Clinical trials: ADHF
Chronic Heart Failure, Fluid Overload
Naturally Controlled Decongestion Using Renal Independent System in ADHF Patients, a European Registry
The AquaPass is a non-invasive, renal-intended system designed to enhance fluid transfer through the skin, by increasing sweat rate, to treat fluid overload in heart failure patients.
- Conditions
- Chronic Heart Failure, Fluid Overload, Acute Decompensated Heart Failure, Edema
- Trial name
- REFORM-HF II (NCT06401109)
- Testing
- AquaPass
- Volunteers
- 30 people
- Sponsor
- AquaPass Medical Ltd.
ADHF
Role of the Mespere Venus 1000 in Predicting Heart Failure Hospital Readmissions
The purpose of this study is to investigate the utility of Venus 1000 in predicting 30-day hospital readmissions for acute decompensated heart failure.
- Trial name
- NCT02003040
- Testing
- Mespere Venus 1000 CVP System
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Mespere Lifesciences Inc.
Acute Decompensated Heart Failure; Renal Dysfunction
Safety and Efficacy Study to Evaluate the Effect of SLV320 on Renal Function in Patients With Worsening Heart Failure
The purpose of this study is to determine the efficacy and safety of IV SLV320 in acute heart failure patients with renal dysfunction.
- Trial name
- NCT00744341
- Testing
- SLV320
- Where
- 105 sites in United States, Canada and 9 more
- Volunteers
- 46 people
- Sponsor
- Solvay Pharmaceuticals
Acute Heart Failure
Heart Failure Hospital Readmissions and Physical Therapy
This is a dissertation study which is divided into three different studies in order to answer the main research question (Study 3).
- Trial name
- NCT03517514
- Testing
- Physical Therapy service
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- The Methodist Hospital Research Institute
Heart Failure, Hyponatremia
Tolvaptan for Advanced or Refractory Heart Failure
This study will clarify the clinical usefulness of Tolvaptan therapy in patients with complicated acute decompensated heart failure and hyponatremia (low blood sodium).
- Trial name
- NCT02959411
- Testing
- Tolvaptan, Standard of care diuretic therapy
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- University of Calgary
Heart Failure, Acute Decompensated Heart Failure
Use of the Impella BTR™ in Patients With Heart Failure: An Early Feasibility Study
This is a prospective, multi-center, single-arm, early feasibility study that aims to evaluate the safety of the Impella BTR™ in adult patients requiring left-ventricular hemodynamic support, and to evaluate the effectiveness of…
- Trial name
- BTR EFS (NCT05291884)
- Testing
- Impella BTR
- Where
- 6 sites in United States
- Volunteers
- 10 people
- Sponsor
- Abiomed Inc.
Acute Decompensated Heart Failure
Point Of Care With Serial NT-proBNP Measurement in Patients With Acute Decompensation of Heart Failure
The goal of this study is to explore whether the availability of serial NT-proBNP measurements together with safety parameters such as electrolytes and creatinine may influence treatment decision in patients with acute…
- Trial name
- NCT04471610
- Testing
- Serial measurements of NT-pro BNP, potassium, sodium, and creatinine every second business day
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- Prof. Dr. Jörg Leuppi
Acute Decompensated Heart Failure
Combination Oral Acetazolamide and Intravenous Furosemide on Acute Decompensated Heart Failure Outcomes
Based on ADVOR trial, the potential of adding acetazolamide in increasing the success of decongestion, the amount of natriuresis and diuresis.
- Trial name
- COAF-HF (NCT06475105)
- Testing
- Oral Acetazolamide
- Where
- 2 sites in Indonesia
- Volunteers
- 66 people
- Sponsor
- Universitas Diponegoro
Heart Failure; With Decompensation
Comparative Effects of Methylprednisolone and Prednisolone on the Risk of Acute Decompensated Heart Failure - An Emulated Target Trial
The investigators aim to emulate a target trial to compare the risk of acute decompensated heart failure in users of methylprednisolone compared to prednisolone.
- Trial name
- NCT06468007
- Testing
- Methylprednisolone Tablet
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Diakonhjemmet Hospital
Acute Decompensated Heart Failure (ADHF)
Efficacy and Safety of Compression Boots in Patients With Acute Decompensated Heart Failure.
The aim of this clinical trial is to investigate whether pulsatile compression therapy can support heart and kidney function in patients admitted with acute heart failure and fluid accumulation in the legs.
- Trial name
- COMPLEX (NCT07377019)
- Testing
- Pulsatile Compression Boots (PCB)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Chronic Heart Failure, Acute Decompensated Heart Failure
PREcision meDICine in Treatment in CardioVascular Disease
The main goal of PREDICT-CVS is to demonstrate that a personalized, AI-derived biomarker-guided medication treatment algorithm that provides advice to the treating professional is superior to prevent clinical events and improve…
- Trial name
- PREDICT-CVD (NCT07369141)
- Testing
- ASSIST-HF AI- algorithm, Standard of Care (Investigator Choice)
- Where
- 4 sites in Netherlands
- Sponsor
- Maastricht University Medical Center
Acute Decompensated Heart Failure
A Study to Investigate the Safety and Efficacy of a Novel Furosemide Regimen
This is a, prospective, single center, open-label, pilot study to evaluate the safety and efficacy of the subcutaneous administration of a novel furosemide formulation.
- Trial name
- DIVERSION-HF (NCT02721511)
- Testing
- Furosemide Injection Solution 8mg/mL
- Where
- United States
- Sponsor
- Todd M Koelling, MD
Cardiogenic Shock, Acute Myocardial Infarction
Clinical Evaluation of NIRSense Tissue Oximetry Sensor Monitoring to Early Detect Cardiogenic Shock
This is a prospective, single-center, observational pilot study of the investigational NIRSense Tissue Oximetry Sensor System (Envello Core), a noninvasive wearable sensor patch that uses near-infrared spectroscopy (NIRS) and…
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, Acute Decompensated Heart Failure
- Trial name
- NCT07825363
- Testing
- NIRSense Tissue Oximetry Sensor System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NIRSense Inc.
Heart Failure; With Decompensation, Heart Failure，Congestive
Dietary Sodium Intake in Acute Heart Failure
This study is design to assess two levels of dietary sodium intake in the treatment of patients with Acute Decompensated Heart Failure.
- Trial name
- SODIC (NCT03722069)
- Testing
- Low sodium diet, Normal sodium diet
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Sao Paulo
Heart Failure
Safety and Efficacy Study of Istaroxime in Acute Decompensated Heart Failure Patients
The purpose of this study is to assess the safety and efficacy of istaroxime in patients hospitalized for Acute Decompensated Heart Failure (ADHF) not requiring inotropic therapy.This will be done by comparing the hemodynamic…
- Trial name
- NCT00838253
- Testing
- Istaroxime
- Sponsor
- Debiopharm International SA
Acute Decompensated Heart Failure
REWORD-HF REverse WOrsening Renal Function in Decompensated Heart Failure
The purpose of this study is to determine whether in patients with acute decompensated congestive heart failure and the cardiorenal syndrome, i.e.
- Trial name
- REWORD-HF (NCT01140399)
- Testing
- Furosemide or Furosemide and Dopamine, Ultrafiltration
- Where
- 16 sites in Italy
- Volunteers
- 10 people
- Sponsor
- Niguarda Hospital
ADHF
Troponin I Release After High Diuretic Doses
High values of cardiac troponin (Ct) in acute heart failure (ADHF) identify patients (pts) at higher risk and worsened prognosis.
- Trial name
- Tra-HSS-Fur (NCT01419132)
- Testing
- Furosemide
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- University of Palermo
Acute Decompensated Heart Failure
Efficacy and Safety of Ularitide for the Treatment of Acute Decompensated Heart Failure
The purpose of this study is to evaluate the efficacy and safety of a continuous intravenous (IV) ularitide infusion on the clinical status and outcome of patients with acute decompensated heart failure (ADHF).
- Trial name
- TRUE-AHF (NCT01661634)
- Testing
- Ularitide
- Where
- 163 sites in United States, Argentina and 20 more
- Volunteers
- 2,157 people
- Sponsor
- Cardiorentis
Heart Decompensation, Heart Failure, Congestive
Pilot Study for the Evaluation of the Safety and Performance of the RenaSense System in Hospitalized Acute Decompensated Heart Failure Patients
The study is intended to verify the safety and assess the performance of up to 3-days treatment protocol with the RenaSense System in ADHF patients.
- Conditions
- Heart Decompensation, Heart Failure, Congestive, Renal Insufficiency
- Trial name
- NCT02324400
- Testing
- RenaSense Stimulation
- Where
- 3 sites in Israel
- Volunteers
- 36 people
- Sponsor
- Nephera Ltd.
Acute Decompensated Heart Failure
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve Decongestion Management System (DMS)
The objective of this study is to prospectively compare decongestive therapy administered by the Reprieve DMS system to Optimal Diuretic Therapy (ODT) in the treatment of patients diagnosed with acute decompensated heart failure…
- Trial name
- FASTR (NCT05174312)
- Testing
- Reprieve Decongestion Management System, Diuretic
- Where
- 16 sites in United States
- Volunteers
- 100 people
- Sponsor
- Reprieve Cardiovascular, Inc