Clinical trials: ARTHROPLASTY, REPLACEMENT
Osteoarthritis, Knee
Clinical Outcomes With Omni Apex Ultracongruent Knee System
A prospective, matched case comparison of total knee arthroplasty with the OMNI Apex Ultracongruent vs. Triathlon® CS tibial insert vs. the Triathlon® PS tibial insert.
- Trial name
- NCT01367938
- Testing
- OMNI Apex Ultracongruent Knee Device
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Spokane Joint Replacement Center
Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
Sleep Patterns After Total Joint Replacement Surgery
The purpose of this study is to determine sleep patterns and sleep quality following total joint arthroplasty, in order to understand when patients should expect to return to baseline or improved sleep following total joint…
- Trial name
- NCT04896892
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Arthroplasty, Replacement, Knee, Nerve Block
Epidural Catheter With or Without Adductor Canal Nerve Block for Postoperative Analgesia Following Total Knee Arthroplasty
The purpose of this study is to further investigate the efficacy of adductor canal nerve blocks for pain management after total knee replacement.
- Trial name
- NCT02121392
- Testing
- Adductor Canal Nerve Block Catheter, Bupivacaine
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Degenerative Joint Disease
Study Comparing Regional Anesthetic Blocks and Periarticular Infiltration for the Management of Post-operative Pain After Direct Anterior Total Hip Arthroplasty
To compare two methods of post-operative pain management in patients undergoing total hip arthroplasty. There is a perception that the periarticular injections may not be as effective in controlling post-operative pain.
- Trial name
- DA THA pain (NCT02904993)
- Testing
- L2 paravertebral block, periarticular injection group
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Osteoarthritis
Assessment of Conventional and Patient-specific Instrumentation in Total Knee Arthroplasty
This study will use a special type of x-ray called radiostereometric analysis (RSA) imaging to determine whether patient-specific instrumentation for total knee arthroplasty (replacement) has an effect on implant loosening…
- Trial name
- NCT02230215
- Testing
- Total Knee Arthroplasty with use of Visionaire Patient-Specific Instrumentation
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteoarthritis
Fixed Bearing Versus Mobile Bearing Patient Satisfaction and Clinical Outcome Study
The purpose of this study is to determine if there is a patient satisfaction preference of Fixed Bearing versus Mobile Bearing Unicompartmental Knee Arthroplasty (UKA) in patients who are at a minimum two years post operative.
- Trial name
- NCT02633085
- Testing
- Fixed Bearing or Mobile Bearing UKA
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medacta USA
Postoperative Cognitive Dysfunction, Mild Cognitive Impairment
Cognitive Changes After Major Joint Replacement
Patients assume that cognitive performance rapidly returns to baseline after anesthesia and surgery. Several studies have shown that one week after major non-cardiac surgery about 27% of patients have postoperative cognitive…
- Conditions
- Postoperative Cognitive Dysfunction, Mild Cognitive Impairment, Delirium, Cognitive Deficit
- Trial name
- Cognigram (NCT02964221)
- Testing
- Cognitive Testing
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dr. Stephen Choi
Arthropathy of Knee, Arthropathy of Hip
Nirvana Super Pro Supplementation in Orthopedic Surgery Patients
The purpose of this study is to investigate orthopedic patients undergoing either a total hip replacement (THR) or total knee arthroplasty (TKR) using two dietary supplements, PREPARE and RECOVER, and their recovery times…
- Trial name
- NCT06203691
- Testing
- Supplementation with Nirvana Super Pro Liquid Supplements, Non-Supplementation Group
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nirvana Water Sciences Corp
Osteoarthritis, Knee
Comparison of Mobile-Bearing and Fixed-Bearing All-Polyethylene Tibia Total Knee Designs
This study will be designed to compare prospectively, in a randomized fashion, the clinical, functional, and radiographic results of a nonmodular (all-polyethylene tibi/AP) fixed-bearing posterior cruciate substituting design…
- Trial name
- NCT00894361
- Testing
- TKA surgery with the rotating platform mobile-bearing knee design, TKA surgery with the all-polyethylene tibia knee design
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Postoperative Delirium
Dexmetomedine for Post Operative Delirium in Elderly Patients Undergoing Elective Total Knee Replacement Under Spinal Anesthesia
Postoperative delirium is a geriatric syndrome occurring after anesthesia and surgery which manifests as acute alterations in mental status, involving changes in cognition, attention, and levels of consciousness that tend to…
- Trial name
- NCT05707741
- Testing
- dexmetomedine infusion
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Knee Infection
Impact of the Type of Stabilization in the Two-stage Knee Reimplantation on Reinfection - Prospective, Randomized Study.
Participants after first-stage of knee infection reimplantation will be assign to one of two groups: with stem vs. with sleeve. Investigators will check participants on clinical, laboratory and reinfection signs.
- Trial name
- NCT04446676
- Testing
- stabilization with stem, stabilization with sleeve
- Where
- Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Prof A Gruca Teaching Hospital
Arthroplasty, Replacement
TKA Melatonin and Sleep Quality
This randomized controlled trial (RCT) will compare the effects of melatonin vs. placebo in patients undergoing primary total knee arthroplasty (TKA). This RCT aims to study the effects melatonin has on sleep quality after TKA.
- Conditions
- Arthroplasty, Replacement, Knee, Sleep Initiation and Maintenance Disorders
- Trial name
- NCT05332717
- Testing
- Melatonin 5 mg
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Knee Osteoarthritis, Blood Loss
Extended Postoperative Oral Tranexamic Acid in Knee Replacement
A comparison of outcomes between use of oral tranexamic acid as compared to oral placebo in the first days after total knee replacement will be made to determine impact on clinical indications and patient reported outcomes.
- Conditions
- Knee Osteoarthritis, Blood Loss, Pain, Postoperative
- Trial name
- NCT05099276
- Testing
- Tranexamic Acid Pill
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Campbell Clinic
Physical Capability Outcomes
Physical Capability Outcomes After Single-Level PD-L vs Single-Level ALIF: a Multi-Center Clinical Trial
The purpose of this study is to compare the physical capability outcomes of patients who undergo single-level ProDisc-L disc replacement with those of patients who undergo stand-alone, single-level anterior lumbar interbody…
- Trial name
- NCT01055574
- Where
- 6 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Gundersen Lutheran Medical Foundation
Osteo Arthritis Shoulders, Avascular Necrosis of the Head of Humerus
Easytech Reversed Shoulder System Clinical Study
The purpose of the study is to collect data to demonstrate the safety and effectiveness of the Easytech Reversed Shoulder System for the treatment of patients who require a reverse total shoulder arthroplasty.
- Conditions
- Osteo Arthritis Shoulders, Avascular Necrosis of the Head of Humerus, Rotator Cuff Tear
- Trial name
- NCT03806842
- Testing
- Easytech group
- Where
- 6 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- FX Shoulder Solutions
Arthroplasties, Knee Replacement, Nerve Block
Post-Operative Urinary Retention on Revision Knee Arthroplasty: the Role of Intrathecal Morphine
Revision total knee arthroplasty (rTKA) is a frequently performed procedure. Adequate pain management is an important feature, especially for fast-track and Enhanced Recovery After Surgery (ERAS) programs.
- Conditions
- Arthroplasties, Knee Replacement, Nerve Block, Urinary Retention Postoperative, Anesthesia, Spinal
- Trial name
- POURRKA (NCT07050277)
- Testing
- Intrathecal Morphine, No Intrathecal Morphine
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Ankle Arthroplasty, Prosthesis User
3D X-ray Motion Analysis of Ankle-foot Motion After Total Ankle Arthroplasty
Patients who have had a total ankle joint replacement surgery typically have limited movement in their ankles possibly due to the fact that commonly used ankle joint prosthetic devices only allow limited axes of motion.
- Conditions
- Ankle Arthroplasty, Prosthesis User, Joint Disease
- Trial name
- NCT03575975
- Testing
- Total Ankle Replacement Prosthesis
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Osteoarthritis, Knee
Outcomes After Standard and High-Flexion Posterior Stabilized Rotating-Platform Mobile-Bearing Total Knee Arthroplasty
The aim of this prospective study is to compare the clinical and radiographic outcomes of standard and high-flexion posterior stabilized (PS) rotating-platform mobile-bearing (RP-MB) total knee arthroplasty.
- Trial name
- NCT00954954
- Testing
- Standard PS RP-MB (P.F.C Sigma Rotating Platform knee), High-flexion PS RP-MB (P.F.C Sigma Rotating Platform Flex)
- Where
- South Korea
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Metal Staple Removal After Total Knee Replacement
Topical Anesthesia for Removal of Stitches After Total Knee Arthroplasty
Lidocaine patch is a safe and effective topical anesthetic agent for removal of metal staples after total knee replacement
- Trial name
- NCT02812602
- Testing
- Lidocaine patch
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Bleeding, Transfusion Related Complication
Use of Transexamic Acid in Hip Replacement
Studies have shown that tranexamic acid reduces blood loss and transfusion need in patients undergoing total hip arthroplasty. However, no to date, no study has been large enough to determine definitively whether the drug is safe…
- Trial name
- NCT02587845
- Testing
- Tranexamic Acid (IV), Tranexamic Acid (Topical)
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center