Clinical trials: ALLOGRAFT
Corneal Transplantation, Corneal Graft Rejection
Study to Assess LX201 for Prevention of Corneal Allograft Rejection or Graft Failure in Subjects Who Have Experienced One or More Rejection Episodes Following Penetrating Keratoplasty
This study will evaluate the use of LX201 to prevent future graft rejection episodes and/or graft failure in patients who have undergone corneal transplantation and who have recently experienced a rejection episode due to an…
- Trial name
- NCT00447642
- Testing
- LX201
- Where
- 30 sites in United States, Germany
- Volunteers
- 122 people
- Sponsor
- Lux Biosciences, Inc.
Hematological Cancer
Evaluation of the Impact of Sports-inspired Onco-coaching on Health-related Quality's Life of the Patients in Cancer Remission After Allogeneic Transplantation of Hematopoietic Stem Cells
To measure the impact of a coaching program on the patient's health-related quality of life 15 months post-transplant (M15/R12).
- Trial name
- NCT05486273
- Testing
- interviews with coachs, semi-structured interviews and questionnaires, semi-structured interviews and questionnaires
- Volunteers
- 108 people
- Sponsor
- Institut Paoli-Calmettes
Acute (Cellular) Renal Allograft Rejection
Single Dose rATG for Renal Allograft Rejection
Rabbit antithymocyte globulin (rATG) is approved for the treatment of acute rejection following kidney transplantation and is routinely administered as a series of 5-7 consecutive daily doses via central intravenous…
- Trial name
- NCT02102854
- Testing
- rATG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Methodist Hospital Research Institute
Kidney Transplantation
Extension Study Of Stage 1 Subjects Of Study A3921009 For The Prevention Of Acute Rejection In Kidney Transplant Patient
A new immunosuppressive drug, based on the inhibition of an important enzyme in the immune system called JAK3, is being developed by Pfizer to prevent transplant rejection.
- Trial name
- NCT00263328
- Testing
- Tacrolimus, CP-690,550
- Where
- 27 sites in United States
- Volunteers
- 46 people
- Sponsor
- Pfizer
Hepatitis B Virus, Allograft
Risk of Hepatitis B Virus Reactivation in Patients Undergoing Allografting
The purpose of this study is to evaluate the risk of hepatitis B reactivation in patients undergoing allografting.
- Conditions
- Hepatitis B Virus, Allograft, Hematological Malignancies
- Trial name
- NCT00876148
- Where
- Italy
- Sponsor
- Azienda Ospedaliera San Giovanni Battista
Failure of Bone Marrow Graft
Donor Enhancement With Plerixafor Post Myeloablative Allogeneic Transplant
This phase I/II clinical trial will test the safety and the efficacy of post transplant administration of plerixafor in enhancing hematological recovery in humans.
- Trial name
- NCT01280955
- Testing
- Plerixafor
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Mitchell Horwitz, MD
Femur Fractures
Types of Fixation of Vancouver B1 Periprosthetic Fractures
The purpose of this study is to compare two different but standard treatments for the fixation of Vancouver B1 periprosthetic. The investigators aim to compare open reduction internal fixation using a locked plating system versus…
- Trial name
- NCT01354535
- Testing
- Isolated Locked Compression Plate, Cable Plating and Strut Allograft with Cerclage Wiring
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- Unity Health Toronto
Kidney Transplant, Kidney Transplant Recipient
Rituximab in Renal Allograft Recipients Who Develop Early De Novo Anti-HLA Alloantibodies
The purpose of this study is to determine whether treatment with rituximab (anti-CD20, Rituxan®, MabThera®) in individuals who develop new anti-HLA antibodies after renal (kidney) transplant will promote longer-term survival of…
- Conditions
- Kidney Transplant, Kidney Transplant Recipient, Graft Function/Survival, de Novo HLA Antibodies Development
- Trial name
- NCT00307125
- Testing
- Rituximab plus immunosuppression
- Where
- 17 sites in United States
- Volunteers
- 757 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anterior Cruciate Ligament Tear
Evaluation of Biocleanse Allografts For ACL Reconstruction
The purpose of this study is to determine the efficacy of patellar tendon allografts that have undergone the BioCleanse™ process.
- Trial name
- NCT00187876
- Testing
- ACL reconstruction control, ACL Biocleanse, surgical
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of Florida
Lung Transplant, Chronic Allograft Rejection
Mechanisms of Lung Allograft Rejection
This study will explore the ways in which lung transplants are rejected. A series of experiments will evaluate the differences in airway gene expression.
- Trial name
- NCT00340418
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Congenital Heart Defect, Right Ventricular Outflow Tract Reconstruction
Contegra Versus Pulmonary Homograft for Right Ventricular Outflow Tract Reconstruction in Newborns
Pulmonary homografts are standard substitutes for right ventricular outflow tract reconstruction in congenital heart surgery. Unfortunately shortage and conduit failure secondary to early calcifications and shrinking are observed…
- Trial name
- NCT03348397
- Testing
- right ventricular outflow tract reconstruction with contegra, right ventricular outflow tract reconstruction with pulmonary homograft
- Where
- Belgium
- Volunteers
- 53 people
- Sponsor
- Queen Fabiola Children's University Hospital
Chronic Myeloid Leukemia
Efficacy and Safety Study of Dasatinib in Patients With Chronic Myeloid Leukemia
This is a phase II efficacy (indicates the capacity for beneficial change or therapeutic effect) and safety study of Dasatinib in patients with relapsed Chronic Myeloid Leukemia (CML) following a Stem Cell Transplant (SCT) and…
- Trial name
- Dasatinib (NCT00895297)
- Testing
- Dasatinib (Sprycel)
- Where
- 7 sites in France, Germany and 2 more
- Volunteers
- 50 people
- Sponsor
- European Society for Blood and Marrow Transplantation
Pancreas Transplantation, Kidney Transplantation
A Study To Compare Sirolimus Versus Tacrolimus In De Novo Simultaneous Pancreas- Kidney Allograft Recipients Receiving An Induction Therapy With Antithymocyte Globulin Plus Mycophenolate Mofetil Plus Corticosteroids
Experience with tacrolimus in pancreas transplantation has become a standard for immunosuppression in almost all pancreas centers over the world.
- Trial name
- NCT00693446
- Testing
- Sirolimus, Tacrolimus
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Nantes University Hospital
Fat Pad Syndrome
Investigating the Clinical Impact of a Novel Adipose Allograft Matrix on Knee Fat Pad Impingement Treatment
This study is to assess the effect of Renuva® on fat pad regeneration in patients with Fat pad Impingement
- Trial name
- NCT05880888
- Testing
- Renuva
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Ohio State University
Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant
Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Double Lung Transplant (BOSTON-2)
The objective of this trial was to assess the efficacy and safety of aerosolized liposomal cyclosporine A (L-CsA) as add-on therapy to standard of care (SoC) as compared to SoC alone in double lung transplant (DLT) recipients…
- Conditions
- Bronchiolitis Obliterans, Chronic Rejection of Lung Transplant, Lung Transplant Rejection, Lung Transplant; Complications
- Trial name
- BOSTON-2 (NCT03656926)
- Testing
- Liposomal Cyclosporine A, Standard of Care
- Where
- 40 sites in United States, Austria and 7 more
- Volunteers
- 169 people
- Sponsor
- Zambon SpA
Cardiac Allograft Vasculopathy
Endothelin-1 and Cardiac Allograft Vasculopathy (CAV)
Many patients with end-stage heart failure, a condition in which the heart fails to pump enough blood to support the body's other organs, are fortunate enough to receive a heart transplant.
- Trial name
- NCT05373108
- Testing
- Macitentan
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of California, Los Angeles
External Hemorrhoid, External Hemorrhoid Thrombosed
Use of Human Dehydrated Amnion Chorion Allograft in Closed Hemorroidectomy
The purpose of this study is to determine the safety and effectiveness of human dehydrated amnion chorion allograft in closed hemorrhoidectomy as assessed by patient and wound assessments.
- Trial name
- NCT03479489
- Testing
- Human dehydrated amnion chorion allograft
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- MiMedx Group, Inc.
Congenital Disorders
Children and Adolescents Receiving Mechanical and Prosthetic Valves
The primary objective of this retrospective study of valve replacement is to document long-term survival and occurrence of valve related complications such as described in the literature; anticoagulant related bleeding event …
- Trial name
- NCT00268008
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Children's Healthcare of Atlanta
Graft Versus Host Disease
Cannabidiol for Graft Versus Host Disease (GVHD) Prophylaxis in Allogeneic Stem Cell Transplantation
Graft versus host disease (GVHD) is one of the major causes of death in patients undergoing allogeneic hematopoietic cell transplantation.
- Trial name
- NCT01385124
- Testing
- Oral Cannabidiol
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Rabin Medical Center
Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma
Bendamustine Bridge to Autologous or Allogeneic Transplant for Relapsed/Refractory Lymphoma
This clinical trial is for men and women with whose lymphoma (non-Hodgkin or Hodgkin) did not respond to treatment or has returned after responding to previous therapy, and who are in need of a stem cell transplant.
- Trial name
- NCT02059239
- Testing
- Bendamustine, Carmustine, Etoposide
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Weill Medical College of Cornell University
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