Clinical trials: Acetaminophen
Healthy Volunteers
Single-Dose PK Study of an Oxycodone/Acetaminophen Solution in Healthy Subjects
A single-dose study evaluating the oral PK of an oxycodone/apap solution in healthy subjects under fasted conditions
- Trial name
- NCT02966860
- Testing
- Oral solution OC/APAP
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mallinckrodt
Unilateral Knee Arthroplasty
Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee
This is a prospective, three-arm, randomized, open-label trial to determine if a new pain control protocol which includes regular dosing of intravenous acetaminophen and orphenadrine for 48 hours after total knee surgery reduces…
- Trial name
- IVAM (NCT02449369)
- Testing
- Preop acetaminophen IV, Preop orphenadrine IV, Postop oral oxycodone & acetaminophen
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Healthy, Obese
A Drug-Drug Interaction Study of Orforglipron (LY3502970) in Healthy Overweight and Obese Participants
The main purpose of this study is to determine effect of orforglipron capsule formulation on the amount of digoxin, rosuvastatin, acetaminophen, midazolam, and simvastatin (each given alone and together with orforglipron) that…
- Conditions
- Healthy, Obese, Overweight
- Trial name
- NCT06186622
- Testing
- Orforglipron, Simvastatin, Digoxin
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Analgesia; Ibuprofen; Acetaminophen; Oxidative Stress
The Effects Of Intravenous Ibuprofen on Pain, Oxidative Stress and Inflammation in Laparoscopic Hysterectomy Operations
Objective: The aim of this study is to evaluate whether the exposure of oxidative stres in the peroperative period and the postoperative 24th hour can be decreased with the thiol-disulfide homeostasis (TDH) method and C-Reactive…
- Trial name
- NCT04881474
- Testing
- Ibuprofen 800 mg
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Healthy
The Effects of Aspirin and Acetaminophen on the Stomach in Healthy Volunteers
Aspirin is a medication commonly used to relieve minor pains. Aspirin has also been used to prevent heart attacks and strokes. Aspirin, however, can also cause damage to the stomach and/or intestinal lining leading to the…
- Trial name
- NCT00594867
- Testing
- Acetaminophen 4 gram per day + Aspirin 325 mg per day
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Opioid Use
Opioid Analgesic Reduction Study
The goal is to provide health care professionals, including dentists, with the best possible evidence for clinical decision making when deciding upon analgesics for acute post-surgical pain management, a double-blind, stratified…
- Trial name
- OARS (NCT04452344)
- Testing
- opioid-containing analgesic, two over-the-counter analgesics
- Where
- 5 sites in United States
- Volunteers
- 1,815 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Healthy
A Relative Bioavailability Study of Acetaminophen Extended Release Gel Tabs 650 mg Under Fasting Condition
The study was to compare single-dose oral bioavailability of acetaminophen 650 mg extended release geltabs (containing acetaminophen 650 mg) of OHM Laboratories Inc.
- Trial name
- NCT01523080
- Testing
- Acetaminophen
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Pain, Orofacial
Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain Management
The purpose of this study is to compare the effectiveness of a combined ibuprofen and acetaminophen regimen in controlling discomfort for 4 days after initial orthodontic appliance placement as compared to ibuprofen alone or a…
- Trial name
- NCT04059172
- Testing
- Ibuprofen 200 mg and acetaminphen 650 mg, Ibuprofen 200 mg
- Where
- United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Orthodontic Pain
A Study of Acetaminophen/Naproxen Sodium Fixed Combination Tablets in Adolescents 12 to <17 Years of Age With Pain
The purpose of this study is to investigate the population pharmacokinetics of acetaminophen and naproxen from a novel acetaminophen /naproxen sodium fixed combination tablet in adolescents 12 to less than (<) 17 years of age…
- Trial name
- NCT05844995
- Testing
- Acetaminophen/Naproxen Sodium
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Pain, Acute
Acetaminophen IV vs Hydromorphone IV in the ED
The purpose of the current study is to compare the analgesic efficacy of intravenous acetaminophen and intravenous hydromorphone in the treatment of acute pain in the ED.
- Trial name
- NCT03107481
- Testing
- Acetaminophen, Hydromorphone
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Acute Post-operative Pain
Ibuprofen Use on Post-operative Pain Following Cholecystectomy
In this study, the investigators compared the effects of IV forms of ibuprofen and acetaminophen on pain perception and opioid consumption following laparoscopic cholecystectomy.
- Trial name
- NCT06478758
- Testing
- Ibuprofen 400 mg, Acetaminophen 100 MG/ML
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Giresun University
Multimodal Analgesic Approach
IV vs Oral Acetaminophen in Spine Fusion Perioperative Care
The United States is currently experiencing an explosive opioid epidemic. In 2014 alone, 28,647 Americans died from an opioid associated overdose; the annual death toll has increased by over 300% since 2000.
- Trial name
- NCT03020875
- Testing
- Ofirmev, Per Os Acetaminophen
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis
Study To Determine The Effects Of Doses Of Relacatib On The Metabolism Of Acetaminophen, Ibuprofen And Atorvastatin
Relacatib is being developed for the treatment of osteoporosis, osteoarthritis and possibly other bone disorders. Recent results suggest that relacatib interacts with the way our bodies metabolise drugs and so some drugs which…
- Trial name
- NCT00411190
- Testing
- Relacatib, Acetaminophen, Ibuprofen
- Where
- 2 sites in Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Fracture
Acute Pediatric Fracture Analgesia Study
A clinical trial comparing ibuprofen and acetaminophen with codeine for children after discharge from the emergency department. We hypothesize that Ibuprofen will provide 20% more effective analgesia compared to acetaminophen…
- Trial name
- NCT00520442
- Testing
- ibuprofen, acetamin w codeine
- Where
- United States
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Healthy
Acetaminophen's Antinociceptive Effect When Associated With N-Acetylcysteneine
Acetaminophen is one of the most widely used analgesic in the world, recommended for the symptomatic treatment of fever and pain.
- Trial name
- PANACE (NCT02206178)
- Testing
- N-acetylcysteine combination with acetaminophen
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Acetaminophen Overdose, Pain
Investigation of Efficacy of Improved Acetaminophen Labeling
The purpose of this study is to evaluate, through brief, one-on-one cognitive interviews, the efficacy of 'enhanced' acetaminophen messages and icons in improving consumer understanding and use of prescription (Rx) and…
- Trial name
- NCT01592448
- Testing
- Active Ingredient Icon
- Where
- 4 sites in United States
- Volunteers
- 662 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Postoperative Pain
Effect of Intravenous Acetaminophen on Postoperative Opioid-related Complications
Some patients have respiratory depression (decreased breaths per minute) after surgery. Acetaminophen, an FDA approved pain medication, may prevent this problem.
- Trial name
- NCT02156154
- Testing
- Intravenous Acetaminophen
- Where
- United States
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Non-alcoholic Fatty Liver Disease (NAFLD)
The Effect of Acetaminophen on Non-alcoholic Fatty Liver Disease Patients
In this first pilot study, we will examine the effects of acetaminophen dosing in adult patients with NAFLD in comparison to the effects in a healthy control group.
- Trial name
- NCT02194894
- Testing
- Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southern California
Pain, Postoperative
Intravenous Versus Oral Acetaminophen for Postoperative Pain Control After Cesarean Delivery
This study will compare IV (intravenous) versus oral (PO) acetaminophen for postoperative pain after scheduled, elective Cesarean delivery.
- Trial name
- NCT02487303
- Testing
- Acetaminophen Intravenous, Acetaminophen Oral
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Acetaminophen,Mechanical Ventilation,Critically Ill Children
Clinical Efficacy of Acetaminophen in Mechanical Ventilation in Children With New Coronary Pneumonia
Patients were randomized to receive either paracetamol during mechanical ventilation. When patients were randomized to receive paracetamol (40 mg/kg per day in 4 doses), a placebo infusion of normal saline was administered…
- Trial name
- NCT05691088
- Testing
- Paracetamol injection
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- The Second Clinical Medical College of Jinan University