Clinical trials: ACL
Injury of Anterior Cruciate Ligament
Real-time Sensorimotor Feedback for Injury Prevention Assessed in Virtual Reality
Traumatic, debilitating anterior cruciate ligament (ACL) injuries occur at a 2 to 10-fold greater rate in female than male athletes.
- Trial name
- NCT02933008
- Testing
- aNMT Biofeedback, Neuromuscular Training
- Where
- 2 sites in United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Emory University
Muscle Atrophy, Proximal, Muscle Atrophy
Ultrasound for Rectus Femoris Measurement
Postoperative protocols for orthopedic procedures on the lower limb often require a period of immobilization to protect the surgical site.
- Conditions
- Muscle Atrophy, Proximal, Muscle Atrophy, ACL Tear, Quadriceps Muscle Atrophy
- Trial name
- NCT04105816
- Testing
- 892.1550 Ultrasonic pulsed doppler imaging system, Thigh circumference measurement
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Robert Westermann
Sports Injury, Anterior Cruciate Ligament Rupture
Comparison of Functional Outcome Between BQT and SBHT ACL Reconstruction
ACL rupture has a high morbidity in productive-age population. The increasing incidence and proper management has become a point of interest in the musculoskeletal sport injury.
- Trial name
- BQTSBHTFMUI (NCT04536246)
- Testing
- Bone Quadriceps Tendon (BQT) arthroscopic-assisted ACL reconstruction, Single-Bundle Hamstring Tendon (SBHT) arthroscopic-assisted ACL reconstruction
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Healthy Subjects, Sports Level 1
Effect of Blood Flow Restriction Training to Muscle Strength, Dynamic Stability, and ACL Injury Prevention
The goal of this randomized clinical trial study is to compare low-load blood flow restriction (LL-BFRt), sham LL-BFRt, and high-load eccentric training (HL-Et) in healthy level 1 sportsman.
- Trial name
- NCT05951036
- Testing
- Low-load Blood Flow Restriction training, High-load Eccentric training
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Udayana University
Anterior Cruciate Ligament Injuries
Spatiotemporal Characteristics and Multi-body Dynamics Modeling Information After ACL Rupture and Reconstruction
High incidence rate of knee osteoarthritis and gait analysis are important for early assessment of biomechanics. ACL injury is an ideal clinical model for studying knee osteoarthritis.
- Trial name
- NCT04462432
- Testing
- no intervention
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Anterior Cruciate Ligament Rupture
BFRT in Adolescents After ACL Reconstruction
This is an interventional study that will examine effects of blood flow restriction training (BFRT) in adolescents aged 12-18 after anterior cruciate ligament reconstruction surgery (ACLR).
- Trial name
- NCT04390035
- Testing
- Blood Flow Restriction using Delfi Personalized Tourniquet System
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Healthcare of Atlanta
ACL Tear, ACL - Anterior Cruciate Ligament Deficiency
Proprioceptive Isokinetic Repositioning, Functional Testing, and a Self-reported Questionnaire Before and After Anterior Cruciate Ligament Reconstruction
This prospectively study aims to evaluate the evolution of knee joint proprioception on isokinetic dynamometer before and after Anterior Cruciate Ligament (ACL) reconstruction and its relationships with muscle strength, self…
- Trial name
- PRO-ACL (NCT04058574)
- Testing
- Proprioception measurement on isokinetic dynamometer
- Where
- 2 sites in France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
ACL-injury
The Effectiveness of Neuromuscular Training in Healthy and ACL-Injured Adolescent Females
Recently, there has been a dramatic rise in the number of children participating in competitive sports. Adolescents involved in sports that require cutting, pivoting or body contact are at greatest risk for sustaining an anterior…
- Trial name
- NCT02316639
- Testing
- Neuromuscular Training
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Athletic Injuries, Sprains and Strains
The Design and Evaluation of an Active Intervention for the Prevention of Non-contact ACL Injury
The overall goal of this project is to reduce the risk for anterior cruciate ligament injuries by designing a targeted intervention that will alter the known kinematic and kinetic risk factors associated with ACL injuries.
- Conditions
- Athletic Injuries, Sprains and Strains, Wounds and Injuries, Knee Injuries
- Trial name
- NCT01021111
- Testing
- Activity Training with Feedback
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Stanford University
ACL, ACL Injury
Acupuncture ACL (Anterior Cruciate Ligament)
Acupuncture research in regards to PONV has been fairly well established, however, studies about perioperative pain control and acupuncture are a little more murky.
- Conditions
- ACL, ACL Injury, Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
- Trial name
- NCT03711734
- Testing
- Acupuncture + Standard of Care
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Acute Injury of Anterior Cruciate Ligament
Feasibility Trial Using Imaging and Biochemical Technologies to Measure Knee Cartilage Composition in Acute ACL Injury
This study will evaluate the bio-mechanical and biochemical abnormalities in acute ACL-injured knees over time. Data will be collected through advanced quantitative MR imaging, functional testing, and bio-specimen collection.
- Trial name
- NCT02010125
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Isolated Anterior Cruciate Ligament Rupture
Changes in Muscle Morphology Resulting From Anterior Cruciate Ligament Reconstruction
The aim of this study is to gain new knowledge on the impact of hamstring tendon harvest and apply that knowledge to the treatment and management of patients who undergo anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT01537588
- Testing
- Autograft STG harvest from ACL-deficient leg, Autograft harvest contralateral to ACL-deficient leg
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Panam Clinic
Anterior Cruciate Ligament Injury, Knee Injuries
Bone Tunnel Widening Following ACL Reconstruction
Hypothesis 1: There is less tunnel-widening with bone-patella tendon-bone graft compared with the hamstring graft when the same fixation method is used.
- Trial name
- NCT00198042
- Testing
- Surgical reconstruction of the ACL
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Genicular Nerve Block for Pain in ACL Arthroscopy
Ultrasound-guided Genicular Nerves Block
Most of arthroscopic ACL repairs are day case surgeries associated with moderate postoperative pain and discomfort. So , finding an effective and safe, analgesic technique with minimal complications is our goal for fast recovery…
- Trial name
- NCT05813834
- Testing
- Genicular Nerves Block
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Cairo University
Anterior Cruciate Ligament Rupture
Return to Play After ACL Reconstruction With Bone Marrow Aspirate, DBM, and an Internal Brace
The Investigators are studying the effect of an ACL reconstruction on return to play by capturing outcome measures and biomechanics information.
- Trial name
- NCT06294314
- Testing
- Fertilized ACL
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Marshall University
ACL Tear, Opioid Misuse
Exparel vs. ACB With Bupivacaine for ACL Reconstruction
Opioid misuse and addiction among children and adolescents is an increasingly concerning problem. Post-surgical opioid prescriptions for commonly performed surgeries such as anterior cruciate ligament reconstruction (ACLR)…
- Conditions
- ACL Tear, Opioid Misuse, Pain, Anxiety
- Trial name
- NCT06274008
- Testing
- Exparel
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Orange County
Anterior Cruciate Ligament Injuries, Meniscus Lesion
The Effect Of Addıtıonal Surgery On Muscle Strength, Proprıoceptıon And Balance In Anterıor Crucıate Lıgament Surgery
Meniscal tears and RAMP lesions are frequently seen together with ACL injuries. The aim of this study was to evaluate the effects of meniscus repair and RAMP lesion repair ACL reconstruction surgery in terms of muscle strength…
- Trial name
- NCT06319040
- Testing
- Muscle strength measurement, Knee joint proprioception, Balance
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Medipol University
Healthy Adult Participants, Anterior Cruciate Ligament (ACL)
Three-dimensional Biomechanics of the Lower Limbs in Healthy Volunteers: Establishment of a Reference Database Using the MERItest® System
Anterior cruciate ligament (ACL) reconstruction is frequently associated with persistent biomechanical impairments despite clinically satisfactory recovery.
- Trial name
- MERITEST TS (NCT07886411)
- Testing
- MERITest
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Clinique du Sport, Bordeaux Mérignac
Knee Ligament Injury
TEL and Clam Shell Exercises Affect After ACL
The purpose of this study to determine the effects of the addition of isolated hip strengthening exercises to traditional rehabilitation after Anterior cruciate ligament reconstruction (ACLR).
- Trial name
- NCT05856071
- Testing
- goniometer, clamshells exercises, traditional physical therapy
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Anterior Cruciate Ligament Injuries, Sports Injury
Neuromusculoskeletal Alterations After ACL Injury
This study investigated how anterior cruciate ligament (ACL) injuries affect not only the knee joint but also brain activity, reaction speed, and psychological readiness to return to sports.
- Conditions
- Anterior Cruciate Ligament Injuries, Sports Injury, Neurocognitive Function
- Trial name
- NEURO-ACL (NCT07163468)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duzce University