Clinical trials: Acid Base Disorder
Metformin Associated Lactic Acidosis
Study of Metformin Overdose
The objective of the METINFO study is an observational single-center retrospective and descriptive study. The main objective is to estimate the real mortality rate associated to a Metformin overdose.
- Trial name
- METINFO (NCT04762966)
- Testing
- Metformin
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Morbid Obesity, Bariatric Surgery Candidate
Preoperative Condition in Giant Obese Patients
The frequency of super-super obese who need immediate weight loss surgery is risen continuously. For those patients a prior-to-surgery conditioning therapy is mandatory to gain technical and physical operability.
- Trial name
- NCT02616003
- Testing
- Liraglutide, Aminosteril hepa 8%, Caloric diet with 1000 kcal
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Sana Klinikum Offenbach
Otits Media With Effusion
Omega-3-Based Nutraceutical Supplementation as Adjunctive Therapy in Adults With Otitis Media With Effusion: A Multicenter, Double-Blind, Randomized Placebo-Controlled Trial
Brief Summary - OMENUTS Trial Otitis media with effusion (OME) is a condition in which fluid accumulates in the middle ear, causing conductive hearing loss, ear fullness, tinnitus, and Eustachian tube dysfunction.
- Trial name
- OMENUTS (NCT07721610)
- Testing
- Omega-3-based nutraceutical combination (Otoair Flogo), Bilastine 20 mg, Intranasal mometasone furoate spray
- Where
- Italy
- Volunteers
- 501 people
- Sponsor
- Isola Tiberina - Gemelli Isola Hospital, Rome, Italy
Gingival Recession
Effects of the Adjunctive Use of Hyaluronic Acid-based Gel With Coranally Advanced Flap in the Gingival Recession
The study aimed to evaluate the effect of Hyaluronic Acid-based gel use in addition to the coronally advanced flap (CAF) technique in type 1 gingival recession (RT1) on postoperative morbidity, clinical parameters, and patient…
- Trial name
- NCT07437885
- Testing
- Hyaluronic acid, Steril saline solution
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ordu University
Fetal Distress, Stillbirth
Introducing Fetal Scalp Stimulation as an Adjunct to Intermittent Auscultation in Low-Resource Settings.
This study is a pilot study taking place in Moshi, Tanzania at the Kilimanjaro Christian Medical Centre (KCMC). The study aims to introduce fetal scalp stimulation into the intermittent auscultation protocols at KCMC, and to…
- Conditions
- Fetal Distress, Stillbirth, Birth Asphyxia, Acidosis
- Trial name
- NCT02862925
- Testing
- Fetal Scalp Stimulation
- Where
- Tanzania
- Volunteers
- 550 people
- Sponsor
- Duke University
Hyperventilation Syndrome, Hypocapnia
Comparison of Transcutaneous Vs End-tidal CO2 Pressure Measurements in Hyperventilation Syndrome Diagnosis
Hyper Ventilation Syndrome is a frequent disease affecting adults whose diagnosis is often belated or even unrecognized due to the lack of "gold standard" criteria.
- Conditions
- Hyperventilation Syndrome, Hypocapnia, Alkalosis, Respiratory, Hyperventilation
- Trial name
- TCvsPETCO2 (NCT03614806)
- Testing
- Simultaneous Transcutaneous and End-tidal CO2 measurements
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Rouen
Lung Disease, Hypoxemia
Inhaled Nitric Oxide in Neonates With Elevated A-a DO2 Gradients Not Requiring Mechanical Ventilation
The purpose of this pilot study is to evaluate whether administration of nitric oxide (NO)gas by oxygen hood at 20 ppm significantly increases PaO2, as compared to placebo gas (oxygen), within one hour of initiation and with no…
- Conditions
- Lung Disease, Hypoxemia, Respiratory Acidosis
- Trial name
- NCT00041548
- Testing
- nitric oxide for inhalation, Oxygen
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Mallinckrodt
Vaginal Disease
Clinical Trial Study To Evaluate The Performance And Safety Of Ainara®
This study evaluates treatment with the medical device Ainara® compared to a HA-based gel (Hyalogin) on the improvement of vaginal dryness
- Trial name
- NCT04245293
- Testing
- Ainara, HyaloGin
- Where
- Romania
- Volunteers
- 50 people
- Sponsor
- Italfarmaco
Ketosis, Ketonemia
Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity in Healthy Subjects
This is a randomized, placebo-controlled, double-blinded crossover design. Fifteen healthy subjects will be randomized to receive either ketone bodies (KE4) or placebo delivered by KetoneAid.
- Trial name
- KETO (NCT05980858)
- Testing
- Beta-hydroxybutyrate
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gødstrup Hospital
Diabetes Mellitus, Diabetic Ketoacidosis
Starvation in the Treatment of Diabetic Ketoacidosis
Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are common, but serious metabolic disorders are often encountered in intensive care.
- Trial name
- NCT06186245
- Testing
- Early feeding with an oral diet
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Low Tidal Volume Ventilation, Acute Respiratory Distress Syndrome
Pulmonary Vascular Effects of Respiratory Rate & Carbon Dioxide
The purpose of this protocol is to perform serial physiological measurements and blood testing on mechanically ventilated patients comparing conditions of eucapnia and hypercapnia in the same patient.
- Trial name
- NCT01927237
- Testing
- HLR, EHR
- Where
- United States
- Sponsor
- Beth Israel Deaconess Medical Center
Alzheimer's Disease
Tricaprilin in Mild to Moderate Alzheimer's Disease
The purpose of this study is to evaluate the safety, tolerability and effectiveness of tricaprilin administered once a day for ninety days in subjects with mild to moderate, probable Alzheimer's disease.
- Trial name
- NCT00142805
- Testing
- Tricaprilin
- Where
- 25 sites in United States
- Volunteers
- 152 people
- Sponsor
- Cerecin
Enamel Discoloration, Fluorosis, Dental
21% Hydrochloric Acid Based Versus 6.6 % Hydrochloric Based Micro Abrasive Kit in Management of Patients With Mild to Moderate Fluorosis
compare the clinical performance of different concentrations of hydrochloric acid based as micro abrasive kits in management of patients with mild to moderate fluorosis over 6month follow up .
- Trial name
- NCT06949878
- Testing
- Antivet, opalustre
- Volunteers
- 35 people
- Sponsor
- Cairo University
Diabetic Ketoacidosis, Postoperative Care
Postoperative Euglycemic Ketoacidosis Frequency in Sodium-Glucose Cotransporter-2 Inhibitor Users
The goal of this observational study is to determine the frequency of postoperative euglycemic diabetic ketoacidosis (EDKA) in patients receiving Sodium- Glucose Cotransporter-2 (SGLT-2) inhibitors.
- Trial name
- SGLT-2I (NCT07127406)
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Kocaeli City Hospital
Metabolic Acidosis, Neonatal Disease
Prevention of Metabolic Acidosis in Preterm Neonates by Replacing Sodium Chloride With Sodium Acetate in Parenteral Nutrition
The goal of this clinical trial is to learn if the addition of sodium acetate in neonatal PN works to prevent and treat metabolic acidosis and associated comorbidities in preterm neonates.
- Conditions
- Metabolic Acidosis, Neonatal Disease, Neonatal Complication
- Trial name
- PROTECT (NCT06545565)
- Testing
- sodium acetate group will receive sodium acetate in the neonatal PN., sodium chloride group will receive sodium chloride in the neonatal PN.
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aga Khan University Hospital, Pakistan
Atherosclerosis Cardiovascular Disease
Variability in Human Fatty Acids Profiles Based on Blood Fractions and Metabolic Conditions
Fatty acids play a crucial role in various metabolic pathways, with their proportions and distributions across different cells and tissues influenced by diet and metabolism.
- Trial name
- NCT06731400
- Testing
- EPA supplementation
- Volunteers
- 6 people
- Sponsor
- University of Sao Paulo
Ketosis, Exercise Performance
Ketone Supplementation and Exercise Performance
The purpose of this study is to observe the effects of exogenous ketone supplements during shorter bouts of exercise testing on twenty collegiate endurance trained athletes (18-25 years of age).
- Conditions
- Ketosis, Exercise Performance, Ketoses, Metabolic
- Trial name
- NCT03954665
- Testing
- 10 km time trial, 30s Wingate, Ketone
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Phenylketonurias
Evaluation of PKU Sphere
A prospective, open-label study of PKU Sphere in patients with PKU following a phenylalanine restricted therapeutic diet.
- Trial name
- NCT03419819
- Testing
- PKU Sphere
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Vitaflo International, Ltd
Muscle Wasting, Protein Intake
Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females
Because of these anabolic properties of ketone bodies and the fact that ketone bodies prevent muscle protein breakdown for gluconeogenesis during energetic stress, ketone bodies can be a promising strategy to prevent or treat…
- Conditions
- Muscle Wasting, Protein Intake, Ketosis, Caloric Restriction
- Trial name
- NCT04744142
- Testing
- Ketone supplementation, Increased protein intake
- Where
- Belgium
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Type 2 Diabetes Mellitus
Metformin Treatment, Renal Function and Lactic Acidosis
From a central registry at the National Board of Health and Welfare in Sweden collect all patients in the city of Malmö prescribed metformin during two years.
- Trial name
- NCT01358994
- Where
- Sweden
- Volunteers
- 4,500 people
- Sponsor
- Skane University Hospital