Clinical trials: Acid Base Disorder
Mild Pre-eclampsia, Severe Pre-eclampsia
Evaluation of Metabolic Acid-base Abnormalities in Pre-eclamptic Women Applying the Stewart-Fencl Approach
Acid/base imbalances are not well understood in pre-eclamptics, and better tools are needed to allow a thorough and meaningful evaluation.
- Trial name
- NCT02164370
- Where
- 2 sites in United States, South Africa
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Washington
Urinary Tract Infections, Proteinuria
Scanadu Urine Device Validation Study Protocol
This study will test Scanadu Urine Device for clinical performance and usability.
- Conditions
- Urinary Tract Infections, Proteinuria, Ketone Urine, Hematuria
- Trial name
- NCT02973178
- Testing
- Scanadu Urine Device
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Scanadu, Inc.
COVID-19 Vaccines
A Study to Learn About a COVID-19 Vaccine in Healthy Adults 18 Through 64 Years of Age
The purpose of this study is to learn about the safety and effects of an updated COVID-19 vaccine (called BNT162b2) in adults 18 to 64 years of age.
- Trial name
- NCT07730450
- Testing
- BNT162b2 Vaccine, Tdap Vaccine
- Where
- 5 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Ketosis, Diabetic
Exogenous Ketones in People With Type 1 Diabetes
The aim of this pilot study is to investigate the metabolic effects of exogenous ketone ester food supplements, by assessing the change in blood acid-base balance, and the level of blood beta-hydroxy-butyrate in people with type…
- Trial name
- NCT04487678
- Testing
- Ketone ester supplement
- Volunteers
- healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Ketonemia, Ketosis
Exogenous Ketone Supplementation and Exercise Performance
20 healthy recreationally active men and woman aged 18-35 will participate in the study. There will be three treatments involved: Caffeinated ketone supplements, non-caffeinated ketone supplement and water-placebo.
- Trial name
- NCT03895892
- Testing
- 20 km time trial, Wingate test, Ketone/Caffeine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Healthy Volunteers and Diabetes Participants
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 Diabetes
This is a Phase 1/2 randomized study of oral doses of PAL-119 in healthy volunteers and participants with diabetes.
- Trial name
- NCT07901595
- Testing
- PAL-119
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Paulex Bio Inc.
Metabolic Acidosis, Neonatal Disease
Prevention of Metabolic Acidosis in Preterm Neonates by Replacing Sodium Chloride With Sodium Acetate in Parenteral Nutrition
The goal of this clinical trial is to learn if the addition of sodium acetate in neonatal PN works to prevent and treat metabolic acidosis and associated comorbidities in preterm neonates.
- Conditions
- Metabolic Acidosis, Neonatal Disease, Neonatal Complication
- Trial name
- PROTECT (NCT06545565)
- Testing
- sodium acetate group will receive sodium acetate in the neonatal PN., sodium chloride group will receive sodium chloride in the neonatal PN.
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aga Khan University Hospital, Pakistan
Alcohol Use Disorder, Alcohol Withdrawal
Does a Ketogenic Dietary Supplement Reduce Alcohol Withdrawal Symptoms in Humans?
A ketogenic diet (KD) is high in fat and low in carbohydrates and induces ketosis. KD is an approved non-pharmacological therapy for drug-resistant child epilepsy.
- Conditions
- Alcohol Use Disorder, Alcohol Withdrawal, Ketosis
- Trial name
- KME (NCT03878225)
- Testing
- H.V.M.N. Ketone Ester
- Where
- 2 sites in Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Ketosis, Exercise Performance
Ketone Supplementation and Exercise Performance
The purpose of this study is to observe the effects of exogenous ketone supplements during shorter bouts of exercise testing on twenty collegiate endurance trained athletes (18-25 years of age).
- Conditions
- Ketosis, Exercise Performance, Ketoses, Metabolic
- Trial name
- NCT03954665
- Testing
- 10 km time trial, 30s Wingate, Ketone
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Bacterial Vaginosis
BASIC (Boric Acid, Alternate Solution for Intravaginal Colonization) Study
Bacterial vaginosis (BV), the world's most common vaginal infection, continues to cost patients time, energy, comfort and money.
- Trial name
- NCT00799214
- Testing
- Boric acid, Metronidazole
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Ketosis, Hypoxia
Effect of Ketone Ester Supplementation on Sleep and Recovery in Hypoxia
This study specifically aims to elucidate the effects of IEK on sleep and recuperation in hypoxia, after training in normoxia. These conditions are in line with the widely applied live-high train-low strategy.
- Conditions
- Ketosis, Hypoxia, Sleep
- Trial name
- NCT06060093
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Hypochlorhydria
Assessment of Gastric pH Changes Induced by Ascorbic Acid Tablets
This study evaluates the use of ascorbic acid, vitamin C, to temporary reduce gastric pH in individuals with omeprazole induced hypochlorhydria.
- Trial name
- NCT04199624
- Testing
- Omeprazole 20mg, Vitamin C
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy Adults
Comparing the Ketogenic Effect of Coconut Oil and Different MCTs
The aim of this study is to compare the ketogenic effect of coconut oil and three MCT oils (60-40 , tricaprylin and triheptanoate) on the production of ketones in healthy adults.
- Trial name
- MCT-Coco (NCT02679222)
- Testing
- Coconut oil, Coconut oil + MCT, MCT
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Ketosis, Glucose Metabolism
Ketone Supplements and Substrate Oxidation and Physical Performance
The objective of this randomized crossover study is to examine the influence of consuming a ketone ester plus carbohydrate (KE+CHO) supplement on substrate oxidation and physical performance in 15 healthy adults.
- Trial name
- NCT04737694
- Testing
- Ketone ester, Glucose
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Diabetes, Diabetic Ketoacidosis
Evaluation of a Non-invasive Brain Compliance Measurement Device
This is a research study to understand how diabetic ketoacidosis may affect the brain and learning and to see if these changes are transient or permanent.
- Trial name
- NCT01753921
- Testing
- this is not an intervention study, MRI
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Stanford University
Hypertensive Disease
Retention of Potassium From Potatoes and Potassium Gluconate, and the Effect on Blood Pressure.
This study is designed to compare the effect of different dietary potassium sources on uptake and retention of potassium, as well as to determine the effect of potassium intake on blood pressure and acid-base balance.
- Trial name
- NCT02697708
- Testing
- Potassium control diet, Potassium gluconate diet, Potato Diet
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Purdue University
COVID-19 Vaccines
A Study of COVID-19 Vaccine(s) in Children and Adults
The purpose of this study is to learn about the safety and effects of updated COVID-19 vaccines (called BNT162b2) in participants 5 Through 64 Years of Age with risk factors for Severe COVID-19, and Participants 65 Years of Age…
- Trial name
- NCT07798648
- Testing
- BNT162b2
- Where
- 14 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Exercise, Ketosis
The Effects of Acute Ketone Monoester Supplementation on Exercise Efficiency and the Influence of Dose and Intensity
Diet can alter blood ketone levels and this in turn may affect exercise capacity. This study will determine if the acute ingestion of a ketone supplement alters cycling exercise efficiency.
- Trial name
- NCT05665855
- Testing
- Ketone monoester
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- McMaster University
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Clinical Stabilization of Hypercapnia: NIPPV v HVNI
This study will evaluate the ability of High Velocity Nasal Insufflation [HVNI] to effect ventilation and related physiologic responses in hypercapnic patients when compared to noninvasive positive pressure ventilation [NIPPV].
- Conditions
- Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Dyspnea, Hypercapnic Acidosis
- Trial name
- HYPERACT (NCT04709562)
- Testing
- High Velocity Nasal Insufflation (HVNI), Noninvasive Positive Pressure Ventilation (NIPPV)
- Where
- 7 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Vapotherm, Inc.
Periodontitis
Hyaluronic Acid for Residual Periodontal Pockets Adjunctive Treatment
Objective: To evaluate the adjunctive effect of hyaluronic acid (HA) gel in the treatment of residual periodontal pockets over a 12-month period.
- Trial name
- NCT04702334
- Testing
- Hyaluronic Acid, Lidocain
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza