Clinical trials: Achalasia
Achalasia
Sensorimotor Dysfunction in Achalasia
This study is being done to assess the esophageal muscle (swallowing tube) in patients with and without achalasia to further understand and help direct the treatment for patients with achalasia.
- Trial name
- NCT02434991
- Testing
- Barostat
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Primary Esophageal Motility Disorders Including Achalasia and Hypertensive LES
Prospective Study on the Feasibility and Effectiveness of Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders
rimary spastic esophageal motility disorders, though uncommon, induce significant symptoms to patients including dysphagia, spastic chest pain, regurgitation as well as heartburn.
- Trial name
- POEM (NCT01524458)
- Testing
- Per-Oral Endoscopic Myotomy
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Chinese University of Hong Kong
Achalasia
Outcome of Symptoms in Patients Undergoing a Heller Myotomy
The objective of this study is to review studies and patient symptoms before and after laparoscopic Heller myotomy to assess outcomes following laparoscopic surgery for achalasia.
- Trial name
- Achalasia (NCT00519220)
- Testing
- Symptom questionnaire
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Achalasia, Esophageal Spasm, Diffuse
Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Disorders
This is prospective data recording study. All patients will receive standard medical care and no experimental interventions will be performed.
- Conditions
- Achalasia, Esophageal Spasm, Diffuse, Gastroparesis, Swallowing Disorder
- Trial name
- POEM (NCT05905016)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- AdventHealth
Achalasia Cardia
Randomised Trial Between LHM Alone Vs LHM With Anterior Fundoplication In Achalasia Cardia
Back ground: Achalasia Cardia (AC) manifests with major symptom dysphagia. Surgery as the treatment modality relieves dysphagia in most of the patients.
- Trial name
- NCT03438838
- Testing
- Laparoscopic Heller's myotomy, Anterior Fundoplication
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Govind Ballabh Pant Hospital
Type I Achalasia, Type II Achalasia
PREcision MEDicine In Achalasia (PREMEDIA)
The goal of this clinical trial is to learn if shorter Per-Oral Endoscopic Myotomy (POEM) works as well as a longer POEM in patients with trouble swallowing due to certain conditions.
- Conditions
- Type I Achalasia, Type II Achalasia, EGJ Outflow Obstruction Without Spastic/Hypercontractile Features
- Trial name
- PREMEDIA (NCT07293650)
- Testing
- Standard Myotomy, Tailored Short Myotomy
- Where
- 16 sites in United States
- Volunteers
- 372 people
- Sponsor
- Northwestern University
Achalasia
Per-Oral Endoscopic Esophagomyotomy (POEM)
Achalasia is an esophageal motility disease that usually requires surgical intervention (esophagomyotomy). Laparoscopic techniques have reduced the morbidity associated with myotomy, but post-op GERD, wound infection, hernia and…
- Trial name
- POEM (NCT01635374)
- Testing
- Per-Oral Endoscopic Esophagomyotomy
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Northwestern University
Achalasia, Gastroesophageal Reflux
Systematic IPP VS Symptomatic IPP in GERD Prevention After POEM for Achalasia. . A Comparative Retrospective Analysis
POEM is a minimally invasive endoscopic therapy that is highly efficacy in the treatment of achalasia of any type. POEM has an increased risk of GERD.
- Trial name
- IPPOEM-Retro (NCT04740437)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Achalasia, Postoperative Complications
Personalized Peroral Endoscopic Myotomy for Achalasia
Achalasia is a rare esophageal motility disorder, characterized by incomplete lower esophageal sphincter relaxation, increased Lower esophageal sphincter (LES) tone, and aperistalsis of the esophagus.
- Trial name
- POEM (NCT01570621)
- Testing
- peroral endoscopic myotomy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Cricopharyngeal Achalasia
Ultrasound-guided Botulinum Toxin Injection on Cricopharyngeal Muscle Dysfunction
Ultrasound-guided injection is a visual, convenient, and radiation-free technique that allows real-time observation of the needle insertion process and drug injection location.
- Trial name
- NCT06271395
- Testing
- Injectable Type A Botulinum Toxin
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Zeng Changhao
Reflux, Gastroesophageal, Achalasia
The Effect of Physiotherapy on Post POEM Reflux
Per-oral endoscopic myotomy has been used as a treatment method of esophageal achalasia. Patients who undergo POEM as a treatment of achalasia are often presented with development of reflux as a side effect of the surgery.
- Conditions
- Reflux, Gastroesophageal, Achalasia, Esophagitis
- Trial name
- NCT05326113
- Testing
- Physiotherapy, Control group
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Achalasia
Endolumenal Partial Myotomy for the Treatment of Esophageal Achalasia
Achalasia is a primary esophageal motility disorder where the lower esophageal sphincter fails to relax in response to swallowing with no well understood underlying cause.
- Trial name
- NCT01302288
- Testing
- Per oral endolumenal myotomy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Oregon Clinic
Achalasia
Endoscopic Versus Laparoscopic Myotomy for Treatment of Idiopathic Achalasia
Achalasia is a rare neurodegenerative esophageal motility disorder characterized by incomplete lower esophageal sphincter (LES) relaxation, increased LES tone, and aperistalsis of the esophagus leading to dysphagia…
- Trial name
- POEMrct (NCT01601678)
- Testing
- Peroral Endoscopic Myotomy (POEM), Laparoscopic Heller Myotomy (LHM)
- Where
- 8 sites in Belgium, Czechia and 4 more
- Volunteers
- 240 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Achalasia
Anterior Orientation vs Posterior Orientation in Per Oral Endoscopic Myotomy POEM for the Treatment of Achalasia
The purpose of this study is to compare the safety and efficacy of the anterior versus posterior myotomy technique in Per Oral Endoscopic Myotomy (POEM) for the treatment of Achalasia.
- Trial name
- NCT03228758
- Testing
- Per Oral Endoscopic Myotomy
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- NYU Langone Health
Achalasia
Achalasia: Mechanisms Underlying Treatment Failure
In patients with achalasia, the relationship between the perception of dysphagia, oesophageal emptying, lower oesophageal sphincter (LOS) distensibility and oesophageal circular and longitudinal muscle contraction is not clear.
- Trial name
- NCT02055469
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Achalasia Cardia, Esophageal Cancer (EsC)
INCIDENCE, PREVALENCE AND OVERALL RISK OF ESOPHAGEAL CANCER IN ACHALASIA: A PROPENSITY-MATCHED POPULATION-BASED STUDY FROM A LARGE MULTICENTER DATABASE
Esophageal Achalasia has been investigated as a potential risk factor for esophageal cancer (EC). Longstanding disease, repeated treatment, age and male sex seem the most relevant risk factors, but no clear effect size estimation…
- Trial name
- RECAP (NCT07022886)
- Testing
- achalasia treatments
- Where
- Italy
- Volunteers
- 47,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele