Clinical trials: A Single-blind Randomized Controlled Trial
Drug Safety, Respiratory Syncytial Virus Infections
A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of MDT-637 in Healthy Volunteers
The purpose of this study is to determine the range of single inhaled doses of a new dry powder product, MDT-637, that are safe and well-tolerated.
- Trial name
- NCT01355016
- Testing
- MDT-637
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- MicroDose Therapeutx, Inc
Pregnancy, Excessive Weight Gain
Effect of Regular Exercise in Prevention of Excessive Weight Gain in Pregnancy
Background: Use of variable definitions of exercise and disparate results, emphasize the need of proper randomized controlled trials examining the relationship between physical activity and weight development during pregnancy.
- Trial name
- NCT00617149
- Testing
- Supervised exercise for the prevention high weight gain
- Where
- Norway
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Oxidative Stress, Inflammation
PsP Ganoderma Lucidum Supplementation and Biomarker Changes in Smokers
The goal of this randomized controlled clinical trial is to evaluate whether polysaccharide peptide (PsP) supplementation from Ganoderma lucidum can modulate biomarkers of oxidative stress, inflammation, nicotine exposure, and…
- Conditions
- Oxidative Stress, Inflammation, Cigarette Smoking
- Trial name
- PSPGL (NCT07316400)
- Testing
- PsP
- Where
- Indonesia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Brawijaya
Healthy Adult Trial Participants
Phase 1 Clinical Study of GenSci155 Injection in Healthy Adults
This is a Phase 1, single-center, randomized, double-blind, placebo-controlled, single and multiple intravenous ascending dose clinical study to evaluate the safety, tolerability, PK, immunogenicity, and biomarker characteristics…
- Trial name
- NCT07638800
- Testing
- GenSci155 Injection
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Safety Issues, Tolerability
SB17170 Phase1 Trial in Healthy Volunteer
This clinical trial aims to learn about the safety, tolerability, and pharmacokinetic properties of SB17170 and its active metabolite SB1703 in single and multiple oral administration in healthy adults.
- Conditions
- Safety Issues, Tolerability, Pharmacokinetics, Pharmacodynamics
- Trial name
- NCT05795192
- Testing
- SB17170
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- SPARK Biopharma
Alzheimer's Disease
A Randomized, Placebo-Controlled Trial to Examine the Efficacy of Oral Donepezil in Subjects With MCI
To purpose of this study is to estimate the effect of donepezil on Neuropsychological Testing (NPT) and brain Proton Magnetic Resonance Spectroscopy.
- Trial name
- NCT00483028
- Testing
- donezepil (Aricept)
- Where
- 2 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Pfizer
Alzheimer's Disease
A Study to Evaluate the Pharmacokinetics and Safety of BEY2153 in Healthy Participants
This is a first in human Phase 1 study to evaluate the safety, tolerability and pharmacokinetics with healthy young and elderly adult male volunteers after receiving single and multiple ascending dose of BEY2153.
- Trial name
- NCT04476303
- Testing
- BEY2153
- Where
- South Korea
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- BeyondBio Inc.
PHA1A
Tolerance, PK and PD Effects Study of TPN-672 in Chinese Healthy Volunteers
This is a single-site, randomized, double-blind, placebo-controlled, incremental phase I clinical trial to evaluate preliminarily the tolerance, pharmacokinetics and pharmacodynamic effects of TPN672 maleate in Chinese healthy…
- Trial name
- NCT03931668
- Testing
- TPN-672
- Where
- China
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Dental Caries Extending Into Dentin, Root Caries
Root Caries Excavation with Air Water/powder Prophylaxis Device for ART Restorations
The main objective of this RCT is to compare the efficacy of a powder/water jet prophylaxis device and conventional hand excavation in excavating root surface caries, with regard to restoration survival/success in older adults.
- Trial name
- ART-AIRFLOW (NCT04822246)
- Testing
- Control: Hand instrumentation for caries excavation, Intervention 1: EMS Airflow device for caries excavation, Intervention 2: Hand excavation + EMS Airflow device for caries excavation
- Where
- Switzerland
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Murali Srinivasan, Dr. med. dent., BDS, MDS, MBA, MAS
Appetite and Hunger, Suppression, Blood Glucose, Postprandial
Evaluation of Subjective Ratings of Appetite and Glucoregulation of a Low Calorie Diet Supplemented With a High Viscosity Polysaccharide (PolyGlycopleX - PGX)
The objective of the study is to compare subjective appetite ratings and after-meal and 24 hour blood glucose levels within overweight and obese female subjects consuming either a standardized 3 day low calorie diet supplemented…
- Trial name
- NCT01108328
- Testing
- PolyGlycopleX (PGX)
- Where
- 2 sites in Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Canadian Center for Functional Medicine
Cicatrix, Scar Prevention
A Study of Single Ascending Dose of LEM-S401 in Healthy Participants
The primary objective of the study is to assess the safety and tolerability of single dose of LEM-S401 in healthy adult subjects.
- Trial name
- NCT04707131
- Testing
- LEM-S401
- Where
- South Korea
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Lemonex Inc.
Influenza
A Randomized, Controlled Trial on the Efficacy and Safety of Live-Attenuated Influenza Vaccine (LAIV) Among Children in Bangladesh
This is a single center, multi-site, double-blind, parallel group, placebo-controlled trial of the clinical efficacy of trivalent Serum Institute of India, Ltd.
- Trial name
- NCT01797029
- Testing
- SIIL Live Attenuated Influenza Vaccine
- Where
- 2 sites in Bangladesh
- Volunteers
- 1,761 people, healthy volunteers welcome
- Sponsor
- PATH
Family Caregiver
Circle Dance for Family Caregivers of the Elderly With Alzheimer.
The primary objective of this research is to compare the effects of a 12-week CircleCare on physical functioning of family caregivers of the elderly with AD.
- Trial name
- CircleCare (NCT03081533)
- Testing
- Circle Dance Program (CircleCare)
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Overactive Bladder and Urge Urinary Incontinence
The New Possibility of Treating Overactive Bladder With Radiofrequency
A prospective, randomized, single-blind, placebo-controlled study was conducted from June 2023 to May 2025. The study enrolled 95 women (N=48 in the study group; N=47 in the placebo group) who presented with confirmed symptoms of…
- Trial name
- RF and OAB (NCT07398014)
- Testing
- radiofrequency - TECAR
- Where
- Slovenia
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University Maribor
Postoperative Pain, Facial Swelling
Aescin-Based Herbal Extract (Reparil) for Postoperative Sequelae After Mandibular Third Molar Surgery
This randomized, single-blind, controlled clinical trial aims to evaluate the efficacy and safety of Aescin-based herbal extract (Reparil®) compared with Ibuprofen in managing postoperative sequelae following surgical removal of…
- Conditions
- Postoperative Pain, Facial Swelling, Trismus
- Trial name
- Reparil (NCT07244029)
- Testing
- Escin, Ibuprofen 400 mg
- Where
- Oman
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Oman Medical Speciality Board
Superficial Skin and Soft Tissue Infections Caused by Gram-positive Bacteria
A Phase I Clinical Trial to Evaluate CMS-F021 Following Single and Multiple Doses in Healthy Participants
"This study is a first-in-human (FIH) trial of CMS-F021 conducted in healthy Chinese adult participants, consisting of two parts: Part 1-a single ascending dose (SAD) study (referred to as Part 1 SAD), and Part 2-a multiple…
- Trial name
- NCT07790770
- Testing
- CMS-F021 Gel, Drug: CMS-F021 Gel healthy participant
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Dermavon Holdings Limited
Infant Development, Glucose, High Blood
Effect of Nutritional Intervention on Metabolic Response in Infants
The purpose of this study is to determine the glucose response of complementary feeding regimens consisting of two different follow-up formulas (FUFs) and infant cereals (ICs).
- Trial name
- NCT04483453
- Testing
- EXPL feeding regimen, CTRL feeding regimen
- Where
- Philippines
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Healthy Population
Immunogenicity and Safety of MCV4 in Volunteers Aged 6 Months-5 Years
The purpose of this study is to evaluate the immunogenicity and safety of Group ACYW135 Meningococcal Polysaccharide Conjugate Vaccine in healthy volunteers aged from 3 months to 5 years old.
- Trial name
- NCT06314685
- Testing
- Group ACYW135 Meningococcal Polysaccharide Conjugate Vaccine, Group A and C Meningococcal Polysaccharide Vaccine, Group ACYW135 Meningococcal Polysaccharide Vaccine
- Where
- China
- Volunteers
- 2,450 people, healthy volunteers welcome
- Sponsor
- Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd
Healthy Volunteers
A Trial to Assess TEV-56286 at Different Doses in Healthy Participants
The purpose of the trial is to evaluate the pharmacokinetics, safety, and tolerability of TEV-56286 at different doses. The main objective is to describe how TEV-56286 is absorbed, distributed, and removed from the body (the…
- Trial name
- NCT07674940
- Testing
- TEV-56286
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Teva Branded Pharmaceutical Products R&D LLC
Diabetes Mellitus, Type 2
A Trial Evaluating AMG 127 in Healthy Participants and Participants With Type 2 Diabetes Mellitus
The main objective of this trial is to assess the safety and tolerability of AMG 127 as single dose and multiple doses in healthy participants and participants with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT07590193
- Testing
- AMG 127
- Where
- 2 sites in United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Amgen