Clinical trials: Acid Base Disorder
Overweight, Mood
Effects of a Ketogenic Diet on Psychological Outcomes
The aim of the study is to investigate how glycemia and ketonemia variations during three different diet protocols: a ketogenic diet without any restriction on calories intake (KD), a calorie-restricted ketogenic-mediterranean…
- Conditions
- Overweight, Mood, Appetitive Behavior
- Trial name
- NCT04086498
- Testing
- Mediterranean diet, KEMEPHY, KD
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Padova
Diabetic Ketoacidosis, Postoperative Care
Postoperative Euglycemic Ketoacidosis Frequency in Sodium-Glucose Cotransporter-2 Inhibitor Users
The goal of this observational study is to determine the frequency of postoperative euglycemic diabetic ketoacidosis (EDKA) in patients receiving Sodium- Glucose Cotransporter-2 (SGLT-2) inhibitors.
- Trial name
- SGLT-2I (NCT07127406)
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Kocaeli City Hospital
Ketonemia, Exercise Performance
Ketone Supplementation, Glycogen Replenishment and Time Trial Performance Following Glycogen Lowering Exercise
20 healthy trained males will volunteer to participate in this study. there will be 2 treatments: Carbohydrate- ketone supplementation and carbohydrate alone.
- Conditions
- Ketonemia, Exercise Performance, Ketosis
- Trial name
- NCT04004676
- Testing
- 20 km time trial performance, Glycogen lowering exercise
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Mitochondrial Disorders, Mitochondrial Genetic Disorders
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
The North American Mitochondrial Disease Consortium (NAMDC) maintains a patient contact registry and tissue biorepository for patients with mitochondrial disorders.
- Conditions
- Mitochondrial Disorders, Mitochondrial Genetic Disorders, Mitochondrial Diseases, Disorder of Mitochondrial Respiratory Chain Complexes
- Trial name
- NAMDC (NCT01694940)
- Where
- 17 sites in United States, Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Diabetic Ketoacidosis, Type 1 Diabetes Mellitus
Early Glargine (Lantus) in DKA Management in Children With Type 1 Diabetes
A frequent complication in the management of diabetic ketoacidosis (DKA) in children with type 1 diabetes is rebound hyperglycemia (blood glucose over 180 mg/dL) which increases the risk of re-developing DKA and can lengthen the…
- Trial name
- NCT03107208
- Testing
- Glargine, Continuous Glucose Monitor (Abbott FreeStyle Libre Pro)
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Ketosis, Metabolic, Immune Functions
The Effect of Acute Exogenous Oral Ketone Supplementation on Immune Cells Function and Immune Cells Histone Β-hydroxybutyrylation
To conduct a single-arm pilot study to determine how acute ingestion of an exogenous ketone monoester supplement alters the histone lysine β-hydroxybutyrylation and immune function in healthy human monocytes and lymphocytes.
- Conditions
- Ketosis, Metabolic, Immune Functions, Histone Deacetylase (HDAC) Activity
- Trial name
- Acute_Ketone (NCT06590623)
- Testing
- Ketone Monoester (KE)
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Post-exercise Period, Ketosis
Acute Effects of Ketone Monoester Co-ingestion With Dietary Protein on Whole-body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Young Males.
The goal of this trial is to determine if ketone monoester supplementation in conjunction with protein supplementation in the post exercise period can augment whole-body protein metabolism following resistance exercise in young…
- Conditions
- Post-exercise Period, Ketosis, Resistance Exercise, Dietary Protein
- Trial name
- (KET-YOUNG-M) (NCT07884539)
- Testing
- Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- McGill University
Folate Deficiency, Iodine Deficiency
Acceptability and Nutritional Impact of Double-fortified Salt Containing Iodine and Folic Acid
The overarching objective of this two-phase project is to assess the effects of fortifying iodized salt with folic acid on improving women's folate status.
- Conditions
- Folate Deficiency, Iodine Deficiency, Anemia Macrocytic, Anemia Deficiency
- Trial name
- DFS-IoFA-2 (NCT06223854)
- Testing
- Iodized salt, Experimental: Iodized salt with lower-dose folic acid fortification, Experimental: Iodized salt with higher-dose folic acid fortification
- Where
- Ethiopia
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Lysosomal Acid Lipase Deficiency, Obesity
Metabolic Effects of Very Low Carbohydrate Ketogenic Diet in Subjects With Severe Obesity
The very low carbohydrates diet (VLCKD) induces liver steatosis amelioration. Lysosomal acid lipase (LAL) deficiency plays a role in fats accumulation in liver. To date, no studies have assessed LAL activity in morbid obesity.
- Conditions
- Lysosomal Acid Lipase Deficiency, Obesity, Ketogenic Dieting, Ketosis
- Trial name
- NCT03564002
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Pulmonary Disease, Chronic Obstructive
A 5-Period, Single Dose, Phase 1 Study in Healthy Elderly Subjects to Assess Relative Bioavailability and Food Effect of Two Oral Formulations of GSK1325756 (Free Base vs HBr Salt) and Food Effect on the HBr Formulation When Given With Omeprazole
The current study will help to increase our understanding of the pharmacokinetics (PK) of danirixin. The primary objective of the study is to estimate the relative bioavailability of danirixin Hydrobromide (HBr) tablet, when…
- Trial name
- NCT02453022
- Testing
- Danirixin HBr 50 mg IR Tablet, Danirixin FB 50 mg IR Tablet, Prilosec (omeprazole) 40mg Delayed-Release capsule
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Alkalosis
Chronic Versus Acute Dosing of Sodium Citrate for Swimming 200m
Ingestion of sodium citrate (Na-Cit), an alkalizing agent, increases extracellular pH via liver oxidation by decreasing [H+] and increasing bicarbonate concentration (HCO3-).
- Trial name
- NCT01835912
- Testing
- Sodium Citrate Dihydrate
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Brock University
Obesity, Inflammatory Markers
Time-Restricted Feeding
We propose to conduct a randomized 6-day isocaloric crossover feeding study in humans with prediabetes and obesity. We will study the effect of restricting the timing of caloric intake to earlier in the day (TRF) versus later in…
- Conditions
- Obesity, Inflammatory Markers, Glycemic Variation, Time Restricted Feeding
- Trial name
- TRIO (NCT04884659)
- Testing
- Time restricted feeding arm, usual feeding pattern arm
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Diet, Healthy, Health
Medium Chain Fatty Acids and Ketones
16 participants were randomized to complete two seven-day intervention periods with twice-daily consumption of Medium-chain fatty acids (MCT) or long-chain fatty acids (LCT) oil.
- Trial name
- MCFA (NCT06289296)
- Testing
- Fatty acid intake in lean and obese males
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Stunting
Food-based Approach Development to Fulfil Amino Acid Gap by Considering the Intestinal Permeability of Children
This study will be comprised of 2 phases. Phase 1 study is a comparative cross-sectional study which will be conducted among children aged 12-24 months living in agricultural area.
- Trial name
- NCT04157413
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Nia Novita Wirawan
Scalp Dermatitis, Dermatitis
Effects on the Scalp Microbiota of a 1% Selenium Disulfide and 1% Salicylic Acid Shampoo After 2% Ketaconazole Foaming Gel Treatment for Scalp Seborrheic Dermatitis
The aim of this study was to investigate the changes in the scalp bacterial and fungal microbiota in subjects afflicted with a scalp seborrheic dermatitis (SSD) during a 2% ketoconazole-based treatment followed by a maintenance…
- Trial name
- NCT04057950
- Testing
- cosmetic product
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- L'Oreal
Exercise, Healthy Male/Female Subjects
Ketone Administration During Inactivity and Retraining
The aim of this study is to investigate the effect of oral ketone administration during inactivity-induced muscle atrophy and retraining-induced regeneration.
- Trial name
- NCT05398042
- Testing
- Ketone ester, Medium Chain Triglyceride (MCT) oil
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Protein Malabsorption, Nutritional Deficiency
Bioavailability of Proteins From Plant Based Diets
Proteins play an important role as structural and functional components for the human body and prevent stunting. Protein quality has a great importance in meeting the nutritional needs of populations across the world throughout…
- Conditions
- Protein Malabsorption, Nutritional Deficiency, Nutritional Stunting
- Trial name
- NCT04866927
- Testing
- Use of stable isotopic dilution to assess protein digestibility from Faba bean and to evaluate amino acid bioavailability
- Where
- Morocco
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- International Atomic Energy Agency
Asthma
The Various Effects of Gaseous Albuterol on Serum Lactate
Empirical data from physician observation indicates an increase in serum lactate in acute asthmatic patients being treated with inhaled albuterol therapy.
- Trial name
- NCT02073747
- Testing
- Normal Saline, Albuterol
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Medical Center of Southern Nevada
Organic Acidemia, Methylmalonic Acidemia
Clinical and Laboratory Study of Methylmalonic Acidemia
Methylmalonic acidemia (MMA), one of the most common inborn errors of organic acid metabolism, is heterogeneous in etiology and clinical manifestations.
- Conditions
- Organic Acidemia, Methylmalonic Acidemia, Inborn Errors of Metabolism
- Trial name
- NCT00078078
- Where
- 3 sites in United States
- Volunteers
- 2,275 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Appetite, Obesity
Exogenous Ketones and Appetite
People with obesity have different appetitive responses to stimuli compared to people without obesity. For example, people with obesity have a blunted postprandial ghrelin ('hunger' hormone) response, lower glucagon-like peptide…
- Conditions
- Appetite, Obesity, Ketones, Appetitive Behavior
- Trial name
- NCT06327464
- Testing
- Exogenous ketones
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of British Columbia