Clinical trials: ACT
Depression, Anxiety
Evaluation of Training Curriculum and Service of Improving Access to Community Therapies
The current study aims to conduct a comprehensive evaluation of a training curriculum designed for teaching low-intensity psychological interventions to bachelor's degree holders, specifically focusing on principles of Acceptance…
- Conditions
- Depression, Anxiety, Mental Health Issue, Stress
- Trial name
- iACT (NCT06111820)
- Testing
- Improving Access to Community Therapies (iACT)
- Where
- 21 sites in China
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Mind Mental Health Hong Kong Limited
Healthy
A Study to Learn How Different Amounts of the Study Medicine Called PF-08049820 Are Tolerated and Act in the Body in Healthy Adults
The purpose of this study is to learn about the safety of the study medicine called PF-08049820 in healthy adults. The study will also see: how the body processes the study medicine and if food affects the amount of study…
- Trial name
- NCT06686797
- Testing
- PF-08049820
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Pfizer
Cancer Prevention
Project MOVE: Increasing Physical Activity Among Breast Cancer Survivors
The purpose of this research is to implement and evaluate the feasibility of Project MOVE, a program aimed to increase physical activity among breast cancer survivors through microgrants and financial incentives.
- Trial name
- NCT03548636
- Testing
- Single-Arm Feasibility Study
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Depression, Anxiety
ACTing Minds: An ACT-based Videogame for Mental Health
The goal of this clinical trial is to test whether a single-session Acceptance and Commitment Therapy (ACT) videogame (ACTing Minds) improves psychological flexibility and mental health in adults who report mild to moderate…
- Conditions
- Depression, Anxiety, Stress (Psychology), Psychological Flexibility
- Trial name
- ACTingMindsRCT (NCT07272096)
- Testing
- ACTing Minds (ACT videogame), Monument Valley (mobile; neutral control)
- Where
- United Kingdom
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Swansea University
Anxiety
Does Treating Anxiety Symptoms With ACT Improve Vascular Inflammation and Function?
The goal of this study is to evaluate the effectiveness of a brief, intensive 1-day psychotherapy group intervention (Acceptance and Commitment Therapy, ACT), compared to a 12 week time control group on anxiety symptoms, vascular…
- Trial name
- ACT on Anxiety (NCT02915874)
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Hematopoietic Steam Cell Transplantation (HCT)
ACT to Reduce Morbidity and Mortality in Hematopoietic Stem Cell Transplant (HCT) Patients
This is a research study to develop and test a novel protocol to reduce physical and psychological vulnerabilities that contribute to treatment intolerance and treatment-related morbidity and mortality among hematopoietic stem…
- Trial name
- NCT04423939
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Duke University
Overweight and Obesity, Eating Behavior
An ACT-Based Physician-Delivered Weight Loss Intervention
The purpose of the present study was to conduct a pilot RCT to test the feasibility of a physician-delivered ACT-based intervention for emotional eaters with overweight/obesity against standard care at a network of weight loss…
- Trial name
- NCT03611829
- Testing
- ACT Intervention, Standard Care
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- McGill University
Malaria
Pyronaridine Artesunate-Ritonavir Drug-drug Interaction Study
The primary objective of the study is to determine any drug interaction between the antimalarial Pyramax (pyronaridine artesunate) and the protease inhibitor ritonavir in healthy subjects.
- Trial name
- NCT01156389
- Testing
- Ritonavir and Pyramax, Pyramax
- Where
- Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Obesity in Childhood
The Baby Act Trial (BAT): a Multimodal Lifestyle Intervention
Childhood obesity is increasing, particularly among Hispanics. Rapid weight gain during childhood increases the risk of obesity in childhood and in adulthood, also increasing the risk of chronic diseases such as diabetes and…
- Trial name
- BAT (NCT03517891)
- Testing
- WIC+
- Where
- Puerto Rico
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- University of Puerto Rico
Chemsex
Acceptance and Commitment Therapy for Chemsex
Quasi-randomized control trial of acceptance and commitment therapy (ACT) for chemsex.
- Trial name
- ACT-for-chemse (NCT06980974)
- Testing
- ACT-for-chemsex, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Rheumatic Heart Disease
Testing a Registry-Based Strategy (ACT+) to Reduce Loss to Follow-Up in Rheumatic Heart Disease Screening in Uganda
This study aims to improve follow-up care after positive rheumatic heart disease (RHD) screening in Northern Uganda. It will identify barriers and co-develop an enhanced ACT+ strategy, then evaluate its effectiveness in…
- Trial name
- SHIELD 2 (NCT07606131)
- Testing
- The ACT+ Strategy
- Where
- Uganda
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Stem Cell Transplant Patients
ACT to Reduce Morbidity and Mortality in Hematopoietic Stem Cell Transplant Patients
This study is a phase 2, multicenter, randomized controlled trial to test the application of Acceptance and Commitment Therapy (ACT) in HCT patients.
- Trial name
- ACTivate (NCT07516314)
- Testing
- ACTivate sessions
- Where
- 2 sites in United States
- Volunteers
- 476 people, healthy volunteers welcome
- Sponsor
- Anthony Sung, MD
Adolescent Behavior, Gender
GAGE Act With Her-Ethiopia Evaluation
This study evaluates the impact of Act With Her Ethiopia (AWH-E), a gender transformative multi-level program that aims to improve the lives of young adolescent boys and girls.
- Trial name
- NCT03890237
- Testing
- Her Spaces, Act With Her, Act With Her + Asset Transfer
- Where
- 3 sites in Ethiopia
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- George Washington University
Influenza, COVID-19 (Coronavirus Disease 2019)
A Study to Learn About How the Flu and COVID-19 Vaccines Act in Healthy People
The purpose of this study is to learn about how the flu and COVID vaccines act when given alone or when mixed together. This study is seeking healthy participants aged 18 or older.
- Trial name
- NCT06821061
- Testing
- Investigational Influenza Vaccine, Investigational COVID-19 Vaccine, Investigational Influenza and COVID-19 Combination Vaccine
- Where
- 31 sites in United States
- Volunteers
- 2,650 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Malaria, Vivax
A Study to Evaluate the Pharmacokinetics of a Single Dose of Tafenoquine Co-administered With Either Artemether + Lumefantrine or Dihydroartemisinin + Piperaquine Tetraphosphate
This will be a single-centre, 5-cohort, randomized open-label, parallel-group study in healthy volunteer subjects. This study aims to provide sufficient pharmacokinetic (PK) evidence to support the safe usage of Tafenoquine (TQ)…
- Trial name
- NCT02184637
- Testing
- Tafenoquine, Dihydroartemisinin + Piperaquine tetraphosphate, Artemether + Lumefantrine
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Autism Spectrum Disorder (ASD)
Guided ACT and for Adults With ASD
This study aims to investigate the efficacy of guided self-help Acceptance Commitment Therapy (ACT) for adults who have a diagnosis for Autistic Spectrum Disorder (ASD) and are experiencing psychological distress (stress, anxiety…
- Trial name
- NCT04376151
- Testing
- Acceptance and Commiment Therapy (ACT) bibliotherapy 'Get Out of Your Mind and Into Your Life'
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Lincoln
Healthy
A Study to Learn How Different Amounts of the Study Medicine Called PF-07314470 Are Tolerated and Act in the Body in Healthy Adults
The purpose of this clinical trial is to learn if the study medicine (called PF-07314470) is safe and how it gets in and out of the body in healthy people.
- Trial name
- NCT06821750
- Testing
- PF-07314470
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Pfizer
Psychological Distress, Psychological Wellbeing
Italian YOLO: A Web-Based ACT Mental Health Promotion Intervention for University Students
The mental health of university students requires urgent attention, as many students are exposed to increased risk of psychological distress, including symptoms of depression, anxiety, academic stress, and reduced well-being.
- Conditions
- Psychological Distress, Psychological Wellbeing, Academic Stress
- Trial name
- YOLO (NCT07654569)
- Testing
- Italian YOLO
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Autism Spectrum Disorder, Attention Deficit Disorder With Hyperactivity (ADHD)
Pai.ACT: AI-Driven ACT Chatbot for Mental Health Triage and Service Evaluation
Parents of children with special needs in Hong Kong often face limited psychological support, which can negatively impact the child rehabilitation process and the well-being of parent-child relationships.
- Conditions
- Autism Spectrum Disorder, Attention Deficit Disorder With Hyperactivity (ADHD), Neurodevelopmental Disorder (Diagnosis), Dyslexia
- Trial name
- NCT06808555
- Testing
- Pai.ACT Group, Control Group
- Where
- 20 sites in Hong Kong
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Type 2 Diabetes Mellitus (T2DM), Obesity
A Study to Learn How Different Amounts of PF-06954522 Are Tolerated and Act in Adults With Type 2 Diabetes Mellitus
The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of multiple escalating oral doses of PF-06954522 in adult participants with inadequately controlled type 2 diabetes…
- Trial name
- NCT06279234
- Testing
- Rosuvastatin, Midazolam, Omeprazole
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pfizer