Clinical trials: Acute Cholangitis
Cholangitis Acute, Biliary Tract Diseases
Antimicrobial Resistance in Acute Cholangitis
This study prospectively explores antimicrobial resistance in patients with acute cholangitis undergoing ERCP procedures. By analyzing patient profiles, microbial cultures, and treatment outcomes, the current study seeks to…
- Conditions
- Cholangitis Acute, Biliary Tract Diseases, Jaundice; Malignant, Jaundice, Obstructive
- Trial name
- ARISE (NCT06197984)
- Testing
- ERCP
- Where
- Romania
- Volunteers
- 1,435 people
- Sponsor
- Emergency County Hospital Pius Brinzeu; Timisoara, Romania
Cholangitis, Post-ERCP Acute Pancreatitis
Optimal Placement Duration of Pancreatic Duct Stent
A randomized controlled trial to determine the optimal placement duration of pancreatic duct stents (PDS) inserted during ERCP: 2 vs 4 weeks
- Conditions
- Cholangitis, Post-ERCP Acute Pancreatitis, Stent Dislodgement
- Trial name
- NCT04691674
- Testing
- Endoscopy
- Where
- South Korea
- Volunteers
- 122 people
- Sponsor
- DongGuk University
Acute Cholangitis
Is Short Antibiotherapy Duration After Drainage Suitable for Patients Admitted in Intensive Care Medicine With a Severe Acute Cholangitis?
Acute cholangitis (AC) occurs when biliary stenosis, due to various benign causes (often gallstones) or the presence of a tumour, leads to cholestasis and biliary infection.
- Trial name
- CASCAD (NCT04173286)
- Testing
- antibiotherapy
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Nantes University Hospital
Acute Cholangitis
Urgent (<24 Hours) Versus Early (24 to 48 Hours) ERCP for Patients With Mild and Moderate Acute Cholangitis
Acute Cholangitis is an emergency associated with significant morbidity and mortality which require prompt recognition and treatment. The decompression of biliary tree along with antibiotics are mainstay of therapy.
- Trial name
- NCT05920954
- Testing
- ERCP
- Where
- India
- Volunteers
- 304 people
- Sponsor
- Asian Institute of Gastroenterology, India
Severe Acute Cholangitis
ERCP Versus PTBD for Severe Acute Cholangitis Caused by Bile Duct Stones
This study is a prospective, randomized controlled trial designed to compare the effectiveness and safety of endoscopic retrograde cholangiopancreatography (ERCP) with percutaneous transhepatic biliary drainage (PTBD) for the…
- Trial name
- NCT07064980
- Testing
- Endoscopic Retrograde Cholangiopancreatography, Percutaneous Transhepatic Biliary Drainage
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Wuhan Integrated Traditional Chinese and Western Medicine Hospital
Choledocholithiasis With Acute Cholangitis
Efficacy and Safety of Single-session Endoscopic Stone Extraction
This is a retrospective study, including approximately 600 patients with acute cholangitis accompanied with choledocholithiasis, who treated with single-session or two-session endoscopic stone extraction at Beijing friendship…
- Trial name
- NCT06327126
- Testing
- two-session ERCP, single-session ERCP
- Where
- China
- Volunteers
- 563 people
- Sponsor
- Beijing Friendship Hospital
Conscious Sedation Failure During Procedure
Ketofol Versus Propofol in Urgent ERCP for Acute Cholangitis
Endoscopic Retrograde Cholangiopancreatography (ERCP) is a lengthy and uncomfortable procedure that requires adequate sedation. Propofol is the commonly used sedative during ERCP.
- Trial name
- NCT04997967
- Testing
- Ketamine/Propofol, Propofol
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Cholangitis
Impact of Positive Bile Cultures on Plastic Biliary Stent Exchange
This prospective, unicenter, randomized controlled trial evaluates whether a positive bile culture at index ERCP with plastic stenting identifies patients who benefit from earlier stent exchange.
- Trial name
- TEMPEST 2 (NCT07379749)
- Testing
- stent exchange, Scheduled biliary stent exchange at one month
- Where
- Romania
- Volunteers
- 140 people
- Sponsor
- Clinical Hospital Colentina
Acute Cholecystitis, Biliary Colic
Transient ECG Changes in Patients With Acute Biliary Disease
Background: The importance of ischemic ECG changes including St segment elevation, ST segment depression or T wave inversion that indicate myocardial ischemia are well established and require appropriate investigation and…
- Conditions
- Acute Cholecystitis, Biliary Colic, Acute Cholangitis
- Trial name
- NCT01706068
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Ziv Hospital
Choledocholithiasis, Choledocholithiasis With Acute Cholangitis
Spanish Registry of Quality Indicators and Adverse Events of Endoscopic Retrograde Cholangiopancreatography
Endoscopic retrograde cholangiopancreatography (ERCP) is a technique which combines endoscopic and radiological vision and allows for therapeutic procedures on pathologies of the pancreas and bile duct.
- Conditions
- Choledocholithiasis, Choledocholithiasis With Acute Cholangitis, Cholangiocarcinoma, Sclerosing Cholangitis
- Trial name
- NCT06670547
- Testing
- Endoscopic retrograde cholangiopancreatography (ERCP)
- Volunteers
- 3,000 people
- Sponsor
- Germans Trias i Pujol Hospital
Cholangitis Acute, Recurrence
Fecal Microbiota Transplant vs Standard Treatment for Recurrent Non-Obstructive Cholangitis
Patients with abnormalities of the biliary tract (the system that connects the liver to the small intestine and allows bile to flow) are prone to the development of strictures, dilations, or other problems that impede bile flow…
- Trial name
- COLANBIOTA (NCT07509346)
- Testing
- Fecal Microbial Transplantation
- Volunteers
- 44 people
- Sponsor
- Puerta de Hierro University Hospital
Sepsis, Community-acquired Pneumonia
A Phase 2 Study Evaluating Efficacy, Safety and Tolerability of Different Doses and Regimens of Allocetra-OTS for the Treatment of Organ Failure in Adult Sepsis Patients
A Phase 2, Multi-Center, Randomized, Placebo-Controlled, Dose-Finding Study Evaluating Efficacy, Safety and Tolerability of Different Doses and Regimens of Allocetra-OTS for the Treatment of Organ Failure in Adult Sepsis Patients
- Conditions
- Sepsis, Community-acquired Pneumonia, Urinary Tract Infections, Cholecystitis, Acute
- Trial name
- NCT04612413
- Testing
- Allocetra-OTS
- Where
- 31 sites in Belgium, France and 3 more
- Volunteers
- 148 people
- Sponsor
- Enlivex Therapeutics Ltd.
Post-ERCP Acute Pancreatitis, Cholangitis
ERCP in Super-aged Patients Considering Difficult Cannulation: Challenges and Adverse Events
Today 11 percent of China's population is over the age of 65, and according to United Nations, it will take China just 20 years for the proportion of the elderly population to double to 25%.
- Trial name
- NCT03771547
- Testing
- ERCP
- Where
- China
- Volunteers
- 614 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Biliary Tract Infection
Ultrasound-guided Biliary Drainage Improving Prognosis in the Frail and High Risk Elderly Patients
Acute biliary tract infection is a kind of disease caused by bacteria of biliary tract infection, mainly including acute cholecystitis and acute cholangitis, especially acute obstructive suppurative cholangitis (AOSC),which can…
- Trial name
- NCT06960486
- Testing
- Bedside ultrasound-guided real-time biliary drainage, traditional appointment ultrasound
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Hebei Medical University
Cholangitis Infective, Elderly Person
Outcomes of Elderly Patients Admitted to the Intensive Care Unit With Severe Acute Cholangitis
The aging of the population goes along with an increased demand for intensive care among very elderly patients (above 75-80 years old). At the same time, there is a decline in the supply of intensive care units (ICU).
- Trial name
- ANGIOCHOLREA (NCT03831529)
- Where
- 2 sites in France
- Volunteers
- 204 people
- Sponsor
- Central Hospital, Nancy, France
Cholangitis
Short-course Antibiotics vs Standard Course Antibiotics in Patients With Cholangitis
The goal of this multicentre randomized controlled trial is to investigate if a very short-course of antibiotics (1 day) for cholangitis after adequate drainage is non-inferior with respect to clinical cure in comparison with a…
- Trial name
- COBRA (NCT05750966)
- Testing
- cefrtriaxone, gentamicin, cefuroxim, ciprofloxin or other antibiotics according to local guideline (24 hours), cefrtriaxone, gentamicin, cefuroxim, ciprofloxin or other antibiotics according to local guideline (4 to 7 days)
- Where
- 31 sites in Netherlands
- Volunteers
- 410 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Cholangitis, Biliary Drainage
Composite Index for Outcome Burden in Acute Cholangitis
The goal of this retrospective observational study is to construct a composite outcome to measure the success of treatment in patients who are presenting with acute cholangitis (blockage and infection of bile ducts) and…
- Trial name
- CHOLINDEX-01 (NCT07667166)
- Testing
- Biliary drainage
- Where
- India
- Volunteers
- 514 people
- Sponsor
- Asian Institute of Gastroenterology, India
Biliary Atresia, Kasai Portoenterostomy Status, Cholangitis
Cholangitis Definition and Treatment After Kasai Hepatoportoenterostomy for Biliary Atresia: TRACK-BA Study (TRacking Cholangitis Post Kasai in Biliary Atresia)
Biliary atresia is a rare liver disease affecting newborns. In those babies bile ducts are blocked, and bile cannot flow from the liver to the intestines.
- Trial name
- TRACK-BA (NCT07129655)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Geneva
Ampullary Cancer, Duodenal Cancer
Interventional Endoscopy Database for Pancreatico-biliary, Gastrointestinal and Esophageal Disorders
Our institution performs therapeutic ERCP (Endoscopic retrograde cholangiopancreatography ), Endoscopic Ultrasound (EUS) and Interventional Endoscopy in around 1000 patients a year.
- Conditions
- Ampullary Cancer, Duodenal Cancer, Bile Duct Cancer, Bile Duct Disorders
- Trial name
- NCT01438385
- Testing
- Interventional Endoscopy
- Where
- United States
- Volunteers
- 12,000 people
- Sponsor
- Weill Medical College of Cornell University
Pneumonia, Acute Pyelonephritis
NGS-Based Assay of Blood Samples of Sepsis Patients for Rapid Bacterial Identification
Rapid detection of microorganisms is a promising approach towards early administration of appropriate antibiotics for sepsis. This study aims to investigate the potential of a new NGS platform for the rapid diagnosis of…
- Conditions
- Pneumonia, Acute Pyelonephritis, Bacteremia, Biliary Tract Infection
- Trial name
- BIOARTE (NCT06141395)
- Testing
- NGS-based assay for bacterial identification
- Where
- 4 sites in Greece
- Volunteers
- 100 people
- Sponsor
- Hellenic Institute for the Study of Sepsis