Clinical trials: Acute Cardiac Failure
Acute Coronary Syndrome, Acute Pulmonary Edema
Prior Statin Use and Risk of CHF, ALO and Malignant Arrhythmia in Indonesian Post-Acute Coronary Syndrome Patients
This study aims to evaluate the effect of statin for primary prevention, towards lowering the incidence of heart failure, acute lung edema, malignant arrhythmia and death in ACS patients.
- Conditions
- Acute Coronary Syndrome, Acute Pulmonary Edema, Arrhythmias, Cardiac, Heart Failure
- Trial name
- NCT03596931
- Testing
- Statins (Cardiovascular Agents)
- Where
- Indonesia
- Volunteers
- 130 people
- Sponsor
- Tarumanagara University
Heart Failure，Congestive
Dapagliflozin on Volume Vascular Outcomes.
The purpose of the DAPA-VOLVO trial is to investigate the effects of Dapagliflozin on top of recommended standard therapy on volume status and vascular function in clinically stable de novo or chronic heart failure patients after…
- Trial name
- DAPA-VOLVO (NCT04869124)
- Testing
- Dapagliflozin
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Frank Ruschitzka
Acute Kidney Injury, Acute Renal Failure
Minimizing Contrast Utilization With IVUS Guidance in Coronary Angioplasty to Avoid Acute Nephropathy
Contrast-induced acute kidney injury (CI-AKI) is an important adverse effect of percutaneous coronary interventions. Despite various efforts, very few preventive measures have been shown effective in reducing its incidence.
- Conditions
- Acute Kidney Injury, Acute Renal Failure, Acute Renal Injury
- Trial name
- Mozart-II (NCT02743156)
- Testing
- IVUS-guided PCI, Angiography-guided PCI
- Where
- 2 sites in Brazil, Spain
- Volunteers
- 300 people
- Sponsor
- InCor Heart Institute
Heart Failure Acute, Discharge Follow-up Phone Calls
Congestion and LActate at diScHarge in Acute Heart Failure
Acute heart failure (AHF) is a leading cause of hospitalization and is associated with high short-term morbidity and mortality, with 20-30% of patients experiencing rehospitalization or death within 30 days.
- Conditions
- Heart Failure Acute, Discharge Follow-up Phone Calls, Mortality Prediction
- Trial name
- CLASH-HF (NCT07345156)
- Testing
- Lung Ultrasound Score, Lactate Blood Test
- Where
- Tunisia
- Volunteers
- 350 people
- Sponsor
- University of Monastir
Acute Heart Failure (AHF), Heart Failure (for Example, Fluid Overload)
ReDS-guided Decongestion Strategy in Patients Hospitalized for Heart Failure
This clinical trial aims to determine whether a ReDS-guided treatment strategy is superior to the current standard of care for adults hospitalized with heart failure.
- Conditions
- Acute Heart Failure (AHF), Heart Failure (for Example, Fluid Overload), Heart Failure Hospitalization
- Trial name
- ReDS-SAFE HF 2 (NCT07484009)
- Testing
- Remote Dielectric Sensing System, Blinded ReDS data
- Where
- 25 sites in Spain
- Volunteers
- 1,014 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Cardiovascular Diseases, Anemia, Iron-deficiency
Iron in Patients With Cardiovascular Disease
It is now recognized that iron deficiency in cardiovascular disease contributes to impaired clinical outcome.
- Conditions
- Cardiovascular Diseases, Anemia, Iron-deficiency, Acute Myocardial Infarction, Atrial Fibrillation
- Trial name
- iCHF-2 (NCT03991000)
- Testing
- Ferric carboxymaltose, Saline
- Where
- 3 sites in Germany
- Volunteers
- 8 people
- Sponsor
- Dr. med. Mahir Karakas
Acute Decompensated Heart Failure, Congestive Heart Failure
Six Months Efficacy and Safety of Aliskiren Therapy on Top of Standard Therapy, on Morbidity and Mortality in Patients With Acute Decompensated Heart Failure
This study evaluated the effect of early initiation of aliskiren therapy, compared to standard therapy, in the reduction of cardiovascular death and heart failure re-hospitalization events within 6 months, in congestive heart…
- Trial name
- ASTRONAUT (NCT00894387)
- Testing
- Aliskiren
- Where
- 308 sites in United States, Argentina and 22 more
- Volunteers
- 1,639 people
- Sponsor
- Novartis Pharmaceuticals
Cardiorenal Syndrome, Heart Failure
Venous Ultrasound Guided Organ Decongestion in Patients Hospitalized with Acute Decompensated Heart Failure
The purpose of this study is to assess the feasibility, safety and effectiveness of VExUS guided organ decongestion compared to standard of care in patients hospitalized with acute decompensated heart failue (ADHF).
- Conditions
- Cardiorenal Syndrome, Heart Failure, Acute Kidney Injury, Acute Decompensated Heart Failure
- Trial name
- VExOUS-ADHF (NCT06714409)
- Testing
- VExUS guided decongestion
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- Oslo University Hospital
Acute Decompensated Heart Failure
Safety and Performance Evaluation of the Nephronyx System for the Treatment of Patients With ADHF
The objective of this interventional study is to evaluate the safety and functional performance of the Nephronyx System in patients with ADHF, presenting clinical signs of volume overload and compromised response to diuretics.
- Trial name
- NCT05759806
- Testing
- Nephronyx system (Perfuser)
- Where
- 4 sites in Israel
- Volunteers
- 10 people
- Sponsor
- Nephronyx LTD
Heart Failure, Acute Kidney Injury
Treatment According to Venous Excess Ultrasound Score in Patients With Heart Failure
Heart failure is a syndrome that progresses with symptoms and signs caused by cardiac dysfunction and results in a shortened life expectancy (1).
- Trial name
- NCT06341816
- Testing
- VEXUS score, NGAL
- Volunteers
- 100 people
- Sponsor
- Inonu University
Prior Acute Myocardial Infarction, Evidence of Systemic Inflammation (C Reactive Protein Plasma >2 mg/l)
Interleukin-1 Blockade With Canakinumab to Improve Exercise Capacity in Patients With Chronic Systolic Heart Failure and Elevated High Sensitivity C-reactive Protein (Hs-CRP)
The proposed study is a sub-study of the CANTOS trial (A randomized, double-blind, placebo-controlled, event driven trial of quarterly subcutaneous canakinumab in the prevention of recurrent cardiovascular events among stable…
- Conditions
- Prior Acute Myocardial Infarction, Evidence of Systemic Inflammation (C Reactive Protein Plasma >2 mg/l), Reduced Left Ventricle Ejection Fraction (<50%), Symptoms of Heart Failure (NYHA Class II-III)
- Trial name
- NCT01900600
- Testing
- Cardiopulmonary exercise test, Echocardiogram
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Virginia Commonwealth University
Congestive Heart Failure, Ischemic Heart Disease
Addressing Social Vulnerabilities in Cardiovascular Disease
The investigators will conduct a feasibility study of an enhanced transitional care intervention, that will: 1) automate identification and risk-stratification of patients with CHF and IHD with social vulnerabilities; 2)…
- Conditions
- Congestive Heart Failure, Ischemic Heart Disease, Acute Myocardial Infarction, Coronary Artery Disease
- Trial name
- NCT03613064
- Testing
- Socially Enhanced Transitional Care Intervention
- Sponsor
- University of California, San Francisco
Acute Coronary Syndrome, Heart Failure
Impact of COVID19 Outbreak in Cardiac Acute Care
This registry will evaluate the impact of the COVID19 outbreak on Cardiac patients admitted in the Intensive Care Unit of the Pitie-Salpetriere Hospital in Paris, France
- Conditions
- Acute Coronary Syndrome, Heart Failure, COVID
- Trial name
- CCU-COVID19 (NCT04344912)
- Testing
- Data collection
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure
Splanchnic Nerve Anesthesia in Heart Failure
Patients admitted for acute heart failure and undergoing right heart catheterization will be enrolled in this study. Subjects will undergo catheterization of the heart to obtain central cardiac pressure and other cardiac…
- Trial name
- NCT02669407
- Testing
- splanchnic nerve anesthesia with a local anesthetic, regional nerve block with a local anesthetic (Lidocaine)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Duke University
Acute Kidney Injury, Cardiorenal Syndrome
Renal Venous Flow and Cardiac Surgery-associated Acute Kidney Injury
The prospective single-center study investigates the association between changes in Doppler-derived renal venous flow and cardiac surgery-associated acute kidney injury (CSA-AKI).
- Trial name
- NCT03753607
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Giessen
Acute Heart Failure
Levosimendan Pharmacokinetics in Children
Levosimendan is a drug used in patients with heart failure and has several advantages over other heart failure drugs. A lot of research has been done with Levosimendan in Adults, and the way the body handles the drug…
- Trial name
- LevoCorKids (NCT01704131)
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- Leiden University Medical Center
Heart Failure
Acute Impact of Cardiac Resynchronization on Vascular Function (RVA-CRT)
Evaluation of the effect of short term activation/deactivation of biventricular pacing (BivP) of the CRT (during routine CRT interrogation) on vascular function as assessed via retinal vessel analysis (RVA), in patients treated…
- Trial name
- RVA-CRT (NCT04379401)
- Testing
- Cardiac Resynchronization Therapy (ON vs. OFF)
- Where
- Switzerland
- Volunteers
- 35 people
- Sponsor
- Andreas Flammer
Acute Kidney Injury, Heart Failure
Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial
This is a prospective, double-blind, sham-controlled, multicenter, randomized clinical trial is to study the effects of remote ischemic preconditioning on contrast-associated acute kidney injury, functional capacity, and major…
- Conditions
- Acute Kidney Injury, Heart Failure, Contrast Induced Nephropathy, Coronary Angiography
- Trial name
- RICH (NCT04982419)
- Testing
- Remote ischemic preconditioning
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Chronic Heart Failure, Heart Diseases
Effect of Intravenous Ferrous Sucrose on Exercise Capacity in Chronic Heart Failure
This is a two-center, randomised, single-blind (physician), prospective, controlled study to assess the acute (8 weeks) and chronic (16 weeks) effects of intravenous (IV) iron sucrose supplementation in anaemic and non-anaemic…
- Conditions
- Chronic Heart Failure, Heart Diseases, Anemia, Iron-Deficiency
- Trial name
- NCT00125996
- Testing
- Venofer (intravenous iron sucrose)
- Where
- 2 sites in Poland, United Kingdom
- Volunteers
- 42 people
- Sponsor
- National Heart and Lung Institute
Respiratory Distress Syndrome
Effect of Different Ventilatory Strategies on Cardiac Function in Patients With Acute Respiratory Failure
Mechanical ventilation with low tidal volume (about 6 ml.kg-1) reduces mortality in ALI/ARDS patients respect to high tidal volume ventilation (about 12 ml.kg-1).
- Trial name
- VITALI (NCT00713713)
- Testing
- Mechanical ventilation with low and high tidal volume
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
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