Clinical trials: Acquired Immune Deficiency Syndrome Virus
Toxoplasmosis, Cerebral, HIV Infections
A Randomized Prospective Study of Pyrimethamine Therapy for Prevention of Toxoplasmic Encephalitis in HIV-Infected Individuals With Serologic Evidence of Latent Toxoplasma Gondii Infection
To evaluate pyrimethamine as a prophylactic agent against toxoplasmic encephalitis in individuals who are coinfected with HIV and latent Toxoplasma gondii.
- Trial name
- NCT00000666
- Testing
- Pyrimethamine
- Where
- 16 sites in United States
- Volunteers
- 600 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV (Human Immunodeficiency Virus), HIV -1 Infection
Combining Latency Reversing Agents to Address the HIV Reservoir
The PLUTO trial aims to contribute to the worldwide search for a functional cure of HIV. One the strategies ("shock and kill' strategy) aims to reverse the HIV-reservoir from latency by increasing cell-associated HIV-RNA, which…
- Trial name
- PLUTO (NCT07384624)
- Testing
- Pyrimethamine (PYR), Lenalidomide, Topiramate (drug)
- Where
- 4 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Erasmus Medical Center
Histoplasmosis, AIDS
Randomized Trial of Liposomal Amphotericin B for Histoplasmosis in AIDS Patients
Disseminated histoplasmosis (DH) is one of the major AIDS-defining infections responsible for high mortality rates in HIV-infected patients.
- Trial name
- NCT04059770
- Testing
- single dose of L-AmB, 2 doses of L-AmB, 2 weeks of L-AmB
- Where
- Brazil
- Volunteers
- 118 people
- Sponsor
- Alessandro Pasqualotto
HIV Infections, Acquired Immunodeficiency Syndrome
Discontinuation of Trimethoprim-sulfamethoxazole Prophylaxis in Adults on Antiretroviral Therapy in Kenya
Both antiretroviral therapy (ART) and prevention of opportunistic infections (OIs) have been associated with significantly decreased mortality in HIV-infected individuals.
- Conditions
- HIV Infections, Acquired Immunodeficiency Syndrome, Disease Progression, Immune System Diseases
- Trial name
- NCT01425073
- Testing
- Discontinue TMP/SMZ prophylaxis
- Where
- 2 sites in Kenya
- Volunteers
- 500 people
- Sponsor
- University of Washington
Chronic Myeloproliferative Disorders, Leukemia
Methemoglobinemia in Young Patients With Hematologic Cancer or Aplastic Anemia Treated With Dapsone
RATIONALE: Gathering information about how often methemoglobinemia occurs in young patients receiving dapsone for hematologic cancer or aplastic anemia may help doctors learn more about the disease and plan the best treatment.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Lymphoproliferative Disorder
- Trial name
- NCT00993694
- Testing
- chemotherapy, dapsone, medical chart review
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Vanderbilt University
HIV/AIDS
A Mobile Phone Game to Prevent HIV Among Young Africans
This project will test the feasibility of an electronic game to prevent HIV among African preadolescents, delivered via inexpensive Android smart phones.
- Trial name
- NCT03054051
- Testing
- Tumaini Mobile Phone Game
- Where
- Kenya
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Emory University
Human Immunodeficiency Virus
A Study of Raltegravir in a Diverse Cohort of HIV-Infected Patients (0518-055)
A study to test the safety and effect of twice daily raltegravir in a diverse cohort of patients currently infected with human immunodeficiency virus (HIV), where at least 50% are African American and at least 25% are female…
- Trial name
- NCT00764946
- Testing
- Comparator: raltegravir
- Volunteers
- 209 people
- Sponsor
- Merck Sharp & Dohme LLC
Aids, Cdc Group I
HIV-1 Peptide Immunisation of Individuals in West Africa to Prevent Disease
Treatment: Immunization with peptide-mix and adjuvant. The vaccine should induce cellular immunity against HIV-1. Target group: Untreated healthy individuals with chronic HIV-1 infection.
- Trial name
- HIV-BIS (NCT01141205)
- Testing
- AFO-18, Saline
- Where
- 2 sites in Guinea-Bissau
- Volunteers
- 18 people
- Sponsor
- Statens Serum Institut
Adherence, Patient, TB
Leveraging mHealth to Enable and Adapt CHW Strategies to Improve TB/HIV Patient Outcomes in SA
mHealth solutions designed to support affordable human resources for health, such as community health workers (CHWs), offer the opportunity to reimagine a patient-centered, system-level solution that may radically change care…
- Conditions
- Adherence, Patient, TB, HIV/AIDS, Care Coordination
- Trial name
- LEAP-TB-SA (NCT04298905)
- Testing
- CHW mHealth patient intervention for trigger escalation
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Johns Hopkins University
HIV Health Literacy
Facilitating HIV/AIDS and HIV Testing Literacy for Emergency Department Patients
The Centers for Disease Control and Prevention (CDC) recommends that all patients should receive information about HIV/AIDS and HIV testing orally or in writing at every HIV testing encounter.
- Trial name
- NCT02284451
- Testing
- Video or Pictorial Brochure
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
ALS, Autism Spectrum Disorder
Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products
This is an observational study of medical marijuana manufactured and dispensed by Ilera and given as standard treatment for a variety of approved serious medical conditions as defined by individual state law.
- Conditions
- ALS, Autism Spectrum Disorder, Cancer, Spasticity, Muscle
- Trial name
- Ilera (NCT03886753)
- Testing
- Registry, PK microsampling of blood
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Philadelphia
HIV/AIDS
Outcomes of Differentiated Models of Antiretroviral Treatment (ART) Provision
The aim of this study is to evalulate the effectiveness and cost-effectiveness of three models of ART provision for stable ART patients.
- Trial name
- [MMD] (NCT03438370)
- Testing
- Three monthly ART supply at CAGs, Six monthly ART supply at outreaches
- Where
- Lesotho
- Volunteers
- 5,760 people, healthy volunteers welcome
- Sponsor
- Equip, Lesotho
HIV Disease
Evaluation of 3TC or FTC Mono-therapy Compared to Continuing HAART as a Bridging Strategy
The purpose of this study was to compare the use of lamivudine (3TC) or emtricitabine (FTC) alone vs. continuing a failing highly active antiretroviral therapy (HAART) regimen in HIV infected children, adolescents and young…
- Trial name
- P1094 (NCT01338025)
- Testing
- HAART regimen, 3TC or FTC monotherapy
- Where
- 17 sites in United States, Argentina and 3 more
- Volunteers
- 33 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
HIV/AIDS
Assessing the Impact of an Educational HIV Prevention Intervention in Zambia
In Zambia, 13% of the 15 to 49 year old population lives with HIV. The highest number of new HIV infections is among young people.
- Trial name
- NCT03316040
- Testing
- JIC
- Where
- 3 sites in United States, Zambia
- Volunteers
- 8,270 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV (Human Immunodeficiency Virus)
Evaluating an Algorithm-Based Implementation Strategy to Improve HIV Care Outcomes
This study tests a strategy for helping Care Management Agencies prioritize patients with HIV (PWH) for outreach and support. Under the new strategy, care managers are given a list of highest-priority patients who have been…
- Trial name
- NCT07279376
- Testing
- predictive emergency room alerts (pERA), Standard of care
- Where
- United States
- Volunteers
- 2,600 people
- Sponsor
- Hunter College of City University of New York
Hiv
A Clinical Trial to Evaluate the Safety and Immunogenicity of a Prophylactic HIV Vaccine Candidate
An Open-Label Study to Evaluate the Safety and Immunogenicity of 2 Doses of 100µg BG505 SOSIP.664 gp140 Vaccine, Adjuvanted, given to a Population of Adults in Good General Health Who have Received 3 doses of 300µg BG505…
- Trial name
- NCT05863585
- Testing
- BG505 SOSIP.664 gp140 Vaccine, Adjuvanted (3M-052 AF plus alum)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Acquired Immunodeficiency Syndrome, Anemia
Erythropoietin for Anemia Due to Zidovudine in Human Immunodeficiency Virus Infection
To determine whether administration of human recombinant erythropoietin (REPO) improved or eliminated the anemia seen in human immunodeficiency virus (HIV) infected patients after therapy with zidovudine (ZDV).
- Conditions
- Acquired Immunodeficiency Syndrome, Anemia, Hematologic Diseases, HIV Infections
- Trial name
- NCT00000587
- Testing
- erythropoietin, recombinant
- Sponsor
- Thomas Jefferson University
Human Immunodeficiency Virus
Elite Controller and ART-treated HIV+ Statin Versus ASA Treatment Intervention Study
Background: The immune system protects the body from infection. But it can also cause harm. For example, the clotting system makes blood clot and protects from bleeding. But blood clots are sometimes harmful.
- Trial name
- NCT02081638
- Testing
- Aspirin, Atorvastatin
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hiv, Lung Injury
Effects of Using E-Cigarettes on Lungs in People With HIV (HBS Ancillary)
This is an ancillary study, thus participants will be recruited from participants in the HBS Study. This project acutely assesses the role of the e-cigarettes and vaping on lung health.
- Trial name
- HBS Ancillary (NCT04794543)
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Pennington Biomedical Research Center
HIV/AIDS and Infections
POSSE Project: A Community-Level Intervention for Black YMSM
Black young men who have sex with men (BYMSM) are at high risk for contracting and transmitting HIV, and represent a priority population for developing effective interventions.
- Trial name
- NCT03198663
- Testing
- POSSE
- Where
- 2 sites in United States
- Volunteers
- 1,037 people, healthy volunteers welcome
- Sponsor
- Cook County Health
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