Clinical trials: sponsored by University of Pittsburgh
ADHD, Autism Spectrum Disorder
AWARE: Management of ADHD in Autism Spectrum Disorder
This study is a pragmatic clinical trial examining the comparative effectiveness of two stimulant medications (methylphenidate and amphetamine) in the treatment of ADHD in children and adolescents with autism.
- Trial name
- NCT05916339
- Testing
- Randomization to either Amphetamine (AMP) class of stimulant medication or Methylphenidate (MPH) class of stimulant medication, Randomization to either Alpha 2 agonist class of medication or alternate class of stimulant.
- Where
- 13 sites in United States, Canada
- Volunteers
- 500 people
- Sponsor
- Daniel Coury
Feasibility, Diet, Healthy
Super Chef - an Online Program Promoting the Mediterranean Dietary Pattern to Lower Income Families
Given the limited effectiveness of single food group-targeted interventions to enhance child nutrition, a key component of current and future health, innovative approaches are needed.
- Trial name
- NCT05863559
- Testing
- Super Chef: Family Fun in the Kitchen!
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Spina Bifida, Cerebral Palsy
The Impact of Community-based Wellness Programs on The Triple Aim
People with disabilities experience a staggering incidence of secondary conditions that can result in death or negatively impact their health, participation in the community, and quality of life.
- Conditions
- Spina Bifida, Cerebral Palsy, Spinal Cord Injury, Traumatic Brain Injury
- Trial name
- NCT02938130
- Testing
- Wellness Programs
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of Pittsburgh
Cancer, Quality of Life
The PRISM Intervention: a Multi-site Randomized Controlled Trial for Adolescents and Young Adults With Advanced Cancer
Multi-Site Randomized Controlled Trial testing the efficacy of the Promoting Resilience in Stress Management (PRISM) intervention among Adolescents and Young Adults with Advanced Cancer
- Conditions
- Cancer, Quality of Life, Anxiety, Depression
- Trial name
- PRISM-AC (NCT03668223)
- Testing
- Promoting Resilience in Stress Management (PRISM)
- Where
- 5 sites in United States
- Volunteers
- 269 people
- Sponsor
- Dana-Farber Cancer Institute
Child Development, Child Language
The Pittsburgh Study Early Childhood
The Early Childhood Collaborative of The Pittsburgh Study is a community-partnered, county-wide implementation of programs for children and families from birth through formal school entry to address real-world challenges that…
- Conditions
- Child Development, Child Language, Child Behavior Problem, Parenting
- Trial name
- TPS-ECC (NCT05444205)
- Testing
- Text4Baby or Bright by Text Referral, Nurture Program Warm Referral, Video Interaction Project
- Where
- 5 sites in United States
- Volunteers
- 2,546 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Pain, Sickle Cell Disease
Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain
The study, known as the Peer suppoRt for adolescents and Emerging adults with Sickle cell pain: promoting ENgagement in Cognitive behavioral thErapy (PRESENCE), aims to determine the effectiveness of digital CBT in reducing pain…
- Trial name
- PRESENCE (NCT06374238)
- Testing
- CBT+ Health coach, CBT w/o Health Coach ( self-guided), Usual Care
- Where
- 14 sites in United States
- Volunteers
- 390 people
- Sponsor
- University of Pittsburgh
Diabetes Mellitus, Type 2, Lifestyle
Real-time Engagement for Learning to Effectively Control Type 2 Diabetes
The goal of this clinical trial is to learn if a new smartphone app that pairs glucose and exercise data will help adolescents and young adults with type 2 diabetes improve glycemic control.
- Conditions
- Diabetes Mellitus, Type 2, Lifestyle, Hyperglycemia, Physical Inactivity
- Trial name
- REFLECT2D (NCT06375460)
- Testing
- Focused App Prompt, No App Prompt
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pittsburgh
Pediatric Brain Tumor
A Multicenter Study to Assess the Feasibility of 5-Aminolevulinic Acid (5-ALA) in Pediatric Brain Tumor Patients
This clinical trial focuses on pediatric patients aged 2 up to 18 years of age with a new or recurrent pediatric brain tumor, suspected to be either a high-grade or low-grade glioma, and scheduled for surgical removal.
- Trial name
- NCT06907485
- Testing
- Aminolevulinic acid hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Costas Hadjipanayis
Violence, Physical, Violence, Non-accidental
Community Resiliency Collective Efficacy Intervention
This study will evaluate, via a cluster-randomized controlled trial, the effectiveness of a community-centered intervention that promotes thriving and resiliency to reduce community violence.
- Conditions
- Violence, Physical, Violence, Non-accidental, Violence, Sexual, Violence, Domestic
- Trial name
- NCT05768217
- Testing
- Community Resiliency Collective Efficacy Intervention (CRCEI), Health Education Sessions
- Where
- United States
- Volunteers
- 4,600 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Pyruvate Dehydrogenase Complex Deficiency Disease
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies
Children and adults with pyruvate dehydrogenase complex deficiency (PDCD) are participating in a research study seeking to better understand the genetic causes, symptoms, usefulness of current treatments, and outcomes for these…
- Trial name
- NCT03056794
- Testing
- No intervention
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Pittsburgh
Asthma, COPD
Acoustic Waveform Respiratory Evaluation
The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.
- Conditions
- Asthma, COPD, Cystic Fibrosis, Ciliary Motility Disorders
- Trial name
- AWARE (NCT06512064)
- Testing
- AWARE
- Where
- 2 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Indiana University
Acanthamoeba Keratitis
Parasitic Ulcer Treatment Trial
The Parasitic Ulcer Treatment Trial (PUTT) is a multi-center, parallel-group, randomized clinical trial. The purpose of this study is to determine whether including topical corticosteroids in a regimen for acanthamoeba keratitis…
- Trial name
- PUTT (NCT06213649)
- Testing
- Polyhexamethylene biguanide (PHMB), Topical corticosteroid
- Where
- 22 sites in United States, Brazil and 2 more
- Volunteers
- 232 people
- Sponsor
- Jeremy Keenan, MD, MPH
Transplant
Improving Medication Adherence in Adolescents Who Had a Liver Transplant
The study's aim is to test a tailored telemetric intervention to reduce rejection incidence by improving medication adherence in a group of adolescent liver transplant recipients identified as nonadherent by a marker (the…
- Trial name
- iMALT (NCT03691220)
- Testing
- Telemetric Intervention
- Where
- 13 sites in United States, Canada
- Volunteers
- 148 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Acute Respiratory Tract Infection, Ear Infection
Enhanced Telemedicine in Primary Care for Acute Respiratory Tract Infections Study
Young children often receive antibiotics for pediatric acute respiratory tract infections (ARTIs) - common childhood diagnoses like ear infections, strep throat, sinusitis, and colds - but many of these antibiotics are prescribed…
- Conditions
- Acute Respiratory Tract Infection, Ear Infection, Throat Infection, Acute Respiratory Tract Infections
- Trial name
- Tele-PARTI (NCT07845526)
- Testing
- Tele-Otoscope Enabled Primary Care, eBook-supported primary care
- Where
- 2 sites in United States
- Volunteers
- 450 people
- Sponsor
- University of Pittsburgh
Skull Base Neoplasm, Cellular Pathology
Molecular and Cellular Characterization of Skull Base Tumors
The purpose of the study is to analyze biological samples and genetic material for basic science research investigating the molecular and cellular characterization of skull base tumors.
- Trial name
- NCT03759717
- Testing
- Observation
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- University of Pittsburgh
Hydrocephalus
HCRN Endoscopic Versus Shunt Treatment of Hydrocephalus in Infants
Hydrocephalus is a potentially debilitating neurological condition that primarily affects babies under a year of age and has traditionally been treated by inserting a shunt between the brain and the abdomen.
- Trial name
- ESTHI (NCT04177914)
- Testing
- Endoscopic Third Ventriculostomy with Choroid Plexus Cauterization (ETV+CPC), Ventriculoperitoneal Shunt
- Where
- 21 sites in United States, Canada
- Volunteers
- 165 people
- Sponsor
- University of Utah
Mild Hypoxic Ischemic Encephalopathy of Newborn
Cool Prime Comparative Effectiveness Study for Mild HIE
To determine effectiveness of therapy to improve neurodevelopmental outcomes in infants with mild HIE. To determine the adverse effects of Therapeutic Hypothermia (TH) in mild HIE on the neonate and his/her family.
- Trial name
- COOLPRIME (NCT04621279)
- Testing
- Normothermia, Whole body therapeutic hypothermia
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- University of Texas Southwestern Medical Center
HIV
SEARCH CAB LA Dynamic Choice HIV Prevention Study Extension
The overall purpose of this SEARCH CAB-LA (Cabotegravir Injectable Suspension) randomized extension study is to determine if adding the option of CAB-LA as a prevention choice using a person-centered dynamic choice HIV (human…
- Trial name
- NCT05549726
- Testing
- Cabotegravir Injectable Suspension, Dynamic Choice Delivery Model, Standard of Care
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 984 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Suicide Prevention, Ketamine
Esketamine Versus Crisis Response Planning Versus Enhanced Treatment as Usual for Suicide Prevention: A Pragmatic Randomized Trial in a Brazilian Municipality (SAVE)
The SAVE study will test whether a single esketamine infusion or a single Crisis Response Planning session, each added to enhanced treatment as usual, reduces future suicide-related events compared with enhanced treatment as…
- Conditions
- Suicide Prevention, Ketamine, Crisis Response Plan
- Trial name
- SAVE (NCT07120477)
- Testing
- Intravenous Esketamine, Crisis Response Planning (CRP), Enhanced Treatment as Usual (eTAU)
- Where
- Brazil
- Volunteers
- 478 people
- Sponsor
- University of Sao Paulo
Severe Maternal Morbidity, Maternal Death
The Effects of Medicaid Policy Interventions on Severe Maternal Morbidity
The goal of this study is to learn about the effects of Medicaid policy interventions on severe maternal morbidity (SMM) and mortality and maternal health. The main questions it aims to answer are: 1.
- Trial name
- NCT05678699
- Testing
- Medicaid healthcare quality interventions (incentive payment and obstetric bundled payment), Doula, Standard Care
- Where
- United States
- Volunteers
- 10,000,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh