Clinical trials: Acute Conditions
Pain, Acute, Analgesia
Preanesthetic Analgesia/Nociception Index (ANI) and Propofol Injection Pain
Recently, Analgesia Nociception Index (ANI) has been evaluated for objectively measuring peri-operative pain and to guide intra-operative opioid administration during various surgeries.
- Conditions
- Pain, Acute, Analgesia, Nociceptive Pain
- Trial name
- NCT05049577
- Testing
- Analgesia/Nociception Index (ANI)
- Where
- South Korea
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Acute Pain
Vasopressin and Pain Perception in the Brain
The feeling of pain is not just a sensory experience, but is also influenced by emotions, beliefs and expectations, making pain a highly subjective experience.
- Trial name
- NCT03446456
- Testing
- Arginine vasopressin, Saline, Observational learning
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Leukemia, Acute Leukemia
Strength Training Exercise in Pediatric Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (STEP-ALL)
Acute lymphoblastic leukemia (ALL) is the most common cancer in children and, along with lymphoblastic lymphoma, represents the most common group of childhood lymphoid malignancies.
- Conditions
- Leukemia, Acute Leukemia, Acute Lymphoid Leukemia, Lymphoblastic Lymphoma
- Trial name
- STEP-ALL (NCT07634653)
- Testing
- Exercises
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Acute Diarrheal Disease, Acute Respiratory Infection
"Alcohol Based Hand Sanitizers for the Prevention of Acute Diarrheal Disease and Acute Respiratory Infection in Children Under 5 Attending Childcare Centers in Bogotá, Cundinamarca and Tolima, in Colombia: a Cluster Randomized Control Trial"
The purpose of this study is to conduct a Randomized Control Trial (RCT) in a developing country setting in order to evaluate the role of alcohol based hand sanitizers (ABHS) in preventing the transmission of infectious diseases…
- Trial name
- NCT00963391
- Testing
- ABHS use
- Where
- Colombia
- Volunteers
- 1,727 people, healthy volunteers welcome
- Sponsor
- Fundación Santa Fe de Bogota
Autoimmune Encephalitis (AE), Acute Disseminated Encephalomyelitis
OPM- MEG in Non-immune And iMmune-medIated Neurological Disease
Over the past 20 years, doctors have gotten much better at spotting and treating brain conditions caused by the immune system attacking the body. These include illnesses like autoimmune encephalitis, ADEM, and multiple sclerosis.
- Conditions
- Autoimmune Encephalitis (AE), Acute Disseminated Encephalomyelitis, Multiple Sclerosis
- Trial name
- O-MEG-A-MIND (NCT07689682)
- Testing
- OPM- Magnetoencephalography
- Where
- 2 sites in United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aston University
Venous Cannulation Pain, Total Knee Arthroplasty
Feasibility Study of Peripheral Venous Cannulation Pain in Predicting Acute Pain After Total Knee Arthroplasty
The goal of this prospective observational study is to explore the feasibility of preoperative peripheral venous cannulation pain score in predicting acute pain after total knee arthroplasty, including resting pain and…
- Conditions
- Venous Cannulation Pain, Total Knee Arthroplasty, Movement-evoked Pain, Acute Pain
- Trial name
- NCT06002724
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Pain, Acute, Anesthesia, Local
Intracervical Anesthesia and Pain Associated With Intrauterine Contraceptive Insertion
The primary aim of our study is to evaluate the effect of intracervical anesthesia on pain scores immediately following levonorgestrel-releasing intrauterine system (LNG-IUS) insertion in nulligravida women.
- Conditions
- Pain, Acute, Anesthesia, Local, IUD Insertion Complication
- Trial name
- NCT03111342
- Testing
- Anesthesia, Dry-needling
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Sleep Deprivation
Study of Single Doses of HBS-104 in Acutely Sleep-deprived Healthy Participants
This is a study to evaluate the pharmacodynamic effects, safety, tolerability, and pharmacokinetics of HBS-104 in acutely sleep-deprived healthy adult participants.
- Trial name
- NCT07848659
- Testing
- HBS-104
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Harmony Biosciences Management, Inc.
Sepsis
HO-1/CREB3 Modulates Golgi Stress in Patients With Sepsis
This study was an ambispective observational cohort study that included sepsis patients hospitalized in the Intensive care unit (ICU) of the Nankai Hospital. All patients met the consensus criteria of sepsis-3.
- Trial name
- NCT06045780
- Testing
- nothing
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tianjin Nankai Hospital
COVID-19
Fascial Tissue Response to Manual Therapy: Implications in Long COVID-19
According to the World Health Organization (WHO), as of mid-September 2022, more than 21 million Brazilians have recovered from COVID-19.
- Trial name
- NCT06348186
- Testing
- Guidebook, Guidebook and Myofascial Reorganization® (RMF).
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of the State of Santa Catarina
Agitated; State, Acute Reaction to Stress
Preemptive Chlorepheniramine Maleate Reducing Postoperative Agitation
The aim of the study is to identify the role of preoperative chlorepheniramine maleate on alleviating or reducing the severity of postoperative agitation following FESS procedures.
- Trial name
- NCT04293081
- Testing
- Preemptive chlorepheniramine maleate intravenous injection, normal saline
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Acute Low Back Pain
Efficacy and Safety of Fixed-dose Combination of Etoricoxib/Tramadol vs Acetaminophen/Tramadol for Acute Low Back Pain
Phase IIIb, longitudinal, multicenter, randomized, open-label clinical trial to evaluate the efficacy and safety of the fixed-dose combination of etoricoxib 90 mg and tramadol 50 mg compared with fixed-dose therapy of…
- Trial name
- NCT04968158
- Testing
- Etoricoxib 90 mg / Tramadol 50 mg, Acetaminophen 325 mg / Tramadol 37.5 mg
- Where
- Mexico
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Acute Ischemic Stroke
Predictive Study of Serum Endocan for Hemorrhagic Transformation After Reperfusion Therapies in Acute Ischemic Stroke
Stroke is the second largest cause of death globally after ischemic heart disease.Of the total number of prevalent strokes, 84.4% are ischemic.
- Trial name
- NCT05228080
- Testing
- enzyme-linked immunosorbent assay(ELISA)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
ALS
Adenosine 2A Receptor Antagonism and AIH in ALS
The purpose of this research study is to determine the effects of a medication, istradefylline, in conjunction with breathing air with reduced oxygen for short periods of time (called acute intermittent hypoxia, or AIH), on…
- Trial name
- NCT05377424
- Testing
- Consume 20mg of istradefylline, Low Oxygen therapy
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Florida
COVID-19, SARS-CoV2 Infection
COVAG - Covid-19 Antigen Study - the Diagnostic Efficacy of SARS-CoV-2 Rapid Detection Tests
The aim of the COVAG study (Covid-19 Antigen study) is to assess the diagnostic efficacy of two of the most used rapid antigen tests (Roche \& Abbott).
- Conditions
- COVID-19, SARS-CoV2 Infection, SARS (Disease)
- Trial name
- COVAG (NCT05074017)
- Testing
- 3 nasopharyngeal swab
- Where
- 2 sites in Germany
- Volunteers
- 2,222 people, healthy volunteers welcome
- Sponsor
- Synlab Holding Deutschland GmbH
Nephrectomy
Systemic Effects of Lidocaine Infusion for TAP Block Catheter
Lidocaine is a local anesthetic that is usually used for nerve blocks to sensory/motor blockade. However, lidocaine can also been given intravenously, and it has been shown that this method can be used to help alleviate chronic…
- Trial name
- NCT03971708
- Testing
- Lidocaine, Ropivacaine
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Laparoscopic Surgery, Post Operative Pain, Acute
Maneuvers to Reduce Laparoscopic Pain
Laparoscopic surgery has revolutionized surgical care by reducing morbidity and improving post operative recovery. Laparoscopic surgery involves the use of carbon dioxide for insufflation to achieve optimal visualization.
- Conditions
- Laparoscopic Surgery, Post Operative Pain, Acute, Pneumoperitoneum
- Trial name
- NCT07583433
- Testing
- Smoke Evacuation Group, Recruitment Breath Group, Control Group
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Ischemia-Reperfusion Injury
Adenosine Receptors Influence Ischemia-Reperfusion Injury
Ischemic preconditioning is defined as the development of tolerance to ischemia-reperfusion injury by a previous short bout of ischemia resulting in a marked reduction in infarct size.
- Trial name
- NCT00184847
- Testing
- acetylcholine, twenty minutes of forearm ischemia, three 5-minute periods of forearm ischemia
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Long Covid19
Diaphragm Dysfunction After COVID-19 as Determined by Dynamic Chest Radiography
Dynamic chest radiography (DCR) is a rapid and easily performed technique that captures real-time continuous images of the moving chest.
- Trial name
- DD-COVID-19 (NCT06175455)
- Testing
- dynamic chest radiography
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Post Operative Pain, Acute
A Comparative Study Between Ultrasound Guided Thoracic Paravertebral Block VS Serrartus Anterior Muscle Block in VATS as Regard Their Effectiveness in Post-operative Analgesia
A comparative study between ultrasound guided thoracic paravertebral block VS ultrasound guided serrartus anterior muscle block in video-assisted thoracoscopic surgeries as regard their effectiveness in post-operative analgesia
- Trial name
- NCT05971368
- Testing
- thoracic paravertebal block, serratus anterior muscle block
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
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