Clinical trials: ACS
ACS, Acute Coronary Syndrome
Study Evaluating How Patients With Acute Coronary Syndrome Are Managed During 2 Years After Discharge
The aim of this international study is to describe the short- and long-term (i.e. up to 2 years following the index event) antithrombotic management patterns (AMPs) in patients hospitalized for acute coronary syndromes (ST…
- Conditions
- ACS, Acute Coronary Syndrome, Myocardial Infarction, Unstable Angina
- Trial name
- EPICOR (NCT01171404)
- Where
- 410 sites in Argentina, Belgium and 18 more
- Volunteers
- 10,568 people
- Sponsor
- AstraZeneca
Coronary Artery Disease, Acute Coronary Syndrome
Recurrent Events After Percutaneous Coronary INterventio for ACS
Patients undergoing PCI for ACS are exposed to a significant ischemic and bleeding risk. The aim of our study is instead to analyze in detail the rates of recurrent events, but also their predictors and impact on outcomes, in a…
- Trial name
- AGAIN (NCT03675347)
- Testing
- angioplasty
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Acute Coronary Syndrome, Depressive Symptoms
Comparison of Depression Identification After Acute Coronary Syndrome: Quality of Life and Cost Outcomes
The purpose of this study is to examine, in a randomized controlled trial, the benefits and costs of the American Heart Association's (AHA) advisory for depression screen and treatment of post-acute coronary syndrome patients.
- Trial name
- CODIACSQoL (NCT01993017)
- Testing
- Cognitive Behavioral Therapy (CBT), Antidepressant Medication, Standard Care
- Where
- 4 sites in United States
- Volunteers
- 1,501 people
- Sponsor
- Columbia University
Coronary Artery Disease, Coronary Atheroscleroses
Risk Evaluation by COronary Imaging and Artificial intelliGence Based fuNctIonal analyZing tEchniques - III
This is a single-center, prospective cohort study. This study is designed to accurately analyze coronary artery plaque characteristics and local hemodynamic parameters in patients diagnosed with chronic coronary syndrome (CCS) or…
- Conditions
- Coronary Artery Disease, Coronary Atheroscleroses, Acute Coronary Syndromes (ACS)
- Trial name
- RECOGNIZE-III (NCT06793774)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Ruijin Hospital
Acute Coronary Syndrome
Angioplasty to Blunt the Rise of Troponin in Acute Coronary Syndrome (ACS)
Release of troponin evaluated by the peak of troponin during the hospital phase.Because of its sensitivity and specificity as well as its widespread use in routine practice, rise in troponin levels is the main assessment criteria…
- Trial name
- ABOARD (NCT00442949)
- Testing
- Catheterization immediate PCI, delayed PCI
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Diseases
Quality of Life Post-ACS in Participants from EMMACE
EMMACE-XL will recruit participants who are survivors of acute coronary syndrome (a type of heart attack) to assess their health-related quality of life five years or more after their heart attack.
- Trial name
- EMMACE-XL (NCT04598048)
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 13,400 people, healthy volunteers welcome
- Sponsor
- University of Leeds
ACS (Acute Coronary Syndrome), Myocardial Infarction (MI)
TIRANA-ACS: A Prospective Registry Study for the Targeted Investigation of Residual Inflammation After Non-ST/ ST Elevation Acute Coronary Syndrome
This prospective observational study aims to evaluate the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) as a predictor of mortality in patients following an episode of Acute Coronary Syndrome (ACS).
- Conditions
- ACS (Acute Coronary Syndrome), Myocardial Infarction (MI), Myocardial Inflammation, Inflammation Biomarkers
- Trial name
- TIRANA (ACS) (NCT07026708)
- Where
- Albania
- Volunteers
- 1,600 people
- Sponsor
- University Hospital Centre Mother Teresa
Percutaneous Coronary Intervention (PCI), Drug Coated Balloon
Registry of Coronary Disease Outcomes Revascularizing With Drug-Coated Balloons
The primary aim of this registry is to systematically collect and analyze real-world data on all patients undergoing PCI with the Protégé paclitaxel-eluting DCB to evaluate procedural outcomes, long-term efficacy, and safety…
- Conditions
- Percutaneous Coronary Intervention (PCI), Drug Coated Balloon, Paclitaxel, CAD - Coronary Artery Disease
- Trial name
- RECORD-DCB (NCT07231835)
- Where
- Netherlands
- Volunteers
- 3,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Coronary Syndrome
The Effect on Blood Cells, Known as Platelets, Using Prasugrel vs Clopidogrel in Patients With the Heart Problem Acute Coronary Syndrome (ACS)
This is a multicenter, randomized, double-blind, cross-over study to compare the pharmacodynamic response in subjects with Acute Coronary Syndrome receiving a 10-mg maintenance dose (MD) of prasugrel compared with a 150-mg…
- Trial name
- NCT00385944
- Testing
- Prasugrel, Clopidogrel
- Where
- 2 sites in France
- Volunteers
- 56 people
- Sponsor
- Eli Lilly and Company
Coronary Artery Disease, Coronary Disease
Interventional Strategy for Non-culprit Lesions With Major Vulnerability Criteria at OCT in Patients With ACS
The INTERCLIMA (Interventional Strategy for Non-culprit Lesions With Major Vulnerability Criteria Identified by Optical Coherence Tomography in Patients With Acute Coronary Syndrome) is a multi-center, prospective, randomized…
- Conditions
- Coronary Artery Disease, Coronary Disease, Ischemic Heart Disease
- Trial name
- INTERCLIMA (NCT05027984)
- Testing
- Optical coherence tomography, iFR/FFR/RFR
- Where
- 34 sites in Greece, Italy and 2 more
- Volunteers
- 1,425 people
- Sponsor
- Centro per la Lotta Contro l'Infarto - Fondazione Onlus
Acute Coronary Syndrome
PCSK9 Inhibitor on ACS Patients With Multivessel Disease and Relatively Low LDL-C Level in Chinese Population
The study is an open-label, multicenter, and randomized study. The objective of this study is to demonstrate the effect of PCSK9 inhibitor on ACS patients with multivessel disease and relatively low LDL-C levels or LDL-C levels…
- Trial name
- NCT05043740
- Testing
- Repatha or Praluent
- Volunteers
- 1,360 people
- Sponsor
- Second Xiangya Hospital of Central South University
Acute Coronary Syndromes
Switching From Fondaparinux to Bivalirudin or Unfractionated Heparin in ACS Patients Undergoing PCI
The primary objective of this clinical trial is to evaluate safety of switching from fondaparinux to either unfractionated heparin or bivalirudin for patients experiencing acute coronary syndrome undergoing percutaneous coronary…
- Trial name
- SWITCHIII (NCT00464087)
- Testing
- Switching from Fondaparinux to Bivalirudin or Unfractionated Heparin
- Where
- 7 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Medstar Health Research Institute
Acute Coronary Syndrome, Online CBT Targeting Cardiac Anxiety
Internet-based Behavioral Intervention Following ACS
The aim of this study is to evaluate if an online Cognitive Behavioral Therapy (CBT) protocol customized for patients following Acute Coronary Syndrome (ACS), reduce cardiac anxiety, enhance Quality of Life (QoL), and promote…
- Trial name
- ACS-CBT (NCT06298864)
- Testing
- Internet-CBT, Internet-CL
- Where
- Sweden
- Volunteers
- 176 people
- Sponsor
- Karolinska Institutet
Complication,Postoperative, Postoperative Period
Predictive Value of QoR15 for Complications
Surgical operations and recovery after anesthesia is a complex process. Studies examining the interventions performed in the preoperative period often focus on classical clinical outcomes such as postoperative organ dysfunction…
- Trial name
- NCT04744376
- Testing
- QoR15, ACS risk calculator, Clavien - Dindo classification
- Where
- 8 sites in Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- Mehmet Ali Koç
Acute Coronary Syndrome (ACS)
EndoTic - Endothelium and Ticagrelor
Randomized clinical trial to assess the influence of treatment with ticagrelor or clopidogrel in the number of CECs (Circulating Endothelial Cells) and EPCs (Endothelial Progenitor Cells) in patients with ACS (Acute Coronary…
- Trial name
- NCT02244710
- Testing
- Ticagrelor vs Clopidogrel
- Where
- 3 sites in Spain
- Volunteers
- 109 people
- Sponsor
- Fundación Investigación Sanitaria en León
Acute Coronary Syndrome
VitalScan MCG Rule-out Multi-centre Pivotal Study - US
A prospective multi-centre observational study to validate the diagnostic accuracy of a transportable magnetocardiograph device for acute coronary syndrome (ACS), focusing on rule-out capability, in patients who present to the…
- Trial name
- MAGNET ACS (NCT03546933)
- Testing
- VitalScan Magnetocardiograph
- Where
- 5 sites in United States
- Volunteers
- 651 people
- Sponsor
- Creavo Medical Technologies Ltd
Tomography, Optical Coherence, Myocardial Revascularization
The FAST OCT Study
This trial is designed to associate angiography-based fractional flow reserve (3D-angio-based FFR) values with optical coherence tomography findings in pre- and post-percutaneous coronary intervention in patients with non-ST…
- Conditions
- Tomography, Optical Coherence, Myocardial Revascularization, NSTEMI - Non-ST Segment Elevation MI, Unstable Angina
- Trial name
- NCT04683133
- Testing
- Optical coherence tomography assessment
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Erasmus Medical Center
Chest Pain, Emergency Medicine
A Study to Assess the Accuracy of Magnetocardiography (MCG) to Diagnose True Ischemia in Patients With Chest Pain in the ED
The purpose of the research is to see if patients that come to the Emergency Department with chest pain can be more accurately and more quickly diagnosed by magnetocardiography (MCG) to see if their chest pain is caused by…
- Trial name
- MCG (NCT05809648)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Mayo Clinic
Acute Coronary Syndrome
VitalScan MCG Rule-out Multi-centre Pivotal Study - UK
The study is a prospective multi-centre observational study to evaluate a portable magnetocardiograph device for the rule-out of acute coronary syndrome (ACS) in patients who present to the emergency department with chest pain…
- Trial name
- MAGNET-ACS (NCT02921438)
- Testing
- VitalScan Magnetocardiograph
- Where
- 5 sites in United Kingdom
- Volunteers
- 756 people
- Sponsor
- Creavo Medical Technologies Ltd
Drug Coated Balloon, Bioresorbable Scaffold
Leave Nothing Behind Study Which Compares DCB With Bail Out BRS Versus BRS Strategy Alone
The goal of this study is to investigate the equivalence in early and long-term efficacy between the two "Leave nothing behind strategies" (Drug-Coated Baloon [DCB] strategy with bail-out BioResorbable Scaffold [BRS] versus BRS…
- Conditions
- Drug Coated Balloon, Bioresorbable Scaffold, Percutaneous Coronary Intervention (PCI), Acute Coronary Syndrome (ACS)
- Trial name
- LNB (NCT07038408)
- Testing
- Angioplasty with DCB (bail-out BRS), Angioplasty with BRS
- Where
- Estonia
- Volunteers
- 2,256 people
- Sponsor
- Ceric Sàrl