Clinical trials: Acute Cerebrovascular Disease
Delirium, Ischemic Stroke
CTSN Embolic Protection Trial
This is a prospective, multi-center, randomized effectiveness trial of the CardioGard Embolic Protection Cannula in high-risk valve surgery patients.
- Conditions
- Delirium, Ischemic Stroke, Acute Kidney Injury, Heart Valve Disease
- Trial name
- EMPRO (NCT06027788)
- Testing
- CardioGard Embolic Protection Cannula, Standard Aortic Cannula
- Where
- 24 sites in United States, Canada
- Volunteers
- 842 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Symptomatic Non-acute Intracranial Artery Occlusion, Ischemic Stroke
Randomized Clinical Trial of Endovascular Recanalization for Symptomatic Non-Acute Intracranial Artery Occlusion（REPAIR）
A multicenter, randomized, open-label, endpoint-blinded trial to compare the effects of endovascular recanalization plus aggressive medical management with aggressive medical management alone on stroke recurrence and mortality in…
- Trial name
- NCT07495969
- Testing
- Endovascular Recanalization Strategy, Aggressive Medical Management
- Where
- China
- Volunteers
- 286 people
- Sponsor
- Feng Gao
Stroke, Acute, Stroke, Ischemic
Endovascular Treatment With Versus Without Intravenous rhTNK-tPA in Stroke
The purpose of this trial is to investigate whether intravenous rhTNK-tPA prior to endovascular treatment can improve 90-day functional outcome of stroke patients with large vessel occlusion who are thrombolysis-eligible within…
- Trial name
- BRIDGE-TNK (NCT04733742)
- Testing
- rhTNK-tPA, Endovascular treatment
- Where
- 6 sites in China
- Volunteers
- 550 people
- Sponsor
- Xinqiao Hospital of Chongqing
Ischemic Stroke, Acute
Electroacupuncture on Modifying Inflammatory Levels of Cytokines and Metabolites in Stroke Patients.
The study will make an association between the diagnosis of traditional Chinese medicine that establishes that the syndrome of blood stagnation generates alteration in blood flow, vascular dysfunction, and damage to the…
- Trial name
- NCT05734976
- Testing
- electroacupuncture
- Where
- Taiwan
- Volunteers
- 17 people
- Sponsor
- China Medical University Hospital
Acute Ischemic Stroke
A Randomized, Controlled Trial to Evaluate the Safety and Effectiveness of the Route 92 Medical Reperfusion System (SUMMIT MAX)
The SUMMIT MAX study is a prospective, randomized, controlled, interventional clinical trial to evaluate the safety and effectiveness of the Route 92 Medical MonoPoint® Reperfusion System with the Hi Point 88 and HiPoint 70…
- Trial name
- NCT05018650
- Testing
- Route 92 Medical Reperfusion System
- Where
- 30 sites in United States, New Zealand
- Volunteers
- 250 people
- Sponsor
- Route 92 Medical, Inc.
Stroke, Rehabilitation
Effect of Technology Enriched Rehabilitation After Stroke
The Biomedical Engineering Dept, University of Strathclyde, co-creates rehabilitation technology. In 2023-2024 a clinical study (NCT06787768) was conducted to understand the feasibility of a multi-technology approach to…
- Trial name
- EFTERS (NCT07360613)
- Testing
- Technology Enriched Rehabilitation
- Volunteers
- 62 people
- Sponsor
- University of Strathclyde
Ischemic Stroke
Methanesulfonic Acid Cinepazide Injection for Treatment of Acute Cerebral Infarction
Using placebo as control, The purpose of this study is to evaluate the efficacy and safety of methanesulfonic acid cinepazide injection to relieve disabled degree of acute cerebral infarction patients, and explore the best safe…
- Trial name
- NCT01851759
- Testing
- cinepazide
- Where
- China
- Volunteers
- 288 people
- Sponsor
- Xijing Hospital
Cerebrovascular Accident
A Study to Evaluate the Effects of ONO-2506 Intravenous Infusion in Patients With Acute Ischemic Stroke
The primary objective of this study is to compare the efficacy of ONO-2506 versus placebo in neurological stroke outcome in patients with acute ischemic stroke.
- Trial name
- NCT00046761
- Testing
- ONO-2506
- Where
- 148 sites in United States, Canada
- Volunteers
- 1,320 people
- Sponsor
- Ono Pharma USA Inc
Stroke, Acute Ischemic, Albumin
Intra-arterial Albumin Infusion After Endovascular Therapy for Stroke Patients
The purpose of this study is to investigate the safety and feasibility of intra-arterial albumin infusion for patients with acute ischemic stroke after successful thrombectomy and to further explore the optimal dose of albumin…
- Conditions
- Stroke, Acute Ischemic, Albumin, Endovascular Procedures, Large Vessel Occlusion
- Trial name
- NCT05953623
- Testing
- Albumin
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Tianjin Huanhu Hospital
Stroke, Acute, Stroke, Ischemic
Personalized Patient and Caregiver Education After Stroke
This is a randomized pilot trial to evaluate the impact of a customizable stroke education app (vs standard of care discharge education) on patient satisfaction and education retention.
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke
- Trial name
- MyStroke (NCT05118503)
- Testing
- Customized education, Standard of care discharge education
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Pennsylvania
Acute Ischemic Stroke
A Study to Assess the Efficacy, Safety, and Pharmacokinetics of TB006 in Participants With Acute Ischemic Stroke
This multi-center, randomized, parallel-group, double-blind, placebo-controlled study will evaluate the efficacy and safety of TB006 in participants with an Acute Ischemic Stroke (AIS) event with 57 days of treatment.
- Trial name
- NCT05156827
- Testing
- TB006
- Sponsor
- TrueBinding, Inc.
Acute Ischemic Stroke
Safety and Efficacy of Remote Ischemic Conditioning in Patients With Severe Stenosis or Occlusion of Anterior Intracranial Circulation Vessels
The primary purpose of this study is to examine whether remote ischemic treatment can better the 90 - day neurological outcomes in acute ischemic stroke patients having severe stenosis or occlusion of anterior intracranial…
- Trial name
- RICASO (NCT06823128)
- Testing
- RIC, Guideline-based therapy
- Where
- China
- Volunteers
- 458 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Stroke, Ischemic
EEG Patterns in Patients With Acute Ischemic Stroke Resulted From Large Vessels Occlusion in the Anterior Circulation
Clinical deterioration is observing in up to forty percent of patients with acute ischemic stroke (AIS) due to large vessels occlusion.
- Trial name
- NCT04412434
- Testing
- Electroencephalography (EEG)
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- rambam62
Acute Ischemic Stroke, Posterior Circulation Brain Infarction
Posterior Circulation Clot Burden Score (Pc-CBS) Predicts Clinical Outcome After Acute Ischemic Stroke Related to Posterior Circulation Occlusions : An Externally Validated Radiological Score
Posterior circulation strokes (PCS) represent ~30% of all ischemic strokes, but existing prognostic tools are limited, especially for non-basilar artery occlusions.
- Conditions
- Acute Ischemic Stroke, Posterior Circulation Brain Infarction, Arterial Occlusion Disease
- Trial name
- PC-CBS (NCT07122934)
- Testing
- Assessment of cervico-cerebral arterial occlusion pattern
- Volunteers
- 1,828 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Ischemic Stroke, Atrial Fibrillation
Timing of Anticoagulation After Emergency Endovascular Therapy for Acute Ischemic Stroke With Atrial Fibrillation
This study evaluates the safety and efficacy of early versus delayed initiation of direct oral anticoagulants (DOACs) in patients with acute ischemic stroke related to atrial fibrillation after emergency endovascular therapy…
- Trial name
- TIMERS-1 (NCT07139301)
- Testing
- Early anticoagulation, Delayed anticoagulation
- Where
- 40 sites in China
- Volunteers
- 438 people
- Sponsor
- Capital Medical University
Stroke, Acute, Stroke, Complication
Feasibility of the mNIHSS in Surgical Patients
This prospective observational study will be assessing whether it is practical and feasible to use a stroke screening tool (the modified NHISS, mNIHSS) in an adult surgical population.
- Trial name
- NCT04044807
- Testing
- Modified National Institutes of Health Stroke Scale
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of British Columbia
Hypertensive Intracerebral Hemorrhage
Efficacy and Safety Study of Urapidil Alone or With Esmolol in Treating Acute Hypertensive Intracerebral Hemorrhage
The objective of this study is to investigate the efficacy and safety of urapidil monotherapy versus the combination of esmolol in treating participants with acute hypertensive intracerebral hemorrhage through a prospective…
- Trial name
- NCT06635707
- Testing
- Urapidil, Urapidil and Esmolol
- Volunteers
- 600 people
- Sponsor
- Qianfoshan Hospital
Acute Ischemic Stroke, Nursing
Feasibility and Effectiveness of Rehabilitation Nursing for Acute Stroke
In the clinical setting, it is difficult to obtain effective rehabilitation during the acute phase, the reasons may include insufficient awareness of early rehabilitation due mainly to a limitation in number and variety of…
- Trial name
- NCT04402736
- Testing
- The modified Barthel Index-based rehabilitation nursing program, Usual care
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ischemic Stroke
The Correlation Between Outcome and Infarct Growth in Patients With Acute Ischemic Stroke
Previous research has shown there wasn't inevitable relationship between mismatch area and infarct growth according to Volumetric-subtraction mismatch volume.The recently published on Stroke paper has proposed Coregistration…
- Trial name
- COIG (NCT01376609)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Hospital of Traditional Chinese Medicine
Ischemic Stroke, Hemorrhagic Stroke
Safety of Autologous M2 Macrophage in Treatment of Non-Acute Stroke Patients
The purpose of this study is to determine whether M2 macrophages are safe and feasible in the treatment of non-acute stroke patients
- Trial name
- NCT01845350
- Testing
- M2 macrophage introduction
- Where
- Russia
- Volunteers
- 13 people
- Sponsor
- Siberian Branch of the Russian Academy of Medical Sciences
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