Clinical trials: AKI, open to volunteers
Acute Kidney Injury, Renal Insufficiency,Chronic
Finerenone for AKI: a Multicenter, Randomized, Placebo-Controlled Feasibility Pilot Trial
This study is testing whether finerenone, when compared to placebo, is a tolerable and safe intervention when administered in patients with acute kidney injury (AKI).
- Conditions
- Acute Kidney Injury, Renal Insufficiency,Chronic, Kidney Diseases
- Trial name
- FiPAKI (NCT07775482)
- Testing
- Finerenone (BAY94-8862 ) 10 mg
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Jean-Maxime Côté
Cardiac Surgery-associated Acute Kidney Injury
A Study to Understand How Cardiac Surgery-associated Acute Kidney Injury Develops in Participants Who Undergo Heart Surgery With the Use of Heart-lung Machine
Researchers are looking for a better way to treat and prevent cardiac surgery-associated acute kidney injury (CSA-AKI) in people who undergo heart surgeries.
- Trial name
- NCT06772025
- Testing
- No investigational study intervention
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 100 people
- Sponsor
- Bayer
Anesthesia, Surgery With General Anesthesia
The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery
Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient…
- Conditions
- Anesthesia, Surgery With General Anesthesia, Noncardiac Surgery, Hypotension During Surgery
- Trial name
- VEGA-2 (NCT06802224)
- Testing
- Norepinephrine, Phenylephrine
- Where
- 10 sites in United States, Canada
- Volunteers
- 18,000 people
- Sponsor
- University of California, San Francisco
AKI - Acute Kidney Injury, Cardiac Surgical Procedures
rhBNP for Prevention of Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI)
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common and serious perioperative complication, independently associated with prolonged hospitalization, increased mortality, and progression to chronic kidney disease.
- Conditions
- AKI - Acute Kidney Injury, Cardiac Surgical Procedures, Cardiopulmonary Bypass
- Trial name
- PROTECT-CS (NCT07617675)
- Testing
- Recombinant Human Brain Natriuretic Peptide (rhBNP)
- Where
- China
- Volunteers
- 694 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Kidney Injury, Surgery Complications
Real-Time Acute Kidney Injury Perioperative Prediction Clinical Trial
This investigator-initiated, pragmatic trial evaluates whether displaying a machine learning (ML)- derived perioperative AKI risk score-alone or paired with an interruptive Best/Our Practice Advisory (BPA/OPA)-improves…
- Conditions
- Acute Kidney Injury, Surgery Complications, Anesthesia
- Trial name
- ML-AKI (NCT07604662)
- Testing
- EHR-Embedded AKI Risk Score, EHR-Embedded AKI Risk Score with Best Practice Advisory
- Where
- United States
- Volunteers
- 25,518 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Contrast-induced Acute Kidney Injury (CI-AKI) Following Coronary Angiogram (CI-AKI), Contrast-induced Nephropathy Following Coronary Angiogram (CIN)
Effectiveness of Remote Ischemic Preconditioning for Prevention of Contrast Induced Acute Kidney Injury in Patients Undergoing Coronary Angiograms.
The use of imaging is increasing in clinical practice, either for diagnosis or intervention. In these imaging processes, contrast medium (CM) is widely used.
- Trial name
- RIP-CI-AKI (NCT05147831)
- Testing
- Remote Ischemic Preconditioning
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Platelets/Albumin and Aki
Platelets to Albumin Ratio for Prediction of Acute Kidney Injury in Patients Admitted to the Intensive Care Unit
To evaluate the role of platelet to albumin ratio to detect Acute kidney injury in patients admitted to intensive care
- Trial name
- NCT06554977
- Testing
- Laboratory
- Volunteers
- 140 people
- Sponsor
- Assiut University
Acute Kidney Injury, Acute Kidney Injury KDIGO 2
Neuromuscular Electrical Stimulation to Improve the Muscle Health of Individuals With Acute Kidney Injury
Acute Kidney Injury is a serious, common illness that is associated with poor health outcomes. Prolonged hospitalisation is a common experience of patients admitted with this illness.
- Conditions
- Acute Kidney Injury, Acute Kidney Injury KDIGO 2, Acute Kidney Injury KDIGO 3, Muscle Wasting
- Trial name
- NMES-AKI (NCT07915713)
- Testing
- Neuromuscular electrical stimulation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Acute Kidney Disease, Acute Kidney Injury (AKI)
AST-120 (Kremezin®) for the Renal Protection and Attenuation of Decline in Acute Kidney Disease
The primary goal of this clinical trial is to evaluate the efficacy of AST-120 (Kremezin®) in combination with standard care in reducing the levels of protein-bound uremic toxins (PBUTs), specifically indoxyl sulfate (IS) and…
- Trial name
- ASTRA-AKD (NCT07182422)
- Testing
- AST-120 (Kremezin®)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Cardiac Surgery Associated - Acute Kidney Injury, AKI - Acute Kidney Injury
Safety & Efficacy of RenalGuard® Therapy in the Prevention of Cardiac Surgery Associated Acute Kidney Injury
The goal of this clinical trial is to assess the effect of RenalGuard Therapy in reducing the rates of Acute Kidney Injury (AKI) within 72 hours after cardiac surgery in patients at risk of developing Cardiac Surgery Associated…
- Trial name
- SAFEGUARD (NCT07123935)
- Testing
- RenalGuard® Therapy, Standard of Care (SOC)
- Where
- 2 sites in Malaysia
- Volunteers
- 300 people
- Sponsor
- CardioRenal Systems, Inc.
Fluid Balance, Acute Kidney Injury
Fluid Balance in Acute Kidney Injury in Critically Ill Patients
This prospective observational cohort study evaluates if fluid balance in the first 48 hours of ICU admission is linked to acute kidney injury (AKI) in critically ill adults.
- Conditions
- Fluid Balance, Acute Kidney Injury, Critically Ill Acute Kidney Injury, Critically Ill
- Trial name
- NCT07338734
- Volunteers
- 120 people
- Sponsor
- Assiut University
Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
VExUS in Ards Patients and Association with AKI
A single-center prospective observational study will be conducted with the aim of determining the prevalence of venous congestion during ARDS using venous Doppler and the VExUS score.
- Trial name
- VEXAKI (NCT06805409)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Urinary Activin A in AKI
Urinary Activin A as Apredictive Marker for Assessement of Acute Kidney Injury Severity in Patient Admitted at Assuit University Hospital
Urinary Activin A as amarker for assessement of acute kidney injury severity in patient admitted at Assuit University Hospital
- Trial name
- NCT06188533
- Testing
- Urinary activin A in AKI
- Volunteers
- 70 people
- Sponsor
- Assiut University
Acute Kidney Injury
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)
The central hypothesis of this research study is that perioperative administration of the proton pump inhibitor (PPI) pantoprazole could reduce the development of acute kidney injury (AKI) following cardiac surgery by activation…
- Trial name
- P2 AKI PPI (NCT06706258)
- Testing
- Protonix (Pantoprazole) 40 mg q 12 hrs for 3 days, Pepcid (Famotidine) 20 mg q 12 hrs for 3 days
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- The University of Texas Health Science Center, Houston
Acute Kidney Injury, Sepsis
MULTIMODAL APPROACH IN THE DIAGNOSIS OF SEPTIC AKI
In recent studies, it has been reported that the renal resistance index is effective in detecting sepsis-related acute renal failure (SA-AKI) in the early period.
- Conditions
- Acute Kidney Injury, Sepsis, Critical Illness, Renal Resistive Index
- Trial name
- SEPTIC AKI (NCT07472452)
- Testing
- Renal Resistive Index (RRI) Doppler Ultrasound, Urinary TIMP-2 and IGFBP-7 biomarkers
- Volunteers
- 130 people
- Sponsor
- Ankara Etlik City Hospital
AKI, Critical Illness
What is the Effect of Acute Kidney Injury on Weaning From Mechanical Ventilation in Critically Ill Adult Patients?
The aim of this study is to evaluate the impact of acute kidney injury (AKI) on the success rate, duration, and complications of weaning from mechanical ventilation in critically ill adult patients admitted to the intensive care…
- Trial name
- NCT07477652
- Testing
- Acute Kidney Injury (AKI) Exposure
- Volunteers
- 85 people
- Sponsor
- Assiut University
AKI - Acute Kidney Injury, Critical Illness
Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay
This large national cohort study, including over 500,000 patients, where around 5% are treated with continuous renal replacement therapy (CRRT) , aims to evaluate the association between time to initiation of CRRT and intensive…
- Trial name
- CIILOS (NCT07586059)
- Testing
- continuous renal replacement therapy
- Volunteers
- 500,000 people
- Sponsor
- Karolinska Institutet
Dialysis, Critically Ill Acute Kidney Injury
Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America
This is an international, multicenter, observational study aimed at investigating acute kidney injury requiring renal replacement therapy (AKI-RRT) in Latin American countries.
- Conditions
- Dialysis, Critically Ill Acute Kidney Injury, Renal Replacement Therapy for Acute Kidney Injury in ICU, Acute Kidney Injury
- Trial name
- LATAM-AKID (NCT07262320)
- Where
- 15 sites in Bolivia, Brazil and 7 more
- Volunteers
- 1,000 people
- Sponsor
- University of Alabama at Birmingham
Acute Kidney Injury, Coronary Artery Disease
Erector Spinae Oxygen Saturation and AKI After OPCAB
Acute kidney injury (AKI) is a frequent and serious complication after cardiac surgery, including off-pump coronary artery bypass (OPCAB).
- Conditions
- Acute Kidney Injury, Coronary Artery Disease, Coronary Artery Bypass, Off-Pump, Postoperative Complications
- Trial name
- NCT07760129
- Testing
- Near-infrared spectroscopy monitoring of erector spinae muscle and renal regional oxygen saturation
- Volunteers
- 138 people
- Sponsor
- Yonsei University
AKI in Cirrhosis
Predictors of Mortality in Cirrhotic Patients With Acute Kidney Injury
Acute kidney injury (AKI) is a common and severe complication in patients with liver cirrhosis, significantly increasing the risk of short-term mortality.
- Trial name
- NCT07797114
- Volunteers
- 100 people
- Sponsor
- Assiut University