Clinical trials: Accident Injury
Opioid Misuse, Trauma Injury
Screening in Trauma for Opioid Misuse Prevention - an Adaptive Intervention
The primary objective of the present pilot, sequential, multiple-assignment randomized trial (Pilot SMART) is to determine feasibility and acceptability of delivering (from the perspective of the treatment/intervention staff) and…
- Trial name
- STOMP-AI (NCT06527599)
- Testing
- Opioid Risk Monitoring (ORM), enhanced Trauma Care Coordination (eTCC), Pain Coping Skills Training - Brief (PCST-LITE)
- Where
- 2 sites in United States
- Volunteers
- 118 people
- Sponsor
- University of Wisconsin, Madison
Concussion Post Syndrome, Head Trauma Injury
Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment
The IMPACT study is a randomized, double-blind clinical trial evaluating two commonly used intravenous medications - metoclopramide and acetaminophen - for treating acute post-concussion symptoms in emergency department patients…
- Trial name
- IMPACT (NCT07634393)
- Testing
- Metoclopramide 10mg, Acetaminophen
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Montefiore Medical Center
Severe Traumatic Brain Injury, Pancreatic Diseases
The Effect of Closed Suction System on the Incidence of Ventilator-associated Pneumonia.
The investigators are suggesting that closed suction systems may reduce the risk of the ventilator - associated pneumoniae (VAP) and the contamination of the closest unanimated surfaces. In 2011 David et al.
- Conditions
- Severe Traumatic Brain Injury, Pancreatic Diseases, Trauma Injury, Seizures
- Trial name
- CSS-VAP (NCT04323150)
- Testing
- Closed suction systems, Conventional suction system
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Northern State Medical University
Traumatic Brain Injury
Evaluation of Biomarker Kinetics After Mild Brain Injury Trauma
The primary objective of the clinical trial is to evaluate the effect of time on levels of Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) and Glial Fibrillary Acidic Protein (GFAP) biomarker levels in a population of head injured…
- Trial name
- VIGILANT (NCT02541123)
- Testing
- Blood draw
- Where
- 10 sites in United States, Germany and 1 more
- Volunteers
- 194 people
- Sponsor
- Banyan Biomarkers, Inc
Occult Bleeding, Hemorrhage
A 48 Subject Study Using Non-invasive Multi-Technology Measurements for Early Detection of Ongoing Hemorrhage
Early detection of ongoing hemorrhage (OH) before onset of hemorrhagic shock is a universally acknowledged great unmet need, and particularly important after traumatic injury.
- Conditions
- Occult Bleeding, Hemorrhage, Hemorrhagic Shock
- Trial name
- NCT04814810
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Surgical Wound, Burns
A Prospective Study Using SupraSDRM® in Promoting Healing and Reducing the Time to Grafting of Full-thickness Wounds
This is a prospective, randomized, controlled, multi-center clinical study comparing SupraSDRM® to standard of care wound dressing, BTM, in the treatment of full-thickness wounds deemed not immediately suitable for definitive…
- Conditions
- Surgical Wound, Burns, Trauma Injury
- Trial name
- NCT06503406
- Testing
- SupraSDRM®, NovoSorb® BTM
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The Metis Foundation
Accidents Sports, Injury Prevention
An Injury Prevention Program for Professional Ballet
The aim of this study is to evaluate the efficacy of an injury prevention program for professional ballet dancers.
- Trial name
- NCT04110002
- Testing
- Injury Prevention Program
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Multiple Trauma
Importance of Forces and Safety Features in Car Crash Multitrauma
The pupose of the study is a prospective evaluation of external and internal factors/causes of importance for the trauma and final outcome experienced by persons inside motor vehicles in serious car accidents.
- Trial name
- NCT00204204
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- University of Oslo
Bleeding
Studying Safety & Efficacy of Axiostat® Dressing in Acute Hemorrhage Due to Trauma-Comparative Study
The aim of this study was to evaluate the efficacy and safety to use external haemostatic between Axiostat® (Chitosan haemostatic dressing) and conventional cotton gauze dressing as a pre hospital acute hemorrhagic control in…
- Trial name
- NCT03035695
- Testing
- Axiostat®, Cotton Gauze
- Where
- India
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Axio Biosolutions Pvt. Ltd.
Head Injury Trauma, Traumatic Brain Injury, Mild
The PIONEER Comparative Effectiveness Study - Project 2
This is a pragmatic, open-label, multicenter, stepped-wedge, Type II hybrid effectiveness-implementation study. It is designed to evaluate both the comparative effectiveness and implementation feasibility of a…
- Trial name
- NCT07829107
- Testing
- Clinical pathway 1: Guidelines plus biomarkers, Clinical guidelines only
- Where
- 6 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- University of Michigan
Bicycle Accident
Pedal Cycle Related Trauma at the Royal London Hospital
Bespoke is an observational, prospective, cohort study. The aim of this study is to explore injury patterns of patients who require admission to the Royal London Hospital (RLH) Emergency Department (ED)or outpatient clinics as a…
- Trial name
- NCT06819332
- Where
- United Kingdom
- Volunteers
- 644 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Trauma, Psychological, Motor Vehicle Accident
Extension of EMDR vs. PC For Motor Vehicle Accident Trauma
This is an extension of a randomized clinical trial comparing eye movement desensitization and reprocessing (EMDR) to progressive counting (PC) for volunteers from the community who are distressed by the memory of a motor vehicle…
- Trial name
- NCT03271411
- Testing
- EMDR-based Flash technique, PC-based Flash technique
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Trauma Institute & Child Trauma Institute
Trauma Injury
Development of WHOLE Score
The aim of this study was to investigate the association between injury mechanism, physical examination findings, and laboratory parameters, and the presence of injuries involving multiple computed tomography (CT) regions on…
- Trial name
- WHOLE (NCT07411235)
- Where
- Turkey (Türkiye)
- Volunteers
- 407 people
- Sponsor
- Ankara City Hospital Bilkent
Trauma Injury
Impairing Drugs and Alcohol as Risk Factors for Traumatic Injuries
Impairing drugs and alcohol are major risk factors for traumatic injuries. Still there is to date little knowledge to what extent these factors affect the epidemiology of trauma.
- Trial name
- IDART (NCT03773614)
- Where
- Norway
- Volunteers
- 5,000 people
- Sponsor
- Oslo University Hospital
Trauma Injury
How Many Patients Suffering Major Trauma Would be Eligible for a Pre-hospital Transfusion
The aim of the study is to measure the number of patients being cared for by a medical team for major trauma who could benefit from a transfusion labile blood products and thus provide a scientific argument in favour of supplying…
- Trial name
- TRAP (NCT06494293)
- Testing
- Data Collection
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Hôpital NOVO
Traumatic and/or Non-traumatic Brain Injury
Assessing Special Features of Impaired Gait After Acquired Brain Injury With an Instrumented Treadmill
Hemiparetic gait following acquired brain injury (ABI) is grossly characterized by decreased speed of walking, increased stance time on the unaffected side, and decreased stance time on the affected side.These abnormalities are…
- Trial name
- NCT01413321
- Where
- Israel
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Poisoning, Safety Issues
Evaluating the Impact of a Safe Medication Storage Device
Despite the initial success of the 1970s Poison Prevention Packaging Act, the incidence of pediatric medication poisonings in the United States remains high.
- Conditions
- Poisoning, Safety Issues, Accidents Injury
- Trial name
- NCT04729894
- Testing
- Medication Lockbox, Education
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Binghamton University
Trauma Injury
Reducing Low-value Care for Trauma Admissions
In Canada, injury leads to more potential years of life lost and to greater costs than heart and stroke diseases combined. Furthermore, more than 50% of patients hospitalised following injury do not receive optimal care, 20% of…
- Trial name
- NCT05744154
- Testing
- Audit & feedback with educational outreach and facilitation, Simple audit & feedback (usual practice)
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Laval University
Trauma/Injury Problem
Pre and Post-Implementation of Injury/Trauma First Aid Training Among Early Secondary School Students in Fako, Cameroon
To save lives, alleviate pain, and prevent injuries from worsening before medical assistance can be summoned, first aid is essential. These fundamental skills are accessible to everyone, including young people.
- Trial name
- NCT07110077
- Testing
- Young First Aiders Traing of Early Secondry School children
- Where
- Cameroon
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- University of Buea
Spasticity, Cerebrovascular Accident
Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity
Phase 2/3, randomized, double-blind, placebo-controlled, single-treatment, multicenter trial assessing the efficacy and safety of MYOBLOC for the treatment of upper limb spasticity in adults followed by an open-label extension…
- Conditions
- Spasticity, Cerebrovascular Accident, Multiple Sclerosis, Traumatic Brain Injury
- Trial name
- NCT04815967
- Testing
- Phase 2; Low Dose MYOBLOC (10,000 Units), Phase 2; High Dose MYOBLOC (20,000 Units), Phase 3; MYOBLOC
- Where
- 9 sites in United States, Hungary and 1 more
- Volunteers
- 32 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC