Clinical trials: Abortion, Second Trimester
Abortion, Dilation and Evacuation
Tranexamic Acid for Second Trimester Dilation and Evacuation and Bleeding Outcomes
Although procedural abortion in the second trimester is extremely safe, hemorrhage is one of the leading causes of morbidity and mortality.
- Conditions
- Abortion, Dilation and Evacuation, Hemorrhage, Prophylactic Tranexamic Acid Use
- Trial name
- NCT06820177
- Testing
- Tranexamic Acid
- Where
- 3 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Abortion, Induced
Cervical Priming Before Dilation & Evacuation
The purpose of this study is to compare the efficacy of buccal misoprostol cervical priming to laminaria priming among women undergoing D\&E at 13-20 weeks gestation in the Western Cape Province, South Africa
- Trial name
- NCT01597726
- Testing
- Misoprostol, Laminaria
- Where
- South Africa
- Volunteers
- 159 people
- Sponsor
- Ibis Reproductive Health
Abortion in First Trimester, Abortion, Second Trimester
Second-trimester TOP : a Retrospective Study Comparing Complications at 12-14 vs 14-16 Weeks of Gestation
In France, the recently adopted law relating to the legal time limit for access to voluntary interruption of pregnancy has set a threshold of the term at which it can be performed up to 16 weeks of gestation.
- Trial name
- NCT05469594
- Volunteers
- 122 people
- Sponsor
- Central Hospital, Nancy, France
Pregnancy
Better Contraceptive Choices: Immediate or Delayed Insertion of IUC After Second Trimester Abortion
Hypothesis Intrauterine contraception placed immediately after a second trimester abortion will result in fewer pregnancies than current standard practice of intended placement at 4 weeks post-abortion.
- Trial name
- NCT00877344
- Testing
- Immediate insertion, Interval insertion
- Where
- 3 sites in Canada
- Volunteers
- 474 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Induced Abortion, Second Trimester Abortion
Midlevel Versus Physician-provided Medical Abortion in the Second Trimester
The purpose of the study is to determine the safety and effectiveness of second trimester medical abortion when provided by nurse midwives compared with physicians.
- Conditions
- Induced Abortion, Second Trimester Abortion, Medical Abortion, Health Personnel
- Trial name
- NCT04181541
- Testing
- Provider type: Physicians, Provider type: Midlevel Providers
- Where
- Ethiopia
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Ipas
Abortion, Induced
Mifepristone Versus Laminaria for Cervical Ripening in Midtrimester Induction
Data from other countries have suggested that oral mifepristone used as a cervical ripening agent may decrease induction to delivery time in midtrimester inductions.
- Trial name
- NCT00383032
- Testing
- mifepristone
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Invitro Fertilization
Factors Associated With Pregnancy Loss in IVF Women
Maternal and clinical characteristics associated with spontaneous second-trimester pregnancy loss (between 12 1/7 and 23 6/7 weeks of gestation) will be assessed.
- Trial name
- NCT02383394
- Testing
- follow up antenatal care
- Where
- Egypt
- Volunteers
- 500 people
- Sponsor
- Cairo University
Pregnancy Termination, Catheter
Foley Catheter vs Double-balloon Catheter
The efficiency of double-balloon and Foley catheters in the second trimester medical termination of pregnancies will be compared.
- Trial name
- NCT03521674
- Testing
- pregnancy termination
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Lactation Suppressed, Second Trimester Abortion
Pharmacological Inhibition of Lactation After 16 to 20 Week Abortion
The goal of this clinical trial is to compare breast symptoms (lactation, engorgement, etc) of individuals who undergo a procedure for second trimester of pregnancy loss between 16 weeks and 20 weeks gestational age.
- Trial name
- NCT06123026
- Testing
- Cabergoline
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Placenta Retained, Uterine Diseases
Effectiveness of Hyaluronic Acid Gel in the Prevention of Intrauterine Adhesions After Second Trimester Abortion
This prospective, randomized, controlled study evaluates the efficacy of self-crosslinked hyaluronic acid gel to prevent the development of de-novo intrauterine adhesions following curettage for retained product after second…
- Trial name
- NCT02868437
- Testing
- intrauterine self-cross-linked hyaluronic acid gel
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Abortion, Induced
Cervical Preparation Before Dilation and Evacuation
The purpose of this research study is to compare three different ways of opening a woman's cervix before her second-trimester surgical abortion.
- Trial name
- NCT01751087
- Testing
- Mifepristone, misoprostol, Osmotic dilators
- Where
- 7 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Legally Induced Abortion Without Mention of Complication
Pre-Operative Effects of Mifepristone on Dilation and Evacuation Services
This research study investigates the use of a drug, mifepristone, given before second trimester abortion. Mifepristone is a medication that is approved for medical abortion during the first trimester.
- Trial name
- POEM (NCT01862991)
- Testing
- Hygroscopic cervical dilators, Misoprostol, Intra-amniotic digoxin
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Stanford University
Abortion, Missed
Misopristol Versus Pitocin for Second Trimester Abortion
Second trimester abortion can be done surgically or medically. Medical abortion with mifepristone and misopristol is one of the common protocol, but misopristol have high rate side effect.
- Trial name
- NCT00784797
- Testing
- mifepristone and misopristol, mifepristone and oxytocin
- Where
- Israel
- Volunteers
- 145 people
- Sponsor
- Hadassah Medical Organization
Abortion
Comparative Psychiatric Problems Between First and Second Trimester Miscarriage
Description of the psychiatric impact of miscarriage on women.
- Trial name
- NCT06742632
- Testing
- Symptoms checklist-90
- Where
- Egypt
- Volunteers
- 155 people
- Sponsor
- Assiut University
Missed Abortion
Evening Primrose Oil Efficacy in Second Trimester Abortion
efficacy of evening primrose oil in shortening the duration of induction in 2nd trimesteric missed abortion
- Trial name
- NCT03698734
- Testing
- Evening primrose oil(EPO)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Lactation Suppressed
Cabergoline for Lactation Inhibition After Second-Trimester Abortion or Loss
This research study investigates the use of a drug, cabergoline, given immediately after second-trimester abortion or perinatal loss to decrease breast engorgement.
- Trial name
- LISTA (NCT04701333)
- Testing
- Cabergoline 1 MG
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Stanford University
Abortion, Induced
Transvaginal Versus Transabdominal Digoxin Prior to Second-trimester Abortion
Current practice for the provision of late second trimester abortion (dilation and evacuation, or D\&E) often involves the administration of digoxin into the fetal compartment to induce fetal demise prior to the procedure.
- Trial name
- NCT02277249
- Testing
- Digoxin (transvaginal administration), Digoxin (transabdominal administration)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Induced Abortion
Same-Day Mifepristone-Misoprostol Compared to Misoprostol Only for Surgical Abortion Cervical Preparation
A randomized double---blinded comparison of same---day mifepristone and misoprostol with misoprostol only for cervical preparation in second---trimester surgical abortion in 100 women at 14 0/7---19 6/7 weeks gestation.
- Trial name
- MMSAP (NCT02412618)
- Testing
- Mifepristone, Misoprostol
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Induction of Abortion
Different Methods of Termination of Second Trimester Abortion
The Patient are divided into 3 groups group 1 included 50 cases using misoprostol only. group 2 included also 50 cases in which using misoprostol with letrozole.
- Trial name
- NCT03400683
- Testing
- Misoprostol, Letrozole, Foley's catheter
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Cairo University
Lactation Suppressed
Cabergoline for Lactation Inhibition After Early Second-Trimester Abortion or Pregnancy Loss
Breast pain following second-trimester abortion is common. Breast engorgement and milk leakage following second-trimester perinatal loss and abortion can cause both physical pain and emotional distress.
- Trial name
- eLISTA (NCT06029673)
- Testing
- Cabergoline 1 MG
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Stanford University