Clinical trials: Acute Cardiac Failure
Cardiac Complications, Cardiopulmonary Bypass
Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) for cardiac operations may be accompanied by different patterns of visceral underperfusion. This could result in clinical patterns of lactic acidosis but in the most severe cases there is the risk for…
- Trial name
- NCT00747331
- Testing
- Fenoldopam mesilate
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Policlinico S. Donato
Heart Failure, Congestive
Heart Failure Registry
The purpose of this registry is to compile a large clinical database on the medical management of patients hospitalized with acute heart failure, using information collected from acute care hospitals across the United States.
- Trial name
- NCT00530426
- Volunteers
- 150,000 people
- Sponsor
- Scios, Inc.
Volume Overload
Oral Sodium to Preserve Renal EfficiencY in Acute Heart Failure
The investigators are proposing a prospective, randomized, double blinded, placebo-controlled single center study evaluating the role of co-administration of oral sodium chloride (NaCl) with intravenous diuretics in patients…
- Trial name
- OSPREY-AHF (NCT04334668)
- Testing
- Oral Sodium Chloride
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- The Cleveland Clinic
Heart Failure, Systolic
Metformin Pharmacokinetics in Patients With Chronic and Acute Heart Failure
The study evaluates the pharmacokinetics of metformin in heart failure patients in acute and chronic state in relation to metformin transporter genotypes.
- Trial name
- MetKin (NCT02797340)
- Testing
- Blood draws and urine samples for metformin concentration measurements, Metformin
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Aarhus University Hospital
Acute Leukemia, Adenomatous Polyposis
Familial Investigations of Childhood Cancer Predisposition
NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll.
- Conditions
- Acute Leukemia, Adenomatous Polyposis, Adrenocortical Carcinoma, AML
- Trial name
- SJFAMILY (NCT03050268)
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- St. Jude Children's Research Hospital
Heart Failure, Lung Congestion
Use of ReDS Technology in Patients With Acute Heart Failure
Background: Fluid overload, especially pulmonary congestion, is one of the main contributors into heart failure (HF) readmission risk and it is a clinical challenge for clinicians.
- Trial name
- NCT04305717
- Testing
- ReDS-guided strategy
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Respiratory Failure, Respiratory Arrest
Postoperative Respiratory Abnormalities
The study aims to determine how historical cases of respiratory abnormalities are documented by clinicians in the electronic health records (EHR) of Memorial Hermann Healthcare System (MHHS) inpatient facilities.
- Conditions
- Respiratory Failure, Respiratory Arrest, Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- AI-ARF (NCT04079829)
- Testing
- Observational retrospective cohort to describe data validity; and Data reliability; and Completeness of the data
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Efficacy Care R&D Ltd
Acute Respiratory Distress Syndrome After Cardiac Surgery Under Cardiopulmonary Bypass
Transpulmonary Gradient After Cardiac Surgery Under Cardiopulmonary Bypass
Get a better understanding of the pathophysiological processes of acute respiratory failure following cardiopulmonary bypass to initiate timely therapies targeted on a cell line.
- Trial name
- NCT01723930
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Coronary Syndromes, Heart Failure
ISGLT2 in Patients Without DM With Acute MI
This study will evaluate the effect of ISGLT2 (Dapagliflozin or Empalgliflozin), administered once daily in addition to standard of care treatments for non-diabetic patients with myocardial infarction (MI) treated with PCI, on…
- Trial name
- ISGTL2-MORMI (NCT06903754)
- Testing
- With ISGLT2
- Where
- Morocco
- Volunteers
- 450 people
- Sponsor
- Mohammed VI University Hospital
Heart Failure
Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure
The purpose of this study is to understand the effects of chloride supplementation on volume-overloaded acute heart failure patients concomitantly treated with IV diuretics.
- Trial name
- NCT03446651
- Testing
- Lysine Chloride
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Acute Heart Failure, Frail Elderly Syndrome
Discharge Planning in Emergency Department for Frail Older With AHF
Objectives: To demonstrate the efficacy of care transition holistic intervention (Multilevel Guided Discharge Planning, MGDP) in reducing 30-day adverse outcomes among frail older patients with acute heart failure (AHF)…
- Trial name
- NCT03696875
- Testing
- Multilevel Guided Discharge Planning, Standard of care
- Where
- Spain
- Volunteers
- 1,260 people
- Sponsor
- F. Javier Martin Sanchez
Acute Heart Failure
Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode.
The purpose of this study was to assess the effect of in-hospital initiation of sacubitril/valsartan (LCZ696) vs. enalapril on time averaged proportional change in NT-proBNP in patients who have been stabilized following…
- Trial name
- PIONEER-HF (NCT02554890)
- Testing
- sacubitril/valsartan (LCZ696), Enalapril
- Where
- 123 sites in United States
- Volunteers
- 887 people
- Sponsor
- Novartis Pharmaceuticals
Myocardial Infarction, Death
Acute Myocardial Infarction Quality Assurance Project
Cohort study aimed at evaluating the incidence of left ventricular (LV) dysfunction after myocardial infraction (MI) and assessing the prognostic utility of change in ejection fraction (EF) over the initial 12 months after MI.
- Conditions
- Myocardial Infarction, Death, Heart Failure
- Trial name
- AMIQA (NCT02399891)
- Testing
- Quality Assurance Implementation, Standard of Care
- Where
- Canada
- Volunteers
- 6,000 people
- Sponsor
- Dr. Derek Exner
Congestive Heart Failure, Ischemic Heart Disease
Addressing Social Vulnerabilities in Cardiovascular Disease
The investigators will conduct a feasibility study of an enhanced transitional care intervention, that will: 1) automate identification and risk-stratification of patients with CHF and IHD with social vulnerabilities; 2)…
- Conditions
- Congestive Heart Failure, Ischemic Heart Disease, Acute Myocardial Infarction, Coronary Artery Disease
- Trial name
- NCT03613064
- Testing
- Socially Enhanced Transitional Care Intervention
- Sponsor
- University of California, San Francisco
Acute Heart Failure (AHF)
Impact of Clinical Ultrasound in Patients With Heart Failure Treated in Home Hospitalization
The purpose of this study is to assess whether clinical ultrasound (CU)-guided treatment in acute heart failure (AHF) is superior to the standard care (SC)-guided treatment.
- Trial name
- AHF-CU (NCT05042752)
- Testing
- CLINICAL ULTRASOUND
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Lara Palacios
Percutaneous Coronary Intervention, Coronary Artery Bypass Graft Surgery, With or Without Valve Surgery
Cardiac Rehabilitation Peer Mentorship
The current study is a randomized controlled trial, being conducted at two hospitals in Toronto, Ontario, Canada, involving the randomization of cardiac inpatients into an intervention group, in which they will receive mentorship…
- Conditions
- Percutaneous Coronary Intervention, Coronary Artery Bypass Graft Surgery, With or Without Valve Surgery, Acute Coronary Syndrome, Chronic Stable Heart Failure
- Trial name
- NCT02204449
- Testing
- Cardiac Rehabilitation Peer Mentorship
- Where
- 2 sites in Canada
- Volunteers
- 94 people
- Sponsor
- University Health Network, Toronto
Acute Decompensated Heart Failure
Registry (Prospective Cohort) for Heart Failure in Korea (KorAHF)
KorAHF is a multi-center registry (prospective cohort) for acute decompensated heart failure patients in Korea. The aim of this registry is to analyze several causes affecting prognosis and survival and to develop new strategies…
- Trial name
- KorAHF (NCT01389843)
- Where
- South Korea
- Volunteers
- 5,625 people
- Sponsor
- Byung-Hee Oh
Acute Cardiovascular Disease, Acute Coronary Syndrome
Naples Federico II Intensive Cardiac Care Unit Registry (Naples FED2-ICCU Registry)
This protocol proposes to prospectively evaluate current epidemiology, pharmacologic and invasive management and clinical outcomes of patients with acute cardiovascular diseases admitted at our ICCU.
- Conditions
- Acute Cardiovascular Disease, Acute Coronary Syndrome, Acute Heart Failure, Cardiogenic Shock
- Trial name
- NCT06162247
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- Federico II University
Delirium in Old Age, Delirium in the Intensive Care Unit
Multi-Component Delirium Prevention Bundle in Older Cardiac Intensive Care Unit Patients
The goal of this randomized controlled clinical trial is to learn whether a structured delirium prevention protocol can reduce the occurrence of delirium in older adults admitted to the cardiac intensive care unit (CICU).
- Conditions
- Delirium in Old Age, Delirium in the Intensive Care Unit, Delirium Confusional State, Delirium
- Trial name
- CICUDEL (NCT07776184)
- Testing
- Multicomponent Delirium Prevention Bundle, Control Group
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Tel Aviv Medical Center
Acute Kidney Injury, Post-Operative Delirium
Short-term Atorvastatin's Effect on Acute Kidney Injury Following Cardiac Surgery
Aim1a: Statin naive patient's scheduled for cardiac surgery will be randomized to 80mg atorvastatin or placebo on the day prior to surgery and then 40mg daily thereafter until hospital discharge to test the hypothesis that…
- Conditions
- Acute Kidney Injury, Post-Operative Delirium, Icu Delirium, Acute Renal Failure
- Trial name
- NCT00791648
- Testing
- atorvastatin
- Where
- United States
- Volunteers
- 653 people
- Sponsor
- Vanderbilt University Medical Center
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