Clinical trials: Acute Cardiac Failure
Dyspnea
Systolic Time Intervals in the Diagnosis of Heart Failure in Emergency Departement
the gold standard for the diagnostic of acute heart failure is based on clinical, biological (BNP levels) and echocardiographic findings, but still in some cases, the diagnosis is difficult and requires further investigations.
- Trial name
- STA/AHF (NCT02161445)
- Testing
- the acoustic cardiographic parameters were calculated
- Where
- Tunisia
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Acute Heart Failure
Acute Heart Failure With Preserved Ejection Fraction - COngestion Discharge Evaluation
The AHF-CODE preserved study is a prospective, non-randomized, monocenter study performed in patients with heart failure with preserved ejection fraction admitted for worsening heart failure.
- Trial name
- AHF-CODE-P (NCT04343430)
- Testing
- Clinical examination centered on congestion, Cardio-pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography, Biological: Blood sample retrieved for biological assessment and biobanking
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Central Hospital, Nancy, France
Renal Failure, Heart Failure
Can Urinary Concentrations of TIMP2 and IGFBP7 be Used to Predict Early Acute Renal Failure Following Cardiac Arrest?
Transient renal insufficiency is frequently observed in the course of cardiovascular arrest. Although elevation of creatinine is reversible in a large majority of cases, severe renal insufficiency is sometimes observed and is…
- Trial name
- ACR-CHECK (NCT03211962)
- Testing
- Analysis of urinary levels of TIMP2 and IGFBP7 within 6 hours after cardiac circulatory arrest
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Heart Failure, Acute Heart Failure
Telemonitoring Program in the Vulnerable Phase After Hospitalization for Heart Failure
This pragmatic clinical trial aims to evaluate the impact of a telemonitoring program with an electronic alert system compared to standard treatment on the perception of self-care in patients after hospitalization for…
- Trial name
- NCT05972746
- Testing
- Telemonitoring with electronic alerts, Standard of care
- Where
- Argentina
- Volunteers
- 110 people
- Sponsor
- Instituto Cardiovascular de Buenos Aires
Myocardial Infarction, Heart Failure, Systolic
VItamin D as a Novel Determinant of Injurious Cardiac Remodelling After acuTE Myocardial Infarction
To provide insight into why vitamin D levels at baseline predict an adverse outcome including hospitalisation, we will establish whether baseline vitamin D levels are an independent marker of LV remodelling in patients…
- Trial name
- VINDICATE-MI (NCT03086746)
- Where
- United Kingdom
- Volunteers
- 800 people
- Sponsor
- University of Leeds
Acute Circulatory Failure
Evaluation of Doppler Flow From the Femoral Artery as a Reflection of Cardiac Flow in a Vascular Fluid Test
In order to identify the responding patients with vascular filling test, this research aims to compare the performance of the increased flow in the femoral artery to the performance of the blood pressure increase.
- Trial name
- RER D (NCT02878369)
- Testing
- Doppler measurement of blood flow in the outflow tract of the left ventricle and the femoral artery,Reading blood pressures displayed on the monitor.
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Heart Failure, Dyspnea
Targeting Acute Congestion With Tolvaptan in Congestive Heart Failure
The primary objective of this study is to compare the effects of oral Tolvaptan vs. placebo as an adjunct to fixed dose IV furosemide on dyspnea relief in patients with acute decompensated heart failure The primary hypothesis is…
- Trial name
- TACTICS-HF (NCT01644331)
- Testing
- Tolvaptan
- Where
- 18 sites in United States
- Volunteers
- 257 people
- Sponsor
- Duke University
Myocardial Infarction, Acute, Heart Failure, Left Sided
Study to Assess Efficacy and Safety of CDR132L in Patients With Reduced Left Ventricular Ejection Fraction After Myocardial Infarction
This is a Phase 2, multicenter, randomized, parallel, 3-arm, placebo-controlled study to assess efficacy and safety of CDR132L in patients with reduced Left Ventricular Ejection Fraction (LVEF) (≤ 45%) after myocardial infarction…
- Trial name
- HF-REVERT (NCT05350969)
- Testing
- CDR132L
- Where
- 49 sites in Czechia, Germany and 6 more
- Volunteers
- 294 people
- Sponsor
- Cardior Pharmaceuticals GmbH
Acute Heart Failure
Sodium NItroPrusside Treatment in Acute Heart Failure
The primary objective of this multicentric observational retrospective study is to assess the efficacy and safety of SNP as part of the treatment regimen of AHF patients and to identify predictors of efficacy.
- Trial name
- SNIP-AHF (NCT05027360)
- Testing
- SNP - Sodium Nitroprusside
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Niguarda Hospital
ARDS Related to Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 2, Acute Refractory Heart Failure Related to SARS-CoV 2
Extracorporeal Membrane Oxygenation (ECMO) and Coronavirus Disease (COVID) 19
The role of ECMO in the treatment of patients with severe COVID-19 (Acute Respiratory Distress Syndrome (ARDS) and/or acute refractory heart failure) is not yet known.
- Trial name
- ECMO-SARS (NCT04397588)
- Where
- 44 sites in France
- Volunteers
- 761 people
- Sponsor
- Rennes University Hospital
Acute Heart Failure
Consultation at 8 Days to Reduce Hospitalisations in Heart Failure Patient
Evaluate the benefit of systematic appointment with a cardiologist a week after hospitalisation for acute heart failure. Randomised, endpoint: number of day alive out of hospital during 6 months
- Trial name
- CHIC (NCT01834833)
- Testing
- Follow-up
- Where
- France
- Volunteers
- 326 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Heart Failure
Study of Safety, Tolerability and Pharmacokinetics of Serelaxin in Japanese Acute Heart Failure (AHF) Patients
This is a multicenter, randomized, double-blind, placebo-controlled study to assess safety, tolerability and pharmacokinetics and to explore efficacy of IV infusion of 10 µg/kg/day and 30 µg/kg/day serelaxin for 48 hours compared…
- Trial name
- NCT02002702
- Testing
- Serelaxin
- Where
- 15 sites in Japan
- Volunteers
- 46 people
- Sponsor
- Novartis Pharmaceuticals
Acute Myocardial Infarction, Acute Coronary Syndrome
Improving Cardiac Rehabilitation Outcomes Through Mobile Case Management (iCARE)
The purpose of this research is to find out if doing cardiac rehab at home, or a mix of cardiac rehab at home and in the clinic, is as effective as coming in to the clinic for cardiac rehab.
- Conditions
- Acute Myocardial Infarction, Acute Coronary Syndrome, Stable Angina Pectoris, Percutaneous Coronary Intervention
- Trial name
- iCARE (NCT04938661)
- Testing
- Center-Based Cardiac Rehab, mHealth, Home-Based Cardiac Rehab
- Where
- 2 sites in United States
- Volunteers
- 206 people
- Sponsor
- Mayo Clinic
Acute Myocardial Infarction
β Blocker Use and Mortality in Hospital Survivors of Acute Myocardial Infarction Without Heart Failure
The aim of the study is to investigate the association between the use of β blockers and mortality among hospital survivors of acute myocardial infarction without heart failure.
- Trial name
- NCT02786654
- Where
- United Kingdom
- Volunteers
- 179,810 people
- Sponsor
- University of Leeds
Cardiac Surgery Requiring Cardiopulmonary Bypass, Acute Kidney Injury
SIRAKI 02 Posthoc Analysis.
Our randomized controlled trial with 343 patients requiring non emergent cardiac surgery with a prolonged expected cardiopulmonary bypass (CPB) time (>90 minutes) demonstrated that the use of an extracorporeal blood purification…
- Conditions
- Cardiac Surgery Requiring Cardiopulmonary Bypass, Acute Kidney Injury, Chronic Kidney Disease(CKD), Kidney Failure, Acute
- Trial name
- OXI-SAFE-CEC (NCT06781294)
- Testing
- Extracorporeal Cytokine hemadsorption therapy
- Where
- Spain
- Volunteers
- 343 people
- Sponsor
- Hospital Universitari de Bellvitge
Acute Heart Failure, Dyspnea
Improving Diagnostic Accuracy for Acute Heart Failure
Acute heart failure is a common reason for emergency department visits and hospitalization, but the diagnosis can be challenging because of non-specific symptoms and signs.
- Conditions
- Acute Heart Failure, Dyspnea, Dyspnea; Cardiac
- Trial name
- INDICATE-HF (NCT04886128)
- Where
- United States
- Volunteers
- 2,469 people
- Sponsor
- Vanderbilt University Medical Center
Kidney Failure, Acute
Preventing Acute Renal Failure After Cardiac Surgery in High Risk Patients Using Sodium Bicarbonate Therapy
The purpose of this study is to determine whether sodium bicarbonate is effective in reducing kidney injury that may occur during cardiac surgery.
- Trial name
- PARACHUTE (NCT00522756)
- Testing
- Sodium bicarbonate, Sodium chloride
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Heart Failure, Congestive, Heart Decompensation
Longitudinal Registry for Advanced Heart Failure Patients
The purpose of this study is to gather information to better understand the characteristics, medical management techniques and outcomes of patients with chronic severe Heart Failure (HF).
- Trial name
- NCT00364416
- Testing
- Any treatment used to treat CHF
- Volunteers
- 1,466 people
- Sponsor
- Scios, Inc.
Acute Heart Failure (AHF), Decompensated Chronic Heart Failure
Assessment of Residual Congestion in Acute Decompensated Heart Failure
DESIGN: A prospective, multicenter, observational cohort study including 580 patients admitted for acute decompensated heart failure (ADHF).
- Trial name
- VExUS-AHF (NCT07682298)
- Where
- 3 sites in Denmark
- Volunteers
- 580 people
- Sponsor
- Aarhus University Hospital
Emergencies, Heart Diseases
Evaluate the Predictive Impact of the EHMRG
External validation of the EHMRG score for hospitalized patients with acute heart failure in the emergency department
- Trial name
- EHMRGscore (NCT05632263)
- Testing
- EHMRGscore
- Volunteers
- 1,500 people
- Sponsor
- University of Monastir