonidine Versus no Alpha 2 Agonist on Emergency Delirium, PACU Length of Stay and Time to Hospital Discharge in Children Undergoing (Adeno)Tonsillectomy: a Prospective Observational Study
Emergence delirium (ED) is a frequent complication in children undergoing general anesthesia, particularly following ENT procedures such as adenotonsillectomy.
- Conditions
- Emergency Delirium, Postoperative Delirium (POD), Adenotonsillectomy, Tonsillectomy
- Trial name
- CLONIDEX (NCT07913308)
- Testing
- Intravenous dexmedetomidine, Intravenous clonidine, Standard Anesthetic Care Without Alpha-2 Agonist
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitair Ziekenhuis Brussel
Inguinal Hernia
Comparing Two Laparoscopic Techniques for Hernia Repair in Children
The purpose of this randomized controlled trial is to compare the outcomes of two laparoscopic techniques for repairing inguinal hernia in children: laparoscopic percutaneous extraperitoneal closure (LPEC) and laparoscopic…
- Trial name
- NCT07915830
- Testing
- Laparoscopic Percutaneous Extraperitoneal Closure (LPEC), Laparoscopic Intracorporeal Suture (LIS)
- Where
- Pakistan
- Volunteers
- 412 people
- Sponsor
- Quaid-e-Azam Medical College
Tuberculosis, HIV Coinfection
Closing -TB GAPs - for People Living With HIV: TB Guidance for Adaptable Patient-Centered Service
Tuberculosis (TB) is the world's leading infectious cause of mortality and responsible for 1/3 of deaths in people living with human immunodeficiency virus (PLHIV).
- Conditions
- Tuberculosis, HIV Coinfection, Tuberculosis Infection
- Trial name
- TB_GAPS (NCT05342064)
- Testing
- patient-centered TB preventive therapy, TB preventive therapy adherence support
- Where
- 5 sites in Eswatini, Lesotho and 3 more
- Volunteers
- 5,733 people
- Sponsor
- Baylor College of Medicine
Obesity
Efficacy, Safety, and Pharmacokinetics of Tirzepatide (LY3298176) Once Weekly Versus Placebo in Pediatric Participants 6 to Less Than 12 Years of Age Who Have Obesity (ADVANCE-SURMOUNT-KIDS)
The main purpose of this study, performed under Master Protocol J4M-MC-PWMP (NCT06672549), is to evaluate the efficacy, safety, and pharmacokinetics of tirzepatide as an addition to healthy lifestyle in participants 6 to less…
- Trial name
- NCT07817875
- Testing
- Tirzepatide
- Where
- 82 sites in United States, Belgium and 8 more
- Volunteers
- 150 people
- Sponsor
- Eli Lilly and Company
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