Clinical trials: ACL
ACL Injury
Neuromuscular Training Improves Single-Limb Stability
Pretest/post-test study design, study will try to determine if a 6-week neuromuscular training program designed to decrease the incidence of anterior cruciate ligament (ACL) injuries would improve single-limb stability in young…
- Trial name
- NCT04967937
- Testing
- Strengthening, resistance exercise, plyometric and dynamic movement training
- Where
- Pakistan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Anterior Cruciate Ligament Injuries, Meniscus Tear
Magic Angle Direction Imaging (MADI) ACL Study
This study will be conducted to see if a new Magnetic Resonance Imaging (MRI) scanner could give additional information or help view the body in a different way.
- Trial name
- MADI (NCT07366619)
- Testing
- Magnetic Resonance Imaging
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Articular Cartilage Degeneration
MechSens - Dose-response Relationship of in Vivo Ambulatory Load and Mechanosensitive Cartilage Biomarkers
This study is to investigate the effects of age, tissue status and the presence of inflammation on the in vivo dose-response relationship of ambulatory load and mechanosensitive blood markers of articular cartilage.
- Trial name
- MechSens (NCT04128566)
- Testing
- walking stress test
- Where
- Switzerland
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
ACL Injury, ACL Reconstruction
Comparative Effectiveness of Blood Flow Restriction With or Without Total Motion Release in ACL Rehabilitation
The aim of this clinical trial is to compare the effectiveness of combined Blood Flow Restriction (BFR) and Total Motion Release (TMR) versus BFR alone in the restoration of muscular strength, balance and knee functionality in…
- Trial name
- BFR-TMR-ACL (NCT07589309)
- Testing
- Blood Flow Restriction, Total Motion Release
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Green International University
Ligament Injury
Do Oral Contraceptives Protect Against ACL Injuries in Female Athletes
The purpose of this research study is to examine the impact of one type of commonly used birth control pill on blood levels of relaxin and measure changes in knee movement to determine whether there are changes in joint…
- Trial name
- OC (NCT04899778)
- Testing
- Oral Contraceptive Pill, norethindrn a-e estradiol-iron
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Knee Injuries, Athletic Injuries
Risk Factors for Anterior Cruciate Ligament (ACL) Injury
The anterior cruciate ligament (ACL) is located inside the knee joint and provides stability to the knee. ACL injuries occur more frequently in women than men; the reason for this is unknown.
- Trial name
- NCT00124319
- Where
- 3 sites in United States
- Volunteers
- 4,800 people, healthy volunteers welcome
- Sponsor
- Steve Marshall
Anterior Cruciate Ligament Injuries
Cartilage Injury and Remodeling After ACL Rupture and Reconstruction: Functional Imaging and Biomarkers
The proposed study will establish novel relationships between intra-articular MSC recruitment, synovial inflammation, biomarkers of cartilage degeneration and joint inflammation, clinical patient factors, and downstream…
- Trial name
- NCT04970706
- Testing
- ACL reconstruction
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Resistance Training, Blood Flow Restriction Therapy
High Intensity Resistance Training With and Without Blood Flow Restriction in ACL Reconstruction
This study is randomized and single-blinded. Ethical approval is taken from the ethical committee of riphah international university, Lahore.
- Conditions
- Resistance Training, Blood Flow Restriction Therapy, Anterior Cruciate Ligament Reconstruction, Volleyball
- Trial name
- NCT06131047
- Testing
- High intensity Traditional Resistance Traning without Blood Flow Restriction, High intensity Traditional Resistance Traning with Blood Flow Restriction
- Where
- Pakistan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Reconstruction
Comparison of Kinematic Movements Between ACL Deficiency With ACL Reconstruction and Healthy People
Comparison of kinematic movements between patients with anterior cruciate ligament rupture and post-operative patients and normal people using a mobile dynamic X-ray device.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Reconstruction, Healthy People
- Trial name
- NCT05619393
- Testing
- Mobilie Bi-planar X-ray Imaging system
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wang Joon Ho
Anterior Cruciate Ligament Injuries
Effect of Visual-Guided Balance Training on Knee Motor Function and Biomechanical Characteristics After ACL Reconstruction
This study aims to investigate the improvement effect of visual-guided balance training on the knee joint function and gait performance of patients after ACLR, and to clarify the advantages of this training program compared to…
- Trial name
- NCT07306221
- Testing
- Traditional group, Intervention Group
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Knee Injuries, Rehabilitation
Biomechanical Determinants of Different Rehabilitation Protocols for ACL Reconstruction
Purpose of the study is to investigate the effects of the criterion rehabilitation protocol versus accelerated rehabilitation protocol on the biomechanical determinants of the quality of performance and risk of reinjury.
- Trial name
- NCT05733936
- Testing
- rehabilitation protocol
- Where
- Egypt
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Anterior Cruciate Ligament (ACL) Tear
Sciatic Technique Comparison of Nerve Blockade for Pain Control Following Hamstring Autograft Harvest in Adolescents
The purpose of this research is to compare the effect of single-injection sciatic PNB to continuous sciatic PNB on 1) postoperative pain control as measured by self-reported pain scores, pain medication use, and unplanned…
- Trial name
- NCT02947633
- Testing
- Single-injection sciatic PNB, Continuous sciatic PNB
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Anterior Cruciate Ligament Rupture
Anterior Cruciate Ligament Radiology Follow-up Study
Following recent advances in the understanding of successful anterior cruciate ligament (ACL) reconstruction, three important factors have been identified: femoral tunnel positioning, femoral tunnel aperture shape, and native…
- Trial name
- NCT02816606
- Testing
- Flexible reamers, 70-degree arthroscope
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Single Leg Hop Sand Surface, Single Leg Hop Grass Surface
Effect of Sand on Knee Load and Muscle Activity During a Single Leg Landing Task
This study evaluates the effect of different surfaces on the load experienced by the knee when landing from a single leg hop. A sand, pliable grass and firm (hard floor) surface will be compared when hopping from a 30 cm height.
- Conditions
- Single Leg Hop Sand Surface, Single Leg Hop Grass Surface, Single Leg Hop Firm Surface
- Trial name
- NCT04502615
- Testing
- Sand, artificial grass, firm ground
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Teesside University
Anterior Cruciate Ligament Injuries
Adding Neurocognitive Component to Balance Test
By introducing BlazePods as a neurocognitive addition to the YBT, this study aims to determine whether this addition impacts balance performance and/or reach distances between the operative and non-operative limbs of patients…
- Trial name
- NCT06827483
- Testing
- Neurocognitive Component
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Duke University
ACL Injury, Sport Injury
Muscular Activations During Eccentric Quadriceps Exercises
The aim of this study is to investigate muscular activations during various quadriceps exercises commonly used in clinical settings.
- Conditions
- ACL Injury, Sport Injury, Sports Physical Therapy, Muscle Weakness
- Trial name
- NCT06162130
- Testing
- Eccentric quadriceps exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Ordu University
ACL Tear, ACL-injury
Do Patients With ACL Tears Demonstrate Weakness of the Soleus Muscle?
The goal of this prospective, cross-sectional study is to test the strength of the soleus muscle in participants who have a ACL tear confirmed by MRI.
- Conditions
- ACL Tear, ACL-injury, ACL - Anterior Cruciate Ligament Rupture
- Trial name
- ACL (NCT06235736)
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Machine Learning
MUSCLE-ML: Multimodal Integration of Muscle Strength, Structure by Machine Learning for Precision Rehabilitation After ACL Injury
The goal of this clinical trial is to use machine learning (ML) to predict functional recovery by integrating muscle-related factors and other relevant parameters for identification of non-responders to conventional…
- Trial name
- NCT07284771
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Patellar Dislocation, ACL Injury
The Faroese Knee Cohort: Etiology and Long-term Implications of Trochlear Dysplasia and Patellar Dislocations.
The investigators intend to establish a national cohort including all persons in the ages from 15-20 years old with patellar instability (PI) or a prior knee injury (ACL-ruptur or meniscus damage) .
- Conditions
- Patellar Dislocation, ACL Injury, Meniscus Lesion, Trochlear Dysplasia
- Trial name
- FKC (NCT04607538)
- Testing
- No intervention is made
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Prevention of ACL Thru Strengthening Program
Female Acl Prevention Study Where we Look at Landing Techniques Pre/Post Nine Week Strenghtening Program
To make reading this consent form easier, the word "participant" refers to you or your child (if a minor) throughout the consent form.
- Trial name
- NCT01729312
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System