Clinical trials: Acquired Immune Deficiency Syndrome (AIDS)
HIV Infections
The Safety and Effectiveness of Interleukin-2 Plus Zidovudine in Patients With AIDS or AIDS Related Complex
To test the safety and tolerance of three different doses of recombinant human interleukin 2 (aldesleukin; IL-2), when it is given for five consecutive days to patients with AIDS or AIDS related complex (ARC), who have also…
- Trial name
- NCT00000986
- Testing
- Zidovudine, Aldesleukin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV, AIDS
Depression Amongst HIV Positive Patients in Lilongwe
Quantitative, validated tools of depression screening will be used to collect data to determine the prevalence of depression and its association with antiretroviral (ARV) adherence amongst HIV positive patients attending ART…
- Trial name
- NCT02646605
- Testing
- depression screening
- Where
- Malawi
- Volunteers
- 206 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV/AIDS, Young Adult
Intervention for Virologic Suppression in Youth
The goal of this randomized clinical trial is to test the effect of a technology-based intervention with an Adaptive Treatment Strategy (ATS) among youth living with HIV (YLWH) (18-29 years old).
- Conditions
- HIV/AIDS, Young Adult, Mobile Health, Mental Health Issue
- Trial name
- iVY (NCT05877729)
- Testing
- Standard of Care, Video-counseling+app
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Francisco
Hiv, Adolescent Behavior
A Pragmatic Trial of An Adaptive eHealth HIV Prevention Program for Diverse Adolescent MSM
This pragmatic trial of an HIV prevention program focuses on HIV risk-reduction in men who have sex with men (MSM) ages 13-18. The design is a three-tiered, internet-based HIV prevention intervention series that uses a sequential…
- Conditions
- Hiv, Adolescent Behavior, Sex, Safe
- Trial name
- SMART (NCT03511131)
- Testing
- Queer Sex Ed, Keep It Up, Keep It Up-Control
- Where
- United States
- Volunteers
- 1,306 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Contraception
A Prospective Observational Study of the Clinical Performance of Femplant in Pakistan
This will be a non-comparative prospective observational study of women using Femplant as a primary method of contraception in Pakistan.
- Trial name
- NCT01463254
- Where
- Pakistan
- Volunteers
- 724 people, healthy volunteers welcome
- Sponsor
- FHI 360
Hiv, Sexual Behavior
Development of a Telehealth-delivered Peer Navigation and Coping Skills Intervention to Increase PrEP Use in Young Black MSM
This proposal seeks to adapt an existing peer navigation protocol (by adding coping skills and using telehealth) to be feasible, acceptable, and capable of supporting both PrEP uptake and P-E adherence for YBMSM ages 15-24.
- Trial name
- NCT05769270
- Testing
- Peer Navigation and Coping Skills, Treatment as Usual
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Human Immunodeficiency Virus
A Safety Study of Brentuximab Vedotin in Participants With HIV
This study will test brentuximab vedotin to see if it is safe for people with human immunodeficiency virus (HIV) who have low CD4+ and have received antiretroviral therapy (ART) treatment.
- Trial name
- NCT05244473
- Testing
- brentuximab vedotin, ART
- Where
- 2 sites in United States
- Sponsor
- Seagen Inc.
HIV Infections
Immune Response to a Therapeutic HIV Vaccine Followed by Treatment Interruption in Patients With Acute or Recent HIV Infection
The purpose of this study is to determine whether the HIV vaccine MRKAd5 HIV-1 gag/pol/nef followed by treatment interruption can increase immune system function in adults with acute or recent HIV infection who have started…
- Trial name
- NCT00183261
- Testing
- MRKAd5 HIV-1 gag/pol/nef
- Where
- 23 sites in United States, American Samoa and 1 more
- Volunteers
- 25 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cardiovascular Diseases, Heart Diseases
HIV-Associated Heart Disease
To develop natural history data regarding the incidence, clinical course, prognosis, and effects of treatment with anti-viral and immunosuppressive agents on HIV-associated heart disease.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Diseases, Acquired Immunodeficiency Syndrome
- Trial name
- NCT00005229
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Human Immunodeficiency Virus, Coronary Artery Disease
Effect of Evolocumab on Coronary Endothelial Function
The investigators propose a pilot study using (1) MRI to assess coronary artery endothelial function, (2) brachial ultrasound to assess systemic endothelial function, (3) serum markers of inflammation and of endothelial cell…
- Trial name
- EVOLVE (NCT03500302)
- Testing
- Evolocumab
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
HIV, AIDS
HIV Prevention for Injecting Drug Users in Kazakhstan
The proposed study addresses a significant public health threat of HIV, HCV and other STIs among a very high risk population of active IDUs and their sexual partners in Kazakhstan a region that is experiencing one of the fastest…
- Trial name
- NCT01690442
- Testing
- Couples Based HIV/STI Risk Reduction Intervention (CHSR), Renaissance Wellness Promotion (WP)
- Where
- Kazakhstan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV Infections
A Comparative Study of a Combination of Zidovudine, Didanosine, and Double-Blinded Nevirapine Versus a Combination of Zidovudine and Didanosine
To assess the safety and toxicity of zidovudine (AZT)/didanosine (ddI) versus AZT/ddI combined with nevirapine in HIV-infected patients, and to obtain preliminary anti-HIV activity data using immunologic and virologic markers.
- Trial name
- NCT00000770
- Testing
- Nevirapine, Zidovudine, Didanosine
- Where
- 44 sites in United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
AIDS Virus, Disorder of Immune Reconstitution
Mesenchymal Stem Cells for Immune Non-responder Patients With HIV Infection
The goal of this clinical trial is to explore the effect of mesenchymal stem cell therapy on immune non-responder patients. The main questions it aims to answer are: 1.
- Trial name
- NCT05872659
- Testing
- normal saline, Mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shandong Qilu Cell Therapy Engineering Technology Co., Ltd
Papillomavirus Infections, HIV Infections
Oral Human Papillomavirus Infection in HIV-infected Men
Human papillomavirus (HPV)-infection belong to the most common sexually transmitted diseases worldwide. HIV-infected men having sex with men /MSM) are strongly associated with a higher prevalence of genitoanal HPV-infection, and…
- Trial name
- NCT00421486
- Testing
- Oral swabs for HPV-typing and high-risk HPV-determination
- Where
- 2 sites in Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Deutsche Luft und Raumfahrt
Alcohol Dependence, HIV/AIDS
Targeting Non-virally Suppressed Adults With Alcohol Use Disorder in HIV Primary Care
The proposed pilot study is a randomized feasibility trial of technology-enhanced brief intervention for drinking reduction and antiretroviral therapy (ART) adherence in 60 non-virally suppressed HIV participants who meet…
- Trial name
- NCT04280068
- Testing
- Clinician Guide (CG), Clinician Guide plus HealthCall
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Hiv, Healthy
Mapping the Human HIV Chronobiome
Individuals infected with HIV have a high risk of developing metabolic comorbidities not traditionally associated with the immune dysregulation and deficiency associated with HIV infection and AIDS.
- Trial name
- HCB (NCT03133559)
- Testing
- Observational
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
HIV-infection/AIDS
Vedolizumab Treatment in Antiretroviral Drug Treated Chronic HIV Infection
Background: In nearly all people with human immunodeficiency virus (HIV) infection, immunity cannot either control or eradicate the infection.
- Trial name
- HAVARTI (NCT03147859)
- Testing
- Vedolizumab (brand name Entyvio)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Ottawa Hospital Research Institute
HIV/AIDS
Traditional Healers as Adherence Partners for Persons Living With HIV in Rural Mozambique
The overall goal of this project is to adapt and assess the impact of a traditional healer training program/intervention on the adherence, retention, and viral load of HIV infected patients newly initiated on anti-retroviral…
- Trial name
- PLHIV (NCT03076359)
- Testing
- Traditional Healer Support Program, Standard of Care
- Where
- Mozambique
- Volunteers
- 320 people
- Sponsor
- Vanderbilt University Medical Center
Infection, Human Immunodeficiency Virus
A Prospective, Non-interventional Study of the Use of Dolutegravir as Part of Combination Antiretroviral Therapy in Routine Daily Practice in Germany
DOL-ART is a multi-center, prospective, non-interventional study of the use of doluetegravir as part of an antiretroviral combination therapy in routine daily practice in Germany.
- Trial name
- DOL-ART (NCT02076386)
- Testing
- Dolutegravir
- Where
- 38 sites in Germany
- Volunteers
- 411 people
- Sponsor
- ViiV Healthcare
Infection, Human Immunodeficiency Virus
Relative Bioavailability Study of a Fixed-dose Combination Dolutegravir/Abacavir/Lamivudine Dispersible Tablet
This is an open-label, randomized, crossover study in healthy adult subjects with 5 treatment groups over 5 dosing periods. This study will evaluate pharmacokinetic parameters and relative bioavailability of a dispersible…
- Trial name
- NCT02893488
- Testing
- DTG/ABC/3TC FDC DISPERSIBLE TABLET, EPZICOM (ABC/3TC), TIVICAY (DTG)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.