Clinical trials: sponsored by Beijing Friendship Hospital
Liver Transplantation, Auxiliary Liver Transplantation
Rejection After Auxiliary Partial Orthotopic Liver Transplantation: An Exploratory Comparison by Native-Liver Cirrhosis Status
This retrospective single-center cohort study aims to investigate the association between native-liver cirrhosis status and post-transplant outcomes in recipients undergoing auxiliary partial orthotopic liver transplantation…
- Trial name
- NCT07275008
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Zhi-Jun Zhu
Cataract, Vitreous Hemorrhage
Study on Eye-Brain Cross-Organ Mapping and Systemic Disease Association Based on Multimodal Big Data
This project integrates multimodal eye data (CFP, OCT, OCTA) from 50,000 cases, brain MR data from 150,000 cases, and ICD diagnoses, medical orders, and test results from an eye-brain paired cohort of 8,000 cases to construct an…
- Conditions
- Cataract, Vitreous Hemorrhage, Diabetic Eye Diseases, Cerebral Small Vessel Disease
- Trial name
- NCT07541651
- Testing
- No interventions were involved in this study.
- Volunteers
- 208,000 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Femoroacetabular Impingement Syndrome
AI-Based Screening and Diagnostic Models for Femoroacetabular Impingement Syndrome (FAIS-AI)
Femoroacetabular impingement syndrome (FAIS) is the leading cause of hip pain in young adults and frequently progresses to osteoarthritis, often exacerbated by delayed diagnosis in primary care.
- Trial name
- FAIS-AI (NCT07737223)
- Where
- China
- Volunteers
- 2,617 people
- Sponsor
- ChunBao Li
Invasive Mold Diseases
Safety and Efficacy of Liposomal Amphotericin B for Patients With Invasive Mold Diseases in Liver Transplant Recipients
Invasive mold diseases (IMD) carry extremely high mortality rates in liver transplant recipients (aspergillosis prevalence ~1.8%, mortality 60%-90%; mucormycosis prevalence ~2%, mortality 38%-95%).
- Trial name
- NCT07725874
- Testing
- AmBisome (Amphotericin B) Liposome
- Volunteers
- 60 people
- Sponsor
- Beijing Friendship Hospital
Drug-induced Liver Injury, Autoimmune Hepatitis
Discrimination of DILI and AIH by Artificial Intelligence
A retrospective, multi-center, non-interventional cohort study has been going to explore whether artificial intelligence can discriminate Drug-induced liver injury and Autoimmune hepatitis.
- Trial name
- NCT05532345
- Where
- China
- Volunteers
- 2,583 people
- Sponsor
- Beijing Friendship Hospital
Severe Aplastic Anemia (SAA), Severe Aplastic Anemia, Refractory
Phase I Clinical Study of Haplo-HSCT Combined With Hypoxic 3D-Cultured Umbilical Cord MSC for the Treatment of SAA
Efficacy and Safety of Sequential Infusion of Hypoxic 3D-Cultured Umbilical Cord Mesenchymal Stem Cells in Haploidentical Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia: A Multicenter, Randomized, Phase 1 Trial
- Conditions
- Severe Aplastic Anemia (SAA), Severe Aplastic Anemia, Refractory, Severe Aplastic Anemia
- Trial name
- NCT07299123
- Testing
- 3D hypoxia-preconditioned UC-MSC group, 2D UC-MSC group
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese PLA General Hospital
Rectal Cancer
SIS-Reinforced vs. Conventional Anastomosis for Mid-to-Low Rectal Cancer: A Multicenter RCT on Anastomotic Leak
The goal of this clinical trial is to learn whether using a reinforcing material called SIS (small intestinal submucosa) during bowel connection after rectal cancer surgery can help prevent anastomotic leakage-a serious…
- Trial name
- NCT07209787
- Testing
- SIS-reinforced anastomosis
- Where
- China
- Volunteers
- 966 people
- Sponsor
- Beijing Chao Yang Hospital
Chronic Diseases, Sub-optimal Health
Real-World Data Linkage Research Platform
This study aims to address the lack of intelligent governance tools in clinical data management to promote efficient governance and secure sharing of real-world health data.
- Trial name
- NCT07635355
- Testing
- This is an observational study. No intervention will be applied.
- Where
- China
- Volunteers
- 300,000 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Liver Transplantation
Research on Using Small-for-size Grafts for Auxiliary Liver Transplantation in the Treatment of Portal Hypertension
The objective of this observational study is to compare the safety profile of auxiliary liver transplantation using small-for-size grafts with that of conventional liver transplantation and to evaluate the efficacy of this…
- Trial name
- NCT07247877
- Volunteers
- 396 people
- Sponsor
- Zhi-Jun Zhu
ABO Incompatibility, Liver Transplant Surgery
Study on the Clinical Outcomes of ABO-Incompatible Living Donor Liver Transplantation
Evaluate the postoperative survival rate and incidence of rejection in patients undergoing ABO-incompatible living donor liver transplantation; analyze the occurrence of secondary endpoint events such as postoperative vascular…
- Conditions
- ABO Incompatibility, Liver Transplant Surgery, Living Donor Liver Transplantation
- Trial name
- NCT07273448
- Volunteers
- 100 people
- Sponsor
- Zhi-Jun Zhu
Acute Liver Failure
Etiology and Prognostic Factors in Patients With Acute Liver Failure
Acute liver failure (ALF) is a rare but life-threatening condition with high mortality. Despite advances in supportive care and liver transplantation, prognosis varies significantly across etiologies, particularly in patients…
- Trial name
- NCT07556055
- Volunteers
- 400 people
- Sponsor
- Li-Ying Sun
Liver Failure, Small-for-Size Syndrome
Safety and Tolerability Study of a Novel Bioartificial Liver in Liver Failure and Small-for-Size Syndrome
The goal of this clinical trial is to evaluate the safety and tolerability of a novel bioartificial liver (CiPS-BAL) in patients with liver failure or small-for-size syndrome.
- Trial name
- NCT07312864
- Testing
- Chemically induced pluripotent stem cells biological Artificial Liver
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Beijing Friendship Hospital
Small-for-size Syndrome
Safety, Tolerability, and Preliminary Efficacy of Hepatocyte-like Cell Injection for the Prevention and Treatment of Small-for-Size Syndrome
To evaluate the safety, tolerability, and preliminary efficacy of rectus sheath injection of hepatocyte-like cells in the treatment and prevention of small-for-size syndrome, with the ultimate goal of improving patient survival.
- Trial name
- NCT07276568
- Testing
- Hepatocyte-like cell administration via rectus sheath intramuscular injection
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Zhi-Jun Zhu
Liver Neoplasm, HBV Infection
Single-cell Multiomics and Spatiotemporal Omics Analyze the Mechanism of Liver Degenerative Disease
The purpose of this observational study is to employ single-cell multi-omics and spatial omics technologies to characterize the spatial and immune structures within the livers of patients with fatty liver, hepatic hemangioma…
- Conditions
- Liver Neoplasm, HBV Infection, Non-alcoholic Fatty Liver Disease NAFLD, Liver Fibrosis
- Trial name
- NCT07265544
- Testing
- Collection of Preoperative Peripheral Blood, Collection of Discarded Liver Tissue During Surgery
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Sub-healthy
Data Mining of Population Health-sub-health-disease Based on Dynamic System Theory
This study aims to explore the dynamic evolution patterns of population health, sub-health, and disease states through dynamic system theory and big data mining methods, providing scientific evidence for personalized prevention…
- Trial name
- NCT07375303
- Testing
- No intervention will be applied.
- Where
- China
- Volunteers
- 380,000 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Klatskin Tumor, Cholangiocarcinoma
Diagnostic Efficacy of EUS-FNA/B Versus ERCP With or Without POCS-TB in Patients With Suspected Hilar Cholangiocarcinoma
This is an observational study with a prospective cohort design. This study enrolled patients with suspected hilar cholangiocarcinoma on imaging.
- Conditions
- Klatskin Tumor, Cholangiocarcinoma, Biopsy, Fine-Needle, Endoscopic Retrograde Cholangiopancreatography
- Trial name
- NCT05993429
- Testing
- The sampling method selected in patients with suspected hilar cholangiocarcinoma
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Qilu Hospital of Shandong University
Lymphohistiocytosis, Hemophagocytic
Prospective Single-Arm Clinical Trial of GO Regimen for HLH.
This study aims to investigate the efficacy and safety of Golidocitinib(GO) monotherapy in the treatment of hemophagocytic lymphohistiocytosis.
- Trial name
- NCT07339345
- Testing
- Golidocitinib
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Beijing Friendship Hospital
Mycoplasma Pneumoniae Pneumonia
Development and Validation of an Early Prediction Model for Severe Mycoplasma Pneumoniae Pneumonia in Children
Pneumonia is a major threat to the health of children. Mycoplasma pneumoniae infection is a core cause of pediatric pneumonia, and the incidence of severe mycoplasma pneumoniae pneumonia (SMPP) has increased in recent years.
- Trial name
- NCT07333833
- Testing
- medical history taking, blood test, pulmonary ultrasound
- Where
- China
- Volunteers
- 964 people
- Sponsor
- Beijing Friendship Hospital
Thyroid Abnormalities, Thyroid
Ultrasound Large-scale Model in Thyroid Field: A Multi-center Study on Medical-Engineering Integration
The goal of this observational study is to evaluate the diagnostic accuracy and clinical workflow integration of an ultrasound intelligent agent (UIA) for thyroid disease management in a real-world multicenter setting.
- Conditions
- Thyroid Abnormalities, Thyroid, Thyroid Cancer
- Trial name
- NCT07296575
- Testing
- No intervention
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Primary Biliary Cholangitis (PBC), Long-term Outcomes
PBC Long-term Outcomes Study
Primary biliary cholangitis (PBC) is an autoimmune liver disease predominantly affecting middle-aged women. While historically it was deemed rare, advancements in specific auto-antibody tests have led to increased recognition of…
- Conditions
- Primary Biliary Cholangitis (PBC), Long-term Outcomes, Prognosis, Multicenter Prospective Study
- Trial name
- NCT07149675
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Beijing Friendship Hospital