Clinical trials: Abortion, Second Trimester
Pregnancy
Better Contraceptive Choices: Immediate or Delayed Insertion of IUC After Second Trimester Abortion
Hypothesis Intrauterine contraception placed immediately after a second trimester abortion will result in fewer pregnancies than current standard practice of intended placement at 4 weeks post-abortion.
- Trial name
- NCT00877344
- Testing
- Immediate insertion, Interval insertion
- Where
- 3 sites in Canada
- Volunteers
- 474 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Pregnancy Termination, Catheter
Foley Catheter vs Double-balloon Catheter
The efficiency of double-balloon and Foley catheters in the second trimester medical termination of pregnancies will be compared.
- Trial name
- NCT03521674
- Testing
- pregnancy termination
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Second Trimester Abortion
Misoprosotol and Isosorbide Mononitrate for Induction of Second Trimester Abortion
the investigators aimed to study the efficacy and safety of nitric oxide donors when combined with prostaglandins in induction of second trimester abortion expecting that both drugs when used together will be of greater…
- Trial name
- NCT03407521
- Testing
- Misoprostol, isosorbide mononitrate
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pain
Analgesia for 2nd Trimester Termination of Pregnancy
There has been very little investigation into the management of pain from 2nd trimester termination of pregnancy or unexpected fetal loss.
- Trial name
- NCT01563835
- Testing
- bupivacaine, fentanyl, fentanyl
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Induced Abortion
Same-Day Mifepristone-Misoprostol Compared to Misoprostol Only for Surgical Abortion Cervical Preparation
A randomized double---blinded comparison of same---day mifepristone and misoprostol with misoprostol only for cervical preparation in second---trimester surgical abortion in 100 women at 14 0/7---19 6/7 weeks gestation.
- Trial name
- MMSAP (NCT02412618)
- Testing
- Mifepristone, Misoprostol
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Abortion in Second Trimester
OPIOID Study - Pain With Osmotic Dilators
Comparison of pain levels and pain medications utilized following insertion of two different types of osmotic dilators.
- Trial name
- OPIOID (NCT03710239)
- Testing
- Dilapan-S, Laminaria
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Abortion, Induced
Mifepristone Versus Laminaria for Cervical Ripening in Midtrimester Induction
Data from other countries have suggested that oral mifepristone used as a cervical ripening agent may decrease induction to delivery time in midtrimester inductions.
- Trial name
- NCT00383032
- Testing
- mifepristone
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Miscarriage
Letrozole Pretreatment With Misoprostol for Second-Trimester Medical Abortion
To compare the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of pregnancy in second trimester abortion.
- Trial name
- NCT02405156
- Testing
- Letrozole, Misoprostol
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Abortion in Second Trimester
Outpatient Service for Mid-trimester Termination of Pregnancy
This study seeks to evaluate the safety, acceptability and feasibility of an outpatient "day procedure" for medical abortion at 13-18 weeks gestation.
- Trial name
- NCT03346629
- Testing
- Mifepristone + Misoprostol
- Where
- 3 sites in Nepal
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Cervical Ripening
Misoprostol Versus Dilapan-S for Cervical Preparation
The purpose of this study is to compare the dilatory effect of 400 mcg of buccally administered misoprostol to one Dilapan-S rod placed 3-4 hours before abortion by dilation and evacuation in women who are 12 weeks 0 days to 15…
- Trial name
- NCT00835731
- Testing
- misoprostol, Dilapan-S, vitamin B-12
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Therapeutic Abortion
Same-day Dilapan-S With Adjunctive Misoprostol
Cervical preparation before second trimester dilation and evacuation (D\&E) reduces risks and complications. Osmotic cervical dilators as well as prostaglandin analogues have been studied for cervical preparation.
- Trial name
- DAM (NCT01818414)
- Testing
- Misoprostol, Folic Acid
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Abortion, Second Trimester, Procedural Pain
Cervical Preparation for Same-Day Dilation & Evacuation
This is a noninferiority randomized control trial of two cervical preparation methods prior to same-day Dilation \& Evacuation (D\&E). Cervical preparation is a process that softens and dilates the cervix prior to a procedure.
- Conditions
- Abortion, Second Trimester, Procedural Pain, Procedural Complication
- Trial name
- NCT06799052
- Testing
- Transcervical single-balloon catheter, Synthetic osmotic dilators
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Second Trimester Abortions
Comparing Misoprostol Alone to Dilapan With Misoprostol and Comparing Buccal to Vaginal Misoprostol
This randomized controlled trial will use a 2 by 2 factorial design to assess methods of cervical preparation prior to Dilation and Evacuations (D\&Es) at 14 0/7 to 19 6/7 weeks gestational age.
- Trial name
- NCT02363556
- Testing
- Misoprostol administered vaginally, Misoprostol administered buccally, Misoprostol administered vaginally with Dilapan
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Abortion, Induced
Mifepristone and Misoprostol Versus Misoprostol Alone for Mid-trimester Termination of Pregnancy (14 - 21 Weeks LMP): A Randomized-controlled Double-blinded Trial
The primary goal of this study is to determine the clinical advantage of pre-treatment with mifepristone in second trimester misoprostol induction abortion.
- Trial name
- NCT00784186
- Testing
- mifepristone+misoprostol, misoprostol
- Where
- 2 sites in Vietnam
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Abortion in Second Trimester
Mifepristone and Misoprostol for Midtrimester Termination of Pregnancy in Uzbekistan
The primary goal is to examine the efficacy and feasibility of a mifepristone-misoprostol medical abortion regimen in terminating pregnancies 13-22 weeks in Uzbekistan.
- Trial name
- NCT02235155
- Where
- 3 sites in Uzbekistan
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects