Clinical trials: Acute Cardiac Failure
Heart Decompensation, Acute
Study With Healthy Japanese and Non-Asian Participants With BMS-986231
The purpose of this Phase 1 study is to evaluate the safety, tolerability, PK, and pharmacodynamics (PD) of BMS-986231 in healthy Japanese and Non-Asian participants. There is no formal hypothesis to be statistically tested.
- Trial name
- NCT02932969
- Testing
- BMS-986231
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Sepsis, Respiratory Physiological Phenomena
Respiratory Variations for Predicting Fluid Responsiveness
Hypovolemia and acute circulatory failure affects more than 60% of patients hospitalized in intensive care or resuscitation. The volume expansion (VE) by fluid replacement therapy is the first treatment improve circulatory…
- Conditions
- Sepsis, Respiratory Physiological Phenomena, Circulatory Failure
- Trial name
- ReVaPreF (NCT03066362)
- Testing
- Echocardiography-Doppler
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Lille
Pulmonary Edema, Dyspnea
Continuous Positive Airway Pressure for Acute Pulmonary Edema
The investigators hypothesise that CPAP + pharmaceutical treatment, compared to pharmaceutical treatment alone, improves the respiratory and hemodynamic status of the patients before H2 after the inclusion time and decreases the…
- Conditions
- Pulmonary Edema, Dyspnea, Paroxysmal, Congestive Heart Failure
- Trial name
- CPAP (NCT00554580)
- Testing
- Continuous Positive Airway Pressure (CPAP), usual care of acute pulmonary oedema
- Where
- France
- Volunteers
- 208 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dyspnea, Acute Heart Failure Syndrome
Precision of IMED-4 Lung Fluid Measurements
The purpose of this study is to determine if IMED-4 recordings have sufficient precision to detect a clinically significant change in lung fluid status in acute heart failure syndrome with pulmonary congestion.
- Conditions
- Dyspnea, Acute Heart Failure Syndrome, Pulmonary Congestion
- Trial name
- NCT02187770
- Testing
- IMED-4
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- Intersection Medical, Inc.
Acute Renal Failure (ARF)
Venous Congestion and Acute Renal Failure in Cardiac Surgery Postoperative
Acute renal failure (ARF) is a frequent complication in the postoperative cardiac surgery, and is a major risk factor for mortality in this context.
- Trial name
- COVD (NCT03013621)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Hypoxemic Respiratory Failure, Post-cardiac Surgery
Automated Analysis of EIT Data for PEEP Setting
First: to develop a computerized algorithm for automated analysis of the electrical impedance tomography (EIT) data. The algorithm calculates the "optimal" positive end-expiratory pressure (PEEP) and inspiratory pressure defined…
- Trial name
- NCT03653806
- Testing
- computerized algorithm for automated analysis
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University Medical Center
Acute Decompensated Heart Failure
Reprieve System Pilot Study
The objective of the study is to evaluate the use of the Reprieve System to decongest subjects with acute decompensated heart failure.
- Trial name
- NCT06272734
- Testing
- Reprieve System
- Where
- Georgia
- Volunteers
- 50 people
- Sponsor
- Reprieve Cardiovascular, Inc
Myocardial Infarction (MI), Heart Failure
Timing of Coronary Angiography in NSTEMI Complicated by Acute HF
Study objectives: To determine the optimal timing of coronary angiography (CAG) in patients with non-ST-segment elevation myocardial infarction (NSTEMI) complicated by acute decompensated heart failure (AHF).
- Trial name
- TIMING-AHF (NCT07002164)
- Testing
- Immediate coronary angiography, Delayed coronary angiography
- Where
- 20 sites in South Korea
- Volunteers
- 780 people
- Sponsor
- Chonnam National University Hospital
Kidney Failure, Acute
Evaluation of Neutrophil Gelatinase-associated Lipocalin (NGAL) in Early and Evolving Acute Kidney Injury
Some patients who undergo cardiovascular surgery requiring cardiopulmonary bypass will develop a kidney injury following their surgery.
- Trial name
- EVOLVE (NCT00445809)
- Where
- 11 sites in United States, Canada
- Volunteers
- 355 people
- Sponsor
- Abbott RDx Cardiometabolic
Acute Heart Failure
Functional Impact of GLP-1 for Heart Failure Treatment (FIGHT)
The primary objective is to test the hypothesis that, compared with placebo, therapy with Subcutaneous (SQ) GLP-1 agonist in the post-Acute Heart Failure Syndrome (AHFS) discharge period will be associated with greater clinical…
- Trial name
- FIGHT (NCT01800968)
- Testing
- Liraglutide
- Where
- 25 sites in United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Acute Myocardial Infarction, Cardiovascular Morbidity
Dapagliflozin Effects on Mayor Adverse Cardiovascular Events in Patients With Acute Myocardial Infarction (DAPA-AMI)
The actual evidence is solid about the use of de SGLT2-inhibitors in wide spectrum of cardiorenal targets, which has been shown in a great amount of randomized clinical trials compared with placebo.
- Conditions
- Acute Myocardial Infarction, Cardiovascular Morbidity, Heart Failure, Angina, Unstable
- Trial name
- DAPA-AMI (NCT04717986)
- Testing
- Dapagliflozin 10Mg Tab
- Where
- Mexico
- Volunteers
- 188 people
- Sponsor
- Instituto Mexicano del Seguro Social
Heart Failure Acute, Ventilator Lung
SGLT2 Inhibitors in Patients With ADHF During Ventilator Weaning
This study will explore the potential benefits of sodium-glucose cotransporter 2 (SGLT2) inhibitors in preventing cardiac ischemia and cardiopulmonary edema in patients with acute decompensated heart failure during weaning from…
- Trial name
- NCT06142474
- Testing
- SGLT2 inhibitor
- Where
- Taiwan
- Volunteers
- 450 people
- Sponsor
- National Taiwan University Hospital
Acute Heart Failure, Left Ventricular Dysfunction
Bi Treatment With Hydralazine/Nitrates Versus Placebo in Africans Admitted With Acute Heart Failure
To investigate the effect of hydralazine isosorbide dinitrate on clinical outcomes, symptoms, cardiac parameters and functional status of African patients hospitalized with AHF and left ventricular dysfunction during 24 weeks of…
- Trial name
- B-AHEF (NCT01822808)
- Testing
- Hydralazine, Isosorbide Dinitrate
- Where
- South Africa
- Volunteers
- 500 people
- Sponsor
- University of Cape Town
Acute Kidney Injury, Heart Failure
Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial
This is a prospective, double-blind, sham-controlled, multicenter, randomized clinical trial is to study the effects of remote ischemic preconditioning on contrast-associated acute kidney injury, functional capacity, and major…
- Conditions
- Acute Kidney Injury, Heart Failure, Contrast Induced Nephropathy, Coronary Angiography
- Trial name
- RICH (NCT04982419)
- Testing
- Remote ischemic preconditioning
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Cardiac Failure Acute, Hemodynamic Monitoring
Comparison of Cardiac Index and Stroke-volume-index Measured by Pulmonary Artery Catheter, FloTrac® and Argos® in Cardiac Surgery Patients.
A comparison of cardiac performance determined by stroke-volume-index measured by different mechanisms in patients during and after cardiac surgery: 1. Pulmonary artery catheter 2. Flo Trac 3.
- Trial name
- NCT06918301
- Testing
- Measurement of cardiac performance
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Karlsburg Hospital
Heart Failure
Patient Journey in Hospital With Acute Heart Failure
A multicentre, prospective, observational, hospital-based registry of patients with acute heart failure (AHF) those whose care was guided by a cardiologist in Turkey.
- Trial name
- JourneyHF-TR (NCT02621203)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Mehdi Zoghi
Heart Failure, Systolic
Acute Changes in Bioimpedance During Cardiac Resynchronization Therapy
This study aims at Optimizing measured parameters to reflect underlying pathology in dyssynchronous hearts. This is an experimental study in patients were bioimpedance measurements are performed during implantation.
- Trial name
- Impel (NCT03640000)
- Testing
- Impedance measurements in Cardiac Resynchronization therapy
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University Hospital
Acute Kidney Injury
Early Versus Late Renal Replacement Therapy After Cardiac Surgery
The question of timing of initiation of renal replacement therapy (RRT), "early" versus "late", has seldom been the focus of high-quality or rigorous evaluation.
- Trial name
- NCT01961999
- Testing
- Early RRT, Late RRT
- Where
- Italy
- Volunteers
- 1,800 people
- Sponsor
- Ospedali Riuniti Ancona
Emergencies, Heart Diseases
Evaluate the Predictive Impact of the EHMRG
External validation of the EHMRG score for hospitalized patients with acute heart failure in the emergency department
- Trial name
- EHMRGscore (NCT05632263)
- Testing
- EHMRGscore
- Volunteers
- 1,500 people
- Sponsor
- University of Monastir
Acute Heart Failure
Prospective Registry of Acute Heart Failure
Context: Heart failure is associated with a high morbidity and mortality rate and represents a significant worldwide public health burden.
- Trial name
- NCT02444416
- Testing
- blood sample
- Where
- Switzerland
- Volunteers
- 1,200 people
- Sponsor
- Sebastian Carballo
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