Clinical trials: Abortion; Induced
Second Trimester Abortion
Second Trimester Pregnancy Termination in Women With Previous Caesarean Sections
it is a randomized controlled trial comparing the safety and efficacy of Vaginal Misoprostol versus combined Intracervical Foley's Catheter and Oxytocin Infusion for Second Trimester Pregnancy Termination.
- Trial name
- NCT04501809
- Testing
- compare misoprostol with combined oxytocin and cervical foly catheter
- Where
- 2 sites in Egypt
- Volunteers
- 158 people
- Sponsor
- Zagazig University
Pregnancy
Telemedicine Medical Abortion Service Using the "No-test" Protocol in Ukraine and Uzbekistan.
The goal of this study is to pilot and evaluate a telemedicine medical abortion service delivery that allows remote communication between the woman and provider and limits medically unnecessary in-person visits to health or…
- Trial name
- NCT05028387
- Testing
- medical abortion
- Where
- 4 sites in Ukraine, Uzbekistan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Medical; Abortion, Fetus
Effectiveness of Pretreatment Letrozole Versus Misoprostol Alone in Missed Abortion
Background and Rationale Abortion accounts for about 8% of maternal mortality worldwide. Surgical intervention is the definitive treatment for abortion but it is invasive.
- Trial name
- NCT04194658
- Testing
- Letrozole 2.5mg
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cairo University
Medical Abortion
Acceptability of an Out-patient Regimen of Medical Abortion With Mifepristone and 800 Mcg Misoprostol Administered at 78-84 Days Gestation
These pilot studies are designed as open label studies to investigate the acceptability of 200 mg mifepristone followed 24-48 hours later by either 1) 800 µg misoprostol administered buccally or 2) 800 µg misoprostol administered…
- Trial name
- NCT01856985
- Testing
- Misoprostol, Mifepristone
- Where
- Vietnam
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Hemorrhage
Uterotonic Prophylaxis Trial
Excessive bleeding after dilation and evacuation (D\&E) requiring interventions is common, occurring in approximately 30% of cases at one large abortion-providing clinic.
- Trial name
- UPT (NCT02408965)
- Testing
- Methergine
- Where
- United States
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Abortion, Missed
Use of Fetoscopy in Missed Abortion
The purpose of this study is to evaluate the use of hysteroscopic embryoscopy or fetoscopy as a powerful diagnostic tool to provide better counseling for couples having experienced pregnancy loss.
- Trial name
- NCT03799081
- Testing
- Fetoscopy
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hillel Yaffe Medical Center
Infertility
Preimplantation Genetic Diagnosis for the Indication of Advanced Reproductive Age
The objective of this study is to demonstrate that Preimplantation Genetic diagnosis will significantly reduce spontaneous abortions and increase ongoing pregnancy rates in patients of advanced maternal age (37-42) undergoing…
- Trial name
- NCT00646893
- Testing
- Preimplantation Genetic Diagnosis (PGD)
- Where
- 5 sites in United States, Spain
- Volunteers
- 1,200 people
- Sponsor
- Reprogenetics
Abortion, Blood Loss
Effect of Preoperative Buccal Misoprostol on Blood Loss in Second-trimester Dilation and Evacuation Abortion
Misoprostol is a medication used extensively in obstetrics and gynecology for its ability to aid in softening the cervix as well as decreasing blood loss after abortion or vaginal delivery.
- Trial name
- PreopMiso (NCT01436266)
- Testing
- Misoprostol, Folic acid
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Boston University
Abortion, Recurrent
Platelet Indices and Recurrent Pregnancy Loss
The aim of this study was to evaluate relationship between platelet indices, red blood cell indices and recurrent pregnancy loss.
- Trial name
- NCT05190796
- Testing
- platelet indices
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Menoufia University
Pregnancy of Unknown Location
Hysteroscopy for the Diagnosis and Treatment of Pregnancy of Unknown Location
Infertility patients have a higher baseline risk of ectopic pregnancy compared to the general population. If an early pregnancy is not visible by ultrasound, patients with a pregnancy of unknown location (PUL) will undergo…
- Trial name
- NCT07469605
- Testing
- Hysteroscopy for diagnosis and treatment of pregnancy of unknown location
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Miscarriage
A Study Looking at Women's Experiences After a Miscarriage
Studies have shown that a majority of pregnancies that end in miscarriage are due to a chromosome abnormality usually involving a duplicated or missing chromosome.
- Trial name
- NCT01223482
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- California State University, Stanislaus
Pregnant, Healthy Females, Healthy Male Newborns
Use of Existing Fibroblast Cells to Convert to Induced Pluripotent Stem Cells
Induced pluripotent stem cells potentially may be useful in the future as an unlimited source of cells for transplantation. The major goal of the project is to develop human iPS cells from existing lines of fibroblasts that were…
- Trial name
- NCT00801372
- Where
- Israel
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Mannose-Binding Lectin Deficiency, Recurrent Pregnancy Loss
Association Between Plasma Level of Mannose Binding Lectin and Human Reproduction
A low plasma level of mannose binding lectin (p-MBL) is associated with unexplained recurrent pregnancy loss (RPL), but it is not investigated if it is associated with unexplained reproductive failure in general, including…
- Conditions
- Mannose-Binding Lectin Deficiency, Recurrent Pregnancy Loss, Recurrent Implantation Failure, Infertility
- Trial name
- NCT05169541
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Aalborg University Hospital
Cervical Insufficiency
Relation of the Area of Cerclage With Preterm Birth
This study is planned prospectively in pregnancies who applied to Etlik Zübeyde Hanım Women's Health Care, Training and Research Hospital which is a teritiary hospital with 15.000 births anually, between January 2022 and January…
- Trial name
- NCT05220839
- Testing
- Type of cerclage procedure Mc Donald
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Anxiety, Pain
Friends/Family in the Abortion Procedure Room (FAIR)
This study aims to explore patient, support person, and health care providers' experience and satisfaction with social support in the abortion procedure room.
- Conditions
- Anxiety, Pain, Abortion
- Trial name
- FAIR (NCT03227614)
- Testing
- Support Person Intervention
- Where
- United States
- Volunteers
- 422 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood of Southwest and Central Florida
Preterm Labour, Cervical Insufficiency
Intramuscular vs Rectal Progesterone in Preventing Preterm Labour After Cervical Cerclage
Preterm labour is a major cause of neonatal morbidity and mortality worldwide. Progesterone supplementation is known to help reduce the risk of preterm birth in high-risk women.
- Conditions
- Preterm Labour, Cervical Insufficiency, Pregnancy, High-Risk
- Trial name
- PROCER (NCT07307092)
- Testing
- Intramuscular Progesterone, Rectal Progesterone
- Where
- Pakistan
- Volunteers
- 820 people
- Sponsor
- Hina Mukhtar
Abortion, Induced, Pain Management
Intrauterine Lidocaine for Laminaria
This is a study to investigate whether instilling a small amount of liquid lidocaine into the uterus will decrease pain felt by women during laminaria insertions done for cervical dilation prior to second trimester abortion.
- Trial name
- NCT01541293
- Testing
- Lidocaine, Normal Saline
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of North Carolina, Chapel Hill
Abortion, Induced
Misoprostol Dose and Timing Before Surgical Abortion at 13 to 16 Weeks' Gestation: a Randomized Trial
This study is a blinded randomized trial to compare two different doses and intervals of buccal misoprostol for cervical preparation before surgical abortion at 13 to 16 weeks' gestation: 400 mcg administered 3 hours before D\&E…
- Trial name
- NCT02279914
- Testing
- Misoprostol 400 mcg 3 hours prior to procedure, Misoprostol 600 mcg 90 minutes prior to procedure
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood of Greater New York
IUC Insertion After Medical Abortion
Intrauterine Contraception (IUC) After Medical Abortion
Today a large proportion of early abortions are medical, in accordance to the woman's choice. The main objective of the present study was to compare, in a randomised fashion, initiation of intrauterine contraception (IUC) at…
- Trial name
- NCT01537562
- Testing
- Timing of IUC insertion
- Where
- Sweden
- Volunteers
- 129 people
- Sponsor
- Karolinska Institutet
Abortion
Gestational Age is Underestimated by Menstrual Dating Compared to Ultrasound Dating in Those Undergoing Abortion up to 20 Weeks
Several large trials report gestational dating by last menstrual period (LMP) overestimates gestational age (GA) vs. ultrasound (US) by approximately one week. Previous studies examined only term pregnancies.
- Trial name
- NCT00884403
- Where
- Canada
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- University of British Columbia