Clinical trials: Achalasia, open to volunteers
Esophageal Achalasia
Per Oral Endoscopic Myotomy (POEM) and Prolonged Dilatation (PRD) for Achalasia
Achalasia is an esophageal motility disorder, which leads to clinical symptoms such as dysphagia, regurgitation, chest pain and consecutive weight loss.
- Trial name
- POETA (NCT02518542)
- Testing
- Endoscopic intervention A, Endoscopic intervention B, Endoscopic intervention C
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Medical University of Vienna
Esophageal Achalasia, Esophageal Motility Disorders
POEM Versus Laparoscopic Heller Myotomy With Dor Fundoplication for Esophageal Achalasia
Achalasia is a disorder of the esophagus in which the muscular valve between the esophagus and the stomach fails to relax, and the body of the esophagus loses its normal coordinated squeezing movement.
- Conditions
- Esophageal Achalasia, Esophageal Motility Disorders, Gastroesophageal Reflux
- Trial name
- POEM-HD (NCT07814027)
- Testing
- Peroral endoscopic myotomy, Laparoscopic Heller myotomy with Dor fundoplication
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Minia University
Dysphagia, Achalasia, Esophageal
Evolution of the Chicago Classification: Bridging Physiology and Mechanics
Swallowing difficulties are extremely common and result in substantial morbidity, reduction in the quality of life, and mortality related to malnutrition and complications from regurgitation and aspiration.
- Conditions
- Dysphagia, Achalasia, Esophageal, Ineffective Esophageal Motility
- Trial name
- NCT06883175
- Testing
- FLIP, HRM, Prucalopride
- Where
- United States
- Volunteers
- 575 people
- Sponsor
- Northwestern University
Achalasia, Esophageal, Achalasia
The Use of Indocyanine Green Fluorescence (ICG) During Laparoscopic Heller- Dor
The aim this prospective observational study is to evaluate the role of Indocyanine Green Fluorescence (ICG) in patients with achalasia underwent to Heller-Dor laparoscopic.
- Conditions
- Achalasia, Esophageal, Achalasia, Indocyanine Green (ICG), Indocyanine Green
- Trial name
- NCT07181070
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Federico II University
Esophageal Motility Disorders, Achalasia
Clinical Outcomes, Safety, and Effectiveness of Speedboat UltraSlim™ in Per-Oral Endoscopic Myotomy (POEM)
This study is a prospective registry designed to evaluate the clinical outcomes, safety, and effectiveness of per-oral endoscopic myotomy (POEM) performed using the Speedboat UltraSlim™ device in patients with achalasia or other…
- Trial name
- SU-POEM (NCT07496840)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor College of Medicine
Esophageal Cancer, Gastroesophageal Reflux Disease (GERD)
Esophageal Cancer Risk Registry
The purpose of this study is to identify markers in the blood and tissue that could indicate risk factors for the development and progression of esophagus cancer.
- Conditions
- Esophageal Cancer, Gastroesophageal Reflux Disease (GERD), Esophageal Diseases, Hiatal Hernia
- Trial name
- NCT00260585
- Testing
- Survey of client health, personal habits, family history, Blood specimen for non-DNA and DNA parts, Biopsy of esophageal/stomach tissue, lymph nodes, tumor
- Where
- United States
- Volunteers
- 7,000 people
- Sponsor
- University of Pittsburgh
Achalasia
POEM-F for Achalasia International Study
Per-oral endoscopic myotomy (POEM) has emerged as the endoscopic treatment of choice for achalasia, offering comparable symptom relief with laparoscopic Heller's cardiomyotomy.
- Trial name
- NCT06042127
- Testing
- POEM-F, Conventional POEM
- Where
- 7 sites in United States, China and 2 more
- Volunteers
- 81 people
- Sponsor
- Chinese University of Hong Kong
Esophageal Achalasia
Routine Versus Symptomatic Protein Pump Inhibitor Therapy for Prevention of Gastroesophageal Reflux After Per Oral Endoscopic Myotomy for Esophageal Achalasia
Per Oral Endoscopic Myotomy (POEM) is a treatment of choice for achalasia with an excellent safety and efficacy profile. There is a high rate of esophagitis related to gastroesophageal reflux following this procedure.
- Trial name
- IPPOEM (NCT05899842)
- Testing
- Protein pump inhibitor therapy systematically
- Where
- 4 sites in France
- Volunteers
- 132 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Esophageal Achalasia, Spastic Esophageal Motility Disorders
Transverse vs Longitudinal Mucosal Incision During POEM
Peroral endoscopic myotomy (POEM) is a minimally invasive endoscopic procedure used to treat achalasia and other spastic esophageal motility disorders.
- Trial name
- NCT07425977
- Testing
- Transverse Mucosal Incision During POEM, Longitudinal Mucosal Incision During POEM
- Where
- Colombia
- Volunteers
- 140 people
- Sponsor
- Universidad Nacional de Colombia
Achalasia, Esophageal Spasm, Diffuse
Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Disorders
This is prospective data recording study. All patients will receive standard medical care and no experimental interventions will be performed.
- Conditions
- Achalasia, Esophageal Spasm, Diffuse, Gastroparesis, Swallowing Disorder
- Trial name
- POEM (NCT05905016)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- AdventHealth
Esophageal Achalasia
Effects of Malnutrition on Respiratory and Renal Functions in Patients Undergoing Peroral Endoscopic Myotomy (POEM)
The hypothesis of this study is to investigate cardiorespiratory and renal complications in patients under general anesthesia undergoing POEM surgery.
- Trial name
- NCT06405412
- Testing
- MUST malnutrition score
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Umraniye Education and Research Hospital
Achalasia Cardia, Achalasia
Full-thickness Versus Progressive Myotomy in Peroral Endoscopic Esophageal Myotomy in Achalasia: A Randomized Controlled Trial
Peroral endoscopic esophageal myotomy (POEM) has been established as an effective therapy for Achalasia. It is still not known how deep the myotomy should be and if it should include the circular and longitudinal muscles or not.
- Trial name
- NCT07875686
- Testing
- Full thickness myotomy, Progressive thickness myotomy
- Where
- 2 sites in Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Achalasia
VZV in the Enteric Nervous System: Pathogenesis and Consequences
Varicella zoster virus (VZV) is the cause of chickenpox and shingles, but it also infects, becomes latent, and reactivates in nerve cells of the bowel to cause a gastrointestinal disorder ("enteric shingles").
- Trial name
- NCT05550194
- Testing
- ValACYclovir 1000 MG, Shingrix
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Achalasia, Esophageal, GERD (Gastroesophageal Reflux Disease)
Sling-Fiber Preservation POEM vs. Conventional POEM for Reducing Post-POEM GERD
Peroral endoscopic myotomy (POEM) is an effective, minimally invasive treatment for achalasia, offering excellent rates of symptom relief.
- Trial name
- SFP-POEM (NCT07178821)
- Testing
- Conventional POEM, Sling Fiber-Preserving POEM
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Irvine
Achalasia Cardia
Comparison of Balloon Dilatation and Per Oral Endoscopic Myotomy in Children With Achalasia Cardia
To compare the efficacy of balloon dilatation (BD) and per oral endoscopic myotomy (POEM) in improving the symptoms of children with achalasia in short and long term Presently most guidelines such as American Society for…
- Trial name
- NCT07167355
- Testing
- POEM, BALLOON DILATATION
- Volunteers
- 70 people
- Sponsor
- Asian Institute of Gastroenterology, India
Dysphagia, Esophageal Stricture
Impact of Body Positioning on EndoFLIP Measurements: A Comparative Study of Supine and Left Lateral Decubitus Positions
This is a prospective, single-center, crossover study comparing EndoFLIP measurements obtained in two patient positions, supine and left lateral decubitus, in pediatric and young adult patients.
- Conditions
- Dysphagia, Esophageal Stricture, Epidermolysis Bullosa (EB), Achalasia
- Trial name
- NCT07780981
- Testing
- EndoFlip
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Johns Hopkins University
Achalasia, Esophageal, Esophagogastric Junction Outflow Obstruction
The Impact of Anesthetics on FLIP
To understand the impact of commonly used anesthetics on esophageal motility during FLIP topography.
- Conditions
- Achalasia, Esophageal, Esophagogastric Junction Outflow Obstruction, Spastic Esophageal Disorders
- Trial name
- NCT07458555
- Testing
- FLIP Imaging under various standard of care anesthetics in the context of endotracheal intubation.
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor Research Institute
Esophageal Cancer Surgery, Esophagectomy
Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. Pyloromyotomy
The goal of this pragmatic, registry-based, randomized clinical trial is to find out if using botulinum toxin (Botox) to help drain the stomach during an esophagectomy works as well as a pyloromyotomy in patients undergoing…
- Conditions
- Esophageal Cancer Surgery, Esophagectomy, Delayed Gastric Emptying Following Procedure, Esophageal Diseases
- Trial name
- EMPTY (NCT06721520)
- Testing
- Botulinum Toxin A (Botox ), Pyloromyotomy
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- The Cleveland Clinic
Achalasia
Per-Oral Endoscopic Myotomy (POEM) for the Treatment of Achalasia, Database Repository
POEM (Per-Oral endoscopic myotomy (creating a muscle [esophagus] opening), an incision-less (no cutting of the surface of the body) endoscopic procedure, is an effective non-surgical alternative to release the muscle \& sphincter…
- Trial name
- POEM (NCT02770859)
- Testing
- POEM (Per Oral Endoscopic Myotomy)
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Indiana University
Esophageal Achalasia, Transcranial Magnetic Stimulation, Repetitive
Randomized Controlled Study of Optical 3D Navigated Repetitive Transcranial Magnetic Stimulation for Achalasia.
The goal of this clinical trial is to investigate the clinical efficacy of repetitive transcranial magnetic stimulation in the treatment of achalasia in patients diagnosed with achalasia by comprehensive evaluation of clinical…
- Conditions
- Esophageal Achalasia, Transcranial Magnetic Stimulation, Repetitive, Vagus Nerve Motor Disorder, Functional Magnetic Resonance Imaging
- Trial name
- NCT06027190
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Zhang Nina