Clinical trials: Abdominoperineal Resection
Parastomal Hernia, Rectal Adenocarcinoma
Chimney Trial of Parastomal Hernia Prevention
Chimney trial is designed to compare the effectiveness and safety of specifically designated polyvinylidene fluoride mesh (PVDF, Dynamesh IPST) to controls in a multi center, randomized setting.
- Conditions
- Parastomal Hernia, Rectal Adenocarcinoma, Abdominoperineal Resection
- Trial name
- NCT03799939
- Testing
- Intervention group
- Where
- 7 sites in Finland, Sweden
- Volunteers
- 141 people
- Sponsor
- University of Oulu
Rectal Cancer
TaTME Versus Open Intersphincteric Resection After Neoadjuvant Concurrent Chemoradiotherapy.
The two surgical options for lower 1/3 rectal cancer is APR and sphincter sparing procedures. Intersphincteric resection is procedure to treat very low rectal cancer within 2 cm from the dentate line to avoid permanent…
- Trial name
- TaTME (NCT01836926)
- Testing
- Open intersphincteric resection, transanal minimally invasive intersphincteric resection
- Where
- 2 sites in Egypt
- Volunteers
- 110 people
- Sponsor
- Osama Mohammad Ali ElDamshety
Anal Cancer, Colorectal Cancer
Anal Sphincter Prosthesis in Treating Patients Who Are Undergoing Surgery for Anal or Rectal Cancer
RATIONALE: An anal sphincter prosthesis may replace the need for a permanent colostomy and may improve the quality of life of patients who are undergoing surgery for anal or rectal cancer.
- Conditions
- Anal Cancer, Colorectal Cancer, Perioperative/Postoperative Complications
- Trial name
- NCT00059891
- Testing
- conventional surgery, management of therapy complications
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Rectal Cancer, Pelvic Cancer
Advanced Pelvic Surgical Oncology Database - Prospective Observational Study
Retrospective and prospective observational study of patients undergoing advanced pelvic oncological resection for maligancy including multi visceral resection, beyond TME resection and sacrectomy/flap reconstruction/urinary…
- Conditions
- Rectal Cancer, Pelvic Cancer, Gynecologic Cancer, Colon Cancer
- Trial name
- NCT05696002
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Glasgow Royal Infirmary
Wound Heal, Abdominoperineal Resection
Gluteal Turnover Flap for Closure of the Perineal Wound After Abdominoperineal Resection for Rectal Cancer
Background: About 700 patients per year undergo an abdominoperineal resection (APR) for distal rectal cancer (Dutch Colorectal Audit 2016).Neoadjuvant (chemo)radiotherapy is often used to further improve locoregional control.
- Conditions
- Wound Heal, Abdominoperineal Resection, Rectal Cancer
- Trial name
- BIOPEX2 (NCT04004650)
- Testing
- Gluteal turnover flap
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Rectal Cancer
Economic Analysis of Robotic Rectal Resection in German Health Care System
Analysis of cost effectiveness of robotic rectal resection, either sphincter preserving or abdominoperineal extirpation, in the German diagnosis related groups (DRG) system.
- Trial name
- NCT06113796
- Testing
- Surgery
- Where
- Germany
- Volunteers
- 65 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Rectal Cancer
A Trial of Robotic-assisted Versus Laparoscopic Abdominoperineal Resection for Treating Low Rectal Cancer
In this study, the investigators assessed the difference in efficacy and safety among robotic-assisted versus laparoscopic abdominoperineal resection for patients with low rectal cancer.
- Trial name
- RLAPR (NCT01985698)
- Testing
- Robotic-assisted resection., Laparoscopic resection
- Where
- China
- Volunteers
- 347 people
- Sponsor
- Fudan University
Rectal Cancer, Abdominoperineal Resection
Abdominoperineal Extra-Elevators Rectal Resection for Cancer: Prone Position vs. Supine Position
Prospective multicenter randomized controlled trial comparing the prone vs. the supine position of the perineal time of the Miles operation in patients with advanced rectal cancer.
- Trial name
- APPRO (NCT02163785)
- Testing
- Abdominoperineal extra-elevators rectal resection for low lying rectal cancer
- Where
- 19 sites in Spain
- Volunteers
- 280 people
- Sponsor
- Hospital Universitario La Fe
Adenocarcinoma, Adenocarcinoma, Mucinous
Low Rectal Cancer Study (MERCURY II)
The MERCURY Study demonstrated the accuracy, feasibility and reproducibility of Magnetic Resonance Imaging (MRI) to stage rectal cancer in a prospective, multidisciplinary, multi-centre study.
- Conditions
- Adenocarcinoma, Adenocarcinoma, Mucinous, Carcinoma, Neoplasms, Glandular and Epithelial
- Trial name
- MERCURY II (NCT02005965)
- Where
- 17 sites in Germany, Serbia and 1 more
- Volunteers
- 542 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Adenocarcinoma (NOS)
Evaluation of the Efficacy of Negative Pressure Wound Therapy on Perineal Healing Following Abdominoperineal Amputation
Abdomino-perineal resection is a surgical procedure involving the removal of the rectum and anus via abdominal and perineal approaches. During this procedure, a terminal colostomy is created and the perineum is closed.
- Trial name
- AAPICO (NCT07489820)
- Testing
- Direct perineal skin suturing with negative pressure wound therapy (PICO 7®), Direct perineal skin suture
- Where
- 5 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Rectal Neoplasms, Colostomy Stoma
Pseudo Continent Perineal Colostomy vs Permanent Left Iliac Colostomy After Abdominoperineal Resection for Ultra Low Rectal Adenocarcinoma
Aim of this study is to compare the cost-effectiveness and the quality of life in the 6 months following the surgery of a pseudo continent perineal colostomy (PCPC) and a permanent left iliac colostomy (PLIC) following an…
- Conditions
- Rectal Neoplasms, Colostomy Stoma, Quality of Life
- Trial name
- NCT04141566
- Testing
- Perineal pseudocontinent colostomy, Permanent left iliac colostomy
- Where
- Morocco
- Volunteers
- 35 people
- Sponsor
- Moroccan Society of Surgery
Parastomal Hernia
Prospective Study of the Use of a Mesh to Prevent Parastomal Hernia After Laparoscopic Abdominoperineal Resection
Introduction: parastomal hernia (PH) is a frequent complication after an ostomy, despite the many prevention and treatment techniques that have been described.
- Trial name
- NCT01722565
- Testing
- laparoscopic abdominoperineal resection with a lightweight mesh (polypropylene and poliglecaprone 25)
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Corporacion Parc Tauli
Locally Advanced Rectal Cancer, Abdominoperineal Resection
Detection and Inflammatory Characterization of Deep Infection After Surgery for Locally Advanced Rectal Cancer With Microdialysis Catheters
The intention of the study is to explore metabolic and inflammatory parameters in the pelvis after abdominoperineal resection for locally advanced rectal cancer in patients that have received radiation therapy before surgery.
- Conditions
- Locally Advanced Rectal Cancer, Abdominoperineal Resection, Infection
- Trial name
- NCT03392584
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Rectal Adenocarcinoma
Prestoma-Trial for Parastomal Hernia Prevention
Prestoma Trial is designed to compare the safety and efficiency of three different meshes and techniques to prevent parastomal hernia after laparoscopic or robotic-assisted abdominoperineal resection for rectal adenocarcinoma.
- Trial name
- NCT03527784
- Testing
- Parietene Macro, Parietex Parastomal, Dynamesh IPST
- Where
- 6 sites in Finland
- Volunteers
- 14 people
- Sponsor
- University of Oulu
Rectal Cancer
APEMESH II - Perineal Reconstruction
The objective of this pilot study is to assess the safety, functional outcome, feasibility and the potential benefits of synthetic mesh strip and gluteus flap reconstruction in perineum in case-control setting.
- Trial name
- NCT04779125
- Testing
- Gluteus plasty enhanced with Progrip self gripping mesh
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- University of Oulu
Abdominoperineal Resection
Cost-utility of Two Strategies of Perineal Reconstruction After Abdominoperineal Resection for Anorectal Carcinoma
Abdominoperineal resection performed for anorectal tumors leaves a large pelvic and perineal defect causing a high rate of morbidity of the perineal wound (40 - 60 %).
- Trial name
- GRECCAR-9 (NCT02841293)
- Testing
- Biological mesh, Primary perineal wound closure
- Where
- 17 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Toulouse
Perineum; Wound, Postoperative Complications
Reconstruction After Abdominoperineal Resection With Robot-assisted Harvest of VRAM Flap
Non-randomized study of robot-assisted perineal reconstruction with rectus abdominis muscle flap in patients operated with abdominoperineal resection for irradiated locally advanced rectal or anal cancer.
- Conditions
- Perineum; Wound, Postoperative Complications, Rectal Neoplasms, Rectus Abdominis Hernia
- Trial name
- NCT05689775
- Testing
- Reconstruction with robot-assisted rectus abdominis muscle flap
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Rectal Cancer, Anal Canal Cancer
"Cross" Closure for Reconstructing the Perineal Wound of Abdominoperineal Resection
How to reduce the complications of perineal wound after abdominoperineal resection (APR) has always been a hot topic in the medical field.To reduce the complications of perineal wound and the primary healing of perineal wound…
- Trial name
- CCRPWAR (NCT03731754)
- Testing
- Traditional Closure, "Cross" closure
- Volunteers
- 346 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Perineal Wound Complications After ELAPE
Pelvic Floor Reconstruction Using Biological Mesh With Negative Pressure Wound Therapy Following ELAPE
Perineal wound healing is a significant challenge after extralevator abdominoperineal excision (ELAPE) due to a high rate of wound breakdown.
- Trial name
- NCT04033484
- Testing
- Negative Pressure Wound Therapy
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Beijing Chao Yang Hospital