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Obstructive Sleep Disordered Breathing
Prediction of Tongue Base Obstruction During Sleep
This study investigates the hypothesis that, in children, tongue motor functions can predict both the anatomical site and the degree of upper airway obstruction contributing to obstructive sleep-disordered breathing.
- Trial name
- PTOS (NCT06792045)
- Testing
- Physiotherapist assessment, ENT assessment, Drug-Induced Sleep Endoscopy
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Université Catholique de Louvain
Refractory Cancer, CNS Tumors
A Study of Avutometinib for People With Solid Tumor Cancers
The purpose of this study is to find out whether avutometinib is a safe treatment for advanced or recurrent solid tumor cancers in children and young adults.
- Conditions
- Refractory Cancer, CNS Tumors, CNS Tumor, Adult, CNS Tumor, Childhood
- Trial name
- NCT06104488
- Testing
- Avutometinib
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Renal Tumor Histology, Cutaneous Leiomyoma
Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer
This study will investigate what causes hereditary leiomyomatosis renal (kidney) cell cancer, or HLRCC, and how the disease is related to the development of kidney tumors.
- Conditions
- Renal Tumor Histology, Cutaneous Leiomyoma, Kidney Cancer
- Trial name
- NCT00050752
- Where
- United States
- Volunteers
- 1,350 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Youth, Sport Performance
THE EFFECTS OF CORRECTIVE EXERCISE AND KT APPLICATIONS IN YOUNG BASKETBALL PLAYERS
The main objective of this research is to comparatively examine the effects of corrective exercise programs and kinesio taping (KT) applications on performance parameters and functional mobility in adolescent male basketball…
- Trial name
- KT:KINESIOTAPE (NCT07358936)
- Testing
- Kinesiotape, Corrective Exercise
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Vedat Göken
Spinal Cord Injury Cervical, Tendon Transfer
Combined Nerve and Tendon Transfer for the Restoration of Hand Function in Individuals With Tetraplegia
Tetraplegia after a cervical spinal cord injury (C-SCI) radically alters an individual's ability to perform normal activities of daily life due to paralysis in all extremities, resulting in lifelong dependence.[1] Traditional…
- Conditions
- Spinal Cord Injury Cervical, Tendon Transfer, Nerve Transfer, Rehabilitation
- Trial name
- [CNaTT] (NCT04276181)
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Göteborg University
Syphilis
Linezolid for Syphilis Pilot Study
The study aims to evaluate the efficacy of linezolid for the treatment of syphilis.
- Trial name
- NCT05548426
- Testing
- Group B, Linezolid 10d, Group A, Penicillin
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Southern California
Pregnancy Related, Pregnancy
A Study to Assess Pregnancy, Neonatal and Infant Outcomes in Participants Exposed to Nipocalimab
The purpose of this study is to find out how often: Pregnancy problems, complications in mothers, and health issues in newborn babies occurred in participants who took nipocalimab just before or during pregnancy.
- Conditions
- Pregnancy Related, Pregnancy, Pregnancy High-risk
- Trial name
- PETUNIA (NCT07915232)
- Volunteers
- 162 people
- Sponsor
- Janssen Research & Development, LLC
Inguinal Hernia, Postoperative Pain
Lumbar ESP Block Versus TAP Block for Postoperative Pain Control in Children Undergoing Open Inguinal Hernia Repair
This study evaluates two ultrasound-guided nerve block techniques-Erector Spinae Plane Block (ESPB) and Transversus Abdominis Plane (TAP) block-for pain relief in children undergoing elective open inguinal hernia repair.
- Trial name
- NCT07916233
- Testing
- Ultrasound-guided Lumbar Erector Spinae Plane Block (ESPB), Ultrasound-guided Transversus Abdominis Plane (TAP) Block
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Beni-Suef University
Clinical Performance, Polyetheretherketone
Clinical Performance of Polyetheretherketone-fabricated Versus Conventional Lingual Arch Space Maintainers
This study aimed to evaluate and compare the clinical performance of peek-fabricated versus conventional lingual arch space maintainers.
- Conditions
- Clinical Performance, Polyetheretherketone, Lingual Arch Space
- Trial name
- NCT07916038
- Testing
- Peek-fabricated lingual arch space maintainer., Traditional lingual arch space maintainer.
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Al-Azhar University
Chronic Pain, Postoperative, Quality of Life
Quality of Life and Pain After Appendectomy in Children
Acute appendicitis is one of the most common emergency general surgical conditions worldwide and represents the leading cause of emergency abdominal surgery in children.
- Conditions
- Chronic Pain, Postoperative, Quality of Life, Functional Ability, Appendectomy
- Trial name
- CAPA-Peds (NCT07629362)
- Where
- Turkey (Türkiye)
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Kocaeli City Hospital
Recurrent Ganglioneuroblastoma, Recurrent Neuroblastoma
Testing the Addition of Iberdomide to Therapy in People With Neuroblastoma That Has Come Back, Not Responded to Treatment, or Gotten Worse
This phase I/II trial studies the side effects and best dose of iberdomide when given together with chemoimmunotherapy drugs and to see how well it works in treating patients with neuroblastoma that has come back after a period…
- Conditions
- Recurrent Ganglioneuroblastoma, Recurrent Neuroblastoma, Refractory Ganglioneuroblastoma, Refractory Neuroblastoma
- Trial name
- NCT07437963
- Testing
- Bone Marrow Aspiration, Bone Marrow Biopsy, Computed Tomography
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- National Cancer Institute (NCI)
Krabbe Disease
Gene Transfer Clinical Trial for Infantile and Late Infantile Krabbe Disease Treated Previously With HSCT
This is a non-blinded, non-randomized dose escalation study of intravenous FBX-101 in which subjects will receive a single infusion of an adeno-associated virus gene therapy product, after more than 21 days of the HSCT (UCBT…
- Trial name
- REKLAIM (NCT05739643)
- Testing
- FBX-101
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Duke University
Safety and Tolerability in Healthy Volunteers
Safety and Tolerability Evaluation of BP-LT
This study evaluates the safety and tolerability of the food ingredient BP-LT when added to a daily diet. BP-LT is a stable protein ingredient being functional in the gastrointestinal tract and without systemic absorption.
- Trial name
- NCT07819695
- Testing
- BP-LT
- Where
- Bangladesh
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bactolife A/S
Anesthesia, Local
Comparison of Digital Intraosseous and Manual Intraligamentary Anesthesia in Children
The aim of this study is to compare the effects of digital intraosseous anesthesia and manual intraligamentary anesthesia techniques on pain scores during the restorative treatment of permanent mandibular molars in pediatric…
- Trial name
- NCT07524569
- Testing
- Intraligamentary anaesthesia, Digital Intraosseous Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Hypophosphatasia (HPP)
Registry of Patients With Hypophosphatasia
In this prospective, observational, long term registry patients of all ages with a diagnosis of hypophosphatasia (HPP) are followed at participating sites in multiple countries.
- Trial name
- NCT02306720
- Where
- 67 sites in United States, Australia and 11 more
- Volunteers
- 1,571 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Myasthenia Gravis
A Study of Nipocalimab in Children Aged 2 to Less Than 18 Years With Generalized Myasthenia Gravis
The purpose of this study is to determine the effect of nipocalimab on total serum immunoglobulin G (IgG) in pediatric participants 2 to less than (<) 18 years of age (globally) and 8 to <18 years of age (for Unites Stated (US)…
- Trial name
- NCT05265273
- Testing
- Nipocalimab
- Where
- 19 sites in United States, Japan and 2 more
- Volunteers
- 12 people
- Sponsor
- Janssen Research & Development, LLC
Plaque Psoriasis
A Study of JNJ-77242113 in Adolescent and Adult Participants With Moderate to Severe Plaque Psoriasis
The purpose of this study is see how effective is JNJ-77242113 in participants with moderate to severe plaque psoriasis.
- Trial name
- ICONIC-LEAD (NCT06095115)
- Testing
- JNJ-77242113
- Where
- 170 sites in United States, Argentina and 14 more
- Volunteers
- 684 people
- Sponsor
- Janssen Research & Development, LLC
Lactation, Inflammatory Bowel Disease
A Study to Measure Mirikizumab Levels in Breast Milk of Lactating Participants Receiving Mirikizumab Therapeutically for an Approved Indication
The main purpose of this study is to assess the amount of mirikizumab in breast milk in women who are breastfeeding who are receiving stable maintenance doses of mirikizumab for an approved indication.
- Trial name
- NCT07612267
- Testing
- Mirikizumab
- Where
- 20 sites in United States, Canada and 5 more
- Volunteers
- 14 people
- Sponsor
- Eli Lilly and Company
Solid Tumor, Rhabdomyosarcoma
VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors
This trial is a multi-center, non-randomized, open-label Phase I/II study evaluating the feasibility and efficacy of vincristine, irinotecan, temozolomide, and atezolizumab in children with relapsed/refractory solid tumors.
- Trial name
- NCT04796012
- Testing
- Atezolizumab, Vincristine, Irinotecan
- Where
- 7 sites in United States
- Volunteers
- 23 people
- Sponsor
- University of Texas Southwestern Medical Center
Scoliosis, Adolescent Scoliosis
Schroth Exercises Alone Versus Schroth Exercises Integrated With Dynamic Stabilization
This assessor-blinded, parallel-group randomized controlled trial compared Schroth exercises alone with Schroth exercises integrated with dynamic (core, pelvic and scapular) stabilization exercises in adolescents aged 10-19 years…
- Trial name
- NCT06716957
- Testing
- Schroth exercise, Dynamic stabilization exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Uskudar University
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