Clinical trials: Acid Base Disorder
Diabetic Ketoacidosis
Thiamine as Adjunctive Therapy for Diabetic Ketoacidosis
This is a randomized, double-blind, placebo-controlled trial to determine if administration of intravenous thiamine will lead to quicker resolution of acidosis in patients admitted to the hospital with diabetic ketoacidosis.
- Trial name
- NCT03717896
- Testing
- 200mg IV thiamine in 50mL 0.9% saline
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Beth Israel Deaconess Medical Center
Alcohol Use Disorder, Ketosis
Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder
This is a randomized, double-blind, crossover trial to evaluate the immediate effects of a nutritional ketone supplement, Kenotic compared to placebo on brain function and alcohol consumption in individuals with alcohol use…
- Trial name
- KABA (NCT06807918)
- Testing
- Kenetik, magnetic resonance imaging scan, Alcohol bar lab
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Pulmonary Disease, Chronic Obstructive, Obesity Hypoventilation Syndrome
Treatment of Metabolic Alkalosis With Acetazolamide. Effect on the Length of Mechanical Ventilation.
The purpose of this study is to analyze whether the treatment of metabolic alkalosis with acetazolamide in intubated patients with chronic obstructive pulmonary disease (COPD) or with obesity hypoventilation syndrome (OHS)…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Obesity Hypoventilation Syndrome, Metabolic Alkalosis
- Trial name
- TRAMA (NCT01499485)
- Testing
- Acetazolamide
- Where
- 8 sites in Spain
- Volunteers
- 140 people
- Sponsor
- Hospital Son Llatzer
End-stage Renal Disease
Arterial pH and Total Body Nitrogen Balances in APD
This study will test the hypothesis that by slightly lowering the acidity of blood (or increasing the pH), dialysis patients utilize protein and amino acids more efficiently.
- Trial name
- NCT00586131
- Testing
- ammonium chloride or sodium citrate/citric acid, Sodium citrate/citratic acid
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Asthma
The Various Effects of Gaseous Albuterol on Serum Lactate
Empirical data from physician observation indicates an increase in serum lactate in acute asthmatic patients being treated with inhaled albuterol therapy.
- Trial name
- NCT02073747
- Testing
- Normal Saline, Albuterol
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Medical Center of Southern Nevada
Acidosis, Renal Tubular
Extension Study in Primary Distal Renal Tubular Acidosis
Open-label study involving longitudinal assessment of the continued safety, tolerability, and efficacy of ADV7103 in maintaining targeted serum bicarbonate levels, preventing metabolic acidosis, and preventing hypokalemia in the…
- Trial name
- NCT03831152
- Testing
- ADV7103
- Where
- United States
- Sponsor
- Advicenne Pharma
Acute Stroke
Effects of a Ketogenic Diet on Acute Stroke
The purpose of this controlled, randomized intervention is to investigate whether a fat-based (ketogenic) diet given for a week has a positive effect on blood sugar, mortality and function in patients hospitalized with acute…
- Trial name
- NCT01997749
- Testing
- Ketocal 4:1 (Nutricia), Control diet: Regular diet offered at the hospitals, Ketogenic meals
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- University of Copenhagen
Diabetes Mellitus Type I, Ketoacidosis
Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection.
Diabetes mellitus type I (DM I) is characterized by lack of endogenous insulin and these patients are 100% dependent on insulin substitution to survive.
- Trial name
- NCT02077348
- Testing
- Insulin withdrawal, Norditropin
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- University of Aarhus
Chronic Periodontitis
New Periodontitis Treatment Based on Hyaluronic Acid and Melatonin
The aim of the present study is to determine whether the association of Melatonin and Hyaluronic Acid to the antimicrobial TM paste (3% Tetracyclin and 3% Metronidazole) for periodontal maintenance therapy can improve the…
- Trial name
- HAMELDENT (NCT03656484)
- Testing
- Tetracycline-Metronidazole (TM) group, TM-Melatonin-Hyaluronic acid (TM-MHa) group
- Where
- 2 sites in Romania
- Volunteers
- 50 people
- Sponsor
- Concordia Dent Srl
Organic Acidemia, Methylmalonic Acidemia
Clinical and Laboratory Study of Methylmalonic Acidemia
Methylmalonic acidemia (MMA), one of the most common inborn errors of organic acid metabolism, is heterogeneous in etiology and clinical manifestations.
- Conditions
- Organic Acidemia, Methylmalonic Acidemia, Inborn Errors of Metabolism
- Trial name
- NCT00078078
- Where
- 3 sites in United States
- Volunteers
- 2,275 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Cow's Milk Allergy
Study to Assess Hypoallergenicity of a New Amino-acid Based Infant Formula in Children With Cow's Milk Allergy
This is a prospective, controlled, multi-country study to verifying the hypoallergenicity of the new amino acid-based formula in infants and children aged< 12 years with documented cow's milk protein allergy (CMPA).
- Trial name
- RAF (NCT02414243)
- Testing
- New Amino Acid formula, Commercially available Amino Acid Formula
- Where
- Italy
- Volunteers
- 41 people
- Sponsor
- Laboratorios Ordesa
Renal Insufficiency, Chronic
Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study
To validate on the mid-term in moderate and severe renal failure (CKD 3-4) a nomogram to adapt a fixed metformin daily posology according to renal function on the basis of the first short-term study made by the investigators.
- Trial name
- METsuiviIRC (NCT02848508)
- Testing
- Metformin
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Appetite, Obesity
Exogenous Ketones and Appetite
People with obesity have different appetitive responses to stimuli compared to people without obesity. For example, people with obesity have a blunted postprandial ghrelin ('hunger' hormone) response, lower glucagon-like peptide…
- Conditions
- Appetite, Obesity, Ketones, Appetitive Behavior
- Trial name
- NCT06327464
- Testing
- Exogenous ketones
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Diabetic Ketoacidosis
Double Blinded Randomized Control Trial of Types of IVF in Children With DKA
Objectives: Intravenous (IV) fluid administration is a fundamental component of diabetic ketoacidosis (DKA) treatment. Normal saline (NS), the most common IV fluid used in DKA management, contains more chloride than human blood.
- Trial name
- NCT03066440
- Testing
- Normal saline, Lactated Ringers
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- State University of New York at Buffalo
Fatigue, Depression
Adaptive Symptom Care Using Fish-Based Nutritional Directives Post Breast Cancer
Inflammation has been consistently associated with psychoneurological symptoms (PNS) among breast cancer survivors (BCS). Evidence supporting interventional strategies promoting symptom-self management in reducing…
- Conditions
- Fatigue, Depression, Pain, Sleep Disturbance
- Trial name
- NCT04293874
- Testing
- Personalized Meal Plan, Dietary Omega-3LC intervention
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Connecticut
Breast Neoplasm, Metastasis
Monotherapy With Eribulin In Her2 Negative Metastatic Breast Cancer as a First Line Treatment
Multicentre, prospective, non-controlled phase II clinical trial to evaluate the efficacy and tolerability of first line single agent Eribulin in patients with HER2-negative metastatic breast carcinoma (MBC) previously exposed to…
- Trial name
- MERIBEL (NCT02061085)
- Testing
- Eribulin
- Where
- 11 sites in Spain
- Volunteers
- 53 people
- Sponsor
- MedSIR
Ketosis, Epilepsy
Market Research - Acceptability Study for a Range of MCT Products
This is a market research, observational study to evaluate the tolerability and acceptability of MCT supplements for young children and young people with intractable epilepsy, GLUT-1 or PDHD from 3 years to adulthood.
- Conditions
- Ketosis, Epilepsy, Ketogenic Diet, Fatty Acid Oxidation Disorder
- Trial name
- NCT04309149
- Testing
- MCT fats
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people
- Sponsor
- Dr. Schär AG / SPA
Cardiac Arrest (CA), Cardiogenic Shock
Evaluation of Acid-base Disorders and Ventilation Settings in Cardiogenic Shock and Post-cardiac Arrest Patients: Comparison With VentilO Algorithm
This study aims to better understand how mechanical ventilation settings affect patients admitted to the coronary care unit after cardiac arrest or with cardiogenic shock.
- Conditions
- Cardiac Arrest (CA), Cardiogenic Shock, Mechanical Ventilation, Acid Base Disorder
- Trial name
- VentilO CU (NCT07484828)
- Testing
- Initiation of mechanical ventilation
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Laval University
Phenylketonuria, Tyrosinemia
GMP Powdered Substitutes in PKU and TYR
Four new GMP-based protein substitutes have been developed to support the dietary management of PKU and TYR. These products are powdered protein substitutes, low in phenylalanine and low in phenylalanine and tyrosine…
- Trial name
- NCT06941532
- Testing
- GMP Intervention Product
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Nutricia UK Ltd
Febrile Seizure
Carbon Dioxide (Carbogen) for the Treatment of Febrile Seizures
The aim of this clinical trail is to evaluate the efficacy of a Carbogen inhalation in patients with febrile seizures compared to a placebo-inhalation.
- Trial name
- CARDIF (NCT01370044)
- Testing
- Carbogen
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- Charite University, Berlin, Germany